Topiramate Tablets USP 15mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Topiramate Dosage & Rx Info | Topiramate Uses, Side Effects Topiramate: Indications, Side Effects, Warnings, Topiramate-Drug Information –Taj Pharma, Topiramate dose Taj pharmaceuticals Topiramate interactions, Taj Pharmaceutical Topiramate contraindications, Topiramate price, Topiramate Taj Pharma Topiramate SmPC-Taj Pharma Stay connected to all updated on Topiramate Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Lamotrigine Tablets 25mg, 50mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lamotrigine Dosage & Rx Info | Lamotrigine Uses, Side Effects Lamotrigine: Indications, Side Effects, Warnings, Lamotrigine-Drug Information –Taj Pharma, Lamotrigine dose Taj pharmaceuticals Lamotrigine interactions, Taj Pharmaceutical Lamotrigine contraindications, Lamotrigine price, Lamotrigine Taj Pharma Lamotrigine SmPC- Taj Pharma Stay connected to all updated on Lamotrigine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Topiramate tablets ip 25mg, 50mg, 100mg taj pharma smpcTajPharmaQC
Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma Dosage & Rx Info | Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma Uses, Side Effects, Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma Indications, Side Effects, Warnings, Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma - Drug Information – Taj Pharma, Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma dose Taj pharmaceuticals Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma interactions, Taj Pharmaceutical Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma contraindications, Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma price, Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma Taj Pharma Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma SMPC- Taj Pharma on Topiramate Tablets IP 25mg; 50mg SmPC
Lamotrigine Dispersible Tablets Taj Pharma SmPCTajPharmaQC
Lamotrigine Dispersible Tablets 25mg, 50mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lamotrigine Dosage & Rx Info | Lamotrigine Uses, Side Effects Lamotrigine: Indications, Side Effects, Warnings, Lamotrigine-Drug Information –Taj Pharma, Lamotrigine dose Taj pharmaceuticals Lamotrigine interactions, Taj Pharmaceutical Lamotrigine contraindications, Lamotrigine price, Lamotrigine Taj Pharma Lamotrigine SmPC- Taj Pharma Stay connected to all updated on Lamotrigine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Dobutamine Injection USP Taj Pharma PILTajPharmaQC
Dobutamine Injection USP 250mg/5ml, 250mg/20ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Dobutamine Dosage & Rx Info | Dobutamine Uses, Side Effects Dobutamine: Indications, Side Effects, Warnings, Dobutamine -Drug Information –Taj Pharma, Dobutamine dose Taj pharmaceuticals Dobutamine interactions, Taj Pharmaceutical Dobutamine contraindications, Dobutamine price, Dobutamine Taj Pharma Dobutamine SmPC-Taj Pharma Stay connected to all updated on Dobutamine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Phenytoin sodium 100 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Phenytoin Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Phenytoin Dosage & Rx Info | Phenytoin Uses, Side Effects -: Indications, Side Effects, Warnings, Phenytoin - Drug Information - Taj Pharma, Phenytoin dose Taj pharmaceuticals Phenytoin interactions, Taj Pharmaceutical Phenytoin contraindications, Phenytoin price, Phenytoin Taj Pharma Phenytoin 100mg Film Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Phenytoin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Domperidone 10mg tablets smpc taj pharmaceuticalsTaj Pharma
Domperidone Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Domperidone Dosage & Rx Info | Domperidone Uses, Side Effects -: Indications, Side Effects, Warnings, Domperidone - Drug Information - Taj Pharma, Domperidone dose Taj pharmaceuticals Domperidone interactions, Taj Pharmaceutical Domperidone contraindications, Domperidone price, Domperidone Taj Pharma Domperidone 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Domperidone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Metformin hydrochloride Tablets Taj Pharma SmPCTajPharmaQC
Metformin hydrochloride ER tablets 500mg/750mg/1000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Metformin hydrochloride Dosage & Rx Info | Metformin hydrochloride Uses, Side Effects Metformin hydrochloride: Indications, Side Effects, Warnings, Metformin hydrochloride-Drug Information –Taj Pharma, Metformin hydrochloride dose Taj pharmaceuticals Metformin hydrochloride interactions, Taj Pharmaceutical Metformin hydrochloride contraindications, Metformin hydrochloride price, Metformin hydrochloride Taj Pharma Metformin hydrochloride SmPC- Taj Pharma Stay connected to all updated on Metformin hydrochloride Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Topiramate Tablets USP 15mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Topiramate Dosage & Rx Info | Topiramate Uses, Side Effects Topiramate: Indications, Side Effects, Warnings, Topiramate-Drug Information –Taj Pharma, Topiramate dose Taj pharmaceuticals Topiramate interactions, Taj Pharmaceutical Topiramate contraindications, Topiramate price, Topiramate Taj Pharma Topiramate SmPC-Taj Pharma Stay connected to all updated on Topiramate Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Lamotrigine Tablets 25mg, 50mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lamotrigine Dosage & Rx Info | Lamotrigine Uses, Side Effects Lamotrigine: Indications, Side Effects, Warnings, Lamotrigine-Drug Information –Taj Pharma, Lamotrigine dose Taj pharmaceuticals Lamotrigine interactions, Taj Pharmaceutical Lamotrigine contraindications, Lamotrigine price, Lamotrigine Taj Pharma Lamotrigine SmPC- Taj Pharma Stay connected to all updated on Lamotrigine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Topiramate tablets ip 25mg, 50mg, 100mg taj pharma smpcTajPharmaQC
Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma Dosage & Rx Info | Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma Uses, Side Effects, Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma Indications, Side Effects, Warnings, Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma - Drug Information – Taj Pharma, Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma dose Taj pharmaceuticals Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma interactions, Taj Pharmaceutical Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma contraindications, Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma price, Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma Taj Pharma Topiramate Tablets IP 25mg; 50mg; 100mg (Topamet) Taj Pharma SMPC- Taj Pharma on Topiramate Tablets IP 25mg; 50mg SmPC
Lamotrigine Dispersible Tablets Taj Pharma SmPCTajPharmaQC
Lamotrigine Dispersible Tablets 25mg, 50mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lamotrigine Dosage & Rx Info | Lamotrigine Uses, Side Effects Lamotrigine: Indications, Side Effects, Warnings, Lamotrigine-Drug Information –Taj Pharma, Lamotrigine dose Taj pharmaceuticals Lamotrigine interactions, Taj Pharmaceutical Lamotrigine contraindications, Lamotrigine price, Lamotrigine Taj Pharma Lamotrigine SmPC- Taj Pharma Stay connected to all updated on Lamotrigine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Dobutamine Injection USP Taj Pharma PILTajPharmaQC
Dobutamine Injection USP 250mg/5ml, 250mg/20ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Dobutamine Dosage & Rx Info | Dobutamine Uses, Side Effects Dobutamine: Indications, Side Effects, Warnings, Dobutamine -Drug Information –Taj Pharma, Dobutamine dose Taj pharmaceuticals Dobutamine interactions, Taj Pharmaceutical Dobutamine contraindications, Dobutamine price, Dobutamine Taj Pharma Dobutamine SmPC-Taj Pharma Stay connected to all updated on Dobutamine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Phenytoin sodium 100 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Phenytoin Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Phenytoin Dosage & Rx Info | Phenytoin Uses, Side Effects -: Indications, Side Effects, Warnings, Phenytoin - Drug Information - Taj Pharma, Phenytoin dose Taj pharmaceuticals Phenytoin interactions, Taj Pharmaceutical Phenytoin contraindications, Phenytoin price, Phenytoin Taj Pharma Phenytoin 100mg Film Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Phenytoin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Domperidone 10mg tablets smpc taj pharmaceuticalsTaj Pharma
Domperidone Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Domperidone Dosage & Rx Info | Domperidone Uses, Side Effects -: Indications, Side Effects, Warnings, Domperidone - Drug Information - Taj Pharma, Domperidone dose Taj pharmaceuticals Domperidone interactions, Taj Pharmaceutical Domperidone contraindications, Domperidone price, Domperidone Taj Pharma Domperidone 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Domperidone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Metformin hydrochloride Tablets Taj Pharma SmPCTajPharmaQC
Metformin hydrochloride ER tablets 500mg/750mg/1000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Metformin hydrochloride Dosage & Rx Info | Metformin hydrochloride Uses, Side Effects Metformin hydrochloride: Indications, Side Effects, Warnings, Metformin hydrochloride-Drug Information –Taj Pharma, Metformin hydrochloride dose Taj pharmaceuticals Metformin hydrochloride interactions, Taj Pharmaceutical Metformin hydrochloride contraindications, Metformin hydrochloride price, Metformin hydrochloride Taj Pharma Metformin hydrochloride SmPC- Taj Pharma Stay connected to all updated on Metformin hydrochloride Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Pyrimethamine 25 mg tablets smpc taj pharmaceuticalsTaj Pharma
Pyrimethamine - Drug Information - Taj Pharma, Pyrimethamine dose Taj pharmaceuticals Pyrimethamine interactions, Taj Pharmaceutical Pyrimethamine contraindications, Pyrimethamine price, Pyrimethamine Taj Pharma Pyrimethamine 25 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Pyrimethamine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Metoclopramide Injection USP Taj Pharma SmPCTajPharmaQC
Metoclopramide Injection USP 10mg/2ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Metoclopramide Dosage & Rx Info | Metoclopramide Uses, Side Effects Metoclopramide: Indications, Side Effects, Warnings, Metoclopramide -Drug Information –Taj Pharma, Metoclopramide dose Taj pharmaceuticals Metoclopramide interactions, Taj Pharmaceutical Metoclopramide contraindications, Metoclopramide price, Metoclopramide Taj Pharma Metoclopramide SmPC-Taj Pharma Stay connected to all updated on Metoclopramide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Temozolomide Capsules 5mg/20mg/100mg/140mg/180mg/250mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Temozolomide Dosage & Rx Info | Temozolomide Uses, Side Effects Temozolomide: Indications, Side Effects, Warnings, Temozolomide -Drug Information –Taj Pharma, Temozolomide dose Taj pharmaceuticals Temozolomide interactions, Taj Pharmaceutical Temozolomide contraindications, Temozolomide price, Temozolomide Taj Pharma Temozolomide SmPC-Taj Pharma Stay connected to all updated on Temozolomide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Aprepitant 80mg, 125 mg hard capsules smpc taj pharmaceuticalsTaj Pharma
Aprepitant - Drug Information - Taj Pharma, Aprepitant dose Taj pharmaceuticals Aprepitant interactions, Taj Pharmaceutical Aprepitant contraindications, Aprepitant price, Aprepitant Taj Pharma Cancer, oncologyAprepitant 80mg, 125 mg hard capsules SMPC- Taj Pharma . Stay connected to all updated on Aprepitant Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Lacosamide Tablets 50mg/100mg/150mg/200mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lacosamide Dosage & Rx Info | Lacosamide Uses, Side Effects Lacosamide : Indications, Side Effects, Warnings, Lacosamide-Drug Information –Taj Pharma, Lacosamide dose Taj pharmaceuticals Lacosamide interactions, Taj Pharmaceutical Lacosamide contraindications, Lacosamide price, Lacosamide Taj Pharma Lacosamide SmPC-Taj Pharma Stay connected to all updated on Lacosamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Ranolazine Tablets 500mg, 750mg, 1000mg Taj Pharma SmPCTajPharmaQC
Ranolazine Tablets 500mg, 750mg, 1000mg Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ranolazine Dosage & Rx Info | Ranolazine Uses, Side Effects, Anti-anginal, Ranolazine : Indications, Side Effects, Warnings, Ranolazine - Drug Information - Taj Pharma, Ranolazine dose Taj pharmaceuticals Ranolazine interactions, Taj Pharmaceutical Ranolazine contraindications, Ranolazine price, Ranolazine Taj Pharma Anti-anginal Ranolazine Powder for Tablets SmPC.
