Tramadol 50mg per ml solution for injection or infusion smpc taj pharmaceuti...Taj Pharma
Tramadol - Drug Information - Taj Pharma, Tramadol dose Taj pharmaceuticals Tramadol interactions, Taj Pharmaceutical Tramadol contraindications, Tramadol price, Tramadol Taj Pharma Tramadol 50mg/ml Solution for Injection or Infusion SMPC- Taj Pharma . Stay connected to all updated on Tramadol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Olmesartan medoxomil/Hydrochlorothiazide Tablets Taj Pharma SmPCTajPharmaQC
This document provides information on olmesartan medoxomil/hydrochlorothiazide combination tablets, including its uses, dosage, side effects and contraindications. It is used for the treatment of hypertension. The dosage varies depending on the severity of hypertension and renal function. Side effects may include dizziness, fatigue and hypokalemia. It should not be used in patients with severe hepatic or renal impairment.
This document provides information on Dobutamine Injection 5mg/ml and 12.5mg/ml from Taj Pharma, including its uses, dosage, administration, and potential side effects. It is indicated for patients requiring positive inotropic support for cardiac decompensation or cardiogenic/septic shock. The dosage varies depending on the patient's condition and response, and must be individually adjusted. Precautions are mentioned regarding patients with severe coronary heart disease or arrhythmia risk.
Tramadol hydrochloride 37.5 mg and paracetamol 325 mg film coated tablets smp...Taj Pharma
Tramadol hydrochloride and Paracetamol Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Tramadol hydrochloride and Paracetamol Dosage & Rx Info | Tramadol hydrochloride and Paracetamol Uses, Side Effects -: Indications, Side Effects, Warnings, Tramadol hydrochloride and Paracetamol - Drug Information - Taj Pharma, Tramadol hydrochloride and Paracetamol dose Taj pharmaceuticals Tramadol hydrochloride and Paracetamol interactions, Taj Pharmaceutical Tramadol hydrochloride and Paracetamol contraindications, Tramadol hydrochloride and Paracetamol price, Tramadol hydrochloride and Paracetamol Taj Pharma Tramadol hydrochloride 37.5 mg and Paracetamol 325 mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on Tramadol hydrochloride and Paracetamol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Tramadol 50mg per ml solution for injection or infusion smpc taj pharmaceuti...Taj Pharma
Tramadol - Drug Information - Taj Pharma, Tramadol dose Taj pharmaceuticals Tramadol interactions, Taj Pharmaceutical Tramadol contraindications, Tramadol price, Tramadol Taj Pharma Tramadol 50mg/ml Solution for Injection or Infusion SMPC- Taj Pharma . Stay connected to all updated on Tramadol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Olmesartan medoxomil/Hydrochlorothiazide Tablets Taj Pharma SmPCTajPharmaQC
This document provides information on olmesartan medoxomil/hydrochlorothiazide combination tablets, including its uses, dosage, side effects and contraindications. It is used for the treatment of hypertension. The dosage varies depending on the severity of hypertension and renal function. Side effects may include dizziness, fatigue and hypokalemia. It should not be used in patients with severe hepatic or renal impairment.
This document provides information on Dobutamine Injection 5mg/ml and 12.5mg/ml from Taj Pharma, including its uses, dosage, administration, and potential side effects. It is indicated for patients requiring positive inotropic support for cardiac decompensation or cardiogenic/septic shock. The dosage varies depending on the patient's condition and response, and must be individually adjusted. Precautions are mentioned regarding patients with severe coronary heart disease or arrhythmia risk.
Tramadol hydrochloride 37.5 mg and paracetamol 325 mg film coated tablets smp...Taj Pharma
Tramadol hydrochloride and Paracetamol Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Tramadol hydrochloride and Paracetamol Dosage & Rx Info | Tramadol hydrochloride and Paracetamol Uses, Side Effects -: Indications, Side Effects, Warnings, Tramadol hydrochloride and Paracetamol - Drug Information - Taj Pharma, Tramadol hydrochloride and Paracetamol dose Taj pharmaceuticals Tramadol hydrochloride and Paracetamol interactions, Taj Pharmaceutical Tramadol hydrochloride and Paracetamol contraindications, Tramadol hydrochloride and Paracetamol price, Tramadol hydrochloride and Paracetamol Taj Pharma Tramadol hydrochloride 37.5 mg and Paracetamol 325 mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on Tramadol hydrochloride and Paracetamol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Clarithromycin for Injection Taj Pharma SmPCTajPharmaQC
Clarithromycin for Infusion 500mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Clarithromycin Dosage & Rx Info | Clarithromycin Uses, Side Effects Clarithromycin: Indications, Side Effects, Warnings, Clarithromycin -Drug Information –Taj Pharma, Clarithromycin dose Taj pharmaceuticals Clarithromycin interactions, Taj Pharmaceutical Clarithromycin contraindications, Clarithromycin price, Clarithromycin Taj Pharma Clarithromycin SmPC-Taj Pharma Stay connected to all updated on Clarithromycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Furosemide Injection USP Taj Pharma SmPCTajPharmaQC
This document provides information on Furosemide 20mg/2ml Solution for Injection Taj Pharma, including its uses, dosage, side effects and interactions. It is used as a potent diuretic to treat conditions like cardiac, pulmonary and renal edema. The dosage varies based on the condition, ranging from 20-50mg initially for adults administered via intramuscular or intravenous injection. Special precautions must be taken for patients with renal or liver impairment, electrolyte imbalances, or who are elderly or dehydrated. Laboratory monitoring of sodium, potassium and renal function is recommended during treatment.
Cyclophosphamide for Injection USP 500mg, 1000mg, 2000mg Taj Pharma PILTajPharmaQC
Cyclophosphamide for Injection USP 500mg/1000mg/2000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Fluorouracil 50mgml injection smpc taj pharmaceuticalsTaj Pharma
FLUOROURACIL Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, FLUOROURACIL Dosage & Rx Info | FLUOROURACIL Uses, Side Effects -: Indications, Side Effects, Warnings, FLUOROURACIL - Drug Information - Taj Pharma, FLUOROURACIL dose Taj pharmaceuticals FLUOROURACIL interactions, Taj Pharmaceutical FLUOROURACIL contraindications, FLUOROURACIL price, FLUOROURACIL Taj Pharma Cancer, oncologyFluorouracil 50mg/ml Injection. SMPC- Taj Pharma
Tramadol 200mg is a leading medicament that is prescribed to treat moderate to severe pain. It comes under the category of centrally acting analgesic. This drug recommended treating both chronic as well as acute pain. It is prescribed in the medical condition of fibromyalgia, motor neuron disease, restless legs syndrome, rheumatoid arthritis and other chronic pain. Generic Tramadol Hydrochloride being the active ingredient of this drug lessens the intensity of the pain by binding it to the µ-opioid
Olmesartan medoxomil and Amlodipine Tablets Taj Pharma SmPCTajPharmaQC
The document discusses Olmesartan medoxomil and Amlodipine besilate tablets, which are fixed-dose combination antihypertensive medications produced by Taj Pharmaceuticals. It provides information on the composition of the tablets, therapeutic indications for treating hypertension, dosing and administration guidance stratified by factors like renal or hepatic impairment, contraindications, and warnings regarding dual renin-angiotensin system blockade or use in pregnancy. The document also includes sections on clinical pharmacology, interactions, adverse effects, and overdose management.
