Presented at 'Changing Perspectives: 1st International Conference on Transport and Health', London, 6 -8 July 2015
Haneen Khreis, Charlotte Kelly, James Tate, Roger Parslow, Karen Lucas
Effects of substituting cigarettes with e-cigarettes in adult smokers Fontem Ventures
Measurement of cardiovascular and pulmonary function endpoints
and other physiological effects following partial or complete
substitution of cigarettes with electronic cigarettes in adult smokers
A systematic review of the association between ptb and the development of chr...EArl Copina
This systematic review examined evidence for an association between pulmonary tuberculosis (PTB) and the development of chronic airflow obstruction (CAO). The review included 19 studies comprising 1 case series, 3 case-control studies, 4 cohort studies, and 8 cross-sectional studies involving over 10,000 subjects total. The majority of studies, including 3 large population-based surveys, found a significant positive association between PTB and CAO, with odds ratios ranging from 1.37 to 2.94. While causality cannot be proven, the evidence confirms that a history of PTB is independently associated with CAO.
The ROAAD Ahead - Preparing Older Adults with Asthma for Climate ChangeJSI
This document summarizes a study examining the impacts of a community health worker-led asthma home visiting program for older adults in Lowell, Massachusetts. Preliminary results show improvements in asthma symptoms, medication adherence, environmental trigger reduction, asthma control status, and reduced preventable healthcare use among participants. The study aims to help prepare vulnerable older adult asthma patients for the health effects of climate change by improving housing conditions and self-management skills. Future research may explore how community health workers can continue supporting this high-risk population in weather emergencies and periods of poor air quality due to climate change.
- The study examined causes of death among 2521 individuals in Lucknow, India to investigate associations with air quality index (AQI).
- Leading causes of death were circulatory diseases (24.1%) including stroke and heart attack, and kidney diseases (11.2%).
- Higher AQI levels were significantly associated with increased risk of death from stroke, circulatory diseases, kidney disease, and other causes.
- After adjusting for factors like age and BMI, higher AQI levels and air pollution exposure were independent risk factors for death.
External Cost of Electricity Generation Systems (2)SSA KPI
AACIMP 2010 Summer School lecture by Yoshio Matsuki. "Sustainable Development" stream. "External Cost of Electricity Generation Systems" course. Part 2.
More info at http://summerschool.ssa.org.ua
Indicators of Innovative Research (Klavans, Boyack, Small, Sorensen, Ioannidis)Kevin Boyack
Most people assume that highly cited papers are "innovative". Using survey results we show that most highly cited papers exemplify normal progress rather than innovation. We also attempt to correlate various indicators with those papers classified as innovative by their authors. Most of these correlations are very weak.
Effects of substituting cigarettes with e-cigarettes in adult smokers Fontem Ventures
Measurement of cardiovascular and pulmonary function endpoints
and other physiological effects following partial or complete
substitution of cigarettes with electronic cigarettes in adult smokers
A systematic review of the association between ptb and the development of chr...EArl Copina
This systematic review examined evidence for an association between pulmonary tuberculosis (PTB) and the development of chronic airflow obstruction (CAO). The review included 19 studies comprising 1 case series, 3 case-control studies, 4 cohort studies, and 8 cross-sectional studies involving over 10,000 subjects total. The majority of studies, including 3 large population-based surveys, found a significant positive association between PTB and CAO, with odds ratios ranging from 1.37 to 2.94. While causality cannot be proven, the evidence confirms that a history of PTB is independently associated with CAO.
The ROAAD Ahead - Preparing Older Adults with Asthma for Climate ChangeJSI
This document summarizes a study examining the impacts of a community health worker-led asthma home visiting program for older adults in Lowell, Massachusetts. Preliminary results show improvements in asthma symptoms, medication adherence, environmental trigger reduction, asthma control status, and reduced preventable healthcare use among participants. The study aims to help prepare vulnerable older adult asthma patients for the health effects of climate change by improving housing conditions and self-management skills. Future research may explore how community health workers can continue supporting this high-risk population in weather emergencies and periods of poor air quality due to climate change.
- The study examined causes of death among 2521 individuals in Lucknow, India to investigate associations with air quality index (AQI).
- Leading causes of death were circulatory diseases (24.1%) including stroke and heart attack, and kidney diseases (11.2%).
- Higher AQI levels were significantly associated with increased risk of death from stroke, circulatory diseases, kidney disease, and other causes.
- After adjusting for factors like age and BMI, higher AQI levels and air pollution exposure were independent risk factors for death.
External Cost of Electricity Generation Systems (2)SSA KPI
AACIMP 2010 Summer School lecture by Yoshio Matsuki. "Sustainable Development" stream. "External Cost of Electricity Generation Systems" course. Part 2.
More info at http://summerschool.ssa.org.ua
Indicators of Innovative Research (Klavans, Boyack, Small, Sorensen, Ioannidis)Kevin Boyack
Most people assume that highly cited papers are "innovative". Using survey results we show that most highly cited papers exemplify normal progress rather than innovation. We also attempt to correlate various indicators with those papers classified as innovative by their authors. Most of these correlations are very weak.
REG Biomarkers Working Group Meeting 26/09/15Zoe Mitchell
This document summarizes the agenda and discussion topics for a biomarker working group meeting on September 25th in Amsterdam. The group will discuss publishing updates, including a perspective article comparing NICE and GINA statements on FeNO and a review on the role of eosinophils in airways disease. They will also discuss potential research ideas using data from the Optimum Patient Care Research Database (OPCRD), including evaluating FeNO and eosinophils as predictors of outcomes in COPD. Additional biomarker data will be added to OPCRD, including IgE testing. The group agreed to further discuss selecting some initial research projects and set a date for their next meeting.
This document summarizes a workshop on cost-effectiveness analysis for respiratory health technologies. The workshop objectives were to introduce cost-effectiveness modeling, discuss what can and cannot be done with these models, and review current evidence gaps. The document then summarizes a cost-effectiveness model developed for ivacaftor treatment of cystic fibrosis. The model found ivacaftor to be cost-effective compared to usual care. Key gaps in COPD and asthma cost-effectiveness studies were identified. Finally, forming a working group to address these evidence gaps through additional research was discussed.
This study evaluated the effectiveness of low-fractional concentration continuous positive airway pressure (CPAP) in the prehospital setting. 340 patients with respiratory distress were treated with CPAP providing a fixed oxygen concentration of 28-30%. Improvements were seen in respiratory rate and oxygen saturation levels. CPAP was discontinued for 16.5% of patients, mostly due to anxiety or requiring intubation. 71.5% of patients' conditions were improved with CPAP treatment based on paramedic assessment. The results suggest CPAP with a low fixed oxygen concentration is effective for commonly encountered respiratory emergencies in the prehospital setting.
1) This review analyzed 30 placebo-controlled trials involving over 11,000 participants to determine if vitamin C reduces the risk of catching a common cold. It found that regular vitamin C intake did not affect cold incidence in the general population but may slightly reduce duration and severity of symptoms.
2) For people exposed to brief periods of extreme physical or cold stress, vitamin C reduced the risk of catching a cold by half based on 6 trials.
3) Trials of high-dose vitamin C administered after cold symptoms began found no consistent effect on duration or severity, though more research is needed, especially in children.
