This document discusses four trends for differentiating instruction in math and science: flexible grouping, learning centers, inquiry-based instruction, and technology. Flexible grouping involves temporarily grouping students based on their needs for a lesson. Learning centers provide hands-on learning materials for students. Inquiry-based instruction engages students through observation and investigation. Technology enhances learning through interactive activities, simulations, and online resources. These differentiation strategies are beneficial for meeting the needs of diverse learners in math and science.