Atomoxetine Capsules USP Taj Pharma SmPCTajPharmaQC
Atomoxetine Capsules USP 10mg/18mg/25mg/40mg/60mg/80mg/100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Atomoxetine Dosage & Rx Info | Atomoxetine Uses, Side Effects Atomoxetine: Indications, Side Effects, Warnings, Atomoxetine -Drug Information –Taj Pharma, Atomoxetine dose Taj pharmaceuticals Atomoxetine interactions, Taj Pharmaceutical Atomoxetine contraindications, Atomoxetine price, Atomoxetine Taj Pharma Atomoxetine SmPC-Taj Pharma Stay connected to all updated on Atomoxetine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Cisplatin for Injection Taj Pharma SmPCTajPharmaQC
Cisplatin Injection BP 10mg/10ml, 10mg/20ml, 50mg/50ml, 100mg/100ml and 200mg/200ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cisplatin Dosage & Rx Info | Cisplatin Uses, Side Effects Cisplatin: Indications, Side Effects, Warnings, Cisplatin -Drug Information –Taj Pharma, Cisplatin dose Taj pharmaceuticals Cisplatin interactions, Taj Pharmaceutical Cisplatin contraindications, Cisplatin price, Cisplatin Taj Pharma Cisplatin SmPC-Taj Pharma Stay connected to all updated on Cisplatin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Bleomycin for Injection Taj Pharma SmPCTajPharmaQC
Bleomycin for Injection 15 Units, 30 Units Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Bleomycin Dosage & Rx Info | Bleomycin Uses, Side Effects Bleomycin: Indications, Side Effects, Warnings, Bleomycin -Drug Information –Taj Pharma, Bleomycin dose Taj pharmaceuticals Bleomycin interactions, Taj Pharmaceutical Bleomycin contraindications, Bleomycin price, Bleomycin Taj Pharma Bleomycin SmPC-Taj Pharma Stay connected to all updated on Bleomycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Imipramine tablets bp 25mg smpc taj pharmaceuticalsTaj Pharma
IMIPRAMINE Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, IMIPRAMINE Dosage & Rx Info | IMIPRAMINE Uses, Side Effects -: Indications, Side Effects, Warnings, IMIPRAMINE - Drug Information - Taj Pharma, IMIPRAMINE dose Taj pharmaceuticals IMIPRAMINE interactions, Taj Pharmaceutical IMIPRAMINE contraindications, IMIPRAMINE price, IMIPRAMINE Taj Pharma IMIPRAMINE TABLETS BP 25mg SMPC- Taj Pharma . Stay connected to all updated on IMIPRAMINE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Bortezomib for Injection 1mg/2mg/3.5mg Taj Pharma PILTajPharmaQC
Bortezomib for Injection 1mg/2mg/3.5mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Bortezomib Dosage & Rx Info | Bortezomib Uses, Side Effects Bortezomib: Indications, Side Effects, Warnings, Bortezomib -Drug Information –Taj Pharma, Bortezomib does Taj pharmaceuticals Bortezomib interactions, Taj Pharmaceutical Bortezomib contraindications, Bortezomib price, Bortezomib Taj Pharma Bortezomib SmPC-Taj Pharma Stay connected to all updated on Bortezomib Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Cytarabine Injection BP Taj Pharma SmPCTajPharmaQC
Cytarabine Injection BP 100mg/1ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cytarabine Dosage & Rx Info | Cytarabine Uses, Side Effects Cytarabine: Indications, Side Effects, Warnings, Cytarabine -Drug Information –Taj Pharma, Cytarabine dose Taj pharmaceuticals Cytarabine interactions, Taj Pharmaceutical Cytarabine contraindications, Cytarabine price, Cytarabine Taj Pharma Cytarabine SmPC-Taj Pharma Stay connected to all updated on Cytarabine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Topotecan 1 mg concentrate for solution for infusion smpc taj pharmaceuticalsTaj Pharma
TOPOTECAN Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, TOPOTECAN Dosage & Rx Info | TOPOTECAN Uses, Side Effects -: Indications, Side Effects, Warnings, TOPOTECAN - Drug Information - Taj Pharma, TOPOTECAN dose Taj pharmaceuticals TOPOTECAN interactions, Taj Pharmaceutical TOPOTECAN contraindications, TOPOTECAN price, TOPOTECAN Taj Pharma Topotecan 1 mg/ml concentrate for solution for infusionSMPC- Taj Pharma . Stay connected to all updated on TOPOTECAN Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Cyclophosphamide for Injection USP Taj Pharma SmPCTajPharmaQC
Cyclophosphamide for Injection USP 500mg/1000mg/2000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Dobutamine Injection USP Taj Pharma SmPCTajPharmaQC
Dobutamine Injection USP 250mg/5ml, 250mg/20ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Dobutamine Dosage & Rx Info | Dobutamine Uses, Side Effects Dobutamine: Indications, Side Effects, Warnings, Dobutamine -Drug Information –Taj Pharma, Dobutamine dose Taj pharmaceuticals Dobutamine interactions, Taj Pharmaceutical Dobutamine contraindications, Dobutamine price, Dobutamine Taj Pharma Dobutamine SmPC-Taj Pharma Stay connected to all updated on Dobutamine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Aprepitant Capsules 80mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Aprepitant Dosage & Rx Info | Aprepitant Uses, Side Effects Aprepitant : Indications, Side Effects, Warnings, Aprepitant -Drug Information –Taj Pharma, Aprepitant dose Taj pharmaceuticals Aprepitant interactions, Taj Pharmaceutical Aprepitant contraindications, Aprepitant price, Aprepitant Taj Pharma Aprepitant SmPC-Taj Pharma Stay connected to all updated on Aprepitant Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Phytomenadione Injection BP 1mg/0.5ml Taj Pharma SmPC (Adult)TajPharmaQC
Phytomenadione Injection BP 1mg/0.5ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Phytomenadione Dosage & Rx Info | Phytomenadione Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Phytomenadione-Drug Information –Taj Pharma, Phytomenadione dose Taj pharmaceuticals Phytomenadione interactions, Taj Pharmaceutical Phytomenadione contraindications, Phytomenadione price, Phytomenadione Taj Pharma Phytomenadione SmPC-Taj Pharma Stay connected to all updated on Phytomenadione Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Tobromycin Injection USP Taj Pharma SmPCTajPharmaQC
Tobromycin Injection USP 20mg/2ml, 80mg/2ml, USP 1.2g/30ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Tobromycin Dosage & Rx Info | Tobromycin Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Tobromycin-Drug Information –Taj Pharma, Tobromycin dose Taj pharmaceuticals Tobromycin interactions, Taj Pharmaceutical Tobromycin contraindications, Tobromycin price, Tobromycin Taj Pharma Tobromycin SmPC-Taj Pharma Stay connected to all updated on Tobromycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Azithromycin Tablets USP 250mg/500mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Azithromycin Dosage & Rx Info | Azithromycin Uses, Side Effects Azithromycin: Indications, Side Effects, Warnings, Azithromycin -Drug Information –Taj Pharma, Azithromycin dose Taj pharmaceuticals Azithromycin interactions, Taj Pharmaceutical Azithromycin contraindications, Azithromycin price, Azithromycin Taj Pharma Azithromycin SmPC-Taj Pharma Stay connected to all updated on Azithromycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Exemestane Tablets USP 25mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Exemestane Dosage & Rx Info | Exemestane Uses, Side Effects Exemestane: Indications, Side Effects, Warnings, Exemestane -Drug Information –Taj Pharma, Exemestane dose Taj pharmaceuticals Exemestane interactions, Taj Pharmaceutical Exemestane contraindications, Exemestane price, Exemestane Taj Pharma Exemestane SmPC-Taj Pharma Stay connected to all updated on Exemestane Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Pyrimethamine 25 mg tablets smpc taj pharmaceuticalsTaj Pharma
Pyrimethamine - Drug Information - Taj Pharma, Pyrimethamine dose Taj pharmaceuticals Pyrimethamine interactions, Taj Pharmaceutical Pyrimethamine contraindications, Pyrimethamine price, Pyrimethamine Taj Pharma Pyrimethamine 25 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Pyrimethamine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Metoclopramide Injection USP Taj Pharma SmPCTajPharmaQC
Metoclopramide Injection USP 10mg/2ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Metoclopramide Dosage & Rx Info | Metoclopramide Uses, Side Effects Metoclopramide: Indications, Side Effects, Warnings, Metoclopramide -Drug Information –Taj Pharma, Metoclopramide dose Taj pharmaceuticals Metoclopramide interactions, Taj Pharmaceutical Metoclopramide contraindications, Metoclopramide price, Metoclopramide Taj Pharma Metoclopramide SmPC-Taj Pharma Stay connected to all updated on Metoclopramide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Temozolomide Capsules 5mg/20mg/100mg/140mg/180mg/250mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Temozolomide Dosage & Rx Info | Temozolomide Uses, Side Effects Temozolomide: Indications, Side Effects, Warnings, Temozolomide -Drug Information –Taj Pharma, Temozolomide dose Taj pharmaceuticals Temozolomide interactions, Taj Pharmaceutical Temozolomide contraindications, Temozolomide price, Temozolomide Taj Pharma Temozolomide SmPC-Taj Pharma Stay connected to all updated on Temozolomide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Aprepitant 80mg, 125 mg hard capsules smpc taj pharmaceuticalsTaj Pharma
Aprepitant - Drug Information - Taj Pharma, Aprepitant dose Taj pharmaceuticals Aprepitant interactions, Taj Pharmaceutical Aprepitant contraindications, Aprepitant price, Aprepitant Taj Pharma Cancer, oncologyAprepitant 80mg, 125 mg hard capsules SMPC- Taj Pharma . Stay connected to all updated on Aprepitant Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Lacosamide Tablets 50mg/100mg/150mg/200mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lacosamide Dosage & Rx Info | Lacosamide Uses, Side Effects Lacosamide : Indications, Side Effects, Warnings, Lacosamide-Drug Information –Taj Pharma, Lacosamide dose Taj pharmaceuticals Lacosamide interactions, Taj Pharmaceutical Lacosamide contraindications, Lacosamide price, Lacosamide Taj Pharma Lacosamide SmPC-Taj Pharma Stay connected to all updated on Lacosamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Ranolazine Tablets 500mg, 750mg, 1000mg Taj Pharma SmPCTajPharmaQC
Ranolazine Tablets 500mg, 750mg, 1000mg Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ranolazine Dosage & Rx Info | Ranolazine Uses, Side Effects, Anti-anginal, Ranolazine : Indications, Side Effects, Warnings, Ranolazine - Drug Information - Taj Pharma, Ranolazine dose Taj pharmaceuticals Ranolazine interactions, Taj Pharmaceutical Ranolazine contraindications, Ranolazine price, Ranolazine Taj Pharma Anti-anginal Ranolazine Powder for Tablets SmPC.
Atomoxetine Capsules USP Taj Pharma SmPCTajPharmaQC
Atomoxetine Capsules USP 10mg/18mg/25mg/40mg/60mg/80mg/100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Atomoxetine Dosage & Rx Info | Atomoxetine Uses, Side Effects Atomoxetine: Indications, Side Effects, Warnings, Atomoxetine -Drug Information –Taj Pharma, Atomoxetine dose Taj pharmaceuticals Atomoxetine interactions, Taj Pharmaceutical Atomoxetine contraindications, Atomoxetine price, Atomoxetine Taj Pharma Atomoxetine SmPC-Taj Pharma Stay connected to all updated on Atomoxetine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Cisplatin for Injection Taj Pharma SmPCTajPharmaQC
Cisplatin Injection BP 10mg/10ml, 10mg/20ml, 50mg/50ml, 100mg/100ml and 200mg/200ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cisplatin Dosage & Rx Info | Cisplatin Uses, Side Effects Cisplatin: Indications, Side Effects, Warnings, Cisplatin -Drug Information –Taj Pharma, Cisplatin dose Taj pharmaceuticals Cisplatin interactions, Taj Pharmaceutical Cisplatin contraindications, Cisplatin price, Cisplatin Taj Pharma Cisplatin SmPC-Taj Pharma Stay connected to all updated on Cisplatin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Bleomycin for Injection Taj Pharma SmPCTajPharmaQC
Bleomycin for Injection 15 Units, 30 Units Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Bleomycin Dosage & Rx Info | Bleomycin Uses, Side Effects Bleomycin: Indications, Side Effects, Warnings, Bleomycin -Drug Information –Taj Pharma, Bleomycin dose Taj pharmaceuticals Bleomycin interactions, Taj Pharmaceutical Bleomycin contraindications, Bleomycin price, Bleomycin Taj Pharma Bleomycin SmPC-Taj Pharma Stay connected to all updated on Bleomycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Imipramine tablets bp 25mg smpc taj pharmaceuticalsTaj Pharma
IMIPRAMINE Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, IMIPRAMINE Dosage & Rx Info | IMIPRAMINE Uses, Side Effects -: Indications, Side Effects, Warnings, IMIPRAMINE - Drug Information - Taj Pharma, IMIPRAMINE dose Taj pharmaceuticals IMIPRAMINE interactions, Taj Pharmaceutical IMIPRAMINE contraindications, IMIPRAMINE price, IMIPRAMINE Taj Pharma IMIPRAMINE TABLETS BP 25mg SMPC- Taj Pharma . Stay connected to all updated on IMIPRAMINE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Bortezomib for Injection 1mg/2mg/3.5mg Taj Pharma PILTajPharmaQC
Bortezomib for Injection 1mg/2mg/3.5mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Bortezomib Dosage & Rx Info | Bortezomib Uses, Side Effects Bortezomib: Indications, Side Effects, Warnings, Bortezomib -Drug Information –Taj Pharma, Bortezomib does Taj pharmaceuticals Bortezomib interactions, Taj Pharmaceutical Bortezomib contraindications, Bortezomib price, Bortezomib Taj Pharma Bortezomib SmPC-Taj Pharma Stay connected to all updated on Bortezomib Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Cytarabine Injection BP Taj Pharma SmPCTajPharmaQC