Chronic obstructive pulmonary disease (COPD), a complex progressive disease, is currently the third leading cause of death worldwide. One recommended treatment option is fixed-dose combination therapy of an inhaled corticosteroid (ICS)/long-acting β-agonist. Clinical trials suggest pressurized metered-dose inhalers (pMDIs) and dry powder inhalers (DPIs) show similar efficacy and safety profiles in COPD. Real-world observational studies have shown that combination therapy has significantly greater odds of achieving asthma control when delivered via pMDIs. Our aim was to compare effectiveness, in terms of moderate/severe COPD exacerbations and long-acting muscarinic antagonist (LAMA) prescriptions, for COPD patients initiating fluticasone propionate (FP)/salmeterol xinafoate (SAL) via pMDI versus DPI at two doses of FP (500 and 1,000 μg/d) using a real-life, historical matched cohort study. COPD patients with $2 years continuous practice data, $2 prescriptions for FP/SAL via pMDI/DPI, and no prescription for ICS were selected from the Optimum Patient Care Research Database. Patients were matched 1:1. Rate of moderate/severe COPD exacerbations and odds of LAMA prescription were analyzed using conditional Poisson and logistic regression, respectively. Of 472 patients on 500 µg/d, we observed fewer moderate/severe exacerbations in patients using pMDI (99 [42%]) versus DPI (115 [49%]) (adjusted rate ratio: 0.71; 95% confidence interval: 0.54, 0.93), an important result since the pMDI is not licensed for COPD in the UK, USA, or China. At 1,000 µg/d, we observed lower LAMA prescription for pMDI (adjusted odds ratio: 0.71; 95% confidence interval: 0.55, 0.91), but no difference in exacerbation rates, potentially due to higher dose of ICS overcoming low lung delivery from the DPI.
Read the full paper: https://doi.org/10.2147/COPD.S141409
This document summarizes a study investigating the health-related quality of life and functional status of individuals who have been cured of pulmonary tuberculosis in the Breede Valley District of South Africa. A total of 45 individuals participated in lung function tests, six-minute walk tests, and quality of life questionnaires. The results found that about half had normal lung function, while 25% had restrictive lung function and 21% had obstructive lung function. Six-minute walk distances were reduced compared to references. Quality of life scores also suggested negative impacts in both physical and mental health domains. Challenges in patient recruitment and accessibility were discussed, with recommendations for future research.
The document discusses pediatric asthma, including when to diagnose it in children under 5 years old. Key points include using a therapeutic trial and symptoms like exercise-induced wheezing to make a diagnosis. Tests can include skin prick tests and FeNO to aid diagnosis but not confirm it. The Asthma Predictive Index uses factors like eczema and family history to predict later asthma. Treatment follows GINA guidelines with a stepwise approach starting with SABAs and considering ICS, LTRAs, and doubling ICS doses if needed. Environmental controls and asthma education are also important for management.
Acrolein and COPD in a Nationally Representative Sample of United States Adul...REY DECASTRO
BACKGROUND: Acrolein is an air toxic and tobacco smoke toxicant that laboratory studies suggest may adversely affect pulmonary function. There is strikingly little epidemiology available, however, even though US EPA's 2005 National-Scale Air Toxics Assessment (NATA) estimates that acrolein is responsible for about 75 percent of non-cancer respiratory health effects attributable to air toxics in the United States. AIMS: Characterize the association between model-estimated outdoor acrolein exposure and the prevalence of self-reported COPD. METHODS: Sample-weighted statistical analysis characterized the association between self-reported doctor-diagnosed COPD ("emphysema") and NATA acrolein exposure estimates at the census tract geographically linked to residences of subjects ≥55-years-old in the National Health Interview Survey (NHIS) 2000 - 2009 (n = 89,475). RESULTS: Preliminary results indicate that among never smokers and never & former smokers, outdoor acrolein exposure (1.38E-4 to 4.57E-1 ug/m3) was not associated with COPD prevalence at a statistically significant level, controlling for potential confounders. CONCLUSIONS: Outdoor acrolein exposure is unrelated to COPD prevalence in a nationally representative sample of United States adults 55 and over.
Heterogeneity of asthma and difficulty in achieving optimal control are the major challenges in the management of asthma. To help attain the best possible clinical outcomes in patients with asthma, several guidelines provide recommendations for patients who will require a referral to a specialist. Such referrals can help in clearing the uncertainty from the initial diagnosis, provide tailored treatment options to patients with persistent symptoms and offer the patients access to health care providers with expertise in the management of the asthma; thus, specialist referrals have a substantial impact on disease prognosis and the patient’s health status. Hurdles in implementing these recommendations include lack of their dissemination among health care providers and nonadherence to these guidelines; these hurdles considerably limit the implementation of specialist referrals, eventually affecting the rate of referrals. In this review, recommendations for specialist referrals from several key international and national asthma guidelines and other relevant published literature are evaluated. Furthermore, we highlight why referrals are not happening, how this can be improved, and ultimately, what should be done in the specialist setting, based on existing evidence in published literature.
Read the full paper: https://doi.org/10.2147/JAA.S134300
Potential health implications of exposure to non-combusted liquefied petroleu...Innspub Net
- The study assessed the effects of chronic exposure to non-combusted liquefied petroleum gas (LPG) on the prevalence of respiratory symptoms and pulmonary function among LPG vendors in Nigeria.
- Seventy-five LPG vendors and seventy-five non-vendors were recruited. The prevalence of nasal irritation/sneezing and cough were significantly higher among vendors.
- Pulmonary function tests showed significantly lower lung function measures like FEV1, FVC and PEF among vendors compared to non-vendors.
- The study concluded that chronic exposure to non-combusted LPG is associated with high prevalence of respiratory symptoms like nasal irritation and cough as well as impaired pulmonary function among LPG
This document describes a study that analyzed the association between fine particulate matter (PM2.5) concentration and adult asthma prevalence in Kent County, Michigan from 2005-2012. The study used health survey data and air quality monitoring data. Poisson regression was used to examine the relationship between annual PM2.5 levels and asthma prevalence, both with and without adjusting for potential confounding factors. The analysis found a non-significant 35% increase in asthma prevalence associated with a 10μg/m3 increase in same-year PM2.5 levels after adjustment. A one-year lag analysis also found a non-significant association. The study was limited by use of secondary data and missing information but adds to evidence on PM2.5
This document presents the results of a survey about knowledge of lung cancer. 250 female respondents aged 21-30 were asked questions about causes, symptoms, prevention and stages of lung cancer. The analysis found that most respondents correctly identified smoking as the leading cause, with air pollution as the second most common cause. The majority believed quitting smoking after diagnosis can help treatment. While knowledge of types and stages was varied, respondents were most familiar with coughing up blood as a symptom. The results provide insight into societal understanding of lung cancer risks and facts.
The document discusses the use of inhalational devices in asthma care. It describes various aerosol delivery technologies used including metered-dose inhalers, dry powder inhalers, nebulizers, and spacer devices. It emphasizes that the goal of asthma therapy is optimal drug delivery to the lower airways while minimizing deposition in the upper airways. The document provides recommendations for inhaler use and techniques to optimize treatment. It also discusses challenges with various devices and potential solutions through patient education.
This document outlines the agenda for a seminar on climate change. The seminar will be chaired by Dr. Arti Bhatia and the seminar committee includes Dr. Bidisha Chakravarti and Dr. Namita Das Saha. The seminar will take place at the Centre for Environment Science and Climate Resilient Agriculture at IARI in New Delhi. The outline includes an introduction, sections on causes and evidence of climate change, impacts of climate change, two case studies, and a conclusion.
