The document discusses various types and causes of memory disorders. It describes theories of forgetting such as decay and interference. It outlines the multi-store model of memory including sensory, short-term and long-term memory. Various memory disorders are explained like amnesia from brain damage or thiamine deficiency. Dissociative disorders involving repressed memories are also covered. Assessment methods for different memory systems and types of memory loss are presented.
Clinical examination of higher function test By Pandian M, Tutor, Dept of Phy...Pandian M
Introduction
Examination of Higher Functions
Higher functions,
Examination of cranial nerves,
Sensory system,
Motor system,
Reflexes and
spine.
1.Level of consciousness:
2. Ask any history of suffering from hallucination or delusion or illusions.
3. Look for the appearance :
Clinical examination of higher function test By Pandian M, Tutor, Dept of Phy...Pandian M
Introduction
Examination of Higher Functions
Higher functions,
Examination of cranial nerves,
Sensory system,
Motor system,
Reflexes and
spine.
1.Level of consciousness:
2. Ask any history of suffering from hallucination or delusion or illusions.
3. Look for the appearance :
Here we'll discuss the Memory Disorders and their types. We'll learn about 3 types of memories. We'll discuss Amnesia and the types of amnesia as well as the various other pathologies related to memory. Hope this will help you all
lecture 20 from a college level introduction to psychology course taught Fall 2011 by Brian J. Piper, Ph.D. (psy391@gmail.com) at Willamette University, Loftus, eyewitness memory
Here we'll discuss the Memory Disorders and their types. We'll learn about 3 types of memories. We'll discuss Amnesia and the types of amnesia as well as the various other pathologies related to memory. Hope this will help you all
lecture 20 from a college level introduction to psychology course taught Fall 2011 by Brian J. Piper, Ph.D. (psy391@gmail.com) at Willamette University, Loftus, eyewitness memory
Maintenance Electroconvulsive Therapy Augmentation on Clozapine-Resistant Psy...Zahiruddin Othman
Case Report: Maintenance electroconvulsive therapy augmentation on clozapine-resistant psychosis with neurosyphilis is effective and safe but has never been reported in the literature to the authors' knowledge. It is hoped that this case report would contribute to the scarce literature on this augmentation strategy
Case Report: Schizophrenia patient with prodromal OCS is probably at increased risk of developing TTM while on atypical
antipsychotics treatment. Atypical antipsychotics and SSRI combination therapy is a useful strategy in such patient
Isolated Cerebellar Stroke Masquerades as DepressionZahiruddin Othman
There are numerous reports on neurological conditions masquerading as psychiatric disorders. However, cerebellar
stroke is not established as one of it. The 2 case reports will highlight that this masquerade is possible and the physician's
high index of suspicion is the key to accurate diagnosis.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
2. Theories of Forgetting
Decay (fade away)
The strength of the
connections between
neurons established by
learning fades away over
time
Storage failure
Interference
The disruption of the
ability to remember one
piece of information by
the presence of other
information
Probably because the
retrieval cues for various
memories are similar.
Retrieval failure
Memory Cues
Cues are stimuli that help
you remember; they are
reminders of an event
Context dependent memory
State-dependent memory
e.g.,. drug, sober
Mood-dependent memory
e.g.,. happy, sad
A helpful retrieval cue matches
fragments of information that
are stored in LTM.
The theory views memory as a
continuum of processing from the
“transient product of sensory
analysis to the highly durable
product of semantic-associative
operations” (Craik & Lockhart)
The greater the depth of
processing, the more “durable” the
memory will be and thus the greater
the retention
Encoding
(forming a memory
code)
Encoding
(forming a memory
code)
Storage
(maintaining encoded
memory over time)
Storage
(maintaining encoded
memory over time)
Retrieval
(recovering information
from memory stores)
Retrieval
(recovering information
from memory stores)
KeyKey ProcessesProcesses
scanner DVD-writer
monitor
3. Sensory Memory
Iconic Memory (vision)
•Capacity: Essentially that of the visual system
•Duration: About 0.5 to 1.0 seconds
•Processing: None beyond raw perceptual processing
Echoic Memory (hearing}
•Capacity: ?
•Duration: About 4 to 5 seconds
•Processing: None beyond raw perceptual processing
Sensory Memory
Iconic Memory (vision)
•Capacity: Essentially that of the visual system
•Duration: About 0.5 to 1.0 seconds
•Processing: None beyond raw perceptual processing
Echoic Memory (hearing}
•Capacity: ?
