This document discusses the ingredients and mechanism of action of Diabeen cream for managing diabetic foot ulcers. Diabeen cream contains extracts of Centella asiatica, Paeonia suffruticosa, Plectranthus amboinicus, Actinidia chinensis, Curcuma longa, and L-arginine. It promotes wound healing through increased collagen synthesis, wound contraction, cellular proliferation, and reduced epithelialization period. The ingredients have anti-inflammatory, antimicrobial, and wound healing properties. Diabeen cream works synergistically to heal diabetic ulcers by improving microcirculation and the extracellular matrix.

1. Rejuvenation Cream
Managing Diabetic Foot Ulcer
Start Early …
Later will be too late

2. Microvascular Complications in Diabetes Patinets.
Pathophysiology
of Foot
Ulceration
0
25
50
75
100
< 10 10 - 15 15 - 20 > 20
Nephropathy
Neuropathy
%ofpatients
Duration of Diabetes
(years)Olsen et al., 1999
Wegners Classification of Diabetics Ulcer

3. 01
02
03
05
06
07
04
Centella asiatica leaf extract
Asiaticoside as a main constituent:
Increased cellular proliferation and collagen synthesis at the wound site, and
increase in collagen content and tensile strengths.
Act on the connective tissues of the vascular wall, being effective in hypertensive
microangiopathy and venous insufficiencyand decreasing capillary filtration rate
by improving microcirculatory parameters.
Paeonia Suffruticosa Extract
Penta-O-galloyl-beta-d-glucose is the main constituent:
Exhibited dramatic antioxidant, anti-mutagenic, neuro-protective, vaso-relaxant,
and anti-inflammatory properties.
Plectranthus amboinicus leaf oil
Carvacrol & Rosmarinic acid are main constituents:
Promote wound healing by increased wound contraction, enhancing collagen
deposition and reducing the wound epithelialization period.
Exhibit anti-inflammatory activity. It possess AP-1 and TNF-inhibitory activities.
Antimicrobial activity (Antibacterial, Antifungal and Antiviral properties).
Actinidia Chinensis (Kiwi) Fruit Extract
Significant wound healing activity.
Significant antibacterial activity.
Curcuma Longa (Turmeric) Extract
Curcumin is the main constituent:
Significant wound healing activity.
Exhibited good antibacterial and antifungal activities with no toxicity.
Curcuma Longa (Turmeric) Extract
Emodin and Rhein are main constituent:
Exhibited good antibacterial and antifungal activities with no toxicity.
Provide iNOS inhibitions thus its anti-inflammatory effect
Arginine
Promote and accelerate the healing of chronic diabetic foot ulcers to a signifi-
cant degree
Ingredients and mechanism of action
Microvascular Complications in Diabetes Patinets.
Pathophysiology
of Foot
Ulceration
0
25
50
75
100
< 10 10 - 15 15 - 20 > 20
Nephropathy
Neuropathy
%ofpatients
Duration of Diabetes
(years)Olsen et al., 1999
Wegners Classification of Diabetics Ulcer

4. 1
2
4
3
MXN of Action
Increased wound
contraction Enhancing collagen
synthesisdeposition
Increased cellular
proliferation
Reducing the wound
epithelialization
period at the wound
site
Diabeen works as synergistic Effect
Epidermis
Dermis
Fibroblasts
Collagen &
Elastin Fibers
New
Extracellular
Matrix
Keratinocytes
1- Triterpenoid Saponins acts on fibroblasts connective tissue, both in the
vascular walls and around the vessel, modulating the synthesis of collagen.
2- It increases the tensile strength of the skin promoting a healing action.
Cross Section
of Blood Vessel
Smooth Muscle Endothelium
Dibeen Mechanism of action
®
Dibeen Mechanism of action
®
L- Arginine are consider as
essential Amino acids for
the skin ,It increases the
tensile strength of the skin
promoting a healing action.
It inhibits the inflammatory
process that could lead to
hypertrophy in scars and
improves capillary
permeability.
L-arginine and nitric oxide are
required for proper cross
linking of collagen fibers.
1-
2-
3-

5. Why Choose Diabeen® cream for curing diabetic
foot and bedsores ulcer?
References:
DiaBeen ®Active Ingredients
Diabeen®
cream exhibit anti-inflammatory
activity. It possess AP 1- and TNF-inhibitory
activities & Provide iNOS inhibitions.
Diabeen®
cream shown antimicrobial
activity and being e ective in decreasing
capillary filtration rate by improving
microcirculatory parameters at the wound
site.
Diabeen®
cream is a herbal formula that have
excellent safty profile.
Pharmacological Review on Centellaasiatica:
A Potential Herbal Cure-allKashmira J. Gohil,
* Jagruti A. Patel, and Anuradha K. Gajjar1.
Diabetes Care. 1995 Jan;46-39:(1)18.Promotion
and acceleration of diabetic ulcer healing by
arginine-glycine-aspartic acid (RGD).
Medicinal Plants of China, Korea, and Japan.
ReviewPlectranthusamboinicus (Lour.) Spreng:
Botanical.
Indian J Surg (December 2015) E ects of Topical
Kiwifruit on Healing.
Planta Med. 2002 Oct;74-869:(10)68.Inducible
nitric oxide synthase inhibitors of Chinese herbs
III. Rheum palmatum.
Indian J Pharmacol. 2015 MarApr;Exploring the
role of curcumin containingethanolic extract.
Scince Behind Nature
Dibeen®
Cream Promote wound healing through Four Ways :
1- Enhancing collagen synthesis deposition.
2- Increased wound contraction.
3- Reducing the wound epithelialization period at the wound site.
4- Increased cellular proliferation .
African Journal of Biotechnology Vol. 10(56),
pp. 1205826 ,12063- September, 2011.
Microvascular Complications in Diabetes Patinets.
Pathophysiology
of Foot
Ulceration
0
25
50
75
100
< 10 10 - 15 15 - 20 > 20
Nephropathy
Neuropathy
%ofpatients
Duration of Diabetes
(years)Olsen et al., 1999
Wegners Classification of Diabetics Ulcer