Tramdol and paracetamol tablets ip 37.5mg 325mg, 50mg 325mg taj pharma_smpcTajPharmaQC
Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaTaj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaDosage & Rx Info | Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaUses, Side Effects, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaIndications, Side Effects, Warnings, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharma- Drug Information – Taj Pharma, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharmadose Taj pharmaceuticals Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharmainteractions, Taj Pharmaceutical Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharma SmPC
Cyclophosphamide Tablets USP Taj Pharma SmPCTajPharmaQC
Cyclophosphamide Tablets USP 25mg/50mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Fludarabine phosphate 25 mgml concentrate for solution for injection or infus...Taj Pharma
This document provides information on Fludarabine phosphate 25 mg/ml Concentrate for Solution for Injection or Infusion, including its uses, dosage, side effects, and warnings. It is indicated for treatment of B-cell chronic lymphocytic leukaemia in adults. Serious potential side effects include severe bone marrow suppression, autoimmune disorders like haemolytic anemia, hepatic impairment, neurotoxicity such as leukoencephalopathy, and tumour lysis syndrome. Special precautions are required in patients with renal or hepatic impairment.
Haloperidol 5mg per ml solution for injection smpc taj pharmaceuticalsTaj Pharma
Haloperidol - Drug Information - Taj Pharma, Haloperidol dose Taj pharmaceuticals Haloperidol interactions, Taj Pharmaceutical Haloperidol contraindications, Haloperidol price, Haloperidol Taj Pharma Haloperidol Injection 5mg/ml SMPC- Taj Pharma . Stay connected to all updated on Haloperidol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Metoclopramide Injection USP Taj Pharma SmPCTajPharmaQC
Metoclopramide Injection USP 10mg/2ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Metoclopramide Dosage & Rx Info | Metoclopramide Uses, Side Effects Metoclopramide: Indications, Side Effects, Warnings, Metoclopramide -Drug Information –Taj Pharma, Metoclopramide dose Taj pharmaceuticals Metoclopramide interactions, Taj Pharmaceutical Metoclopramide contraindications, Metoclopramide price, Metoclopramide Taj Pharma Metoclopramide SmPC-Taj Pharma Stay connected to all updated on Metoclopramide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Dobutamine Injection USP Taj Pharma SmPCTajPharmaQC
This document provides information on Dobutamine Injection USP 250mg/5ml Taj Pharma, including its uses, dosage, administration, contraindications and other details. Dobutamine is indicated for patients who require positive inotropic support to treat cardiac decompensation due to depressed contractility or cardiogenic/septic shock. It lists recommended dosages for adults and pediatric patients. Administration is by continuous intravenous infusion and the document provides tables of infusion rates based on dosage. Contraindications include mechanical obstruction of ventricular filling/outflow and hypersensitivity to the drug.
Metoclopramide hydrochloride 10 mg tablets smpc taj pharmaceuticalsTaj Pharma
Metoclopramide Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Metoclopramide Dosage & Rx Info | Metoclopramide Uses, Side Effects -: Indications, Side Effects, Warnings, Metoclopramide - Drug Information - Taj Pharma, Metoclopramide dose Taj pharmaceuticals Metoclopramide interactions, Taj Pharmaceutical Metoclopramide contraindications, Metoclopramide price, Metoclopramide Taj Pharma Metoclopramide Hydrochloride 10 mg tablets SMPC- Taj Pharma . Stay connected to all updated on Metoclopramide Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Tramadol is a narcotic-like pain reliever used to treat moderate to severe pain. It works by binding to opioid receptors in the brain and also inhibiting the reuptake of serotonin and norepinephrine. Common side effects include nausea, dizziness, and constipation. Tramadol can interact dangerously with other drugs and should be used carefully, as prescribed, due to risks of addiction, overdose, and adverse effects.
Amiodarone 30mgml injection smpc taj pharmaceuticalsTaj Pharma
This document is the summary of product characteristics for Amiodarone 30mg/ml Injection, manufactured by Taj Pharmaceuticals. It provides information on the composition of the drug, approved therapeutic uses for cardiac arrhythmias, dosing and administration via intravenous infusion, warnings about side effects and drug interactions, and contraindications. The document contains detailed technical information on the pharmaceutical formulation and clinical studies on the use of intravenous amiodarone.
Zolpidem tartrate 5 mg tablets smpc taj pharmaceuticalsTaj Pharma
Zolpidem Tartrate - Drug Information - Taj Pharma, Zolpidem Tartrate dose Taj pharmaceuticals Zolpidem Tartrate interactions, Taj Pharmaceutical Zolpidem Tartrate contraindications, Zolpidem Tartrate price, Zolpidem Tartrate Taj Pharma Zolpidem Tartrate 5 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Zolpidem Tartrate Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Clarithromycin for Injection Taj Pharma SmPCTajPharmaQC
Clarithromycin for Infusion 500mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Clarithromycin Dosage & Rx Info | Clarithromycin Uses, Side Effects Clarithromycin: Indications, Side Effects, Warnings, Clarithromycin -Drug Information –Taj Pharma, Clarithromycin dose Taj pharmaceuticals Clarithromycin interactions, Taj Pharmaceutical Clarithromycin contraindications, Clarithromycin price, Clarithromycin Taj Pharma Clarithromycin SmPC-Taj Pharma Stay connected to all updated on Clarithromycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Furosemide Injection USP Taj Pharma SmPCTajPharmaQC
This document provides information on Furosemide 20mg/2ml Solution for Injection Taj Pharma, including its uses, dosage, side effects and interactions. It is used as a potent diuretic to treat conditions like cardiac, pulmonary and renal edema. The dosage varies based on the condition, ranging from 20-50mg initially for adults administered via intramuscular or intravenous injection. Special precautions must be taken for patients with renal or liver impairment, electrolyte imbalances, or who are elderly or dehydrated. Laboratory monitoring of sodium, potassium and renal function is recommended during treatment.