Cytarabine Injection BP 100mg/1ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cytarabine Dosage & Rx Info | Cytarabine Uses, Side Effects Cytarabine: Indications, Side Effects, Warnings, Cytarabine -Drug Information –Taj Pharma, Cytarabine dose Taj pharmaceuticals Cytarabine interactions, Taj Pharmaceutical Cytarabine contraindications, Cytarabine price, Cytarabine Taj Pharma Cytarabine SmPC-Taj Pharma Stay connected to all updated on Cytarabine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Topotecan 1 mg concentrate for solution for infusion smpc taj pharmaceuticalsTaj Pharma
TOPOTECAN Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, TOPOTECAN Dosage & Rx Info | TOPOTECAN Uses, Side Effects -: Indications, Side Effects, Warnings, TOPOTECAN - Drug Information - Taj Pharma, TOPOTECAN dose Taj pharmaceuticals TOPOTECAN interactions, Taj Pharmaceutical TOPOTECAN contraindications, TOPOTECAN price, TOPOTECAN Taj Pharma Topotecan 1 mg/ml concentrate for solution for infusionSMPC- Taj Pharma . Stay connected to all updated on TOPOTECAN Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Cyclophosphamide for Injection USP Taj Pharma SmPCTajPharmaQC
Cyclophosphamide for Injection USP 500mg/1000mg/2000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Dobutamine Injection USP Taj Pharma SmPCTajPharmaQC
Dobutamine Injection USP 250mg/5ml, 250mg/20ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Dobutamine Dosage & Rx Info | Dobutamine Uses, Side Effects Dobutamine: Indications, Side Effects, Warnings, Dobutamine -Drug Information –Taj Pharma, Dobutamine dose Taj pharmaceuticals Dobutamine interactions, Taj Pharmaceutical Dobutamine contraindications, Dobutamine price, Dobutamine Taj Pharma Dobutamine SmPC-Taj Pharma Stay connected to all updated on Dobutamine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Aprepitant Capsules 80mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Aprepitant Dosage & Rx Info | Aprepitant Uses, Side Effects Aprepitant : Indications, Side Effects, Warnings, Aprepitant -Drug Information –Taj Pharma, Aprepitant dose Taj pharmaceuticals Aprepitant interactions, Taj Pharmaceutical Aprepitant contraindications, Aprepitant price, Aprepitant Taj Pharma Aprepitant SmPC-Taj Pharma Stay connected to all updated on Aprepitant Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Phytomenadione Injection BP 1mg/0.5ml Taj Pharma SmPC (Adult)TajPharmaQC
Phytomenadione Injection BP 1mg/0.5ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Phytomenadione Dosage & Rx Info | Phytomenadione Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Phytomenadione-Drug Information –Taj Pharma, Phytomenadione dose Taj pharmaceuticals Phytomenadione interactions, Taj Pharmaceutical Phytomenadione contraindications, Phytomenadione price, Phytomenadione Taj Pharma Phytomenadione SmPC-Taj Pharma Stay connected to all updated on Phytomenadione Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Tobromycin Injection USP Taj Pharma SmPCTajPharmaQC
Tobromycin Injection USP 20mg/2ml, 80mg/2ml, USP 1.2g/30ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Tobromycin Dosage & Rx Info | Tobromycin Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Tobromycin-Drug Information –Taj Pharma, Tobromycin dose Taj pharmaceuticals Tobromycin interactions, Taj Pharmaceutical Tobromycin contraindications, Tobromycin price, Tobromycin Taj Pharma Tobromycin SmPC-Taj Pharma Stay connected to all updated on Tobromycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Azithromycin Tablets USP 250mg/500mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Azithromycin Dosage & Rx Info | Azithromycin Uses, Side Effects Azithromycin: Indications, Side Effects, Warnings, Azithromycin -Drug Information –Taj Pharma, Azithromycin dose Taj pharmaceuticals Azithromycin interactions, Taj Pharmaceutical Azithromycin contraindications, Azithromycin price, Azithromycin Taj Pharma Azithromycin SmPC-Taj Pharma Stay connected to all updated on Azithromycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Exemestane Tablets USP 25mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Exemestane Dosage & Rx Info | Exemestane Uses, Side Effects Exemestane: Indications, Side Effects, Warnings, Exemestane -Drug Information –Taj Pharma, Exemestane dose Taj pharmaceuticals Exemestane interactions, Taj Pharmaceutical Exemestane contraindications, Exemestane price, Exemestane Taj Pharma Exemestane SmPC-Taj Pharma Stay connected to all updated on Exemestane Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Etoposide Injection USP 100mg/5ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Etoposide Dosage & Rx Info | Etoposide Uses, Side Effects Etoposide: Indications, Side Effects, Warnings, Etoposide -Drug Information –Taj Pharma, Etoposide dose Taj pharmaceuticals Etoposide interactions, Taj Pharmaceutical Etoposide contraindications, Etoposide price, Etoposide Taj Pharma Etoposide SmPC-Taj Pharma Stay connected to all updated on Etoposide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Gentamicin Injection USP Taj Pharma SmPCTajPharmaQC
Gentamicin Injection USP 20mg/2ml, 80mg/2ml, 800mg/20ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Gentamicin Dosage & Rx Info | Gentamicin Uses, Side Effects Gentamicin: Indications, Side Effects, Warnings, Gentamicin -Drug Information –Taj Pharma, Gentamicin dose Taj pharmaceuticals Gentamicin interactions, Taj Pharmaceutical Gentamicin contraindications, Gentamicin price, Gentamicin Taj Pharma Gentamicin SmPC-Taj Pharma Stay connected to all updated on Gentamicin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Daptomycin for Injection Taj Pharma SmPCTajPharmaQC
Daptomycin for Injection or Infusion 350mg, 500mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Daptomycin Dosage & Rx Info | Daptomycin Uses, Side Effects Daptomycin: Indications, Side Effects, Warnings, Daptomycin -Drug Information –Taj Pharma, Daptomycin dose Taj pharmaceuticals Daptomycin interactions, Taj Pharmaceutical Daptomycin contraindications, Daptomycin price, Daptomycin Taj Pharma Daptomycin SmPC-Taj Pharma Stay connected to all updated on Daptomycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Trimethoprim 80mg and sulfamethoxazole 400mg tablets smpc taj pharmaceuticalsTaj Pharma
Trimethoprim and sulfamethoxazole Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Trimethoprim and sulfamethoxazole Dosage & Rx Info | Trimethoprim and sulfamethoxazole Uses, Side Effects -: Indications, Side Effects, Warnings, Trimethoprim and sulfamethoxazole - Drug Information - Taj Pharma, Trimethoprim and sulfamethoxazole dose Taj pharmaceuticals Trimethoprim and sulfamethoxazole interactions, Taj Pharmaceutical Trimethoprim and sulfamethoxazole contraindications, Trimethoprim and sulfamethoxazole price, Trimethoprim and sulfamethoxazole Taj Pharma Trimethoprim 80mg and sulfamethoxazole 400mg tablets SMPC- Taj Pharma . Stay connected to all updated on Trimethoprim and sulfamethoxazole Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Pemetrexed 100mg and 500mg powder for concentrate for solution for infusion s...Taj Pharma
PEMETREXED Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, PEMETREXED Dosage & Rx Info | PEMETREXED Uses, Side Effects -: Indications, Side Effects, Warnings, PEMETREXED - Drug Information - Taj Pharma, PEMETREXED dose Taj pharmaceuticals PEMETREXED interactions, Taj Pharmaceutical PEMETREXED contraindications, PEMETREXED price, PEMETREXED Taj Pharma Pemetrexed 100mg and 500mg powder for concentrate for solution for infusion.SMPC- Taj Pharma . Stay connected to all updated on PEMETREXED Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Imatinib Capsules 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Imatinib Dosage & Rx Info | Imatinib Uses, Side Effects Imatinib: Indications, Side Effects, Warnings, Imatinib -Drug Information –Taj Pharma, Imatinib dose Taj pharmaceuticals Imatinib interactions, Taj Pharmaceutical Imatinib contraindications, Imatinib price, Imatinib Taj Pharma Imatinib SmPC-Taj Pharma Stay connected to all updated on Imatinib Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Ifosfamide for Injection USP Taj Pharma SmPCTajPharmaQC
Ifosfamide for Injection USP 100mg, 500mg, 1000mg, and 2000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Ifosfamide Dosage & Rx Info | Ifosfamide Uses, Side Effects Ifosfamide: Indications, Side Effects, Warnings, Ifosfamide -Drug Information –Taj Pharma, Ifosfamide dose Taj pharmaceuticals Ifosfamide interactions, Taj Pharmaceutical Ifosfamide contraindications, Ifosfamide price, Ifosfamide Taj Pharma Ifosfamide SmPC-Taj Pharma Stay connected to all updated on Ifosfamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Imatinib, 400mg, 100mg, film coated tablets smpc- taj pharmaceuticalsTaj Pharma
IMATINIB Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, IMATINIB Dosage & Rx Info | IMATINIB Uses, Side Effects -: Indications, Side Effects, Warnings, IMATINIB - Drug Information - Taj Pharma, IMATINIB dose Taj pharmaceuticals IMATINIB interactions, Taj Pharmaceutical IMATINIB contraindications, IMATINIB price, IMATINIB Taj Pharma Cancer, oncologyImatinib, 400mg, 100mg, film-coated tablets. SMPC- Taj Pharma . Stay connected to all updated on IMATINIB Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Tapentadol 50mg/100mg/150mg/200mg Extended-Release Tablets Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Tapentadol Dosage & Rx Info | Tapentadol Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Tapentadol-Drug Information –Taj Pharma, Tapentadol dose Taj pharmaceuticals Tapentadol interactions, Taj Pharmaceutical Tapentadol contraindications, Tapentadol price, Tapentadol Taj Pharma Tapentadol SmPC-Taj Pharma Stay connected to all updated on Tapentadol Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Trihexyphenidyl 5mg tablets smpc taj pharmaceuticalsTaj Pharma
Trihexyphenidyl - Drug Information - Taj Pharma, Trihexyphenidyl dose Taj pharmaceuticals Trihexyphenidyl interactions, Taj Pharmaceutical Trihexyphenidyl contraindications, Trihexyphenidyl price, Trihexyphenidyl Taj Pharma Trihexyphenidyl Tablets 5mg SMPC- Taj Pharma . Stay connected to all updated on Trihexyphenidyl Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Dobutamine Injection 5mg/ml, 12.5mg/ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Dobutamine Dosage & Rx Info | Dobutamine Uses, Side Effects Dobutamine: Indications, Side Effects, Warnings, Dobutamine -Drug Information –Taj Pharma, Dobutamine dose Taj pharmaceuticals Dobutamine interactions, Taj Pharmaceutical Dobutamine contraindications, Dobutamine price, Dobutamine Taj Pharma Dobutamine SmPC-Taj Pharma Stay connected to all updated on Dobutamine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Gabapentin 300mg capsules smpc taj pharmaceuticalsTaj Pharma
Gabapentin Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Gabapentin Dosage & Rx Info | Gabapentin Uses, Side Effects -: Indications, Side Effects, Warnings, Gabapentin - Drug Information - Taj Pharma, Gabapentin dose Taj pharmaceuticals Gabapentin interactions, Taj Pharmaceutical Gabapentin contraindications, Gabapentin price, Gabapentin Taj Pharma Gabapentin 300mg capsules SMPC- Taj Pharma . Stay connected to all updated on Gabapentin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Flutamide Tablets USP 250mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Flutamide Dosage & Rx Info | Flutamide Uses, Side Effects Flutamide: Indications, Side Effects, Warnings, Flutamide -Drug Information –Taj Pharma, Flutamide dose Taj pharmaceuticals Flutamide interactions, Taj Pharmaceutical Flutamide contraindications, Flutamide price, Flutamide Taj Pharma Flutamide SmPC-Taj Pharma Stay connected to all updated on Flutamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Co trimoxazole 960 mg tablets smpc- taj pharmaceuticalsTaj Pharma
Co-Trimoxazole - Drug Information - Taj Pharma, Co-Trimoxazole dose Taj pharmaceuticals Co-Trimoxazole interactions, Taj Pharmaceutical Co-Trimoxazole contraindications, Co-Trimoxazole price, Co-Trimoxazole Taj Pharma Co-Trimoxazole 800 mg/160 mg TabletsSMPC- Taj Pharma . Stay connected to all updated on Co-Trimoxazole Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Exemestane 25 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
EXEMESTANE Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, EXEMESTANE Dosage & Rx Info | EXEMESTANE Uses, Side Effects -: Indications, Side Effects, Warnings, EXEMESTANE - Drug Information - Taj Pharma, EXEMESTANE dose Taj pharmaceuticals EXEMESTANE interactions, Taj Pharmaceutical EXEMESTANE contraindications, EXEMESTANE price, EXEMESTANE Taj Pharma Cancer, oncologyExemestane 25 mg Film-coated Tablets SMPC- Taj Pharma
Ondansetron Injection USP Taj Pharma SmPCTajPharmaQC
Ondansetron Injection USP 4mg/2ml, 8mg/4ml, 40mg/20ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Ondansetron Dosage & Rx Info | Ondansetron Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Ondansetron-Drug Information –Taj Pharma, Ondansetron dose Taj pharmaceuticals Ondansetron interactions, Taj Pharmaceutical Ondansetron contraindications, Ondansetron price, Ondansetron Taj Pharma Ondansetron SmPC-Taj Pharma Stay connected to all updated on Ondansetron Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Similar to Fosaprepitant Dimeglumine for Injection USP Taj Pharma SmPC (20)
