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SLEEP APNEA
Dr Aditya Agrawal
Consultant Chest Physician
Allergy, Critical Care and Sleep Medicine Specialist
Bhatia Hospital
Apollo Spectra I Cumballa I Motinben Dalvi I St Elizabeth I Masina
Tel No: 9022163859
What is Apnea?
• Apnea: a Greek word - “want of breath”
• Obstructive
• Central
• Mixed
Barriers to Diagnosis & Treatment
What are the screening tools?
Berlin questionnaire (primary care setting)
10 items
Snoring severity, significance of daytime sleepiness, witnessed apnea,
obesity, hypertension
STOP-BANG screening test (preoperative setting)
8 items
STOP: Snoring, Tired, Observed apnea, high blood Pressure history
BANG: elevated BMI, Age > 50, increased Neck circumference, Gender male
Neither tool precludes formal sleep testing
Berlin questionnaire
Snoring severity,
significance of daytime sleepiness,
witnessed apnea,
obesity,
hypertension
STOP-BANG screening test
STOP:
Snoring,
Tired,
Observed apnea,
High blood Pressure history
BANG:
elevated BMI,
Age > 50,
increased Neck circumference,
Gender male
Screening and Prevention
Ask all adults about sleep problems or daytime sleepiness
If response is positive: perform OSA screening
 Take further clinical history
 Use validated questionnaire
Screen is also warranted for all patients with:
 Significant obesity
 CVD
 History of drowsiness while driving
What symptoms should prompt consideration of
OSA?
Witnessed episodes of apnea
Loud, frequent, bothersome snoring
Choking/gasping during sleep
Excessive daytime sleepiness
Drowsy driving
Unrefreshing sleep, sleep fragmentation
Insomnia
Nocturia
Morning headaches
Decreased concentration, memory loss
Decreased libido
Nocturnal presentation
• Apnea
• Dyspnea
• Snoring
• Mouth breathing
• Restless sleep
In the absence of symptoms, what other
diseases should prompt evaluation?
Morbid obesity
If patient scheduled for bariatric surgery
Hypertension
If refractory to medical therapy
What other conditions should be considered?
Chronic sleep deprivation disorder (shift-work
disorder)
Circadian rhythm disorder
Depression and anxiety
Hypothyroidism
Obesity hypoventilation syndrome
Central sleep apnea syndrome
Congestive heart failure (Cheyne-Stokes
respiration)
Opiate-induced central sleep apnea
Physical Examination
• Respiratory,
• Cardiovascular and
• Neurologic systems
• Presence of and degree of obesity
• Signs of upper airway narrowing
• Neck >16” women, >17” men
• Mallampati score of 3 or 4
• Macroglossia, tonsillar hypertrophy
• Enlarged or elongated uvula, high/arched
palate
• Nasal obstruction
• Retrognathia
Sources of Cost for Undiagnosed OSA
Comorbidities &
Mental Health
Hypertension
Heart Disease
Diabetes
Asthma/Breathing Disorders
Insomnia
Depression/Anxiety/Mental Health
Includes cost of healthcare
services, medication, and
quality of life.
Motor Vehicle
Accidents
Commercial
Non-Commercial
Includes medical costs,
emergency services, property
damage, lost productivity, and
monetized quality adjusted life
years (QALYs) incurred by
company, insurer, victims,
government and others.
Fatal
Non-Fatal
Fatal
Non-Fatal
$6.9 B
Includes fatal and non-fatal accidents. Includes medical costs and lost
productivity.
Workplace Accidents
Lost Productivity
Productivity
Absenteeism
TREATMENT
Initial Management
Counsel overweight patients about weight loss
Treat any nasal congestion
Advise alcohol avoidance close to bedtime
Offer trial of therapy (CPAP) if patient has
Daytime sleepiness or frequent nocturnal awakenings
Recent accident or near-miss attributable to sleepiness
Controversial: whether to treat asymptomatic patients with mild or moderate OSA
Alternative Treatment Modalities
Uvulopharyngopalatoplasty (UPPP):
 in CP pt and hypotonic upper airway muscles;
 it has not been studied in the uncomplicated pediatric patients
Oral appliances
 have not been reported in children (it may adversely affect the facial
configuration of the growing child)
 In children, CPAP is usually used when T&A is unsuccessful or
contraindicated rather than as a primary treatment
 Young infants
 Medical conditions

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Diagnosis Of Sleep Disordered Breathing by Dr. Aditya Agrawal

  • 1. SLEEP APNEA Dr Aditya Agrawal Consultant Chest Physician Allergy, Critical Care and Sleep Medicine Specialist Bhatia Hospital Apollo Spectra I Cumballa I Motinben Dalvi I St Elizabeth I Masina Tel No: 9022163859
  • 2. What is Apnea? • Apnea: a Greek word - “want of breath” • Obstructive • Central • Mixed
  • 3.