Cyclophosphamide for Injection USP 500mg, 1000mg, 2000mg Taj Pharma PILTajPharmaQC
Cyclophosphamide for Injection USP 500mg/1000mg/2000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Fluorouracil 50mgml injection smpc taj pharmaceuticalsTaj Pharma
FLUOROURACIL Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, FLUOROURACIL Dosage & Rx Info | FLUOROURACIL Uses, Side Effects -: Indications, Side Effects, Warnings, FLUOROURACIL - Drug Information - Taj Pharma, FLUOROURACIL dose Taj pharmaceuticals FLUOROURACIL interactions, Taj Pharmaceutical FLUOROURACIL contraindications, FLUOROURACIL price, FLUOROURACIL Taj Pharma Cancer, oncologyFluorouracil 50mg/ml Injection. SMPC- Taj Pharma
Tramadol 200mg is a leading medicament that is prescribed to treat moderate to severe pain. It comes under the category of centrally acting analgesic. This drug recommended treating both chronic as well as acute pain. It is prescribed in the medical condition of fibromyalgia, motor neuron disease, restless legs syndrome, rheumatoid arthritis and other chronic pain. Generic Tramadol Hydrochloride being the active ingredient of this drug lessens the intensity of the pain by binding it to the µ-opioid
Olmesartan medoxomil and Amlodipine Tablets Taj Pharma SmPCTajPharmaQC
The document discusses Olmesartan medoxomil and Amlodipine besilate tablets, which are fixed-dose combination antihypertensive medications produced by Taj Pharmaceuticals. It provides information on the composition of the tablets, therapeutic indications for treating hypertension, dosing and administration guidance stratified by factors like renal or hepatic impairment, contraindications, and warnings regarding dual renin-angiotensin system blockade or use in pregnancy. The document also includes sections on clinical pharmacology, interactions, adverse effects, and overdose management.
Tramdol and paracetamol tablets ip 37.5mg 325mg, 50mg 325mg taj pharma_smpcTajPharmaQC
Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaTaj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaDosage & Rx Info | Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaUses, Side Effects, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaIndications, Side Effects, Warnings, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharma- Drug Information – Taj Pharma, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharmadose Taj pharmaceuticals Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharmainteractions, Taj Pharmaceutical Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharma SmPC
Cyclophosphamide Tablets USP Taj Pharma SmPCTajPharmaQC
Cyclophosphamide Tablets USP 25mg/50mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Fludarabine phosphate 25 mgml concentrate for solution for injection or infus...Taj Pharma
This document provides information on Fludarabine phosphate 25 mg/ml Concentrate for Solution for Injection or Infusion, including its uses, dosage, side effects, and warnings. It is indicated for treatment of B-cell chronic lymphocytic leukaemia in adults. Serious potential side effects include severe bone marrow suppression, autoimmune disorders like haemolytic anemia, hepatic impairment, neurotoxicity such as leukoencephalopathy, and tumour lysis syndrome. Special precautions are required in patients with renal or hepatic impairment.
Haloperidol 5mg per ml solution for injection smpc taj pharmaceuticalsTaj Pharma
Haloperidol - Drug Information - Taj Pharma, Haloperidol dose Taj pharmaceuticals Haloperidol interactions, Taj Pharmaceutical Haloperidol contraindications, Haloperidol price, Haloperidol Taj Pharma Haloperidol Injection 5mg/ml SMPC- Taj Pharma . Stay connected to all updated on Haloperidol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Metoclopramide Injection USP Taj Pharma SmPCTajPharmaQC
Metoclopramide Injection USP 10mg/2ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Metoclopramide Dosage & Rx Info | Metoclopramide Uses, Side Effects Metoclopramide: Indications, Side Effects, Warnings, Metoclopramide -Drug Information –Taj Pharma, Metoclopramide dose Taj pharmaceuticals Metoclopramide interactions, Taj Pharmaceutical Metoclopramide contraindications, Metoclopramide price, Metoclopramide Taj Pharma Metoclopramide SmPC-Taj Pharma Stay connected to all updated on Metoclopramide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Dobutamine Injection USP Taj Pharma SmPCTajPharmaQC
This document provides information on Dobutamine Injection USP 250mg/5ml Taj Pharma, including its uses, dosage, administration, contraindications and other details. Dobutamine is indicated for patients who require positive inotropic support to treat cardiac decompensation due to depressed contractility or cardiogenic/septic shock. It lists recommended dosages for adults and pediatric patients. Administration is by continuous intravenous infusion and the document provides tables of infusion rates based on dosage. Contraindications include mechanical obstruction of ventricular filling/outflow and hypersensitivity to the drug.
Metoclopramide hydrochloride 10 mg tablets smpc taj pharmaceuticalsTaj Pharma
Metoclopramide Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Metoclopramide Dosage & Rx Info | Metoclopramide Uses, Side Effects -: Indications, Side Effects, Warnings, Metoclopramide - Drug Information - Taj Pharma, Metoclopramide dose Taj pharmaceuticals Metoclopramide interactions, Taj Pharmaceutical Metoclopramide contraindications, Metoclopramide price, Metoclopramide Taj Pharma Metoclopramide Hydrochloride 10 mg tablets SMPC- Taj Pharma . Stay connected to all updated on Metoclopramide Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Tramadol is a narcotic-like pain reliever used to treat moderate to severe pain. It works by binding to opioid receptors in the brain and also inhibiting the reuptake of serotonin and norepinephrine. Common side effects include nausea, dizziness, and constipation. Tramadol can interact dangerously with other drugs and should be used carefully, as prescribed, due to risks of addiction, overdose, and adverse effects.
Amiodarone 30mgml injection smpc taj pharmaceuticalsTaj Pharma
This document is the summary of product characteristics for Amiodarone 30mg/ml Injection, manufactured by Taj Pharmaceuticals. It provides information on the composition of the drug, approved therapeutic uses for cardiac arrhythmias, dosing and administration via intravenous infusion, warnings about side effects and drug interactions, and contraindications. The document contains detailed technical information on the pharmaceutical formulation and clinical studies on the use of intravenous amiodarone.
Zolpidem tartrate 5 mg tablets smpc taj pharmaceuticalsTaj Pharma
Zolpidem Tartrate - Drug Information - Taj Pharma, Zolpidem Tartrate dose Taj pharmaceuticals Zolpidem Tartrate interactions, Taj Pharmaceutical Zolpidem Tartrate contraindications, Zolpidem Tartrate price, Zolpidem Tartrate Taj Pharma Zolpidem Tartrate 5 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Zolpidem Tartrate Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Topiramate tablets are available in 15mg and 100mg strengths from Taj Pharma. Topiramate is indicated as monotherapy for partial seizures in adults and children over 6, and as adjunctive therapy for partial seizures, primary generalized tonic-clonic seizures, and Lennox-Gastaut syndrome in children and adults. It is also indicated for migraine prophylaxis in adults. Common side effects include mood disturbances, depression, and kidney stones. Dosage should be titrated slowly from low starting doses and monitored based on clinical response and tolerability. Special precautions are needed in patients with renal or hepatic impairment.
Tramadol is a narcotic-like pain reliever used to treat moderate to severe pain. It comes in both immediate and extended release forms, with the extended release form intended for around-the-clock pain treatment rather than as-needed use. Common side effects include nausea, dizziness, constipation, and drowsiness. Tramadol is metabolized in the liver and excreted by the kidneys, so dosage reductions may be needed for those with liver or kidney impairment. Its use during pregnancy and breastfeeding requires caution.