This document discusses the relationship between air pollution and COVID-19 transmission. It notes that industrial areas like Wuhan that experienced major COVID-19 outbreaks are highly polluted. The lockdowns and quarantines led to a sharp reduction in air pollution as measured by satellites. The authors hypothesize that decreased air pollution may have contributed to reducing disease spread. Several studies are cited showing links between air pollutants like PM2.5 and respiratory illness. The conclusion is that measures to reduce air pollution should be considered when evaluating pathways of disease diffusion.
- The study aimed to determine if the risk of pneumonia for patients prescribed honey thick liquids is equal to or lower than the general population by analyzing medical records of 100 patients prescribed honey thick liquids.
- The cumulative incidence of pneumonia was 5% at 3 months for both the honey thick liquid group and general population, 1% higher for the honey thick liquid group at 6 months, and 4% lower for the honey thick liquid group at 12 months.
- No definitive conclusions could be drawn due to limitations including sample size, variability in medical histories, and pneumonia diagnoses not specifically being aspiration pneumonia. Larger studies were recommended.
REG Child Health Working Group Meeting 26/09/15Zoe Mitchell
This document provides details of a child health working group meeting, including the agenda, completed work, publication status, and a presentation on a comparative effectiveness study of extra-fine particle inhaled corticosteroids and alternative guideline-recommended step-up options in preschool children with asthma. The meeting will take place on September 26th in Amsterdam, chaired by Steve Turner, and will discuss a real-life MASCOT study, abstracts previously presented, the publication status of three papers, and a proposed comparative effectiveness study using the Optimum Patient Care Research Database to compare outcomes of different treatment approaches for preschool wheeze/asthma.
Prof Margaret Bell CBE (Newcastle University) http://www.ncl.ac.uk/transport/people/profile/margaret.bell speaking at Acorn Road group meeting 18 July 2013
Air pollution occurs when harmful substances including particulates and biological molecules are introduced into Earth's atmosphere. It may cause diseases, allergies or death in humans; it may also cause harm to other living organisms such as animals and food crops, and may damage the natural or built environment. Human activity and natural processes can both generate air pollution.
AIR POLLUTION CONTROL course material by Prof S S JAHAGIRDAR,NKOCET,SOLAPUR for BE (CIVIL ) students of Solapur university. Content will be also useful for SHIVAJI and PUNE university students
Dr. B. Victor presented on air pollution. He discussed different types of pollution sources and air pollutants. Some key effects of air pollution include damage to health, vegetation, and structures. Increased carbon dioxide contributes to global warming and climate change through the greenhouse effect. Air pollutants like sulfur dioxide and nitrogen oxides can cause acid rain when dissolved in water, harming aquatic life and soil.
Air pollution: its causes,effects and pollutantsMaliha Eesha
This presentation gives the complete detail of air, air pollution, air pollutants and their types, each pollutant in detail and its causes and effects, acid rain, methods of prevention,smog,acidification,indoor pollution and so on. It is a complete package and I hope it'll be helpful in school! :)
REG Biomarkers Working Group Meeting 26/09/15Zoe Mitchell
This document summarizes the agenda and discussion topics for a biomarker working group meeting on September 25th in Amsterdam. The group will discuss publishing updates, including a perspective article comparing NICE and GINA statements on FeNO and a review on the role of eosinophils in airways disease. They will also discuss potential research ideas using data from the Optimum Patient Care Research Database (OPCRD), including evaluating FeNO and eosinophils as predictors of outcomes in COPD. Additional biomarker data will be added to OPCRD, including IgE testing. The group agreed to further discuss selecting some initial research projects and set a date for their next meeting.
This document summarizes a workshop on cost-effectiveness analysis for respiratory health technologies. The workshop objectives were to introduce cost-effectiveness modeling, discuss what can and cannot be done with these models, and review current evidence gaps. The document then summarizes a cost-effectiveness model developed for ivacaftor treatment of cystic fibrosis. The model found ivacaftor to be cost-effective compared to usual care. Key gaps in COPD and asthma cost-effectiveness studies were identified. Finally, forming a working group to address these evidence gaps through additional research was discussed.
This study evaluated the effectiveness of low-fractional concentration continuous positive airway pressure (CPAP) in the prehospital setting. 340 patients with respiratory distress were treated with CPAP providing a fixed oxygen concentration of 28-30%. Improvements were seen in respiratory rate and oxygen saturation levels. CPAP was discontinued for 16.5% of patients, mostly due to anxiety or requiring intubation. 71.5% of patients' conditions were improved with CPAP treatment based on paramedic assessment. The results suggest CPAP with a low fixed oxygen concentration is effective for commonly encountered respiratory emergencies in the prehospital setting.
1) This review analyzed 30 placebo-controlled trials involving over 11,000 participants to determine if vitamin C reduces the risk of catching a common cold. It found that regular vitamin C intake did not affect cold incidence in the general population but may slightly reduce duration and severity of symptoms.
2) For people exposed to brief periods of extreme physical or cold stress, vitamin C reduced the risk of catching a cold by half based on 6 trials.
3) Trials of high-dose vitamin C administered after cold symptoms began found no consistent effect on duration or severity, though more research is needed, especially in children.
Chronic obstructive pulmonary disease (COPD), a complex progressive disease, is currently the third leading cause of death worldwide. One recommended treatment option is fixed-dose combination therapy of an inhaled corticosteroid (ICS)/long-acting β-agonist. Clinical trials suggest pressurized metered-dose inhalers (pMDIs) and dry powder inhalers (DPIs) show similar efficacy and safety profiles in COPD. Real-world observational studies have shown that combination therapy has significantly greater odds of achieving asthma control when delivered via pMDIs. Our aim was to compare effectiveness, in terms of moderate/severe COPD exacerbations and long-acting muscarinic antagonist (LAMA) prescriptions, for COPD patients initiating fluticasone propionate (FP)/salmeterol xinafoate (SAL) via pMDI versus DPI at two doses of FP (500 and 1,000 μg/d) using a real-life, historical matched cohort study. COPD patients with $2 years continuous practice data, $2 prescriptions for FP/SAL via pMDI/DPI, and no prescription for ICS were selected from the Optimum Patient Care Research Database. Patients were matched 1:1. Rate of moderate/severe COPD exacerbations and odds of LAMA prescription were analyzed using conditional Poisson and logistic regression, respectively. Of 472 patients on 500 µg/d, we observed fewer moderate/severe exacerbations in patients using pMDI (99 [42%]) versus DPI (115 [49%]) (adjusted rate ratio: 0.71; 95% confidence interval: 0.54, 0.93), an important result since the pMDI is not licensed for COPD in the UK, USA, or China. At 1,000 µg/d, we observed lower LAMA prescription for pMDI (adjusted odds ratio: 0.71; 95% confidence interval: 0.55, 0.91), but no difference in exacerbation rates, potentially due to higher dose of ICS overcoming low lung delivery from the DPI.
Read the full paper: https://doi.org/10.2147/COPD.S141409
This document summarizes a study investigating the health-related quality of life and functional status of individuals who have been cured of pulmonary tuberculosis in the Breede Valley District of South Africa. A total of 45 individuals participated in lung function tests, six-minute walk tests, and quality of life questionnaires. The results found that about half had normal lung function, while 25% had restrictive lung function and 21% had obstructive lung function. Six-minute walk distances were reduced compared to references. Quality of life scores also suggested negative impacts in both physical and mental health domains. Challenges in patient recruitment and accessibility were discussed, with recommendations for future research.