Telbivudine Tablet 600mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Telbivudine Dosage & Rx Info | Telbivudine Uses, Side Effects Telbivudine: Indications, Side Effects, Warnings, Telbivudine -Drug Information –Taj Pharma, Telbivudine dose Taj pharmaceuticals Telbivudine interactions, Taj Pharmaceutical Telbivudine contraindications, Telbivudine price, Telbivudine Taj Pharma Telbivudine SmPC-Taj Pharma Stay connected to all updated on Telbivudine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Raltegravir Tablets USP Taj Pharma SmPCTajPharmaQC
Raltegravir Tablet USP 25mg/100mg/400mg/600mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Raltegravir Dosage & Rx Info | Raltegravir Uses, Side Effects Raltegravir: Indications, Side Effects, Warnings, Raltegravir -Drug Information –Taj Pharma, Raltegravir dose Taj pharmaceuticals Raltegravir interactions, Taj Pharmaceutical Raltegravir contraindications, Raltegravir price, Raltegravir Taj Pharma Raltegravir SmPC-Taj Pharma Stay connected to all updated on Raltegravir Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Linezolid Tablets USP 600mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Linezolid Dosage & Rx Info | Linezolid Uses, Side Effects Linezolid: Indications, Side Effects, Warnings, Linezolid -Drug Information –Taj Pharma, Linezolid dose Taj pharmaceuticals Linezolid interactions, Taj Pharmaceutical Linezolid contraindications, Linezolid price, Linezolid Taj Pharma Linezolid SmPC-Taj Pharma Stay connected to all updated on Linezolid Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Digoxin Tablets USP 62.5mcg/125mcg/250mcg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Digoxin Dosage & Rx Info | Digoxin Uses, Side Effects Digoxin : Indications, Side Effects, Warnings, Digoxin -Drug Information –Taj Pharma, Digoxin dose Taj pharmaceuticals Digoxin interactions, Taj Pharmaceutical Digoxin contraindications, Digoxin price, Digoxin Taj Pharma Digoxin SmPC-Taj Pharma Stay connected to all updated on Digoxin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Digoxin Tablets USP 62.5mcg/125mcg/250mcg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Digoxin Dosage & Rx Info | Digoxin Uses, Side Effects Digoxin : Indications, Side Effects, Warnings, Digoxin -Drug Information –Taj Pharma, Digoxin dose Taj pharmaceuticals Digoxin interactions, Taj Pharmaceutical Digoxin contraindications, Digoxin price, Digoxin Taj Pharma Digoxin SmPC-Taj Pharma Stay connected to all updated on Digoxin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Ciprofloxacin Tablets USP 250mg/500mg/750mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Ciprofloxacin Dosage & Rx Info | Ciprofloxacin Uses, Side Effects Ciprofloxacin : Indications, Side Effects, Warnings, Ciprofloxacin -Drug Information –Taj Pharma, Ciprofloxacin dose Taj pharmaceuticals Ciprofloxacin interactions, Taj Pharmaceutical Ciprofloxacin contraindications, Ciprofloxacin price, Ciprofloxacin Taj Pharma Ciprofloxacin SmPC-Taj Pharma Stay connected to all updated on Ciprofloxacin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Vildagliptin Tablets 50mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Vildagliptin Dosage & Rx Info | Vildagliptin Uses, Side Effects Vildagliptin: Indications, Side Effects, Warnings, Vildagliptin -Drug Information –Taj Pharma, Vildagliptin dose Taj pharmaceuticals Vildagliptin interactions, Taj Pharmaceutical Vildagliptin contraindications, Vildagliptin price, Vildagliptin Taj Pharma Vildagliptin SmPC-Taj Pharma Stay connected to all updated on Vildagliptin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Theophylline Extended-Release Tablets 100mg, 200mg, 300mg, 400mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Theophylline Dosage & Rx Info | Theophylline Uses, Side Effects Theophylline: Indications, Side Effects, Warnings, Theophylline -Drug Information –Taj Pharma, Theophylline dose Taj pharmaceuticals Theophylline interactions, Taj Pharmaceutical Theophylline contraindications, Theophylline price, Theophylline Taj Pharma Theophylline SmPC-Taj Pharma Stay connected to all updated on Theophylline Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Sofosbuvir/Velpatasvir Tablets Taj Pharma SmPCTajPharmaQC
Sofosbuvir/Velpatasvir Tablets 400mg/100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Sofosbuvir/Velpatasvir Dosage & Rx Info | Sofosbuvir/Velpatasvir Uses, Side Effects Sofosbuvir/Velpatasvir: Indications, Side Effects, Warnings, Sofosbuvir/Velpatasvir -Drug Information –Taj Pharma, Sofosbuvir/Velpatasvir dose Taj pharmaceuticals Sofosbuvir/Velpatasvir interactions, Taj Pharmaceutical Sofosbuvir/Velpatasvir contraindications, Sofosbuvir/Velpatasvir price, Sofosbuvir/Velpatasvir Taj Pharma Sofosbuvir/Velpatasvir SmPC-Taj Pharma Stay connected to all updated on Sofosbuvir/Velpatasvir Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Sofosbuvir Tablets 400mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Sofosbuvir Dosage & Rx Info | Sofosbuvir Uses, Side Effects Sofosbuvir: Indications, Side Effects, Warnings, Sofosbuvir -Drug Information –Taj Pharma, Sofosbuvir dose Taj pharmaceuticals Sofosbuvir interactions, Taj Pharmaceutical Sofosbuvir contraindications, Sofosbuvir price, Sofosbuvir Taj Pharma Sofosbuvir SmPC-Taj Pharma Stay connected to all updated on Sofosbuvir Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Nicorandil Tablets BP 10mg, 20mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Nicorandil Dosage & Rx Info | Nicorandil Uses, Side Effects Nicorandil: Indications, Side Effects, Warnings, Nicorandil -Drug Information –Taj Pharma, Nicorandil dose Taj pharmaceuticals Nicorandil interactions, Taj Pharmaceutical Nicorandil contraindications, Nicorandil price, Nicorandil Taj Pharma Nicorandil SmPC-Taj Pharma Stay connected to all updated on Nicorandil Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Ledipasvir and Sofosbuvir Tablets Taj Pharma SmPCTajPharmaQC
Ledipasvir and Sofosbuvir Tablets 90mg/400mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Ledipasvir and Sofosbuvir Dosage & Rx Info | Ledipasvir and Sofosbuvir Uses, Side Effects Ledipasvir and Sofosbuvir: Indications, Side Effects, Warnings, Ledipasvir and Sofosbuvir -Drug Information –Taj Pharma, Ledipasvir and Sofosbuvir dose Taj pharmaceuticals Ledipasvir and Sofosbuvir interactions, Taj Pharmaceutical Ledipasvir and Sofosbuvir contraindications, Ledipasvir and Sofosbuvir price, Ledipasvir and Sofosbuvir Taj Pharma Ledipasvir and Sofosbuvir SmPC-Taj Pharma Stay connected to all updated on Ledipasvir and Sofosbuvir Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Clozapine Tablets USP 25mg, 50mg and 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Clozapine Dosage & Rx Info | Clozapine Uses, Side Effects Clozapine: Indications, Side Effects, Warnings, Clozapine -Drug Information –Taj Pharma, Clozapine dose Taj pharmaceuticals Clozapine interactions, Taj Pharmaceutical Clozapine contraindications, Clozapine price, Clozapine Taj Pharma Clozapine SmPC-Taj Pharma Stay connected to all updated on Clozapine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Artemether and lumefantrine Tablets Taj Pharma SmPCTajPharmaQC
Artemether and lumefantrine Tablets 20mg/120mg, 40mg/240mg, 80mg/480mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Artemether and lumefantrine Dosage & Rx Info | Artemether and lumefantrine Uses, Side Effects Artemether and lumefantrine: Indications, Side Effects, Warnings, Artemether and lumefantrine -Drug Information –Taj Pharma, Artemether and lumefantrine dose Taj pharmaceuticals Artemether and lumefantrine interactions, Taj Pharmaceutical Artemether and lumefantrine contraindications, Artemether and lumefantrine price, Artemether and lumefantrine Taj Pharma Artemether and lumefantrine SmPC-Taj Pharma Stay connected to all updated on Artemether and lumefantrine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Hemodialysis: Chapter 3, Dialysis Water Unit - Dr.Gawad
Fosaprepitant Dimeglumine for Injection USP Taj Pharma SmPC
1. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
Fosaprepitant Dimegluminefor
Injection USP 150mg Taj
Pharma
1. NAME OF THE MEDICINAL
PRODUCT
Fosaprepitant Dimegluminefor Injection
USP 150mg Taj Pharma
2. QUALITATIVE AND
QUANTITATIVE COMPOSITION
Fosaprepitant Dimegluminefor Injection
USP 150mg Taj Pharma
Each vial contains:
Fosaprepitant DimeglumineUSP
Equivalent to Fosaprepitant 150mg
Excipients: Q.S.
Which corresponds to 130.5mg of
Fosaprepitant Taj Pharma. After
reconstitution and dilution 1ml of solution
contains 1mgFosaprepitant Taj Pharma
(1mg/ml) (see section 6.6).
For the full list of excipients, see section 6.1.
3. PHARMACEUTICAL FORM
Powder for solution for infusion. White to
off-white amorphous powder.
4. CLINICAL PARTICULARS
4.1 Therapeutic indications
Prevention of nausea and vomiting
associated with highly and moderately
emetogenic cancer chemotherapy in adults
and paediatric patients aged 6 months and
older.
Fosaprepitant Taj Pharma
Dimeglumine150mg is given as part of a
combination therapy (see section 4.2).
4.2 Posology and method of
administration
Posology
Adults
The recommended dose is 150mg
administered as an infusion over 20-30
minutes on Day 1, initiated approximately
30 minutes prior to chemotherapy (see
section 6.6). Fosaprepitant Taj Pharma
Dimeglumine should be administered in
conjunction with a corticosteroid and a 5-
HT3 antagonist as specified in the tables
below.
The following regimens are recommended
for the prevention of nausea and vomiting
associated with emetogenic cancer
chemotherapy.
Table 1: Recommended dosing for the
prevention of nausea and vomiting
associated with highly emetogenic
chemotherapy regimen in adults
Day 1 Day
2
Day
3
Day
4
Fosaprepitan
t Taj Pharma
Dimeglumin
e
150mg
intravenously
non
e
none none
Dexamethas
one
12mg orally 8mg
orall
y
8mg
orall
y
twic
e
dail
y
8mg
orall
y
twic
e
dail
y
5-
HT3 antagon
Standard
dose of 5-
non none none
2. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
ists HT3 antagoni
sts. See the
product
information
for the
selected 5-
HT3 antagoni
st for
appropriate
dosing
information
e
Dexamethasone should be administered 30
minutes prior to chemotherapy treatment on
Day 1 and in the morning on Days 2 to 4.
Dexamethasone should also be administered
in the evenings on Days 3 and 4. The dose
of dexamethasone accounts for active
substance interactions.
Table 2: Recommended dosing for the
prevention of nausea and vomiting
associated with moderately emetogenic
chemotherapy regimen in adults
Day 1
Fosaprepitant Taj
Pharma Dimeglumine
150mg
intravenously
Dexamethasone 12mg orally
5-HT3 antagonists Standard dose of 5-
HT3 antagonists.
See the product
information for the
selected 5-
HT3 antagonist for
appropriate dosing
information
Dexamethasone should be administered 30
minutes prior to chemotherapy treatment on
Day 1. The dose of dexamethasone accounts
for active substance interactions.
Paediatric population
Paediatric patients aged 6 months and
older, and not less than 6 kg
The recommended dose regimen of
Fosaprepitant Taj Pharma Dimeglumine, to
be administered with a 5-HT3 antagonist,
with or without a corticosteroid, for the
prevention of nausea and vomiting
associated with administration of single or
multi-day chemotherapy regimens of Highly
Emetogenic Chemotherapy (HEC) or
Moderately Emetogenic Chemotherapy
(MEC), is shown in Table 3. Single day
chemotherapy regimens include those
regimens in which HEC or MEC is
administered for a single day only. Multi-
day chemotherapy regimens include
chemotherapy regimens in which HEC or
MEC is administered for 2 or more days.
An alternative dose regimen that may be
used with single-day chemotherapy
regimens is shown in Table 4.
Dosing for Single or Multi-Day
Chemotherapy Regimens
For paediatric patients receiving single or
multi-day regimens of HEC or MEC,
administer Fosaprepitant Taj Pharma
Dimeglumine as an intravenous infusion
through a central venous catheter on Days 1,
2, and 3. EMEND capsules or EMEND for
oral suspension may be used on Days 2 and
3 instead of Fosaprepitant Taj Pharma
Dimeglumine, as shown in Table 3. See the
Summary of Product Characteristics (SmPC)
for EMEND capsules or EMEND for oral
suspension for appropriate dosing
instructions.
Table 3: Recommended dosing for the
prevention of nausea and vomiting
associated with single or multi-day
3. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
regimens of HEC or MEC in paediatric
patients
Popul
ation
Day 1 Day 2 Day 3
Fosaprepit
ant Taj
Pharma
Dimeglum
ine *
Paedia
tric
patient
s 12
years
and
older
115mg
intrave
nously
80mg
intrave
nously
OR
80mg
orally
(EMEN
D
capsule
s)
80mg
intrave
nously
OR
80mg
orally
(EMEN
D
capsule
s)
Paedia
tric
patient
s 6
month
s to
less
than
12
years
and
not
less
than 6
kg
3mg/kg
intrave
nously
Maxim
um
dose
115mg
2mg/kg
intrave
nously
OR
2mg/kg
orally
(EMEN
D oral
suspens
ion)
Maxim
um
dose
80mg
2mg/kg
intrave
nously
OR
2mg/kg
orally
(EMEN
D oral
suspens
ion)
Maxim
um
dose
80mg
Dexameth
asone**
All
paedia
tric
patient
s
If a corticosteroid, such
as dexamethasone, is co-
administered, administer
50% of the
recommended
corticosteroid dose on
days 1 through 4
5-
HT3 antag
onist
All
paedia
tric
patient
s
See selected 5-
HT3 antagonist
prescribing information
for the recommended
dosage
* For paediatric patients 12 years and older,
administer Fosaprepitant Taj Pharma
Dimeglumine intravenously over 30
minutes, completing the infusion
approximately 30 minutes prior to
chemotherapy. For paediatric patients less
than 12 years, administer Fosaprepitant Taj
Pharma Dimeglumine intravenously over 60
minutes, completing the infusion
approximately 30 minutes prior to
chemotherapy.