Alprazolam 250 microgram tablets smpc taj pharmaceuticalsTaj Pharma
Alprazolam Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Alprazolam Dosage & Rx Info | Alprazolam Uses, Side Effects -: Indications, Side Effects, Warnings, Alprazolam - Drug Information - Taj Pharma, Alprazolam dose Taj pharmaceuticals Alprazolam interactions, Taj Pharmaceutical Alprazolam contraindications, Alprazolam price, Alprazolam Taj Pharma Alprazolam 250 microgram Tablets SMPC- Taj Pharma . Stay connected to all updated on Alprazolam Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Tolterodine Tartrate2mg and 4mg Prolonged-release Capsules (Dezrol La) Taj Ph...TajPharmaQC
This document describes Tolterodine Tartrate 2mg and 4mg prolonged-release capsules produced by Taj Pharma for the treatment of overactive bladder. It includes information on uses, dosages, side effects and interactions. The capsules contain either 2mg or 4mg of Tolterodine Tartrate as the active ingredient. Common side effects include dry mouth. It should be used with caution in patients with conditions like QT prolongation, renal or hepatic impairment. The document provides the full patient information leaflet and prescribing information for this medication.
Thalidomide Capsule USP Taj Pharma SmPCTajPharmaQC
Thalidomide Capsule USP 50mg/100mg/200mg/250mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Thalidomide Dosage & Rx Info | Thalidomide Uses, Side Effects Thalidomide: Indications, Side Effects, Warnings, Thalidomide -Drug Information –Taj Pharma, Thalidomide dose Taj pharmaceuticals Thalidomide interactions, Taj Pharmaceutical Thalidomide contraindications, Thalidomide price, Thalidomide Taj Pharma Thalidomide SmPC-Taj Pharma Stay connected to all updated on Thalidomide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Paracetamol 10 mg per ml solution for infusion smpc taj pharmaceuticalsTaj Pharma
Paracetamol - Drug Information - Taj Pharma, Paracetamol dose Taj pharmaceuticals Paracetamol interactions, Taj Pharmaceutical Paracetamol contraindications, Paracetamol price, Paracetamol Taj Pharma Paracetamol 10 mg/ml Solution for Infusion SMPC- Taj Pharma . Stay connected to all updated on Paracetamol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Cyclophosphamide for Injection USP Taj Pharma SmPCTajPharmaQC
Cyclophosphamide for Injection USP 500mg/1000mg/2000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Trazodone Hydrochloride Tablets IP 25mg; 50mg; 100mg (Sesyrin) Taj Pharma SmPCTajPharmaQC
Trazodone Hydrochloride Tablets IP 25mg; 50mg; 100mg (Sesyrin) Taj Pharma Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Trazodone Hydrochloride Tablets IP 25mg; 50mg; 100mg (Sesyrin) Taj Pharma Dosage & Rx Info | Trazodone Hydrochloride Tablets IP 25mg; 50mg; 100mg (Sesyrin) Taj Pharma Uses, Side Effects, Trazodone Hydrochloride Tablets IP 25mg; 50mg; 100mg (Sesyrin) Taj Pharma Indications, Side Effects, Warnings, Trazodone Hydrochloride Tablets IP 25mg; 50mg; 100mg SmPC
Domperidone 10mg tablets smpc taj pharmaceuticalsTaj Pharma
Domperidone Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Domperidone Dosage & Rx Info | Domperidone Uses, Side Effects -: Indications, Side Effects, Warnings, Domperidone - Drug Information - Taj Pharma, Domperidone dose Taj pharmaceuticals Domperidone interactions, Taj Pharmaceutical Domperidone contraindications, Domperidone price, Domperidone Taj Pharma Domperidone 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Domperidone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Zolpidem 5mg, 10mg tablets IP Taj Pharma SmPCTajPharmaQC
Zolpidem Tablets IP 5mg; 10mg (Zolep) Taj Pharma Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Zolpidem Tablets IP 5mg; 10mg (Zolep) Taj Pharma Dosage & Rx Info | Zolpidem Tablets IP 5mg; 10mg (Zolep) Taj Pharma Uses, Side Effects, Zolpidem Tablets IP 5mg; 10mg (Zolep) Taj Pharma Indications, Side Effects, Warnings, Zolpidem Tablets IP 5mg; 10mg (Zolep) Taj Pharma - Drug Information – Taj Pharma, Zolpidem Tablets IP 5mg; 10mg (Zolep) Taj Pharma dose Taj pharma SmPC
Metformin hydrochloride Tablets Taj Pharma SmPCTajPharmaQC
Metformin hydrochloride ER tablets 500mg/750mg/1000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Metformin hydrochloride Dosage & Rx Info | Metformin hydrochloride Uses, Side Effects Metformin hydrochloride: Indications, Side Effects, Warnings, Metformin hydrochloride-Drug Information –Taj Pharma, Metformin hydrochloride dose Taj pharmaceuticals Metformin hydrochloride interactions, Taj Pharmaceutical Metformin hydrochloride contraindications, Metformin hydrochloride price, Metformin hydrochloride Taj Pharma Metformin hydrochloride SmPC- Taj Pharma Stay connected to all updated on Metformin hydrochloride Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Promethazine 10 mg tablets smpc taj pharmaceuticalsTaj Pharma
Promethazine hydrochloride Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Promethazine hydrochloride Dosage & Rx Info | Promethazine hydrochloride Uses, Side Effects -: Indications, Side Effects, Warnings, Promethazine hydrochloride - Drug Information - Taj Pharma, Promethazine hydrochloride dose Taj pharmaceuticals Promethazine hydrochloride interactions, Taj Pharmaceutical Promethazine hydrochloride contraindications, Promethazine hydrochloride price, Promethazine hydrochloride Taj Pharma Promethazine hydrochloride 10 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Promethazine hydrochloride Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
This document provides information on lacosamide tablets produced by Taj Pharma, including:
- It describes the composition, pharmaceutical form, clinical uses, dosages, and administration details for lacosamide tablets in 50mg, 100mg, 150mg, and 200mg strengths.
- The tablets are indicated as monotherapy or adjunctive therapy for partial-onset seizures. Common side effects include nausea and vomiting. Special populations may require adjusted dosages.
- Detailed posology and dosage adjustment recommendations are provided for various patient populations including children, elderly patients, and those with renal or hepatic impairment.
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This document provides information on Sofosbuvir Tablets 400mg by Taj Pharma, including its uses, dosage, administration instructions, and safety information. Key details include:
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Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
1. Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma: Uses, Side Effect s, Interactions, Pict ures, Warnings, Tramadol Hydrochloride Injection 50mg /1ml Taj Pharma Dosage & Rx Info | Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma Uses, Side Effects, Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma : Indications, Side Effects, Warnings, Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma - Drug Information - TajPharma, Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma dose Taj pharmaceuticals Tramadol Hydrochloride Injection 50mg /1ml Taj Pharma interactions, Taj Pharmaceutical Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma contraindications, Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma price, Tramadol Hy drochloride Injection 50mg/1ml Taj PharmaTajPharma Tramadol Hydrochloride Injection 50mg /1ml Taj Pharma PIL-
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Tramadol Hydrochloride
Injection 50mg/1ml,
100mg/2ml
1. Name of the medicinal product
Tramadol Hydrochloride Injection
50mg/1ml Taj Pharma
Tramadol Hydrochloride Injection
100mg/2ml Taj Pharma
2. Qualitative and quantitative
composition
a) Tramadol Hydrochloride Injection
50mg/1ml
Each ml contains:
Tramadol Hydrochloride 50mg
Water for injection q.s
b) Tramadol Hydrochloride Injection
100mg/2ml
Each ml contains:
Tramadol Hydrochloride 50mg
Water for injection q.s
For the full list of excipients, see Section
6.1.