The document discusses pediatric asthma, including when to diagnose it in children under 5 years old. Key points include using a therapeutic trial and symptoms like exercise-induced wheezing to make a diagnosis. Tests can include skin prick tests and FeNO to aid diagnosis but not confirm it. The Asthma Predictive Index uses factors like eczema and family history to predict later asthma. Treatment follows GINA guidelines with a stepwise approach starting with SABAs and considering ICS, LTRAs, and doubling ICS doses if needed. Environmental controls and asthma education are also important for management.
Acrolein and COPD in a Nationally Representative Sample of United States Adul...REY DECASTRO
BACKGROUND: Acrolein is an air toxic and tobacco smoke toxicant that laboratory studies suggest may adversely affect pulmonary function. There is strikingly little epidemiology available, however, even though US EPA's 2005 National-Scale Air Toxics Assessment (NATA) estimates that acrolein is responsible for about 75 percent of non-cancer respiratory health effects attributable to air toxics in the United States. AIMS: Characterize the association between model-estimated outdoor acrolein exposure and the prevalence of self-reported COPD. METHODS: Sample-weighted statistical analysis characterized the association between self-reported doctor-diagnosed COPD ("emphysema") and NATA acrolein exposure estimates at the census tract geographically linked to residences of subjects ≥55-years-old in the National Health Interview Survey (NHIS) 2000 - 2009 (n = 89,475). RESULTS: Preliminary results indicate that among never smokers and never & former smokers, outdoor acrolein exposure (1.38E-4 to 4.57E-1 ug/m3) was not associated with COPD prevalence at a statistically significant level, controlling for potential confounders. CONCLUSIONS: Outdoor acrolein exposure is unrelated to COPD prevalence in a nationally representative sample of United States adults 55 and over.
Heterogeneity of asthma and difficulty in achieving optimal control are the major challenges in the management of asthma. To help attain the best possible clinical outcomes in patients with asthma, several guidelines provide recommendations for patients who will require a referral to a specialist. Such referrals can help in clearing the uncertainty from the initial diagnosis, provide tailored treatment options to patients with persistent symptoms and offer the patients access to health care providers with expertise in the management of the asthma; thus, specialist referrals have a substantial impact on disease prognosis and the patient’s health status. Hurdles in implementing these recommendations include lack of their dissemination among health care providers and nonadherence to these guidelines; these hurdles considerably limit the implementation of specialist referrals, eventually affecting the rate of referrals. In this review, recommendations for specialist referrals from several key international and national asthma guidelines and other relevant published literature are evaluated. Furthermore, we highlight why referrals are not happening, how this can be improved, and ultimately, what should be done in the specialist setting, based on existing evidence in published literature.
Read the full paper: https://doi.org/10.2147/JAA.S134300
Potential health implications of exposure to non-combusted liquefied petroleu...Innspub Net
- The study assessed the effects of chronic exposure to non-combusted liquefied petroleum gas (LPG) on the prevalence of respiratory symptoms and pulmonary function among LPG vendors in Nigeria.
- Seventy-five LPG vendors and seventy-five non-vendors were recruited. The prevalence of nasal irritation/sneezing and cough were significantly higher among vendors.
- Pulmonary function tests showed significantly lower lung function measures like FEV1, FVC and PEF among vendors compared to non-vendors.
- The study concluded that chronic exposure to non-combusted LPG is associated with high prevalence of respiratory symptoms like nasal irritation and cough as well as impaired pulmonary function among LPG
This document describes a study that analyzed the association between fine particulate matter (PM2.5) concentration and adult asthma prevalence in Kent County, Michigan from 2005-2012. The study used health survey data and air quality monitoring data. Poisson regression was used to examine the relationship between annual PM2.5 levels and asthma prevalence, both with and without adjusting for potential confounding factors. The analysis found a non-significant 35% increase in asthma prevalence associated with a 10μg/m3 increase in same-year PM2.5 levels after adjustment. A one-year lag analysis also found a non-significant association. The study was limited by use of secondary data and missing information but adds to evidence on PM2.5
This document presents the results of a survey about knowledge of lung cancer. 250 female respondents aged 21-30 were asked questions about causes, symptoms, prevention and stages of lung cancer. The analysis found that most respondents correctly identified smoking as the leading cause, with air pollution as the second most common cause. The majority believed quitting smoking after diagnosis can help treatment. While knowledge of types and stages was varied, respondents were most familiar with coughing up blood as a symptom. The results provide insight into societal understanding of lung cancer risks and facts.
The document discusses the use of inhalational devices in asthma care. It describes various aerosol delivery technologies used including metered-dose inhalers, dry powder inhalers, nebulizers, and spacer devices. It emphasizes that the goal of asthma therapy is optimal drug delivery to the lower airways while minimizing deposition in the upper airways. The document provides recommendations for inhaler use and techniques to optimize treatment. It also discusses challenges with various devices and potential solutions through patient education.
This document outlines the agenda for a seminar on climate change. The seminar will be chaired by Dr. Arti Bhatia and the seminar committee includes Dr. Bidisha Chakravarti and Dr. Namita Das Saha. The seminar will take place at the Centre for Environment Science and Climate Resilient Agriculture at IARI in New Delhi. The outline includes an introduction, sections on causes and evidence of climate change, impacts of climate change, two case studies, and a conclusion.
This document discusses the relationship between air pollution and COVID-19 transmission. It notes that industrial areas like Wuhan that experienced major COVID-19 outbreaks are highly polluted. The lockdowns and quarantines led to a sharp reduction in air pollution as measured by satellites. The authors hypothesize that decreased air pollution may have contributed to reducing disease spread. Several studies are cited showing links between air pollutants like PM2.5 and respiratory illness. The conclusion is that measures to reduce air pollution should be considered when evaluating pathways of disease diffusion.
- The study aimed to determine if the risk of pneumonia for patients prescribed honey thick liquids is equal to or lower than the general population by analyzing medical records of 100 patients prescribed honey thick liquids.
- The cumulative incidence of pneumonia was 5% at 3 months for both the honey thick liquid group and general population, 1% higher for the honey thick liquid group at 6 months, and 4% lower for the honey thick liquid group at 12 months.
- No definitive conclusions could be drawn due to limitations including sample size, variability in medical histories, and pneumonia diagnoses not specifically being aspiration pneumonia. Larger studies were recommended.
REG Child Health Working Group Meeting 26/09/15Zoe Mitchell
This document provides details of a child health working group meeting, including the agenda, completed work, publication status, and a presentation on a comparative effectiveness study of extra-fine particle inhaled corticosteroids and alternative guideline-recommended step-up options in preschool children with asthma. The meeting will take place on September 26th in Amsterdam, chaired by Steve Turner, and will discuss a real-life MASCOT study, abstracts previously presented, the publication status of three papers, and a proposed comparative effectiveness study using the Optimum Patient Care Research Database to compare outcomes of different treatment approaches for preschool wheeze/asthma.
