1. Hint, Hint : The arrows represent the amount of
amplification that occurs. The bigger the arrow the
more the step is amplified.
• The pathway of an erection, Nitric Oxide is
the first signal messenger. It diffuses into the
membrane to its intracellular receptor.
• The second messenger is cGMP. This is
made when guanylyl cyclase is activated by
nitric oxide.
• The response of this signal is the relaxation
of the smooth muscle cell which causes
more blood flow into the penis.
• More blood flow = ERECTION ;)
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2. Ginseng increses the amount of
nitric oxide which eventually a
greater production of cGMP,
leading to more PKG, leading to
more relation in the end.
Viagra inhibits PDE5. PDE5
breaks down cGMP. Without
PDE5 there will be more cGMP
which will cause a domino effect of
more relaxation for a longer time.
Mlc p’lase- relaxation will not
occur,
K+ chnnel- effect concentration
IP; receptor- doesn’t release ca+
channel closed
P’lamban- Ca+ will not be moved
If neither of these drugs work
then there may be too much
Ca2+ inside the cell which
causes more contraction of the
cell. We don’t want that.