** Dexamethasone should be administered
30 minutes prior to chemotherapy treatment
on Day 1.
Alternative Dosing for Single Day
Chemotherapy Regimens
For paediatric patients receiving single day
HEC or MEC, Fosaprepitant Taj Pharma
Dimeglumine may be administered as an
intravenous infusion through a central
venous catheter on Day 1.
Table 4: Alternative dosing for the
prevention of nausea and vomiting
associated with single day regimens of
HEC or MEC in paediatric patients
Populatio
n
Day 1
Fosaprepitant
Taj Pharma
Dimeglumine *
Paediatric
patients 12
years and
older
150mg
intravenously
Paediatric
patients 2
4mg/kg
4. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
to less
than 12
years
intravenously
Maximum
dose 150mg
Paediatric
patients 6
months to
less than 2
years and
not less
than 6 kg
5mg/kg
intravenously
Maximum
dose 150mg
Dexamethasone*
*
All
paediatric
patients
If a
corticosteroid,
such as
dexamethason
e, is co-
administered,
administer
50% of the
recommended
corticosteroid
dose on days 1
and 2.
5-HT3 antagonist All
paediatric
patients
See selected 5-
HT3 antagonist
prescribing
information
for the
recommended
dosage
* For paediatric patients 12 years and older,
administer Fosaprepitant Taj Pharma
Dimeglumine intravenously over 30
minutes, completing the infusion
approximately 30 minutes prior to
chemotherapy. For paediatric patients less
than 12 years, administer Fosaprepitant Taj
Pharma Dimeglumine intravenously over 60
minutes, completing the infusion
approximately 30 minutes prior to
chemotherapy.
** Dexamethasone should be administered
30 minutes prior to chemotherapy treatment
on Day 1.
The safety and efficacy of Fosaprepitant Taj
Pharma Dimeglumine in infants below 6
months of age have not been established. No
data are available.
General
Efficacy data in combination with other
corticosteroids and 5-HT3 antagonists are
limited. For additional information on the
co-administration with corticosteroids, see
section 4.5.
Refer to the Summary of Product
Characteristics of co-administered 5-
HT3 antagonist medicinal products.
Special populations
Elderly (≥65 years)
No dose adjustment is necessary for the
elderly (see section 5.2).
Gender
No dose adjustment is necessary based on
gender (see section 5.2).
Renal impairment
No dose adjustment is necessary for patients
with renal impairment or for patients with
end stage renal disease undergoing
haemodialysis (see section 5.2).
Hepatic impairment
No dose adjustment is necessary for patients
with mild hepatic impairment. There are
limited data in patients with moderate
hepatic impairment and no data in patients
with severe hepatic impairment.
Fosaprepitant Taj Pharma Dimeglumine
5. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
should be used with caution in these patients
(see sections 4.4 and 5.2).
Method of administration
Fosaprepitant Taj Pharma Dimeglumine
150mg should be administered intravenously
and should not be given by the
intramuscular or subcutaneous route.
Intravenous administration in adults occurs
preferably through a running intravenous
infusion over 20-30 minutes. Intravenous
administration in paediatric patients aged 6
months and older is recommended through a
central venous catheter and should be
administered over 30 minutes in patients
aged 12 years and older or over 60 minutes
in patients less than 12 years of age (See
section 6.6). Do not administer
Fosaprepitant Taj Pharma Dimeglumine as a
bolus injection or undiluted solution.
For instructions on reconstitution and
dilution of the medicinal product before
administration, see section 6.6.
4.3 Contraindications
Hypersensitivity to the active substance or to
polysorbate 80 or any of the other excipients
listed in section 6.1.
Co-administration with pimozide,
terfenadine, astemizole or cisapride (see
section 4.5).
4.4 Special warnings and precautions for
use
Patients with moderate to severe hepatic
impairment
There are limited data in patients with
moderate hepatic impairment and no data in
patients with severe hepatic impairment.
Fosaprepitant Taj Pharma Dimeglumine
should be used with caution in these patients
(see section 5.2).
CYP3A4 interactions
Fosaprepitant Taj Pharma Dimeglumine
should be used with caution in patients
receiving concomitant active substances that
are metabolised primarily through CYP3A4
and with a narrow therapeutic range, such as
cyclosporine, tacrolimus, sirolimus,
everolimus, alfentanil, ergot alkaloid
derivatives, fentanyl, and quinidine (see
section 4.5). Additionally, concomitant
administration with irinotecan should be
approached with particular caution as the
combination might result in increased
toxicity.
Co-administration with warfarin (a CYP2C9
substrate)
In patients on chronic warfarin therapy, the
International Normalised Ratio (INR) should
be monitored closely for 14 days following
the use of Fosaprepitant Taj Pharma (see
section 4.5).
Co-administration with hormonal
contraceptives
The efficacy of hormonal contraceptives
may be reduced during and for 28 days after
administration of Fosaprepitant Taj Pharma .
Alternative non-hormonal back-up methods
of contraception should be used during
treatment withFosaprepitant Taj Pharma and
for 2 months following the use of
Fosaprepitant Taj Pharma (see section 4.5).
Hypersensitivity reactions
Immediate hypersensitivity reactions
including flushing, erythema, dyspnoea, and
anaphylaxis/anaphylactic shock have
occurred during or soon after infusion of
Fosaprepitant Taj Pharma . These
6. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
hypersensitivity reactions have generally
responded to discontinuation of the infusion
and administration of appropriate therapy. It
is not recommended to reinitiate the infusion
in patients who experience hypersensitivity
reactions.
Administration and infusion site reactions
Infusion site reactions (ISRs) have been
reported with the use of Fosaprepitant Taj
Pharma Dimeglumine (see section 4.8). The
majority of severe ISRs, including
thrombophlebitis and vasculitis, were
reported with concomitant vesicant (e.g.,
anthracycline-based) chemotherapy
administration, particularly when associated
with extravasation. Necrosis was also
reported in some patients with concomitant
vesicant chemotherapy. Mild injection site
thrombosis has been observed at higher
doses without concomitant vesicant
chemotherapy.
Fosaprepitant Taj Pharma Dimeglumine
should not be given as a bolus injection, but
should always be diluted and given as a slow
intravenous infusion (see section 4.2).
Fosaprepitant Taj Pharma Dimeglumine
should not be administered intramuscularly
or subcutaneously (see section 5.3). If signs
or symptoms of local irritation occur, the
injection or infusion should be terminated
and restarted in another vein.
4.5 Interaction with other medicinal
products and other forms of
interaction
When administered
intravenouslyFosaprepitant Taj Pharma is
rapidly converted to Fosaprepitant Taj
Pharma.
Fosaprepitant Taj Pharma 150mg, given as a
single dose, is a weak inhibitor of CYP3A4.
Fosaprepitant Taj Pharma does not seem to
interact with the P-glycoprotein transporter,
as demonstrated by the lack of interaction of
oral Fosaprepitant Taj Pharma with digoxin.
It is anticipated thatFosaprepitant Taj
Pharma would cause less or no greater
induction of CYP2C9, CYP3A4 and
glucuronidation than that caused by the
administration of oral Fosaprepitant Taj
Pharma. Data are lacking regarding effects
on CYP2C8 and CYP2C19.
Interactions with other medicinal products
following administration of
intravenousFosaprepitant Taj Pharma are
likely to occur with active substances that
interact with oral Fosaprepitant Taj Pharma.
The potential for interactions with multi-
dayFosaprepitant Taj Pharma regimens are
anticipated to be no greater than those for
oral Fosaprepitant Taj Pharma regimens.
Therefore, the recommendations for use of
Fosaprepitant Taj Pharma Dimeglumine
with other medicinal products in paediatric
patients are based upon adult data
fromFosaprepitant Taj Pharma and
Fosaprepitant Taj Pharma studies. When
using combined Fosaprepitant Taj Pharma
Dimeglumine and EMEND regimens, please
refer to the Summary of Product
Characteristics (SmPC) section 4.5 for
EMEND capsules or EMEND for oral
suspension.
The following information was derived from
studies conducted with oral Fosaprepitant
Taj Pharma and studies conducted with
intravenous single-doseFosaprepitant Taj
Pharma co-administered with
dexamethasone, midazolam, or diltiazem.
Effect of Fosaprepitant Taj Pharma on the
pharmacokinetics of other active substances
CYP3A4 inhibition
7. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
As a weak inhibitor of CYP3A4,
theFosaprepitant Taj Pharma 150mg single
dose can cause a transient increase in plasma
concentrations of co-administered active
substances that are metabolised through
CYP3A4. The total exposure of CYP3A4
substrates may increase up to 2-fold on Days
1 and 2 after co-administration with a single
150mgFosaprepitant Taj Pharma dose.
Fosaprepitant Taj Pharma must not be used
concurrently with pimozide, terfenadine,
astemizole, or cisapride. Inhibition of
CYP3A4 byFosaprepitant Taj Pharma could
result in elevated plasma concentrations of
these active substances, potentially causing
serious or life-threatening reactions. (See
section 4.3). Caution is advised during
concomitant administration of Fosaprepitant
Taj Pharma and active substances that are
metabolised primarily through CYP3A4 and
with a narrow therapeutic range, such as
cyclosporine, tacrolimus, sirolimus,
everolimus, alfentanil, diergotamine,
ergotamine, fentanyl, and quinidine (see
section 4.4).
Corticosteroids
Dexamethasone: The oral dexamethasone
dose should be reduced by approximately 50
% when co-administered withFosaprepitant
Taj Pharma (see section 4.2). Fosaprepitant
Taj Pharma 150mg administered as a single
intravenous dose on Day 1 increased the
AUC0-24hr of dexamethasone, a CYP3A4
substrate, by 100 % on Day 1, 86 % on Day
2 and 18 % on Day 3 when dexamethasone
was co-administered as a single 8mg oral
dose on Days 1, 2, and 3.
Chemotherapeutic medicinal products
Interaction studies withFosaprepitant Taj
Pharma 150mg and chemotherapeutic
medicinal products have not been
conducted; however, based on studies with
oral Fosaprepitant Taj Pharma and
docetaxel and vinorelbine,
FOSAPREPITANT DIMEGLUMINE TAJ
PHARMA 150mg is not expected to have a
clinically relevant interaction with
intravenously administered docetaxel and
vinorelbine. An interaction with orally
administered chemotherapeutic medicinal
products metabolised primarily or partly by
CYP3A4 (e.g. etoposide, vinorelbine)
cannot be excluded. Caution is advised and
additional monitoring may be appropriate in
patients receiving medicinal products
metabolized primarily or partly by CYP3A4
(see section 4.4). Post-marketing events of
neurotoxicity, a potential adverse reaction of
ifosfamide, have been reported after
Fosaprepitant Taj Pharma and ifosfamide
co-administration.
Immunosuppressants
Following a single 150mgFosaprepitant Taj
Pharma dose, a transient moderate increase
for two days possibly followed by a mild
decrease in exposure of
immunosuppressants metabolised by
CYP3A4 (e.g. cyclosporine, tacrolimus,
everolimus and sirolimus) is expected.
Given the short duration of increased
exposure, dose reduction of the
immunosuppressant based on Therapeutic
Dose Monitoring is not recommended on the
day of and the day after administration of
Fosaprepitant Taj Pharma Dimeglumine .
Midazolam
Fosaprepitant Taj Pharma 150mg
administered as a single intravenous dose on
Day 1 increased the AUC0-∞ of midazolam
by 77 % on Day 1 and had no effect on Day
4 when midazolam was co-administered as a
single oral dose of 2mg on Days 1 and 4.
Fosaprepitant Taj Pharma 150mg is a weak
CYP3A4 inhibitor as a single dose on Day 1
8. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
with no evidence of inhibition or induction
of CYP3A4 observed on Day 4.
The potential effects of increased plasma
concentrations of midazolam or other
benzodiazepines metabolised via CYP3A4
(alprazolam, triazolam) should be
considered when co-administering these
medicinal products with Fosaprepitant Taj
Pharma Dimeglumine .
Diltiazem
Interaction studies withFosaprepitant Taj
Pharma 150mg and diltiazem have not been
conducted; however, the following study
with 100mg of Fosaprepitant Taj Pharma
should be considered when using
FOSAPREPITANT DIMEGLUMINE TAJ
PHARMA 150mg with diltiazem. In patients
with mild to moderate hypertension,
infusion of 100mg of Fosaprepitant Taj
Pharma over 15 minutes with diltiazem
120mg 3 times daily, resulted in a 1.4-fold
increase in diltiazem AUC and a small but
clinically meaningful decrease in blood
pressure, but did not result in a clinically
meaningful change in heart rate, or PR
interval.