Prof Margaret Bell CBE (Newcastle University) http://www.ncl.ac.uk/transport/people/profile/margaret.bell speaking at Acorn Road group meeting 18 July 2013
Air pollution occurs when harmful substances including particulates and biological molecules are introduced into Earth's atmosphere. It may cause diseases, allergies or death in humans; it may also cause harm to other living organisms such as animals and food crops, and may damage the natural or built environment. Human activity and natural processes can both generate air pollution.
AIR POLLUTION CONTROL course material by Prof S S JAHAGIRDAR,NKOCET,SOLAPUR for BE (CIVIL ) students of Solapur university. Content will be also useful for SHIVAJI and PUNE university students
Dr. B. Victor presented on air pollution. He discussed different types of pollution sources and air pollutants. Some key effects of air pollution include damage to health, vegetation, and structures. Increased carbon dioxide contributes to global warming and climate change through the greenhouse effect. Air pollutants like sulfur dioxide and nitrogen oxides can cause acid rain when dissolved in water, harming aquatic life and soil.
Air pollution: its causes,effects and pollutantsMaliha Eesha
This presentation gives the complete detail of air, air pollution, air pollutants and their types, each pollutant in detail and its causes and effects, acid rain, methods of prevention,smog,acidification,indoor pollution and so on. It is a complete package and I hope it'll be helpful in school! :)
Replication allows data from a MySQL master database to be synchronized with one or more slave databases. The master records all data changes in its binary log. Slave databases connect to the master and receive the binary log transactions, which they then apply locally to stay synchronized with the master database. Replication can be used for load balancing reads across multiple slave servers or for high availability by failing over to a slave if the master fails.
Computer hardware devices include webcams, scanners, mice, speakers, trackballs, and light pens. Webcams connect via USB or network and are used for video calls and conferencing. Scanners optically scan images and documents into digital formats. Mice are pointing devices that detect motion to move a cursor. Speakers have internal amplifiers and audio jacks. Trackballs contain ball and sensors to detect rotation for cursor movement. Light pens allow pointing directly on CRT displays.
This document defines air pollution as occurring when air contains harmful amounts of gases, dust, fumes or odors. It discusses outdoor sources like smog and indoor sources like burning wood. Natural sources include wildfires and volcanoes, while human sources are things like vehicles, power plants, and burning wood. Air pollution can cause health issues for humans and environmental effects like acid rain. The document recommends mitigating air pollution through sustainable development, international agreements, and new technologies.
The document defines and describes five main types of pollution: air, water, noise, land, and radioactive. It provides details on the causes and effects of each type of pollution, as well as some methods to prevent or reduce pollution. The five types of pollution covered are air (from vehicles, industries), water (from organic and inorganic wastes), noise (from traffic, construction, industries), land (from mining, waste, urbanization), and radioactive (from nuclear power and waste). The document emphasizes that pollution harms human health, other living things, and the environment.
Epidemiology is the study of health outcomes in populations. Air pollution epidemiology focuses specifically on air pollution as a risk factor for health effects. Key study designs include time-series analyses for short-term exposures and cohort studies for long-term exposures. Cohort studies are considered the gold standard as they can establish temporality between exposure and outcome. Epidemiological findings have influenced air quality standards and policies by demonstrating adverse health effects even below existing limits.
Health effects of PM2.5. Is there anything new to add? - Dr Ian MudwayIES / IAQM
This document summarizes the key findings from numerous studies on the health effects of PM2.5 published between 2006-2019. It notes that thousands of new health studies and reviews have found that PM2.5 contributes significantly to the global burden of disease, with effects seen even below WHO guideline values. Specific topics covered include the impacts of primary combustion pollutants like diesel and biomass burning, the effects of prenatal exposures and impacts across the lifespan, and the use of alternative pollution metrics like black carbon to help disentangle health effects. The document questions whether a mass-based approach or targeted actions on specific components and sources may be most effective for improving health outcomes.
This document provides an introduction to air pollution epidemiology. It discusses key concepts in epidemiology such as distribution, determinants, and populations. It also covers study designs used in air pollution epidemiology including time-series studies, case-crossover studies, ecological studies, cross-sectional studies, case-control studies, and cohort studies. Examples of each type of study assessing the relationship between air pollution and health outcomes are also provided.
This document discusses the history and development of causal modeling in environmental health research. It describes some early milestones in the field, including John Snow identifying the source of a cholera outbreak in 1854 and the British Doctors Study linking smoking to lung cancer in 1954. During this "prepersonalized computer era", epidemiologists used matching strategies to limit confounding bias by finding similar exposed and unexposed individuals. The document discusses how these early strategies preceded modern causal inference methods and computational power to properly address questions of causality in observational studies.
This study analyzed data from over 5,000 individuals to investigate exacerbation-like events in those without chronic obstructive pulmonary disease (COPD). The key findings were:
1) Exacerbation-like events occurred in 3.9% of individuals without COPD or asthma in the past year, about half as frequently as in those with COPD (8.2%).
2) In those without COPD, female sex, presence of wheezing, use of respiratory medications, and poor self-perceived health were independent risk factors for exacerbation-like events.
3) Those without COPD but with exacerbation-like events were more likely to report poorer quality of life, missed
This document discusses the high burden of cardiovascular disease (CVD) in India and the link between air pollution and increased risk of CVD. It provides the following key points:
1. CVD is the leading cause of death in India, with rates higher than global averages. Major CVDs include IHD, cerebrovascular disease, and hypertension.
2. Risk factors for CVD like hypertension and diabetes are rising dramatically in India and projected to affect hundreds of millions by 2030.
3. Existing evidence suggests air pollution likely increases the risk of CVD and its risk factors through mechanisms like endothelial dysfunction, inflammation, and increased blood pressure.
4. Research aims to better characterize the associations between long-term air
This document provides background information on asthma. It discusses how asthma is a chronic lung disease that causes inflammation and narrowing of the airways. The prevalence of asthma has increased globally and in the US over the past 20 years. Both genetic and environmental factors like air pollution contribute to the development and exacerbation of asthma. The document outlines research on asthma induction and risk factors. It also discusses government and non-governmental organization efforts to address asthma as a public health issue through research, guidelines, programs and advocacy.
Ambient air pollution_and_population_hea (1)cpinchel
The document summarizes research presented at a 2003 conference on air pollution and human health. It discusses studies on:
1) Exposure assessment that examined variations in particle concentrations and compositions across locations and time periods. Studies found higher ultrafine particle levels in winter and near traffic.
2) Toxicology research demonstrating adverse health effects from air pollution exposure, including increased biomarkers of lung and heart damage. Studies also found evidence of genotoxic and mutagenic effects.
3) Epidemiology research further supporting associations between air pollution exposure and negative health impacts like hospitalizations. Studies improved methods for estimating exposures near traffic sources.
Epidemiology is the study of the distribution and determinants of health-related states or events in populations. It has several aims including describing disease occurrence, identifying risk factors, and evaluating prevention programs. Key events in the history of epidemiology include John Snow's investigation of a cholera outbreak in London and Florence Nightingale's studies on epidemic typhus. Epidemiology is used in public health to investigate health issues and inform interventions and policies.
Airborne Particulate Matter And Human Health:Perspective And Case Study-Garg ...ECRD IN
This document summarizes research on the health effects of airborne particulate matter. It discusses epidemiological studies that have found associations between particulate exposure and increased mortality and morbidity. Specifically, exposures to PM10 and PM2.5 have been linked to increased hospital admissions and decreased lung function. The document also reviews the gaps in understanding these health impacts in India, noting that more research is needed that focuses specifically on PM10 and PM2.5, as most Indian data so far has examined total suspended particulates only. It calls for efforts to better understand the epidemiology, toxicology and exposure levels related to particulate air pollution in India.