3. Pharmaceutical form
Clear, colourless sterile solution for
injection or infusion.
4. Clinical particulars
4.1 Therapeutic indications
Treatment of moderate to severe pain.
4.2 Posology and method of
administration
The dose should be adjusted to the intensity
of the pain and the sensitivity of the
individual patient. The lowest effective dose
for analgesia should generally be selected.
The total daily dose of 400 mg tramadol
hydrochloride should not be exceeded,
except in special clinical circumstances.
Unless otherwise prescribed, Tramadol
hydrochloride 50 mg/ml solution for
injection or infusion should be administered
as follows:
Adults and adolescents above the age of
12 years:
The usual dose is 50 or 100mg 4-6 hourly by
the intravenous or intramuscular route.
Dosage should be adjusted according to pain
severity and response.
Intravenous injections must be given slowly
over 2-3 minutes.
For post-operative pain administer an initial
bolus of 100mg. During the 60 minutes
following the initial bolus, further doses of
50mg may be given every 10-20 minutes, up
to a total dose of 250mg including the initial
bolus. Subsequent doses should be 50mg or
100mg 4-6 hourly up to a total daily dose of
400mg.
Children
Tramadol hydrochloride 50 mg/ml solution
for injection or infusion is not suitable for
children below the age of 12 years.
Geriatric patients
A dose adjustment is not usually necessary
in elderly patients (up to 75 years) without
clinically manifest hepatic or renal
insufficiency. In elderly patients (over 75
years) elimination may be prolonged.
Therefore, if necessary the dosage interval is
to be extended according to the patient's
requirements.
Renal Insufficiency/Dialysis and Hepatic
Insufficiency
2. Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma: Uses, Side Effect s, Interactions, Pict ures, Warnings, Tramadol Hydrochloride Injection 50mg /1ml Taj Pharma Dosage & Rx Info | Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma Uses, Side Effects, Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma : Indications, Side Effects, Warnings, Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma - Drug Information - TajPharma, Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma dose Taj pharmaceuticals Tramadol Hydrochloride Injection 50mg /1ml Taj Pharma interactions, Taj Pharmaceutical Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma contraindications, Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma price, Tramadol Hy drochloride Injection 50mg/1ml Taj PharmaTajPharma Tramadol Hydrochloride Injection 50mg /1ml Taj Pharma PIL-
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In patients with renal and/or hepatic
insufficiency the elimination of tramadol is
delayed. In these patients prolongation of
the dosage intervals should be carefully
considered according to the patient's
requirements.
Method of administration
Tramadol hydrochloride 50 mg/ml solution
for injection or infusion may be
administered intramuscularly, by slow
intravenous injection, or diluted in solution
(see Section 6.6) for administration by
infusion or patient controlled analgesia.
Duration of administration
Tramadol hydrochloride 50 mg/ml solution
for injection or infusion should under no
circumstances be administered for longer
than absolutely necessary. If long-term pain
treatment with Tramadol hydrochloride 50
mg/ml solution for injection or infusion is
necessary in view of the nature and severity
of the illness, then careful regular
monitoring should be carried out (if
necessary with breaks in treatment) to
establish whether and to what extent further
treatment is necessary.
4.3 Contraindications
Tramadol hydrochloride 50 mg/ml solution
for injection or infusion is contraindicated
- in patients who have previously shown
hypersensitivity to the active substance
tramadol or to any of the excipients listed in
section 6.1.
- in patients suffering from acute
intoxication with alcohol, hypnotics,
analgesics, opioids, or psychotropic
medicinal products.
- in patients who are receiving monoamine
oxidase (MAO) inhibitors or who have taken
them within the last 14 days (see section
4.5)
- in patients with epilepsy not adequately
controlled by treatment.
- for use in narcotic withdrawal treatment.
4.4 Special warnings and precautions for
use
Tramadol hydrochloride 50 mg/ml solution
for injection or infusion may only be used
with particular caution in opioid-dependent
patients, patients with head injury, shock, a
reduced level of consciousness of uncertain
origin, disorders of the respiratory centre or
function, increased intracranial pressure.
In patients sensitive to opiates the product
should only be used with caution.
Care should be taken when treating patients
with respiratory depression, or if
concomitant CNS depressant drugs are
being administered (see section 4.5), or if
the recommended dosage is significantly
exceeded (see section 4.9) as the possibility
of respiratory depression cannot be excluded
in these situations.
Convulsions have been reported in patients
receiving tramadol at the recommended dose
levels. The risk may be increased when
doses of tramadol exceed the recommended
upper daily dose limit (400 mg). In addition,
tramadol may increase the seizure risk in
patients taking other medicinal products that
lowers the seizure threshold (see section
4.5). Patients with epilepsy or those
susceptible to seizures should only be
treated with tramadol if there are compelling
circumstances.
Tolerance, psychological and physical
dependence may develop, especially after
long-term use. In patients with a tendency to
drug abuse or dependence, treatment with
3. Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma: Uses, Side Effect s, Interactions, Pict ures, Warnings, Tramadol Hydrochloride Injection 50mg /1ml Taj Pharma Dosage & Rx Info | Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma Uses, Side Effects, Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma : Indications, Side Effects, Warnings, Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma - Drug Information - TajPharma, Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma dose Taj pharmaceuticals Tramadol Hydrochloride Injection 50mg /1ml Taj Pharma interactions, Taj Pharmaceutical Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma contraindications, Tramadol Hydrochloride Injection 50mg/1ml Taj Pharma price, Tramadol Hy drochloride Injection 50mg/1ml Taj PharmaTajPharma Tramadol Hydrochloride Injection 50mg /1ml Taj Pharma PIL-
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tramadol should only be carried out for short
periods under strict medical supervision.
Tramadol hydrochloride 50 mg/ml solution
for injection or infusion is not a suitable
substitute in opioid dependent patients.
Although it is an opioid agonist, tramadol
cannot suppress morphine withdrawal
symptoms.
When a patient no longer requires therapy
with tramadol, it may be advisable to taper
the dose gradually to prevent symptoms of
withdrawal.
CYP2D6 metabolism
Tramadol is metabolised by the liver
enzyme CYP2D6. If a patient has a
deficiency or is completely lacking this
enzyme an adequate analgesic effect may
not be obtained. Estimates indicate that up to
7% of the Caucasian population may have
this deficiency. However, if the patient is an
ultra-rapid metaboliser there is a risk of
developing side effects of opioid toxicity
even at commonly prescribed doses.