  • 4. Barriers to Diagnosis & Treatment
  • 5. What are the screening tools? Berlin questionnaire (primary care setting) 10 items Snoring severity, significance of daytime sleepiness, witnessed apnea, obesity, hypertension STOP-BANG screening test (preoperative setting) 8 items STOP: Snoring, Tired, Observed apnea, high blood Pressure history BANG: elevated BMI, Age > 50, increased Neck circumference, Gender male Neither tool precludes formal sleep testing
  • 6. Berlin questionnaire Snoring severity, significance of daytime sleepiness, witnessed apnea, obesity, hypertension
  • 7. STOP-BANG screening test STOP: Snoring, Tired, Observed apnea, High blood Pressure history BANG: elevated BMI, Age > 50, increased Neck circumference, Gender male
  • 8. Screening and Prevention Ask all adults about sleep problems or daytime sleepiness If response is positive: perform OSA screening  Take further clinical history  Use validated questionnaire Screen is also warranted for all patients with:  Significant obesity  CVD  History of drowsiness while driving
  • 9. What symptoms should prompt consideration of OSA? Witnessed episodes of apnea Loud, frequent, bothersome snoring Choking/gasping during sleep Excessive daytime sleepiness Drowsy driving Unrefreshing sleep, sleep fragmentation Insomnia Nocturia Morning headaches Decreased concentration, memory loss Decreased libido
  • 10. Nocturnal presentation • Apnea • Dyspnea • Snoring • Mouth breathing • Restless sleep
  • 11. In the absence of symptoms, what other diseases should prompt evaluation? Morbid obesity If patient scheduled for bariatric surgery Hypertension If refractory to medical therapy
  • 12. What other conditions should be considered? Chronic sleep deprivation disorder (shift-work disorder) Circadian rhythm disorder Depression and anxiety Hypothyroidism Obesity hypoventilation syndrome Central sleep apnea syndrome Congestive heart failure (Cheyne-Stokes respiration) Opiate-induced central sleep apnea
  • 13. Physical Examination • Respiratory, • Cardiovascular and • Neurologic systems • Presence of and degree of obesity • Signs of upper airway narrowing • Neck >16” women, >17” men • Mallampati score of 3 or 4 • Macroglossia, tonsillar hypertrophy • Enlarged or elongated uvula, high/arched palate • Nasal obstruction • Retrognathia
  • 14. Sources of Cost for Undiagnosed OSA Comorbidities & Mental Health Hypertension Heart Disease Diabetes Asthma/Breathing Disorders Insomnia Depression/Anxiety/Mental Health Includes cost of healthcare services, medication, and quality of life. Motor Vehicle Accidents Commercial Non-Commercial Includes medical costs, emergency services, property damage, lost productivity, and monetized quality adjusted life years (QALYs) incurred by company, insurer, victims, government and others. Fatal Non-Fatal Fatal Non-Fatal $6.9 B Includes fatal and non-fatal accidents. Includes medical costs and lost productivity. Workplace Accidents Lost Productivity Productivity Absenteeism
  • 16. Initial Management Counsel overweight patients about weight loss Treat any nasal congestion Advise alcohol avoidance close to bedtime Offer trial of therapy (CPAP) if patient has Daytime sleepiness or frequent nocturnal awakenings Recent accident or near-miss attributable to sleepiness Controversial: whether to treat asymptomatic patients with mild or moderate OSA
  • 17. Alternative Treatment Modalities Uvulopharyngopalatoplasty (UPPP):  in CP pt and hypotonic upper airway muscles;  it has not been studied in the uncomplicated pediatric patients Oral appliances  have not been reported in children (it may adversely affect the facial configuration of the growing child)  In children, CPAP is usually used when T&A is unsuccessful or contraindicated rather than as a primary treatment  Young infants  Medical conditions

Editor's Notes