Chronic obstructive pulmonary disease (COPD) is defined by several medical organizations and involves persistent airflow limitation that is usually progressive. Key indicators for considering COPD include dyspnea, chronic cough, sputum production, exposure to risk factors like smoking, and family history. COPD is assessed based on symptoms, degree of airflow limitation via spirometry, risk of exacerbations, and comorbidities. Exacerbations, which involve worsening of respiratory symptoms, are usually caused by infections and can be mild, moderate, or severe requiring hospitalization. COPD is a major cause of death and disability worldwide.
What is the Association between COPD and HRQoL in Manchester in 2011? Helen Beaumont-Kellner
This study examined the association between Chronic Obstructive Pulmonary Disease (COPD) and health-related quality of life in Manchester, UK in 2011. The study found that COPD patients reported lower health-related quality of life scores compared to a control group without chronic conditions. COPD patients were also more likely to be current or former smokers and less likely to have received education after age 16. However, the study had some limitations due to its small sample size and inability to account for all confounding variables like age.
This is basically a protocol upon the basis of P.G Public Health presentation on behalf of the Health effects due to environmental pollution on population.
5ALos Angeles is known for its smog, but air quality has impro.docxfredharris32
5A
Los Angeles is known for its smog, but air quality has improved since the 1990’s and so have children’s lungs. The percent of children with lung defects has decreased from 8 out of 100 in 1998 to 3.5 out of 100 in 2011 and is applauded as an environmental success story (N Engl J Med 2015; 372:905-913). For this forum, you are going to find, read and report on a scientific, peer-reviewed research article. The topic is air pollution’s effect on exercise and sports. For example, air pollution was a big concern for the Olympics held in Beijing, China and Rio, Brazil. What impact does it have on athletic performance and health?
You are to find a scientific, peer-reviewed research article. The best place is the library or PubMed. Do not report on a peer-reviewed review paper on the topic. Remember, a review paper summarizes several original research papers. You can use a review to help you find a scientific study. Also, a research study paper usually has the following sections: abstract, introduction, methods, results, conclusions, figures and tables. A review paper does not have these sections.
In your initial Forum post:
· list your selected article
· provide the reference for your chosen article
· describe the study and the results
· state what the study concludes
· evaluate the article. Do you think the study made appropriate conclusions from its data? Was the study designed correctly to address the hypothesis?
· Finally, provide your opinion on the matter. Be sure to justify your position.
Rundell, Kenneth William. “Effect of Air Pollution on Athlete Health and Performance.” British Journal of Sports Medicine 46.6 (2012): 407–412. Web.
Gryka, A et al. “Global Warming: Is Weight Loss a
Solution
?” International Journal of Obesity 36.3 (2012): 474–476. Web.
Raherison, C, and Filleul, L. “Asthma in Exercising Children Exposed to Ozone.” The Lancet 360.9330 (2002): 411–411. Web.
5b
This week we will have two topics in this forum. You will be assigned one topic an then you are expected to respond to both topics in your follow-up posts.
If your last name falls between these letters than your topic is:
· A-M: Topic 1, Qualitative, Quantitative and Mixed Methods Studies
Topic 1: There are several different types of research data. We divide these into qualitative, quantitative, and mixed methods.
For this forum, find one example of the study type you are assigned. Tell the class the following:
· Complete reference of the paper
· The kind of study
· Why you feel it is that type of research
The study type you are assigned is based on the first letter of your last name. Letter C ( Qualitative)
Study Type
First Letter of Your Last Name
Qualitative
A-D
Quantitative
E-H
Mixed Methods
I-M
Topic 2: There are many different types of study designs. Find a study design that is one of these: case-controlled studies, cohort study, randomized controlled trials, meta-analysis, or case study.
Tell the class the following:
Complete re.
The document summarizes a summer internship that Juliann Chen completed at the Health Effects Institute in Boston. The Health Effects Institute is an independent non-profit organization that funds research on health effects of air pollution, especially from vehicles. During the internship, Chen helped review studies on health effects of air pollution in Asian cities and identified gaps where more research is needed. The internship provided experience in conducting literature reviews and epidemiology studies to understand impacts of air pollution.
This document discusses evidence-based practice and how it applies to assessing clinical intervention studies. It begins by listing the learning objectives for Lecture c, which include explaining how evidence-based medicine can be applied to intervention studies. The document then discusses how the best evidence for assessing interventions comes from randomized controlled trials (RCTs) or systematic reviews of RCTs. It provides examples of RCTs and outlines key questions one should ask to critically appraise an intervention study, such as whether the results are valid and can be applied to patient care.
This study aimed to reduce blood culture contamination rates in an emergency department through an educational nursing program. The baseline contamination rate was 4.8%, above the standard of less than 3%. A quantitative quasi-experimental design was used to examine the relationship between an educational intervention and contamination rates. Nurses were provided additional training on proper blood culture collection techniques. The study hypothesized that this education would decrease contamination rates. Contamination can increase costs and unnecessary treatment, so reducing it through effective training could improve patient outcomes and experience of care.
Select one (1) peer-reviewed research article that you used in you.docxzenobiakeeney
Select one (1) peer-reviewed research article that you used in your research paper to share with the class.
Do not discuss en editorial or letter to editor.
After reading your selected article, post the following information:
1. Why is the research question significant to your research paper?
2. What was the purpose of the study?
3. What was the study design?
4. Who was in the study population(s)/sample(s)?
5. What was the outcome and was it consistent with the researcher(s)' original research question?
6. What recommendation(s) did the researcher offer for future studies?
7. How do you know this article was peer-reviewed?
OBSTRUCTIVE PULMONARY
DI
SEASE (COPD)
1
Chronic Obstructive Pulmonary Disease (
COPD
)
Name
Course
Tutor
Date
Chronic Obstructive Pulmonary Disease (
COPD
)
Abstract
A chronic obstructive pulmonary disease (COPD) is one of the current killers in the world. It is a preventable disease that makes it difficult for the affected individual to empty air out of the lungs otherwise referred to as airflow obstruction. The difficulties in breathing that is brought about by this condition leaves one feeling tired because they use
much
energy to
breathe
than required.
The c
hronic
obstructive pulmonary disease is a term that is used to include other types of pulmonary diseases that include chronic bronchitis, emphysema or both. Although asthma is a health condition that results in difficulties in breathing it is not included among the chronic obstructive pulmonary disease.
The effects of the disease are not instant but rather evolve at a slower rate inhibiting the breathing system of a patient.
However,
the
most important thing to note is that the disease can
be prevented
and it is relatively easier when it
is detected
in its earlier stages than in advanced stage.
In the United States, between 10 % and 20% of the chronic obstructive pulmonary disease is said to have been caused by occupational or exposure to chemical vapors,
irritants
,
and fumes which are very much contaminated. A
large
percentage of patients who are suffering from COPD are said to be
smokers
,
but a recent research indicated that 25 % of patients with COPD have never smoked in the United States. This paper provides an in-depth analysis into chronic obstructive pulmonary diseases including the historical perspective,
symptoms, and causes
of COPD,
method of spread, how it can
be contained
, and its implication on the economy,
treatment
,
and efforts being put in place to ensure that the disease is
contained
.