General symptoms of opioid toxicity include
confusion, somnolence, shallow breathing,
small pupils, nausea, vomiting, constipation
and lack of appetite. In severe cases this
may include symptoms of circulatory and
respiratory depression, which may be life
threatening and very rarely fatal. Estimates
of prevalence of ultra-rapid metabolisers in
different populations are summarised below:
Population Prevalence %
African/Ethiopian 29%
African American 3.4% to 6.5%
Asian 1.2% to 2%
Caucasian 3.6% to 6.5%
Greek 6.0%
Hungarian 1.9%
Northern European 1% to 2%
Post-operative use in children
There have been reports in the published
literature that tramadol given post-
operatively in children after tonsillectomy
and/or adenoidectomy for obstructive sleep
apnoea, led to rare, but life threatening
adverse events. Extreme caution should be
exercised when tramadol is administered to
children for post-operative pain relief and
should be accompanied by close monitoring
for symptoms of opioid toxicity including
respiratory depression.
Children with compromised respiratory
function
Tramadol is not recommended for use in
children in whom respiratory function might
be compromised including neuromuscular
disorders, severe cardiac or respiratory
conditions, upper respiratory or lung
infections, multiple trauma or extensive
surgical procedures. These factors may
worsen symptoms of opioid toxicity.
Risk from concomitant use of sedative
medicines such as benzodiazepines or
related drugs
Concomitant use of Tramadol hydrochloride
50 mg/ml solution for injection or infusion
and sedative medicines such as
benzodiazepines or related drugs may result
in sedation, respiratory depression, coma
and death. Because of these risks,
concomitant prescribing with these sedative
medicines should be reserved for patients for
whom alternative treatment options are not
possible. If a decision is made to prescribe
Tramadol hydrochloride 50 mg/ml solution
for injection or infusion concomitantly with
sedative medicines, the lowest effective dose
should be used, and the duration of
treatment should be as short as possible.
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The patients should be followed closely for
signs and symptoms of respiratory
depression and sedation. In this respect, it is
strongly recommended to inform patients
and their caregivers to be aware of these
symptoms (see section 4.5).
4.5 Interaction with other medicinal
products and other forms of interaction
Tramadol hydrochloride 50 mg/ml solution
for injection or infusion should not be
combined with MAO inhibitors (see section
4.3).
In patients treated with MAO inhibitors in
the 14 days prior to the use of the opioid
pethidine, life-threatening interactions on
the central nervous system, respiratory and
cardiovascular function have been observed.
The same interactions with MAO inhibitors
cannot be ruled out during treatment with
Tramadol hydrochloride 50 mg/ml solution
for injection or infusion.
The results of pharmacokinetic studies have
so far shown that on the concomitant or
previous administration of cimetidine
(enzyme inhibitor) clinically relevant
interactions are unlikely to occur.
Simultaneous or previous administration of
carbamazepine (enzyme inducer) may
reduce the analgesic effect and shorten the
duration of action.
Tramadol can induce convulsions and
increase the potential for selective serotonin
reuptake inhibitors (SSRIs), serotonin-
norepinephrine reuptake inhibitors (SNRIs),
tricyclic antidepressants, antipsychotics and
other seizure threshold-lowering medicinal
products (such as bupropion, mirtazapine,
tetrahydrocannabinol) to cause convulsions.
Concomitant therapeutic use of tramadol
and serotonergic drugs, such as selective
serotonin reuptake inhibitors (SSRIs),
serotonin-norepinephrine reuptake inhibitors
(SNRIs), MAO inhibitors (see section 4.3),
tricyclic antidepressants and mirtazapine
may cause serotonin toxicity. Serotonin
syndrome is likely when one of the
following is observed:
• Spontaneous clonus
• Inducible or ocular clonus with agitation or
diaphoresis
• Tremor and hyperreflexia
• Hypertonia and body temperature > 38 °C
and inducible or ocular clonus.
Withdrawal of the serotonergic drugs
usually brings about a rapid improvement.
Treatment depends on the type and severity
of the symptoms.
Caution should be exercised during
concomitant treatment with tramadol and
coumarin derivatives (e.g. warfarin) due to
reports of increased INR with major
bleeding and ecchymoses in some patients.
Other active substances known to inhibit
CYP3A4, such as ketoconazole and
erythromycin, might inhibit the metabolism
of tramadol (N-demethylation) probably also
the metabolism of the active O-
demethylated metabolite. The clinical
importance of such an interaction has not
been studied (see section 4.8).
In a limited number of studies, the pre- or
postoperative application of the antiemetic
5-HT3 antagonist ondansetron increased the
requirement of tramadol in patients with
postoperative pain.
The administration of Tramadol
hydrochloride 50 mg/ml solution for
injection or infusion with other centrally
depressant medicinal products, including
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alcohol, may potentiate the CNS effects (see
section 4.8).
Sedative medicines such as benzodiazepines
or related drugs
The concomitant use of opioids with
sedative medicines such as benzodiazepines
or related drugs increases the risk of
sedation, respiratory depression, coma and
death because of additive CNS depressant
effect. The dose and duration of concomitant
use should be limited (see section 4.4).
4.6 Fertility, pregnancy and lactation
Pregnancy
Animal studies with tramadol revealed at
very high doses effects on organ
development, ossification and neonatal
mortality. Tramadol crosses the placenta.
There is inadequate evidence available on
the safety of tramadol in human pregnancy.
Therefore Tramadol hydrochloride 50
mg/ml solution for injection or infusion
should not be used in pregnant women.
Tramadol - administered before or during
birth - does not affect uterine contractility.
In neonates it may induce changes in the
respiratory rate which are usually not
clinically relevant. Chronic use during
pregnancy may lead to neonatal withdrawal
symptoms.
Breast-feeding
Approximately 0.1 % of the maternal dose is
excreted into the milk. In the immediate
post-partum period, for maternal oral daily
dosage up to 400 mg, this corresponds to a
mean amount of tramadol ingested by
breast-fed infants of 3% of the maternal
weight-adjusted dosage. For this reason
tramadol should not be used during lactation
or alternatively, breast-feeding should be
discontinued during treatment with
tramadol. Discontinuation of breast-feeding
is generally not necessary following a single
dose of tramadol.
Fertility
Post marketing surveillance does not suggest
an effect of tramadol on fertility. Animal
studies did not show an effect of tramadol
on fertility.
4.7 Effects on ability to drive and use
machines
Even when taken according to instructions,
Tramadol hydrochloride 50 mg/ml solution
for injection or infusion may cause effects
such as somnolence and dizziness and
therefore may impair a patient's ability to
drive safely or operate machinery. This
applies particularly in conjunction with
alcohol and other psychotropic substances.
Patients should, therefore, not drive or
operate machinery.