Induction
TheFosaprepitant Taj Pharma 150mg single
dose did not induce CYP3A4 on Days 1 and
4 in the midazolam interaction study. It is
anticipated that Fosaprepitant Taj Pharma
Dimeglumine would cause less or no greater
induction of CYP2C9, CYP3A4, and
glucuronidation than that caused by the
administration of the 3-day oral
Fosaprepitant Taj Pharma regimen, for
which a transient induction with its
maximum effect 6-8 days after first
Fosaprepitant Taj Pharma dose has been
observed. The 3-day oral Fosaprepitant Taj
Pharma regimen resulted in an about 30-35
% reduction in AUC of CYP2C9 substrates
and up to a 64 % decrease in ethinyl
estradiol trough concentrations. Data are
lacking regarding effects on CYP2C8 and
CYP2C19. Caution is advised when
warfarin, acenocoumarol, tolbutamide,
phenytoin or other active substances that are
known to be metabolised by CYP2C9 are
administered with Fosaprepitant Taj Pharma
Dimeglumine .
Warfarin
In patients on chronic warfarin therapy, the
prothrombin time (INR) should be
monitored closely during treatment with and
for 14 days following the use of
Fosaprepitant Taj Pharma Dimeglumine for
the prevention of chemotherapy induced
nausea and vomiting (see section 4.4).
Hormonal contraceptives
The efficacy of hormonal contraceptives
may be reduced during and for 28 days after
administration of Fosaprepitant Taj Pharma.
Alternative non-hormonal back-up methods
of contraception should be used during
treatment withFosaprepitant Taj Pharma and
for 2 months following the use of
Fosaprepitant Taj Pharma.
5-HT3 antagonists
Interaction studies withFosaprepitant Taj
Pharma 150mg and 5-HT3 antagonists have
not been conducted; however, in clinical
interaction studies, the oral Fosaprepitant
Taj Pharma regimen did not have clinically
important effects on the pharmacokinetics of
ondansetron, granisetron, or hydrodolasetron
(the active metabolite of dolasetron).
Therefore, there is no evidence of
interaction with the use of Fosaprepitant Taj
Pharma Dimeglumine 150mg and 5-
HT3 antagonists.
9. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
Effect of other medicinal products on the
pharmacokinetics of Fosaprepitant Taj
Pharma resulting from administration of
Fosaprepitant Taj Pharma 150mg
Concomitant administration of Fosaprepitant
Taj Pharma with active substances that
inhibit CYP3A4 activity (e.g., ketoconazole,
itraconazole, voriconazole, posaconazole,
clarithromycin, telithromycin, nefazodone,
and protease inhibitors) should be
approached cautiously, as the combination is
expected to result in several-fold increased
plasma concentrations of Fosaprepitant Taj
Pharma (see section 4.4). Ketoconazole
increased the terminal half-life of oral
Fosaprepitant Taj Pharma about 3-fold.
Concomitant administration of Fosaprepitant
Taj Pharma with active substances that
strongly induce CYP3A4 activity (e.g.
rifampicin, phenytoin, carbamazepine,
phenobarbital) should be avoided as the
combination could result in reductions of the
plasma concentrations of Fosaprepitant Taj
Pharma that may result in decreased
efficacy. Concomitant administration of
Fosaprepitant Taj Pharma with herbal
preparations containing St. John's Wort
(Hypericum perforatum) is not
recommended. Rifampicin decreased the
mean terminal half-life of oral Fosaprepitant
Taj Pharma by 68 %.
Diltiazem
Interaction studies withFosaprepitant Taj
Pharma 150mg and diltiazem have not been
conducted; however, the following study
with 100mg of Fosaprepitant Taj Pharma
should be considered when using
Fosaprepitant Taj Pharma Dimeglumine
150mg with diltiazem. Infusion of
100mgFosaprepitant Taj Pharma over 15
minutes with diltiazem 120mg 3 times daily,
resulted in a 1.5-fold increase of
Fosaprepitant Taj Pharma AUC. This effect
was not considered clinically important.
Paediatric population
Interaction studies have only been
performed in adults.
4.6 Fertility, pregnancy and lactation
Contraception in males and females
The efficacy of hormonal contraceptives
may be reduced during and for 28 days after
administration of Fosaprepitant Taj Pharma.
Alternative non-hormonal back-up methods
of contraception should be used during
treatment withFosaprepitant Taj Pharma and
for 2 months following the last dose of
Fosaprepitant Taj Pharma (see sections 4.4
and 4.5).
Pregnancy
ForFosaprepitant Taj Pharma and
Fosaprepitant Taj Pharma no clinical data on
exposed pregnancies are available. The
potential for reproductive toxicities of
Fosaprepitant Taj Pharma and Fosaprepitant
Taj Pharma have not been fully
characterised, since exposure levels above
the therapeutic exposure in humans could
not be attained in animal studies. These
studies did not indicate direct or indirect
harmful effects with respect to pregnancy,
embryonal/foetal development, parturition
or postnatal development (see section 5.3).
The potential effects on reproduction of
alterations in neurokinin regulation are
unknown. Fosaprepitant Taj Pharma
Dimeglumine should not be used during
pregnancy unless clearly necessary.
Breast-feeding
Fosaprepitant Taj Pharma is excreted in the
milk of lactating rats after intravenous
10. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
administration of Fosaprepitant Taj Pharma
as well as after oral administration of
Fosaprepitant Taj Pharma. It is not known
whether Fosaprepitant Taj Pharma is
excreted in human milk. Therefore, breast-
feeding is not recommended during
treatment with Fosaprepitant Taj Pharma
Dimeglumine .
Fertility
The potential for effects of Fosaprepitant Taj
Pharma and Fosaprepitant Taj Pharma on
fertility has not been fully characterised
because exposure levels above the
therapeutic exposure in humans could not be
attained in animal studies. These fertility
studies did not indicate direct or indirect
harmful effects with respect to mating
performance, fertility, embryonic/foetal
development, or sperm count and motility
(see section 5.3).
4.7 Effects on ability to drive and use
machines
Fosaprepitant Taj Pharma Dimeglumine
may have minor influence on the ability to
drive and use machines. Dizziness and
fatigue may occur following administration
of FOSAPREPITANT DIMEGLUMINE
TAJ PHARMA (see section 4.8).
4.8 Undesirable effects
Summary of the safety profile
In clinical studies, various formulations of
Fosaprepitant Taj Pharma have been
administered to a total of 2,687 adults
including 371 healthy subjects and 2,084
patients, and 199 children and adolescents
with chemotherapy induced nausea and
vomiting (CINV). SinceFosaprepitant Taj
Pharma is converted to Fosaprepitant Taj
Pharma, those adverse reactions associated
with Fosaprepitant Taj Pharma are expected
to occur withFosaprepitant Taj Pharma. The
safety profile of Fosaprepitant Taj Pharma
was evaluated in approximately 6,500 adults
and 184 children and adolescents.
Oral Fosaprepitant Taj Pharma
The most common adverse reactions
reported at a greater incidence in adults
treated with the Fosaprepitant Taj Pharma
regimen than with standard therapy in
patients receiving HEC were: hiccups (4.6
% versus 2.9 %), alanine aminotransferase
(ALT) increased (2.8 % versus 1.1 %),
dyspepsia (2.6 % versus 2.0 %), constipation
(2.4 % versus 2.0 %), headache (2.0 %
versus 1.8 %), and decreased appetite (2.0 %
versus 0.5 %). The most common adverse
reaction reported at a greater incidence in
patients treated with the Fosaprepitant Taj
Pharma regimen than with standard therapy
in patients receiving MEC was fatigue (1.4
% versus 0.9 %).
The most common adverse reactions
reported at a greater incidence in paediatric
patients treated with the Fosaprepitant Taj
Pharma regimen than with the control
regimen while receiving emetogenic cancer
chemotherapy were hiccups (3.3 % versus
0.0 %) and flushing (1.1 % versus 0.0 %).
Tabulated list of adverse reactions -
Fosaprepitant Taj Pharma
The following adverse reactions were
observed in a pooled analysis of the HEC
and MEC studies at a greater incidence with
oral Fosaprepitant Taj Pharma than with
standard therapy in adults or paediatric
patients or in postmarketing use.
The frequency categories given in the table
are based on the studies in adults; the
observed frequencies in the paediatric
11. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
studies were similar or lower, unless shown
in the table. Some less common ADRs in the
adult population were not observed in the
paediatric studies.
Frequencies are defined as: very common
(≥1/10); common (≥1/100 to <1/10);
uncommon (≥1/1,000 to <1/100); rare
(≥1/10,000 to <1/1,000) and very rare
(<1/10,000), not known (cannot be
estimated from the available data).
Table 5: Tabulated list of adverse
reactions - Fosaprepitant Taj Pharma
System organ
class
Adverse
reaction
Frequency
Infection and
infestations
candidiasis,
staphylococcal
infection
rare
Blood and
lymphatic
system
disorders
febrile
neutropenia,
anaemia
uncommo
n
Immune system
disorders
hypersensitivity
reactions
including
anaphylactic
reactions
not known
Metabolism
and nutrition
disorders
decreased
appetite
common
polydipsia rare
Psychiatric
disorders
anxiety uncommo
n
disorientation,
euphoric mood
rare
Nervous
system
disorders
headache common
dizziness,
somnolence
uncommo
n
cognitive
disorder,
lethargy,
dysgeusia
rare
Eye disorders conjunctivitis rare
Ear and
labyrinth
disorders
tinnitus rare
Cardiac
disorders
palpitations uncommo
n
bradycardia,
cardiovascular
disorder
rare
Vascular
disorders
hot
flush/flushing
uncommo
n
Respiratory,
thoracic and
mediastinal
disorders
hiccups common
oropharyngeal
pain, sneezing,
cough, postnasal
drip, throat
irritation
rare
Gastrointestinal
disorders
constipation,
dyspepsia
common
eructation,
nausea*,
vomiting*,
gastroesophagea
l reflux disease,
abdominal pain,
dry mouth,
uncommo
n
12. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
flatulence
duodenal ulcer
perforation,
stomatitis,
abdominal
distension,
faeces hard,
neutropenic
colitis
rare
Skin and
subcutaneous
tissue disorders
rash, acne uncommo
n
photosensitivity
reaction,
hyperhidrosis,
seborrhoea, skin
lesion, rash
pruritic,
Stevens-
Johnson
syndrome/toxic
epidermal
necrolysis
rare
pruritus,
urticaria
not known
Musculoskeleta
l and
connective
tissue disorders
muscular
weakness,
muscle spasms
rare
Renal and
urinary
disorders
dysuria uncommo
n
pollakisuria rare
General
disorders and
administration
fatigue common
asthaenia,
malaise
uncommo
n
site conditions oedema, chest
discomfort, gait
disturbance
rare
Investigations ALT increased common
AST increased,
blood alkaline
phosphatase
increased
uncommo
n
red blood cells
urine positive,
blood sodium
decreased,
weight
decreased,
neutrophil count
decreased,
glucose urine
present, urine
output increased
rare
*Nausea and vomiting were efficacy
parameters in the first 5-days of post-
chemotherapy treatment and were reported
as adverse reactions only thereafter.
Description of selected adverse reactions
The adverse reactions profiles in the
Multiple-Cycle extension of HEC and MEC
studies in adults for up to 6 additional cycles
of chemotherapy were generally similar to
those observed in Cycle 1.
In an additional active-controlled clinical
study in 1,169 adult patients receiving
Fosaprepitant Taj Pharma and HEC, the
adverse reactions profile was generally
similar to that seen in the other HEC studies
with Fosaprepitant Taj Pharma.
Additional adverse reactions were observed
in adult patients treated with Fosaprepitant
Taj Pharma for postoperative nausea and
13. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
vomiting (PONV) and a greater incidence
than with ondansetron: abdominal pain
upper, bowel sounds abnormal,
constipation*, dysarthria, dyspnoea,
hypoaesthesia, insomnia, miosis, nausea,
sensory disturbance, stomach discomfort,
sub-ileus*, visual acuity reduced, wheezing.
*Reported in patients taking a higher dose of
Fosaprepitant Taj Pharma.
Fosaprepitant Taj Pharma
In an active-controlled clinical study in adult
patients receiving HEC, safety was
evaluated for 1,143 patients receiving the 1-
day regimen of Fosaprepitant Taj Pharma
Dimeglumine 150mg compared to 1,169
patients receiving the 3-day regimen of
Fosaprepitant Taj Pharma. Additionally, in a
placebo-controlled clinical trial in adult
patients receiving MEC, safety was
evaluated for 504 patients receiving a single
dose of Fosaprepitant Taj Pharma
Dimeglumine 150mg compared to 497
patients receiving the control regimen.
In a pooled analysis of 3 active-controlled
clinical studies in paediatric patients (aged 6
months to 17 years) receiving either HEC or
MEC and a single dose of Fosaprepitant Taj
Pharma Dimeglumine at or above the
recommended 1-day regimen dose, safety
was evaluated for 139 patients receiving the
1-day regimen of Fosaprepitant Taj Pharma
Dimeglumine . In the same analysis, safety
was evaluated for 199 patients receiving
either HEC or MEC and a single dose of
Fosaprepitant Taj Pharma Dimeglumine at
or above the recommended 3-day regimen of
Fosaprepitant Taj Pharma Dimeglumine .
Safety data following the administration of
the 3-day IV/oral/oral regimen were also
included.
No data are available following the
administration of a 3-day IVFosaprepitant
Taj Pharma regimen in paediatric patients.
The safety profile of the 3-day
IVFosaprepitant Taj Pharma regimen in
paediatric patients is expected to be similar
to that of the 1-dayFosaprepitant Taj Pharma
regimen as the low daily through levels do
not significantly increase the exposures on
subsequent days.