Keywords
COPD,
Chronic, Obstructive. Bronchodilators,
Pulmonary,
Prevalence, Mortality
.
History of the diseases
The c
hronic
obstructive pulmonary disease has been in existence for the last 200
years;
the only difference is that its prevalence back in the day was much lower mainly because of
the
lower
presence of risk factors than they are currently.
The disease
was recognized
by the.
1. The study analyzed the association between air pollution (PM2.5 and O3) and mortality in Los Angeles using a cohort from the American Cancer Society and controlling for individual and neighborhood factors.
2. It found that all-cause mortality was associated with higher PM2.5 levels, with a relative risk of 1.17 for each 10 μg/m3 increase in PM2.5. Risks were higher for deaths from ischemic heart disease and lung cancer.
3. The results provide evidence that intra-city variations in air pollution exposure lead to stronger health effects than prior studies using average exposures across cities, suggesting localized pollution drives additional health impacts.
Similar to Does traffic related air pollution cause childhood asthma (20)
www.nhtnetwork.org/cqc-efficiency-network/home
The CQC Efficiency Network is a collaborative venture between ITS researcher Dr Phill Wheat and leading
performance and benchmarking company measure2improve (m2wi). Dr Wheat has used funding from the EPSRC
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the economic returns that benefit UK plc.
This document discusses using big telematics data from vehicle tracking to assess vehicular emissions. It provides details on:
- Sources of telematics data like fleet surveillance and insurance data.
- Benefits like accounting for local driving conditions like traffic flow and weather in emission assessments.
- Methodology used to clean the data, model instantaneous emissions, and scale emission factors based on fleet mix and traffic flows.
- Case studies conducted in Sheffield and Leeds examining variability in driver behavior and emissions by time of day, weather, and other factors.
- Ongoing work to refine estimates and model scenarios like potential clean air zones.
Posters summarizing dissertation research projects - presented by MSc students at the Institute for Transport Studies (ITS), University of Leeds, April 2017. http://bit.ly/2re35Cs
www.its.leeds.ac.uk/courses/masters/dissertation
This document provides an overview of London's Crossrail scheme, including its long evolution, governance, financing, and challenges. Some key points:
- Crossrail was first proposed in the 1940s but faced many delays until being approved in 2007, with construction starting in 2009 and completion in 2018.
- Its benefits case was strengthened over time by considering wider economic impacts like agglomeration effects, showing links between transport investment and economic growth.
- Funding came from national and local government as well as farepayers, with London able to raise additional revenue through a business rates supplement.
- Strong governance including a joint sponsor board helped ensure delivery on time and on budget.
- Crossrail 2 is
Cutting-edge transport research showcased to Secretary of State during the event to officially re- open the Institute building www.leeds.ac.uk/news/article/4011/cutting-edge_transport_research_showcased_to_secretary_of_state
The document discusses business model innovation opportunities for electric vehicle adoption. It identifies 10 potential new business models that link the auto industry, energy systems, and transportation infrastructure. These models are evaluated based on their ability to meet stakeholder needs across these sectors and catalyze innovation. The top performing models bundle mobility and energy services, allowing optimized energy usage and new revenue streams. The report recommends actions like tariff innovation to encourage transitioning to these models and capturing benefits of increased electric vehicle use.
Presentation Fiona Crawford - winner of the Smeed prize for best student paper at the UTSG Conference 2017
www.its.leeds.ac.uk/people/f.crawford
www.utsg.net/web/index.php?page=annual-conference
Efforts to reduce the emissions from car travel have so far been hampered by a lack of specific information on car ownership and use. The Motoring and vehicle Ownership Trends in the UK (MOT) project seeks to address this by bringing together new sources of data to give a spatially and disaggregated diagnosis of car ownership and use in Great Britain and the associated energy demand and emissions.
Data from annual car M.O.T tests, made available by the Department for Transport, will be used as a platform upon which to develop and undertake a set of inter-linked modelling and analysis tasks using multiple sources of vehicle-specific and area-based data. Through this the project will develop the capability to understand spatial and temporal differences in car ownership and use, the determinants of those differences, and how levels may change over time and in response to various policy measures. The relationship between fuel use and emissions, and the demographic, economic, infrastructural and socio-cultural factors influencing these will also be tested.
Consequently, the MOT project has the potential to transform the way in which energy and emissions related to car use are quantified, understood and monitored to help refine future research and policy agendas and to inform transport and energy infrastructure planning.
www.its.leeds.ac.uk/research/featured-projects/mot
The University's Annual Review covering the 2015-16 academic year. This new publication gives an overview of some of the most important initiatives and activities that the University has undertaken recently and a sense of the scale of the ambition for the future.
www.its.leeds.ac.uk/people/c.calastri
Social networks, i.e. the circles of people we are socially connected to, have been recognised to play a role in shaping our travel and activity behaviour. This not only has to do with socialisation being the purpose of travel, but also with enabling mobility and other activities through the so-called social capital. Another theme in the literature connecting social environment and travel behaviour is social influence, i.e. the investigation of how travel behaviour can be affected by observation or comparison with other people. Research about the impact of social influence on travel choices is still at its infancy. In this talk, I will give an overview of how choice modelling can be used to investigate the relationships between social networks, travel and activities. I will touch upon work that I have done so far, in particular I will describe my applications of the Multiple Discrete-Continuous Extreme Value (MDCEV) model to frequency of social interactions as well as to allocation of time to different activities, taking the social dimension into account. In these studies, I make use of social network and travel data collected in places as diverse as Switzerland and Chile. I will also discuss ongoing work making use of longitudinal life-course data to model the impact of family of origin and the “mobility environment” people grew up in on travel decision of adults. Finally, I will outline future plans about modelling behavioural changes due to social influence using the smartphone app travel data that are being collected in Leeds within the “Choices and consumption: modelling long and short term decisions in a changing world” (“DECISIONS”) project.
Shigeki Oxawa is Associate Professor at the Department of Integrated Informatics, Daido University and part-time Lecturer in Transport Economics at Hosei University. He is a transport economist with a strong interest in transport policy. He is currently an academic visitor at Leeds University (April 2016-March 2017) working in the area of intermodal transport (with a focus on rail freight transport) and in turn track access charges.
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In the vertical separation system, freight companies cannot get access to the slots required and efficient allocation of rail track cannot be achieved. The vertical separation is a very significant issue in railway policy and freight transport policy in Japan. In the presentation, causes and possible solutions to the issue will be shown.
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Presentation from NORTHMOST - a new biannual series of meetings on the topic of mathematical modelling in transport.
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The focus of the meetings will alternate; NORTHMOST 02 - planned for Spring 2017 - will be led by practitioners who are modelling experts. Practitioners will give presentations, with academic researchers in the audience. In addition to giving a forum for expert practitioners to meet and share best practice, a key aim of the series is to close the gap between research and practice, establishing a feedback loop to communicate the needs of practitioners to those working in university research.
Presentation from NORTHMOST - a new biannual series of meetings on the topic of mathematical modelling in transport.
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Presentation from NORTHMOST - a new biannual series of meetings on the topic of mathematical modelling in transport.
Hosted at its.leeds.ac.uk, NORTHMOST 01 focussed on academic research, to encourage networking and collaboration between academics interested in the methodological development of mathematical modelling applied to transport.