This class of medicine is in the list of drugs
included in regulations under 5a of the Road
Traffic Act 1988. When prescribing this
medicine, patients should be told:
• The medicine is likely to affect your ability
to drive
• Do not drive until you know how the
medicine affects you
• It is an offence to drive while under the
influence of this medicine
• However, you would not be committing an
offence (called 'statutory defence') if:
o The medicine has been prescribed to treat
a medical or dental problem and
o You have taken it according to the
instructions given by the prescriber and in
the information provided with the medicine
and
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o It was not affecting your ability to drive
safely
4.8 Undesirable effects
Rapid intravenous administration may be
associated with a higher incidence of
adverse effects and therefore should be
avoided.
The most commonly reported adverse drug
reactions are nausea and dizziness, both
occurring in more than 10% of patients.
The frequencies are defined as follows:
Very common: ≥1/10
Common: ≥1/100, <1/10
Uncommon: ≥1/1000, <1/100
Rare: ≥1/10 000, <1/1000
Very rare: <1/10 000
Not known: cannot be estimated from the
available data
Cardiovascular disorders:
uncommon: cardiovascular regulation
(palpitation, tachycardia). These adverse
reactions may occur especially on
intravenous administration and in patients
who are physically stressed.
rare : bradycardia
Investigations:
Rare: increase in blood pressure
Vascular disorders:
Uncommon: cardiovascular regulation
(postural hypotension or cardiovascular
collapse). These adverse reactions may
occur especially on intravenous
administration and in patients who are
physically stressed.
Metabolism and nutrition disorders:
Rare: changes in appetite
Not known: hypoglycaemia
Respiratory, thoracic and mediastinal
disorders:
Rare: respiratory depression, dyspnoea
If the recommended doses are considerably
exceeded and other centrally depressant
substances are administered concomitantly
(see section 4.5), respiratory depression may
occur.
Worsening of asthma has been reported,
though a causal relationship has not been
established.
Nervous system disorders:
very common : dizziness
common : headache, somnolence
rare : changes in appetite, paraesthesia,
tremor, respiratory depression, epileptiform
convulsions, involuntary muscle
contractions, abnormal coordination,
syncope.
not known: speech disorders
Convulsions occurred mainly after
administration of high doses of tramadol or
after concomitant treatment with medicinal
products which can lower the seizure
threshold (see sections 4.4 and 4.5).
Psychiatric disorders:
rare : hallucinations, confusion, sleep
disturbance, delirium, anxiety and
nightmares. Psychological adverse reactions
may occur following administration of
Tramadol hydrochloride 50 mg/ml solution
for injection or infusion which vary
individually in intensity and nature
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(depending on personality and duration of
treatment). These include changes in mood
(usually elation, occasionally dysphoria),
changes in activity (usually suppression,
occasionally increase) and changes in
cognitive and sensorial capacity (e.g.
decision behaviour, perception disorders).
Dependence may occur.
Symptoms of withdrawal reactions, similar
to those occurring during opiate withdrawal,
may occur as follows: agitation, anxiety,
nervousness, insomnia, hyperkinesia, tremor
and gastrointestinal symptoms. Other
symptoms that have very rarely been seen
with tramadol discontinuation include: panic
attacks, severe anxiety, hallucinations,
paraesthesias, tinnitus and unusual CNS
symptoms (i.e. confusion, delusions,
depersonalisation, derealisation, paranoia).
Eye disorders:
rare : miosis, mydriasis, blurred vision
Gastrointestinal disorders:
very common : nausea
common : vomiting, constipation, dry mouth
uncommon : retching; gastrointestinal
irritation (a feeling of pressure in the
stomach, bloating), diarrhoea
Skin and subcutaneous tissue disorders:
common : sweating
uncommon :dermal reactions (e.g. pruritus,
rash, urticaria)
Musculoskeletal and connective tissue
disorders:
rare : motorial weakness
Hepatobiliary disorders:
In a few isolated cases an increase in liver
enzyme values has been reported in a
temporal connection with the therapeutic use
of tramadol.
Renal and urinary disorders:
rare : micturition disorders (difficulty in
passing urine, dysuria and urinary retention)
Immune system disorders:
Rare: allergic reactions (e.g. dyspnoea,
bronchospasm, wheezing, angioneurotic
oedema) and anaphylaxis
General disorders:
common : fatigue
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after
authorisation of the medicinal product is
important.
4.9 Overdose
Symptoms
In principle, on intoxication with tramadol
symptoms similar to those of other centrally
acting analgesics (opioids) are to be
expected. These include in particular miosis,
vomiting, cardiovascular collapse,
consciousness disorders up to coma,
convulsions and respiratory depression up to
respiratory arrest.
Treatment
The general emergency measures apply.
Keep open the respiratory tract (aspiration!),
maintain respiration and circulation
depending on the symptoms. The antidote
for respiratory depression is naloxone. In
animal experiments naloxone had no effect
on convulsions. In such cases diazepam
should be given intravenously.
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In case of intoxication orally,
gastrointestinal decontamination with
activated charcoal or by gastric lavage is
only recommended within 2 hours after
tramadol intake. Gastrointestinal
decontamination at a later time point may be
useful in case of intoxication with
exceptionally large quantities.
Tramadol is minimally eliminated from the
serum by haemodialysis or haemo-filtration.
Therefore treatment of acute intoxication
with Tramadol hydrochloride 50 mg/ml
solution for injection or infusion with
haemodialysis or haemofiltration alone is
not suitable for detoxification.
5. Pharmacological properties
5.1 Pharmacodynamic properties
Tramadol is a centrally acting analgesic
which possesses opioid agonist properties.
Tramadol consists of two enantiomers, the
(+)-isomer is predominantly active as an
opioid with preferential activity for the μ-
receptor. The (-)-isomer potentiates the
analgesic effect of the (+)-isomer and is
active as an inhibitor of noradrenaline and
serotonin uptake thereby modifying the
transmission of pain impulses.
Tramadol also has an antitussive action. At
the recommended dosages, the effects of
tramadol given orally on the respiratory and
cardiovascular systems appear to be
clinically insignificant. The potency of
tramadol is reported to be 1/10th
to 1/6th
that
of morphine.
Paediatric population
Effects of enteral and parenteral
administration of tramadol have been
investigated in clinical trials involving more
than 2000 paediatric patients ranging in age
from neonate to 17 years of age. The
indications for pain treatment studied in
those trials included pain after surgery
(mainly abdominal), after surgical tooth
extractions, due to fractures, burns and
traumas as well as other painful conditions
likely to require analgesic treatment for at
least 7 days.
At single doses of up to 2 mg/kg or multiple
doses of up to 8 mg/kg per day (to a
maximum of 400 mg per day) efficacy of
tramadol was found to be superior to
placebo, and superior or equal to
paracetamol, nalbuphine, pethidine or low
dose morphine. The conducted trials
confirmed the efficacy of tramadol. The
safety profile of tramadol was similar in
adult and paediatric patients older than 1
year (see section 4.2).