  1. What symptoms should prompt consideration of OSA? Snoring is the symptom with the highest sensitivity for OSA but is very nonspecific (19). To distinguish simple snoring from that suggestive of OSA, patients should be asked for details. Patients with OSA are more likely than simple snorers to report loud, nightly snoring that is bothersome to others (14). Symptoms of OSA are given in the Box. Daytime sleepiness, defined as sleepiness that occurs in a context where alertness would be expected, is also a nonspecific finding. The Epworth Sleepiness Scale (ESS) is an 8-item scale quantifying sleepiness in everyday activities, and although it inconsistently correlates with objective measurements of sleepiness, it can help standardize the evaluation of a patient’s subjective perception (20) (Figure 2). A history of drowsiness or falling asleep while driving should be explicitly explored during evaluation. Patients should be also questioned on use of caffeine or other stimulants because it may indicate attempts to self-treat sleepiness. Although relatively insensitive, choking or gasping during sleep is highly specific for moderate-to-severe OSA, as is the presence of morning headaches (19). Other suggestive symptoms include observed episodes of apnea as well as nocturia and nocturnal awakenings. Obtaining a history from a bed partner or cohabitant can be particularly helpful because many of these symptoms may not be apparent to the patient. Manifestations of untreated OSA may also include decreased libido, decreased concentration, or memory loss. Of note, OSA frequently presents in an atypical fashion, with insomnia and fatigue as the predominant symptoms, particularly in women. Despite population-based studies that find a 2:1 male–female prevalence, utilization data indicate that the ratio for referrals is 9:1 male, suggesting that clinicians do not adequately consider OSA in women (21). Box: Symptoms of Obstructive Sleep Apnea Witnessed episodes of apnea Loud, frequent, bothersome snoring Choking/gasping during sleep Excessive daytime sleepiness Drowsy driving (recent sleepiness-associated motor vehicle accident or near-miss) Unrefreshing sleep Sleep fragmentation Insomnia Nocturia Morning headaches Decreased concentration Memory loss Decreased libido
  2. In the absence of symptoms, what other diseases should prompt evaluation? No high-level evidence currently supports routine evaluation for OSA in asymptomatic populations. However, routine diagnostic testing in asymptomatic, morbidly obese patients scheduled for bariatric surgery may be reasonable given the prevalence in this population (22) and evidence that perioperative treatment reduces postoperative complications (23, 24). Screening other high-prevalence groups undergoing surgery might also be considered, and it may also benefit patients with hypertension refractory to medical therapy. Prevalence of OSA is high among these patients and randomized trials have shown that treatment leads to a modest blood pressure reduction even when superimposed on aggressive antihypertensive medication regimens (25).
  3. What other conditions should be considered? Chronic sleep deprivation and circadian rhythm disorders, particularly shift-work sleep disorder, are common examples of other conditions that can cause significant daytime sleepiness and/or sleep disturbances and should be considered when evaluating patients for OSA. Depression and anxiety not only exacerbate sleep symptoms they may reduce adherence to therapy. Similarly, hypothyroidism can cause fatigue and also worsen OSA severity. Although thyroid function should not be routinely evaluated in all OSA patients, those with preexisting hypothyroidism should be appropriately treated. Of note, OSA frequently coexists with the obesity hypoventilation syndrome, a condition defined by daytime hypercapnia among obese patients without other causes of hypoventilation. This syndrome is present in up to 10%–20% of morbidly obese patients with OSA, and it is important to distinguish these patients from those with uncomplicated OSA because OHS patients have higher rates of cardiovascular complications, such as cor pulmonale. Finally, daytime sleepiness, poor-quality sleep, observed episodes of apnea, and nocturnal gasping may indicate the presence of a central sleep apnea syndrome rather than OSA. Patients with congestive heart failure are at risk for Cheyne-Stokes respiration, and patients on long-acting opiates are at risk for opiate-induced central sleep apnea.