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Presentation from NORTHMOST - a new biannual series of meetings on the topic of mathematical modelling in transport.
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The focus of the meetings will alternate; NORTHMOST 02 - planned for Spring 2017 - will be led by practitioners who are modelling experts. Practitioners will give presentations, with academic researchers in the audience. In addition to giving a forum for expert practitioners to meet and share best practice, a key aim of the series is to close the gap between research and practice, establishing a feedback loop to communicate the needs of practitioners to those working in university research.
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Presentation from NORTHMOST - a new biannual series of meetings on the topic of mathematical modelling in transport.
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It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
Microbiology & Parasitology Exercises Parts of the Microscope
Does traffic related air pollution cause childhood asthma
1. Session: New perspectives on vulnerable groups
Does traffic-related air pollution
cause childhood asthma?
Haneen Khreis1, Charlotte Kelly1,2, James Tate1, Roger Parslow3
and Karen Lucas1
1 Institute for Transport Studies, 2 Leeds Institute of Health Sciences, 3 Leeds Institute of
Cardiovascular and Metabolic Medicine, University of Leeds
Changing Perspectives: 1st International Conference
on Transport and Health, London, 6 – 8 July 2015
2. 50 years of asthma: UK trends from 1955 to 2004
Trends in the prevalence of a diagnosis of asthma ever in children. m, month; y, year. Source: Anderson et al. (2007)
3. Why such steady and rapid increases?
“… the increase in disease must
be attributable to a change in
as-yet unknown environmental
factors… ” (Cookson, 2004, p. 979)
Source: Brook (2012)
4. Does children’s exposure to traffic-
related air pollution increase their
risks of developing asthma?
Meta-analysis
Case study - The Born in Bradford
Systematic review
Provide data
Learn and apply lessons
5. Does children’s exposure to traffic-related air pollution increase
their risks of developing asthma?
3. Include studies which investigate children’s
exposure to traffic-related air pollution only1. Include human
studies only 2. and
children’s studies only 4. Include studies which investigate exposure to
traffic-related air pollution or traffic-related air
pollutants when road traffic is specified as their source
6. Include studies which specifically
investigate the subsequent risk of
asthma development in childhood
7. Include observational studies only
5. Include studies which
report measures of
association and their
confidence interval precision
Khreis et al. (2014). Exposure to traffic-related air pollution and the development of childhood asthma. PROSPERO 2014:CRD42014015448,
available from: http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42014015448
7. Research gaps and impact on validity: asthma definitions
• Heterogeneous disease
• No universally accepted definition
• Has many phenotypes
• AND non-specific symptoms….
8. Research gaps and impact on validity: asthma definitions
Self-report of doctor-diagnosis = 12.0%
Hospitalization registry = 6.6%
Prescription registry = 32.2%
Source: Hansen et al. (2012)
9. Research gaps and impact on validity: asthma definitions
Self-report of doctor-diagnosis = 12.0%
Hospitalization registry = 6.6%
Prescription registry = 32.2%
1
12
Source: Hansen et al. (2012)
10. Research gaps and impact on validity: exposure models
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Background
Site
Background
Site
Intersection
Corner
Bus
Stop
Road
Crossing
Bus
Stop
Intersection
Corner
Road
Crossing
Intersection
Corner
Intersection
Corner
Road
Crossing
Fay D, Tate J, Khreis H (2015): Investigating pedestrians PNC exposures in urban micro-environments near a busy road traffic intersection
11. Research gaps and impact on validity: exposure models
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16:45:52
16:46:47
16:47:42
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16:58:42
16:59:37
17:00:32
17:01:27
17:02:22
17:03:17
17:04:12
17:05:07
17:06:02
17:06:57
17:07:52
17:08:47
17:09:42
17:10:37
17:11:32
17:12:27
17:13:22
17:14:17
17:15:12
17:16:07
17:17:02
17:17:57
17:18:52
17:19:47
17:20:42
Background
Site
Background
Site
Intersection
Corner
Bus
Stop
Road
Crossing
Bus
Stop
Intersection
Corner
Road
Crossing
Intersection
Corner
Intersection
Corner
Road
Crossing
Fay D, Tate J, Khreis H (2015): Investigating pedestrians PNC exposures in urban micro-environments near a busy road traffic intersection
12. Research gaps and impact on validity: exposure models
Proximity to
roadways
Regulatory
monitoring stations
Land-use regression
models
Dispersion models
13. Research gaps and impact on validity: exposure models
10 studies reporting 30
risk estimates, 53%
were positive (31%
significant)
4 studies reporting 28 risk
estimates, 93% were
positive (65% significant)
10 studies reporting 55
risk estimates, 93% were
positive (29% significant)
4 studies reporting 40
risk estimates, 50% were
positive (35% significant)
14. 23 studies, 153 main risk estimates from 4 exposure models,
114 (75%) positive, 45 (39%) statistically significant… and
more from the other exposure models…
3
5
1
1
3
3
1
2
3
1
15. So does traffic-related air pollution cause asthma?
“The results found across the studies
followed a pattern that would be
expected under the plausible
assumption that the pollutants really
are causally associated with asthma
development, if only among a subset
of children…”
(HEI, 2010, p.363)
17. But…
… and why this heterogeneity?
• Differences in study designs,
populations, exposure models,
outcome definitions and
confounders selection
• Certain susceptibility factors may
be one reason (early life
exposures, sex)
• Only certain phenotypes of
asthma may be affected?
18. • Traffic-related air pollution might have
contributed to the recent asthma epidemic
• Effect estimates are very likely to have been
distorted/ underestimated
• Many effects were detected in areas meeting
the relevant air quality guidelines
• Black Carbon (and ultra-fine particles) are yet
unregulated
Implications
19. • Traffic-related air pollution is a modifiable
environmental factor
• Black Carbon (and ultra-fine particles) are truly
traffic-related pollutants
• -28% / -40% decreases in Black Carbon in the
Milan congestion charging area (Mattioli, 2014)
• A substantial proportion of asthma cases can
be prevented?
Implications
21. References
• Anderson, H. R., Gupta, R., Strachan, D. P., & Limb, E. S. (2007). 50 years of asthma: UK trends from 1955 to 2004. Thorax,
62(1), 85-90.
• Brook, J. R. (2012) 'Estimating exposure to traffic-related air pollution', in Health Effects Institute Annual Conference,
Chicago, Illinois, 15-17th April 2012.
• Cookson, W. (2004). The immunogenetics of asthma and eczema: a new focus on the epithelium. Nature Reviews
Immunology, 4(12), 978-988.
• Hansen, S., Strom, M., Maslova, E., Mortensen, E. L., Granstrom, C., & Olsen, S. F. (2012). A comparison of three methods to
measure asthma in epidemiologic studies: results from the Danish National Birth Cohort. PloS one, 7(5), e36328.
• Health Effects Institute, H. E. I. (2010) Traffic-related air pollution: a critical review of the literature on emissions, exposure,
and health effects, Health Effects Institute.
• Khreis H, Kelly C, Tate J, Parslow R (2014). Exposure to traffic-related air pollution and the development of childhood
asthma. PROSPERO :CRD42014015448, available from:
http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42014015448
• Mattioli, G. (2015). Pollution or congestion charging? Air quality measures and road pricing in Milan, Italy, in Institute for
Transport Studies Research Seminar Series, University of Leeds, 05 March 2015.