5.2 Pharmacokinetic properties
a) General
The mean absolute bioavailability after
intramuscular administration was found to
be 100%.
The distribution of tramadol following
intravenous administration is rapid and in
two phases with different half-lives of 0.31
± 0.17 hours (initial rapid phase) and 1.7±
0.4 hours (slower phase) respectively.
After intravenous administration of 100 mg
tramadol, the serum concentration was 613
± 221 ng/ml at 15 minutes post dosing and
409 ± 79 ng/ml at 2 hours post dosing.
Tramadol has a high tissue affinity with an
apparent volume of distribution of 203 L
after intravenous dosing in healthy
volunteers.
Tramadol undergoes hepatic metabolism
with approximately 85% of an intravenous
dose being metabolised in young healthy
volunteers. In humans tramadol is mainly
metabolised by means of N- and O-
demethylation and conjugation of the O-
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demethylation products with glucuronic
acid. Only O-desmethyltramadol is
pharmacologically active. There are
considerable interindividual quantitative
differences between the other metabolites.
So far, eleven metabolites have been found
in the urine. Animal experiments have
shown that O-desmthyltramadol is more
potent than the parent substance by the
factor 2-4. Its half life t½β (6 healthy
volunteers) is 7.9 h (range 5.4-9.6 h) and is
approximately that of tramadol.
The inhibition of one or both cytochrome
P450 isoenzymes, CYP3A4 and CYP2D6
involved in the metabolism of tramadol,
may affect the plasma concentration of
tramadol or its active metabolite.
Tramadol is essentially excreted via the
kidneys. The mean elimination half-life of
tramadol following intravenous
administration is 5-6 hours. Total clearance
of tramadol was 28.0 L/h following
intravenous administration.
b) Characteristics in patients
Effect of age: Tramadol pharmacokinetics
show little age-dependence in volunteers up
to the age of 75 years. In volunteers aged
over 75 years, the terminal elimination half-
life was 7.0 ± 1.6 h compared to 6.0 ± 1.5 h
in young volunteers after oral
administration. Effect of hepatic or renal
impairment: As both tramadol and its
pharmacologically active metabolite, O-
desmethyl tramadol, are eliminated both
metabolically and renally, the terminal half-
life of elimination (t½) may be prolonged in
patients with hepatic or renal dysfunction.
However, the increase in t½ is relatively
small if either excretory organ is functioning
normally. In liver cirrhosis patients, the
mean t½ of tramadol was 13.3 ± 4.9 hours.
In patients with renal failure (creatinine
clearance < 5 mL/min) the t½ of tramadol
was 11.0 ± 3.2 hours and that of M1 was
16.9 ± 3.0 hours. Extreme values observed
to date are 22.3 hours (tramadol) and 36.0
hours (M1) in liver cirrhosis patients and
19.5 hours (tramadol) and 43.2 hours (M1)
in renal failure patients.
Paediatric population
The pharmacokinetics of tramadol and O-
desmethyltramadol after single-dose and
multiple-dose oral administration to subjects
aged 1 year to 16 years were found to be
generally similar to those in adults when
adjusting for dose by body weight, but with
a higher between-subject variability in
children aged 8 years and below.
In children below 1 year of age, the
pharmacokinetics of tramadol and O-
desmethyltramadol have been investigated,
but have not been fully characterized.
Information from studies including this age
group indicates that the formation rate of O-
desmethyltramadol via CYP2D6 increases
continuously in neonates, and adult levels of
CYP2D6 activity are assumed to be reached
at about 1 year of age. In addition, immature
glucuronidation systems and immature renal
function may result in slow elimination and
accumulation of O-desmethyltramadol in
children under 1 year of age.
5.3 Preclinical safety data
On repeated oral and parenteral
administration of tramadol for 6 - 26 weeks
in rats and dogs and oral administration for
12 months in dogs, haematological, clinico-
chemical and histological investigations
showed no evidence of any substance-
related changes. Central nervous
manifestations only occurred after high
doses considerably above the therapeutic
range: restlessness, salivation, convulsions,
and reduced weight gain. Rats and dogs
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tolerated oral doses of 20 mg/kg and 10
mg/kg body weight respectively, and dogs
rectal doses of 20 mg/kg body weight
without any reactions.
In rats tramadol dosages from 50 mg/kg/day
upwards caused toxic effects in dams and
raised neonate mortality. In the offspring
retardation occurred in the form of
ossification disorders and delayed vaginal
and eye opening. Male fertility was not
affected. After higher doses (from 50
mg/kg/day upwards) females exhibited a
reduced pregnancy rate. In rabbits there
were toxic effects in dams from 125 mg/kg
upwards and skeletal anomalies in the
offspring.
In some in-vitro test systems there was
evidence of mutagenic effects. In-vivo
studies showed no such effects. According
to knowledge gained so far, tramadol can be
classified as non-mutagenic.
Studies on the tumorigenic potential of
tramadol hydrochloride have been carried
out in rats and mice. The study in rats
showed no evidence of any substance-
related increase in the incidence of tumours.
In the study in mice there was an increased
incidence of liver cell adenomas in male
animals (a dose-dependent, non-significant
increase from 15 mg/kg upwards) and an
increase in pulmonary tumours in females of
all dosage groups (significant, but not dose-
dependent).
6. Pharmaceutical particulars
6.1 List of excipients
Sodium acetate trihydrate
Water for injections
6.2 Incompatibilities
Precipitation will occur if Tramadol
hydrochloride 50 mg/ml solution for
injection or infusion is mixed in the same
syringe with injections of diazepam,
diclofenac sodium, indomethacin,
midazolam and piroxicam.
6.3 Shelf life
36 months. From a microbiological point of
view, the product should be used
immediately. If not used-immediately, in-
use storage times and conditions prior to use
are the responsibility of the user.
6.4 Special precautions for storage
Do not store above 30°C.
6.5 Nature and contents of container
Colourless glass ampoule containing either 1
ml or 2 ml of injection solution. Ampoules
are contained in a pre-fabricated blister strip,
which is enclosed in a cardboard outer
carton. Cartons contain either 1, 5 or 10
ampoules.
6.6 Special precautions for disposal and
other handling
Based on described observations Tramadol
50 mg/ml solution for injection or infusion
is physically and chemically compatible for
up to 24 hours with water for injections
(WFI), sodium chloride solution for
injection 0.9% and glucose solution for
injection 5% at given concentrations.
Obtained results show no necessity for cold
storage.
The prepared infusion solution should be
made immediately before use.
7.Manufactured in India by:
TAJ PHARMACEUTICALS LTD.
Mumbai, India
Unit No. 214.Old Bake House,
Maharashtra chambers of Commerce Lane,
Fort, Mumbai - 400001
at:Gujarat, INDIA.
Customer Service and Product Inquiries:
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1-800-TRY-FIRST (1-800-222-434 & 1-
800-222-825)
Monday through Saturday 9:00 a.m. to 7:00
p.m. EST
E-mail: tajgroup@tajpharma.com