•Duration: About 4 to 5 seconds
•Processing: None beyond raw perceptual processing
Short-term memory (STM) a.k.a. working memory
•Capacity: About 7 ± 2 "chunks" of information
•Duration: About 18 to 20 seconds
•Processing: information is often encoded verbally
Short-term memory (STM) a.k.a. working memory
•Capacity: About 7 ± 2 "chunks" of information
•Duration: About 18 to 20 seconds
•Processing: information is often encoded verbally
Long-term memory (LTM)
•Capacity: Virtually unlimited
•Duration: Up to a lifetime
•Processing: Information is organized according to
meaning and is associatively linked
Long-term memory (LTM)
•Capacity: Virtually unlimited
•Duration: Up to a lifetime
•Processing: Information is organized according to
meaning and is associatively linked
InputAttention
Storage
Retrieval
Rehearsal
Multi-StoreMulti-Store ModelModel
decay
interference
retrieval
failure
Forgetting
4. Computer MemoryComputer Memory Human MemoryHuman Memory
Unreliable and fallible
High confidence doesn’t
necessarily mean high accuracy
Source problems: we mix up
things that happen to us with
things we hear about, see on TV,
etc.
Memory is constructive and can
be heavily influenced by our prior
beliefs and schemas
When information is stored in the hard
disk, it remain unchanged indefinitely, and
you can retrieve an exact copy.
The original 2-stage model of the Atkinson-Shiffrin memory model (1968); lacking
the "sensory memory" stage, which was devised at a later stage in research
5. Photographic Memory:Photographic Memory:
Luria studied Shereshevski who had an unusual
form of eidetic imagery. He could look at a table
of numbers arranged randomly in rows and
columns for a couple of minutes, after which he
could read the table backward, diagonally, or any
other way by calling up the mental picture.
However, the test was a curse. He had trouble
forgetting what he wanted to
Eidetic imagery:Eidetic imagery:
Some children can hold a complex picture in
mind for a couple of minutes. The ability is rare
in adults and usually disappears by the middle
school years.
Mnemonists:Mnemonists:
Make use of rapid coding schemes.
6. THE REAL GOD OF GAMBLERTHE REAL GOD OF GAMBLER
Professional gin rummy and poker player, the late
Stu Ungar, was said to have had eidetic memoryeidetic memory.
He was able to keep track of every card in a six-
deck blackjack shoe. In 1977 he was bet
$100,000 by Bob Stupak, an owner and designer
of casinos, that he could not count down the last
three decks in a six deck shoe. Ungar won the
bet.
http://en.wikipedia.org/wiki/Stu_Ungar
RAIN MANRAIN MAN
At a restaurant, a waitress is
slightly puzzled when Raymond
says her name and home
phone number. He had read
and memorized up to the letter
G — halfway through G — in
the residential directory of a
phone book the previous night.
Charlie is able to convince the
waitress that Raymond means
well, and she seems slightly
impressed. Later, the waitress
drops a box of toothpicks,
spilling its contents, prompting
Raymond to instantly calculate
the number of toothpicks on
the floor (246). Charlie thinks
his brother is wrong (since the
box is a 250-count size), until
the waitress says that four of
the toothpicks remained in the
box.
http://en.wikipedia.org/wiki/The_Rain_Man
Eidetic memory, photographic memory, or total recall, is the ability to recall images, sounds, or
objects in memory with great accuracy and in seemingly unlimited volume. The word eidetic
(pronounced: /a d t k/) comes from the Greek word είδος (eidos), which means "image" or "form".ɪˈ ɛ ɪ
7. Sensory
Memory
< 5 seconds
Sensory
Memory
< 5 seconds
InputAttention
Storage
Retrieval
Rehearsal
Recent
Memory
Last few days-weeks
Recent
Memory
Last few days-weeks
Remote
Memory
Last few years
Remote
Memory
Last few years
Word List
Memory Test
-recall a list of unrelated
word after 5 minutes
Word List
Memory Test
-recall a list of unrelated
word after 5 minutes
Memory ModelMemory Model Clinical AssessmentClinical Assessment
Events in the
previous days
or weeks
Events in the
previous days
or weeks
Events in the
previous months
or years
Events in the
previous months
or years
LTM>Declarative>LTM>Declarative>Events (episodic memory)Events (episodic memory)
LTM
< lifetime
LTM
< lifetime
Delayed
Memory
Last few minutes
Delayed
Memory
Last few minutes
STM
< 20 seconds
STM
< 20 seconds
Immediate
Memory
Last few seconds
Immediate
Memory
Last few seconds
8. Disorders of Memory:
AmnesiaAmnesia
(loss of memory)
AmnesiaAmnesia
(loss of memory)
AmnesticAmnestic
DisordersDisorders
(organic)
AmnesticAmnestic
DisordersDisorders
(organic)
Paramnesia
(errors of memory)
Paramnesia
(errors of memory)
Dissociative
Disorders
(psychogenic)
Dissociative
Disorders
(psychogenic)
The character Neo experiencesThe character Neo experiences déjà vudéjà vu when he sees a black cat go past twice in awhen he sees a black cat go past twice in a
row. Trinity explains to Neo thatrow. Trinity explains to Neo that "a déjà vu is usually a glitch in the matrix""a déjà vu is usually a glitch in the matrix" whichwhich
occurs when the machines change something inside the matrix. The black cat passedoccurs when the machines change something inside the matrix. The black cat passed
twice when the machines placed brick walls outside all the windows in a buildingtwice when the machines placed brick walls outside all the windows in a building..