The safety profile of Fosaprepitant Taj
Pharma in adult and paediatric patients was
generally similar to that observed with
Fosaprepitant Taj Pharma.
Tabulated list of adverse reactions –
Fosaprepitant Taj Pharma
The following are adverse reactions reported
in adult patients receivingFosaprepitant Taj
Pharma in clinical studies or postmarketing
that have not been reported with
Fosaprepitant Taj Pharma as described
above. The frequency categories in the table
are based on studies in adults; the observed
frequencies in the paediatric studies were
similar or lower. Some adverse reactions
that are commonly observed in the adult
population were not observed in the
paediatric studies. Infusion site reactions
(ISRs) have been reported with the use of
Fosaprepitant Taj Pharma Dimeglumine (see
section 4.4).
Frequencies are defined as: very common
(≥1/10); common (≥1/100 to <1/10);
uncommon (≥1/1,000 to <1/100); rare
(≥1/10,000 to <1/1,000) and very rare
(<1/10,000), not known (cannot be
estimated from the available data).
Table 6: Tabulated list of adverse
reactions -Fosaprepitant Taj Pharma
14. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
System
organ class
Adverse reaction Frequenc
y
Vascular
disorders
flushing,
thrombophlebitis
(predominantly,
infusion-site
thrombophlebitis)
uncommo
n
Skin and
subcutaneou
s tissue
disorders
erythema uncommo
n
General
disorders
and
administrati
on site
conditions
infusion site
erythema, infusion
site pain, infusion
site pruritus
uncommo
n
infusion site
induration
rare
immediate
hypersensitivity
reactions including
flushing, erythema,
dyspnoea,
anaphylactic
reactions/anaphylac
tic shock
not
known
Investigation
s
blood pressure
increased
uncommo
n
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after
authorisation of the medicinal product is
important. It allows continued monitoring of
the benefit/risk balance of the medicinal
product.
4.9 Overdose
In the event of overdose,Fosaprepitant Taj
Pharma should be discontinued and general
supportive treatment and monitoring should
be provided. Because of the antiemetic
activity of Fosaprepitant Taj Pharma,
emesis induced by a medicinal product may
not be effective.
Fosaprepitant Taj Pharma cannot be
removed by haemodialysis.
5. Pharmacological properties
5.1 Pharmacodynamic properties
Pharmacotherapeutic group: Antiemetics
and antinauseants.
Fosaprepitant Taj Pharma is the prodrug of
Fosaprepitant Taj Pharma and when
administered intravenously is converted
rapidly to Fosaprepitant Taj Pharma (see
section 5.2). The contribution of
Fosaprepitant Taj Pharma to the overall
antiemetic effect has not fully been
characterised, but a transient contribution
during the initial phase cannot be ruled out.
Fosaprepitant Taj Pharma is a selective
high-affinity antagonist at human substance
P neurokinin 1 (NK1) receptors. The
pharmacological effect of Fosaprepitant Taj
Pharma is attributed to Fosaprepitant Taj
Pharma.
1-Day Regimen of Fosaprepitant Taj
Pharma in Adults
Highly Emetogenic Chemotherapy (HEC)
In a randomized, parallel, double-blind,
active-controlled study, Fosaprepitant Taj
Pharma Dimeglumine 150mg (N=1,147)
was compared with a 3-day Fosaprepitant
Taj Pharma regimen (N=1,175) in adult
patients receiving a HEC regimen that
included cisplatin (≥70mg/m2
).
TheFosaprepitant Taj Pharma regimen
15. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
consisted of Fosaprepitant Taj Pharma
150mg on Day 1 in combination with
ondansetron 32mg IV on Day 1 and
dexamethasone 12mg on Day 1, 8mg on
Day 2, and 8mg twice daily on Days 3 and
4. The Fosaprepitant Taj Pharma regimen
consisted of Fosaprepitant Taj Pharma
125mg on Day 1 and 80mg/day on Days 2
and 3 in combination with ondansetron
32mg IV on Day 1 and dexamethasone
12mg on Day 1 and 8mg daily on Days 2
through 4. Fosaprepitant Taj Pharma
placebo, Fosaprepitant Taj Pharma placebo,
and dexamethasone placebo (in the evenings
on Days 3 and 4) were used to maintain
blinding (see section 4.2). Although a 32mg
intravenous dose of ondansetron was used in
clinical trials, this is no longer the
recommended dose. See the product
information for the selected 5-
HT3 antagonist for appropriate dosing
information.
Efficacy was based on evaluation of the
following composite measures: complete
response in both the overall and delayed
phases and no vomiting in the overall phase.
Fosaprepitant Taj Pharma Dimeglumine
150mg was shown to be non-inferior to that
of the 3-day regimen of Fosaprepitant Taj
Pharma. A summary of the primary and
secondary endpoints is shown in Table 7.
Table 7: Percent of adult patients
receiving Highly Emetogenic
Chemotherapy responding by treatment
group and phase — Cycle 1
ENDPOIN
TS*
Fosaprepit
ant Taj
Pharma
regimen
(N
=1,106)
Fosaprepit
ant Taj
Pharma
regimen
Differen
ce†
(95 %
CI)
**
%
(N
=1,134)
**
%
Complete response‡
Overall§
71.9 72.3 -0.4 (-
4.1, 3.3)
Delayed
phase§§
74.3 74.2 0.1 (-3.5,
3.7)
No vomiting
Overall§
72.9 74.6 -1.7 (-
5.3, 2.0)
*Primary endpoint is bolded.
**N: Number of adult patients included in
the primary analysis of complete response.
†Difference and confidence interval (CI)
were calculated using the method proposed
by Miettinen and Nurminen and adjusted for
gender.
‡Complete response = no vomiting and no
use of rescue therapy.
§Overall = 0 to 120 hours post-initiation of
cisplatin chemotherapy.
§§Delayed phase = 25 to 120 hours post-
initiation of cisplatin chemotherapy.
Moderately Emetogenic Chemotherapy
(MEC)
In a randomized, parallel, double-blind,
placebo-controlled study, Fosaprepitant Taj
Pharma Dimeglumine150mg (N=502) in
combination with ondansetron and
dexamethasone was compared with
ondansetron and dexamethasone alone
16. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
(control regimen) (N=498) in adult patients
receiving a moderately emetogenic
chemotherapy regimen. The Fosaprepitant
Taj Pharma regimen consisted of
Fosaprepitant Taj Pharma 150mg on Day 1
in combination with oral ondansetron 8mg
for 2 doses and oral dexamethasone 12mg.
On Days 2 and 3, patients in the
Fosaprepitant Taj Pharma group received
placebo for ondansetron every 12 hours. The
control regimen consisted of Fosaprepitant
Taj Pharma placebo 150mg IV on Day 1 in
combination with oral ondansetron 8mg for
2 doses and oral dexamethasone 20mg. On
Days 2 and 3, patients in the control group
received 8mg oral ondansetron every 12
hours. Fosaprepitant Taj Pharma placebo
and dexamethasone placebo (on Day 1) were
used to maintain blinding.
The efficacy of Fosaprepitant Taj Pharma
was evaluated based on the primary and
secondary endpoints listed in Table 8 and
was shown to be superior to the control
regimen with regard to complete response in
the delayed and overall phases.
Table 8: Percent of adult patients
receiving Moderately Emetogenic
Chemotherapy responding by treatment
group and phase
ENDPOINTS
*
Fosaprepitan
t Taj Pharma
regimen
(N =502) **
%
Control
regime
n
(N
=498)
**
%
P-
Value
Complete response†
Delayed
phase‡
78.9 68.5 <0.00
1
Complete response†
Overall§ 77.1 66.9 <0.00
1
Acute phase§§ 93.2 91 0.184
*Primary endpoint is bolded.
**N: Number of adult patients included in
the intention to treat population.
† Complete response = no vomiting and no
use of rescue therapy.
‡ Delayed phase = 25 to 120 hours post-
initiation of chemotherapy.
§Overall = 0 to 120 hours post-initiation of
chemotherapy.
§§Acute= 0 to 24 hours post-initiation of
chemotherapy.
The estimated time to first emesis is
depicted by the Kaplan-Meier plot in Figure
1.
Figure 1:
Percent of adult patients receiving
Moderately Emetogenic Chemotherapy
who remain emesis free over time
17. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
Paediatric population
In 3 active-controlled, open-label clinical
studies, paediatric patients aged 6 months to
17 years received either highly or
moderately emetogenic chemotherapy and a
single dose of Fosaprepitant Taj Pharma at
or above the recommended 1-day regimen
dose (139 patients) or 3-day regimen (199
patients), in combination with ondansetron
with or without dexamethasone.
Paediatric Patients Receiving 1-
DayFosaprepitant Taj Pharma Regimen
The efficacy of the 1-dayFosaprepitant Taj
Pharma regimen in paediatric patients was
extrapolated from that demonstrated in
adults receiving the 1-dayFosaprepitant Taj
Pharma regimen as described in the 1-Day
Regimen of Fosaprepitant Taj Pharma in
Adults subsection.
The efficacy of a 1-dayFosaprepitant Taj
Pharma regimen in paediatric patients is
expected to be similar to that of the 1-day
adultFosaprepitant Taj Pharma regimen.
Paediatric Patients Receiving 3-
DayFosaprepitant Taj Pharma Regimen
The efficacy of the 3-dayFosaprepitant Taj
Pharma regimen in paediatric patients was
based on that demonstrated in paediatric
patients receiving the 3-day oral
Fosaprepitant Taj Pharma regimen.
The efficacy of a 3-dayFosaprepitant Taj
Pharma regimen in paediatric patients is
expected to be similar to that of the 3-day
oral Fosaprepitant Taj Pharma regimen. See
the summary of product characteristics for
EMEND capsules and EMEND powder for
oral suspension for complete clinical
information regarding studies performed
with oral Fosaprepitant Taj Pharma.
5.2 Pharmacokinetic properties
Fosaprepitant Taj Pharma, a prodrug of
Fosaprepitant Taj Pharma, when
administered intravenously is rapidly
converted to Fosaprepitant Taj Pharma.
Plasma concentrations of Fosaprepitant Taj
Pharma are below quantifiable levels within
30 minutes of the completion of infusion.
Fosaprepitant Taj Pharma
afterFosaprepitant Taj Pharma
administration
Following a single intravenous 150-mg dose
of Fosaprepitant Taj Pharma administered
as a 20-minute infusion to healthy adult
volunteers, the mean AUC0-∞ of
Fosaprepitant Taj Pharma was 35.0 µg·hr/ml
and the mean maximal Fosaprepitant Taj
Pharma concentration was 4.01 µg/ml.
Distribution
Fosaprepitant Taj Pharma is highly protein
bound, with a mean of 97 %. The geometric
mean volume of distribution at steady state
(Vdss) of Fosaprepitant Taj Pharma
estimated from a single 150mg intravenous
18. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
dose of Fosaprepitant Taj Pharma is
approximately 82 l in humans.
Biotransformation
Fosaprepitant Taj Pharma was rapidly
converted to Fosaprepitant Taj Pharma in in
vitro incubations with liver preparations
from humans. Furthermore,Fosaprepitant
Taj Pharma underwent rapid and nearly
complete conversion to Fosaprepitant Taj
Pharma in S9 preparations from other
human tissues including kidney, lung and
ileum. Thus, it appears that the conversion
of Fosaprepitant Taj Pharma to
Fosaprepitant Taj Pharma can occur in
multiple tissues. In humans,Fosaprepitant
Taj Pharma administered intravenously was
rapidly converted to Fosaprepitant Taj
Pharma within 30 minutes following the end
of infusion.
Fosaprepitant Taj Pharma undergoes
extensive metabolism. In healthy young
adults, Fosaprepitant Taj Pharma accounts
for approximately 19 % of the radioactivity
in plasma over 72 hours following a single
intravenous administration 100mg dose of
[14
C]-Fosaprepitant Taj Pharma, a prodrug
for Fosaprepitant Taj Pharma, indicating a
substantial presence of metabolites in the
plasma. Twelve metabolites of Fosaprepitant
Taj Pharma have been identified in human
plasma. The metabolism of Fosaprepitant
Taj Pharma occurs largely via oxidation at
the morpholine ring and its side chains and
the resultant metabolites were only weakly
active. In vitro studies using human liver
microsomes indicate that Fosaprepitant Taj
Pharma is metabolised primarily by
CYP3A4 and potentially with minor
contribution by CYP1A2 and CYP2C19.
All metabolites observed in urine, faeces
and plasma following an intravenous 100mg
[14
C]- Fosaprepitant Taj Pharma dose were
also observed following an oral dose of
[14
C]- Fosaprepitant Taj Pharma. Upon
conversion of 245.3mg of Fosaprepitant Taj
Pharma Dimeglumine (equivalent to
150mgFosaprepitant Taj Pharma) to
Fosaprepitant Taj Pharma, 23.9mg of
phosphoric acid and 95.3mg of meglumine
are liberated.
Elimination
Fosaprepitant Taj Pharma is not excreted
unchanged in urine. Metabolites are excreted
in urine and via biliary excretion in faeces.
Following a single intravenously
administered 100mg dose of [14
C]-
Fosaprepitant Taj Pharma to healthy
subjects, 57 % of the radioactivity was
recovered in urine and 45 % in faeces.
The pharmacokinetics of Fosaprepitant Taj
Pharma is non-linear across the clinical dose
range. The terminal half-life of
Fosaprepitant Taj Pharma following a
150mg intravenous dose of Fosaprepitant
Taj Pharma was approximately 11 hours.
The geometric mean plasma clearance of
Fosaprepitant Taj Pharma following a
150mg intravenous dose of Fosaprepitant
Taj Pharma was approximately 73ml/min.
Pharmacokinetics in special populations
Hepatic impairment:Fosaprepitant Taj
Pharma is metabolized in various
extrahepatic tissues; therefore hepatic
impairment is not expected to alter the
conversion of Fosaprepitant Taj Pharma to
Fosaprepitant Taj Pharma. Mild hepatic
impairment (Child-Pugh class A) does not
affect the pharmacokinetics of Fosaprepitant
Taj Pharma to a clinically relevant extent.
No dose adjustment is necessary for patients
with mild hepatic impairment. Conclusions
regarding the influence of moderate hepatic
impairment (Child-Pugh class B) on
19. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
Fosaprepitant Taj Pharma pharmacokinetics
cannot be drawn from available data. There
are no clinical or pharmacokinetic data in
patients with severe hepatic impairment
(Child-Pugh class C).
Renal impairment: A single 240mg dose of
oral Fosaprepitant Taj Pharma was
administered to patients with severe renal
impairment (CrCl< 30ml/min) and to
patients with end stage renal disease (ESRD)
requiring haemodialysis.
In patients with severe renal impairment, the
AUC0-¥ of total Fosaprepitant Taj Pharma
(unbound and protein bound) decreased by
21 % and Cmax decreased by 32 %, relative
to healthy subjects. In patients with ESRD
undergoing haemodialysis, the AUC0-¥ of
total Fosaprepitant Taj Pharma decreased by
42 % and Cmax decreased by 32 %. Due to
modest decreases in protein binding of
Fosaprepitant Taj Pharma in patients with
renal disease, the AUC of pharmacologically
active unbound Fosaprepitant Taj Pharma
was not significantly affected in patients
with renal impairment compared with
healthy subjects. Haemodialysis conducted 4
or 48 hours after dosing had no significant
effect on the pharmacokinetics of
Fosaprepitant Taj Pharma ; less than 0.2 %
of the dose was recovered in the dialysate.
No dose adjustment is necessary for patients
with renal impairment or for patients with
ESRD undergoing haemodialysis.
Paediatric population: As part of a 3-day
IV/IV/IV regimen, simulated median AUC0-
24hr of Fosaprepitant Taj Pharma with
median peak plasma concentration (Cmax) on
Day 1 and the median concentrations at the
end of Day 1, Day 2 and Day 3 in paediatric
patients (6 months to 17 years old) are
shown in Table 9.
Table 9: Pharmacokinetic parameters of
Fosaprepitant Taj Pharma for 3-day
IVFosaprepitant Taj Pharma regimen in
paediatric patients
Popul
ation
3-day
IV/I
V/IV
dose
AUC 0-
24 hr.
(ng*hr/
mL)
Cmax
(ng/
mL)
C24
(ng/
mL)
C48
(ng/
mL)
C72
(ng/
mL)
12 -
17
years
old
115m
g,
80mg
,
80mg
21172 2475 454 424 417
6 - <
12
years
old
3mg/
kg,
2mg/
kg,
2mg/
kg
25901 2719 518 438 418
2 - < 6
years
old
20568 2335 336 248 232
6
month
s – < 2
years
old
16979 1916 256 179 167
In the 1-day IVFosaprepitant Taj Pharma
setting, simulated median AUC0-24hr of
Fosaprepitant Taj Pharma with median peak
plasma concentration (Cmax) on Day 1 and
the median concentrations at the end of Day
1, Day 2 and Day 3 in paediatric patients (6
months to < 12 years old) and observed
mean AUC0-24hr with median peak plasma
concentration (Cmax) on Day 1 and mean
concentrations at the end of Day 1, Day 2
and Day 3 in paediatric patients (12 to 17
years old) are shown in Table 10.
20. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
Table 10: Pharmacokinetic parameters of
Fosaprepitant Taj Pharma for 1-day
IVFosaprepitant Taj Pharma regimen in
paediatric patients
Popula
tion
1-
day
IV
dose
AUC 0-
24 hr.
(ng*hr/
mL)
Cmax
(ng/
mL)
C24
(ng/
mL)
C48
(ng/
mL)
C72
(ng/
mL)
12 -
17
years
old
150
mg
30400 3500 735 NR* NR*
6 - <
12
years
old
4mg
/kg
35766 3637 746 227 69.2
2 - < 6
years
old
28655 3150 494 108 23.5
6
month
s – <2
years
old
5mg
/kg
30484 3191 522 112 24.4
*NR = Not Reported
A population pharmacokinetic analysis of
Fosaprepitant Taj Pharma in paediatric
patients (aged 6 months through 17 years)
suggests that gender and race have no
clinically meaningful effect on the
pharmacokinetics of Fosaprepitant Taj
Pharma.
Relationship between concentration and
effect
Positron emission tomography (PET)
imaging studies, using a highly specific
NK1-receptor tracer, in healthy young men
administered a single intravenous dose of
150mgFosaprepitant Taj Pharma (N=8)
demonstrated brain NK1 receptor occupancy
of ≥100 % at Tmax, and 24 hours, ≥97 % at
48 hours, and between 41 % and 75 % at
120 hours, following dosing. Occupancy of
brain NK1 receptors, in this study, correlate
well with Fosaprepitant Taj Pharma plasma
concentrations.
5.3 Preclinical safety data
Pre-clinical data obtained with intravenous
administration of Fosaprepitant Taj Pharma
and oral administration of Fosaprepitant Taj
Pharma reveal no special hazard for humans
based on conventional studies of single and
repeated dose toxicity, genotoxicity
(including in vitro tests), and toxicity to
reproduction and development.
Carcinogenic potential in rodents was only
investigated with orally administered
Fosaprepitant Taj Pharma. However, it
should be noted that the value of the toxicity
studies carried out with rodents, rabbits and
monkeys, including the reproduction
toxicity studies, are limited since systemic
exposures toFosaprepitant Taj Pharma and
Fosaprepitant Taj Pharma were only similar
or even lower than therapeutic exposure in
adult humans. In the performed safety
pharmacology and repeated dose toxicity
studies with dogs,Fosaprepitant Taj Pharma
Cmax and Fosaprepitant Taj Pharma AUC
values were up to 3 times and 40 times,
respectively, higher than clinical values.
In a toxicity study in juvenile dogs treated
withFosaprepitant Taj Pharma from
postnatal day 14 to day 42, a decreased
testicular weight and Leydig cell size were
seen in the males at 6mg/kg/day and
increased uterine weight, hypertrophy of the
uterus and cervix, and oedema of vaginal
21. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
tissues were seen in females from
4mg/kg/day. In a juvenile toxicity study in
rats treated with Fosaprepitant Taj Pharma
from postnatal day 10 to day 63, earlier
vaginal opening in females from 250mg/kg
b.i.d. and delayed preputial separation in
males from 10mg/kg b.i.d was seen. There
were no treatment-related effects on mating,
fertility or embryonic/foetal survival, and no
pathological changes in the reproductive
organs. There were no margins to clinically
relevant exposure of Fosaprepitant Taj
Pharma. For short term treatment, these
findings are considered unlikely to be
clinically relevant.
In laboratory animals, Fosaprepitant Taj
Pharma in non-commercial formulations
caused vascular toxicity and hemolysis at
concentrations below 1mg/ml and higher,
dependent on the formulation. In human
washed blood cells also evidence of
hemolysis was found with non-commercial
formulations at Fosaprepitant Taj Pharma
concentrations of 2.3mg/ml and higher,
although tests in human whole blood were
negative. No hemolysis was found with the
commercial formulation up to a
Fosaprepitant Taj Pharma concentration of
1mg/ml in human whole blood and washed
human erythrocytes.
In rabbits, Fosaprepitant Taj Pharma caused
initial transient local acute inflammation
following paravenous, subcutaneous and
intramuscular administration. At the end of
the follow-up period (post-dose day 8), up to
slight local subacute inflammation was
noted following paravenous and
intramuscular administration and additional
up to moderate focal muscle
degeneration/necrosis with muscle
regeneration following intramuscular
administration.
6. Pharmaceutical particulars
6.1 List of excipients
Disodium edetate
Polysorbate 80
Lactose anhydrous
Sodium hydroxide (for pH adjustment)
and/or
Hydrochloric acid diluted (for pH
adjustment)
6.2 Incompatibilities
Fosaprepitant Taj Pharma Dimeglumine is
incompatible with any solutions containing
divalent cations (e.g., Ca2+
, mg2+
), including
Hartman's and lactated Ringer's solutions.
This medicinal product must not be mixed
with other medicinal products except those
mentioned in section 6.6.
6.3 Shelf life
2 years.
After reconstitution and dilution, chemical
and physical in-use stability has been
demonstrated for 24 hours at 25°C.
From a microbiological point of view, the
medicinal product should be used
immediately. If not used immediately, in-use
storage times and conditions prior to use are
the responsibility of the user and would
normally not be longer than 24 hours at 2 to
8°C.
6.3 Special precautions for storage
Store in a refrigerator (2°C - 8°C).
For storage conditions after reconstitution
and dilution of the medicinal product, see
section 6.3.
22. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
6.4 Nature and contents of container
10ml Type I clear glass vial with a
chlorobutyl or bromobutyl rubber stopper
and an aluminum seal with a grey plastic flip
off cap.
Pack sizes: 1 or 10 vials.
Not all pack sizes may be marketed.
6.5 Special precautions for disposal and
other handling
Fosaprepitant Taj Pharma Dimeglumine
must be reconstituted and then diluted prior
to administration.
Preparation of Fosaprepitant Taj Pharma
Dimeglumine 150mg for intravenous
administration:
1. Inject 5ml sodium chloride 9mg/ml (0.9
%) solution for injection into the vial.
Assure that sodium chloride 9mg/ml (0.9 %)
solution for injection is added to the vial
along the vial wall in order to prevent
foaming. Swirl the vial gently. Avoid
shaking and jetting sodium chloride 9mg/ml
(0.9 %) solution for injection into the vial.
2. Prepare an infusion bag filled
with 145ml of sodium chloride 9mg/ml (0.9
%) solution for injection (for example, by
removing 105ml of sodium chloride 9mg/ml
(0.9 %) solution for injection from a 250ml
sodium chloride 9mg/ml (0.9 %) solution for
injection infusion bag).
3. Withdraw the entire volume from the vial
and transfer it into an infusion bag
containing 145ml of sodium chloride
9mg/ml (0.9 %) solution for injection
to yield a total volume of 150ml and final
concentration of 1mg/ml. Gently invert the
bag 2-3 times.
4. Determine the volume to be administered
from this prepared infusion bag, based on
the recommended dose (see section 4.2).
Adults
The entire volume of the prepared infusion
bag (150ml) should be administered.
Paediatrics
In patients 12 years and older, the volume to
be administered is calculated as follows:
• Volume to administer (ml) equals the
recommended dose (mg)
In patients 6 months to less than 12 years,
the volume to be administered is calculated
as follows:
• Volume to administer (ml) =
recommended dose (mg/kg) x weight
(kg)
Note: Do not exceed maximum doses (see
section 4.2).
5. If necessary, for volumes less than 150ml,
the calculated volume can be transferred to
an appropriate size bag or syringe prior to
administration by infusion.
The appearance of the reconstituted solution
is the same as the appearance of the diluent.
The reconstituted and diluted medicinal
product should be inspected visually for
particulate matter and discoloration before
administration.
Discard any remaining solution and waste
material. Any unused medicinal product or
waste material should be disposed of in
accordance with local requirements.
The medicinal product must not be
reconstituted or mixed with solutions for
23. Fosaprepitant Dimeglumine for Injection USP 150mg Taj Pharma : Uses-Anti-Cancer, Side Effects, Interactions, Pictures, Warnings, Fosaprepitant Dimeglumine Taj Pharma Dosage & Rx Info | Fosaprepitant Dimeglumine Taj Pharma Uses, Side Effect s- Nausea and Vomiting , Fosaprepitant Dimeglumine Taj Pharma : Indications To treat emetogenic cancer, Side Effects - Nausea, diarrhea, vomiting, dizziness, Warnings, Fosaprepitant Dimeglumine Taj Pharma - Drug Information - Taj Pharma, Fosaprepitant Dimeglumine Taj Pharma dose Taj pharmaceuticals Fosaprepitant Dimeglumine Taj Pharma interactions, Taj Pharmaceutical Fosaprepitant Dimeglumine Taj Pharma contraindi cations, Fosaprepitant Dimeglumine Taj Pharma price, Fosaprepitant Dimeglumine Taj Pharma Taj Pharma Fosaprepitant Dimeglumine Taj Pharma 150mg, SMPC- Taj Pharma Stay connected t o all updated on Fosaprepitant Dimeglumine Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals. Patient Information Leaflets, SMPC.
which physical and chemical compatibility
has not been established (see section 6.2).
Manufactured in India By:
TAJ PHARMACEUTICALS LIMITED
At SURVEY NO.188/1 TO 189/1,190/1 TO
4, ATHIYAWAD, DABHEL, DAMAN-
396210 (INDIA)