EpisodicEpisodic
Semantic
Source
EpisodicEpisodic
Semantic
Source
Confabulation
(unconscious filling up gaps
in memory)
Confabulation
(unconscious filling up gaps
in memory)
Déjà vu
(French; “already seen“)
Déjà vu
(French; “already seen“)
Déjà vécu
(already lived
through)
Déjà senti
(already felt)
Déjà visité
(already visited)
Déjà vécu
(already lived
through)
Déjà senti
(already felt)
Déjà visité
(already visited)
Dis. amnesia
Dis. Fugue
Dis. Identity
Dis. amnesia
Dis. Fugue
Dis. Identity
Retrograde
Anterograde
Retrograde
Anterograde
9. • Syndromes
– Alcoholic blackouts
– Korsakoff syndrome
– Transient global
amnesia
• Causes
– Trauma or surgery
– Drugs: anticonvulsants
– Toxin: lead, mercury,
organophosphate
insecticides, and
industrial solvents
Amnestic Disorders:
10. Memory Loss: Patient "H.M." &Memory Loss: Patient "H.M." &
Damage to the HippocampusDamage to the Hippocampus
11. The Day His World Stood StillThe Day His World Stood Still
12. • Thiamine (B1) cause damage in the
diencephalondiencephalon
– including the thalamus, basal forebrain,
mamillary bodies, and raphe nuclei
• AnterogradeAnterograde amnesia is severe but
incomplete.
– Patients are able to repeat a series of
numbers or objects as they are stated but not
after a recall period.
• RetrogradeRetrograde amnesia is demonstrated by
gaps in patients' memories of recent and
remote past that antedate the onset of
illness.
• These gaps in memory are associated with
confabulationconfabulation
– i.e., filling in of memory gaps with data the
patient can readily recall.
Korsakoff Syndrome:
13. • Localized amnesiaLocalized amnesia
– occurs when patients cannot remember certain time
periods or events such as experiences in battle or
situations of torture.
• Selective amnesiaSelective amnesia
– occurs when the person can recall some, but not all,
of the events during a circumscribed period of time
e.g., a combat veteran can recall only some part of a
series of violent combat experiences.
• Generalized amnesiaGeneralized amnesia
– occurs when patients cannot remember anything in
their lifetime, including their own identity.
• Continuous amnesiaContinuous amnesia
– occurs when patients have no memory of events up
to and including the present time. This means that
patients are alert and aware of their surroundings
but are not able to remember anything.
• Systematized amnesiaSystematized amnesia
– occurs when patients have a loss of memory for
certain categories of information, such as certain
places or persons.
Dissociative Disoders:
Repressed Memories
14. Dissociative Disorders:
DissociativeDissociative
AmnesiaAmnesia
DissociativeDissociative
AmnesiaAmnesia
DissociativeDissociative
FugueFugue
DissociativeDissociative
FugueFugue
DissociativeDissociative
Identity DisorderIdentity Disorder
(multiple personality disorder)
DissociativeDissociative
Identity DisorderIdentity Disorder
(multiple personality disorder)
Lunch (Ranchi) has dissociative identity disorder; whenever
she sneezes, she switches between a sweet innocent girl
with blue hair, and a blonde who commits crimes for fun and
is quick to respond with gunfire when angered (pulling a
machine-gun out from nowhere when needed). Neither of
Lunch’s personalities remembers what the other says or
does, and it is never said if the evil side knows of the
innocent self; however, the innocent Lunch is aware of her
evil side (although she doesn't really seem very concerned
over her presence). http://en.wikipedia.org/wiki/Lunch_
%28Dragon_Ball%29
Unexpected travelUnexpected travel
AmnesiaAmnesia
± New identityNew identity
Unexpected travelUnexpected travel
AmnesiaAmnesia
± New identityNew identity
15.
16.
17. Confabulation
• ‘‘False statements that are not made to deceive,
are typically more coherent than thoughts
produced during delirium”
• It ranges from small distortions on laboratory
tasks to striking bizarre stories that patients tell
in describing their personal histories
• Typically occurs in the context of executive
deficits such as perseveration, poor self-
monitoring, and difficulty with self-initiated
processes
18.
19. Cryptamnesia
"concealed recollection"
• It refers to cases where (apparently)
a person believes that he or she is
creating or inventing something new,
such as a story, poem, artwork, or
joke, but is actually recalling a similar
or identical work which he or she has
previously encountered.
• The Frost King was a short story
written by Helen Keller at the age of
twelve, in 1892, which was an
apparent product of cryptomnesia.
http://en.wikipedia.org/wiki/The_Frost_King
20. Further Reading
• Korsakoff syndrome: http://www.emedicine.com/med/topic2405.htm
• Transient global amnesia: http://www.emedicine.com/neuro/topic380.htm
• Dissociative disorders: http://www.emedicine.com/med/topic3484.htm
• Atkinson-Shiffrin: http://users.ipfw.edu/abbott/120/AtkinsonShifrin.html