2. 2
Diabetic Foot Ulcers market
size
The annual incidence of diabetic foot ulcer
worldwide is between 9.1 to 26.1 million.
Around 15 to 25% of patients with diabetes mellitus
will develop a diabetic foot ulcer during their lifetime.
In 2019, the highest prevalence of diabetes in the
world at 12.2%, with its associated morbidity and
mortality, was found in the Middle East and North
Africa region.
73 million adults (20-79) are living with diabetes in
the IDF MENA Region in 2021. This figure is
estimated to increase to 95 million by 2030 .
3. The diabetic foot ulcer market size is expected to reach $7,793.83 million by 2028 from $4,279.65
million in 2020; it is estimated to grow at a CAGR of 7.9% from 2021 to 2028.
(The insight partner – Feb. / 2022)
4,279.65
million
7,793.83
million
2020
2028
4. Diabetic foot ulcer grades
Gangrene localized to portion
of forefoot or heal.
.
Grade (4)
Superficial diabetic ulcer
(partial or full thickness).
Grade (1)
Deep ulcer with abscess,
osteomyelitis or joint sepsis.
.
Grade (3)
Diabetic
foot ulcers
grade
1
3
4
5 2
0
Insert your text Here. This
is a sample text.
Grade (5)
Ulcer extension to
ligament, tendon, joint
capsule or deep fascia
without abscess or
osteomyelitis.
.
Grade (2)
No open lesions, may have deformity or
cellulites.
Grade (0)
5. Local wound treatment (Diabetic foot ulcer)
Tissue
debridement
Infection Exudates
management
Management
- Occasionally,
neuropathy can
be associated
with pain, for
people with
painful diabetic
neuropathy,
consider the
following
treatment:
* Tricyclic
antidepressants.
* 2nd generation
TCA agents.
* 1st generation
TCA.
* Anticonvulsants
like pregabalin.
- Sharp
surgery
preferred.
- Hydrogels,
alignates and
enzymes.
- Biosyrgery.
- Dependent
on the
outcomes of
the wound
assessment.
- Topical
antimicrobial
s.
- Systemic
antibiotic
therapy.
- Foams,
alginates.
- The treatment of
the edge depends
on the outcomes
of the assessment
of the edge of the
wound. In
general, healthy
wounds have a
pink wound bed
and an advancing
wound margin,
while unhealthy
wounds have a
dark and
undermined
wound margin.
Neuropathic
pain
6. 6
DiaBeen® Cream
DiaBeen® Cream is a herbal, scientific -
based and well-studied formula with
distinctive efficacy for the treatment of
Diabetic Foot Ulcers and Bedsores.
9. Healing and angiogenesis
-Increasing epithelization
-Increasing
epithelizatioand the
and the synthesis of
collagen and acidic
mucopolysacharides.
- Decrease the matrix
metalloproteinase
enzyme expression in
accidental, surgical and
diabetic wounds.
- Promote wound
healing by increasing
the tensile strength of
newly formed skin.
Enhances
epithelialization and
increase wound
contraction.
01 02 03 04
Plectranthus
amboinicus
Paeonia
suffruticosa
Actinida
chinensis
(Kiwi)
Stimulate the viability
and proliferation of
human primary dermal
fibroplasts and
keratinicytes which
lead to wound healing
Kiwifruit ext.
contains a protein
called Actinidin,
which improve
different aspects of
the wound healing
process including
debridement of the
devitalized tissues,
increase
granulation score,
epithelialization
score and collagen
formation with
excellent
angiogenesis effect
Centella
asiatica
- Enhances re-
epithelialization and
neo vascularization.
- It improves
migration of dermal
myofibroblasts.
-It increase
fibroblasts and
macrophages into
the wound bed along
with higher collagen
content.
Curcuma longa
(Turmeric)
05
10. Anti-inflammatory effect
Supression of
proinflammatory cytokines
TNF-alpha and IL-6
It has a significant anti-
inflammatory and nociceptive
effect.
01 02 03
Curcuma longa Rheum palmatum
-Inhibits the production of IL-6.
Paeonia
suffruticosa
11. Antimicrobial effect
It has broad spectrum
antimicrobial.
It has a broad spectrum
antimicrobial effect (covers
the most pathogens infect the
diabetic foot ulcers – G+ve &
G-ve)
effect.
01 02 03
Curcuma longa Rheum palmatum
Has a broad spectrum anti
microbial effect
Actinida
chinensis (Kiwi)
12. Enhancement of vasodilatation
induces vasodilatation in part by
NO generation and in part by
inhibiting vasoconstrictors
including angiotensin II,
vasopressin and endothelin-1.
Arginine is converted by the enzyme
NO synthase (NOS) to citrulline with
the liberation of (NO) and nitric oxide
increase blood circulation and
vasodilatation effect.
01 02 Arginine
Paeonia suffruticosa
13. 13
DiaBeen® Cream … Story behind efficacy
and safety:
⚫ DiaBeen Cream is scientifically approved
formula for the treatment of diabetic foot ulcer
and bedsores.
DiaBeen Cream exhibits a potent anti-
inflammatory activity.
DiaBeen Cream has broad spectrum
antimicrobial activity.
DiaBeen Cream has a potent healing and
angiogenesis activities, Increase wound
contraction, enhancing collagen synthesis and
deposition, Increase cellular proliferation and
Reducing the wound epithilialization period at the
wound site.
14. 14
DiaBeen® Cream … Story behind efficacy
and safety :
⚫ DiaBeen Cream has a potent healing and angiogenesis
activities, Increase wound contraction, enhancing collagen
synthesis and deposition, Increase cellular proliferation
and Reducing the wound epithilialization period at the
wound site.
⚫ DiaBeen Cream is very effective in decreasing capillary
filtration rate by improving microcirculatory parameters at
the wound site
⚫ DiaBeen Cream is a scientific choice to be used in any
treatment protocol for diabetic foot ulcers and bedsores.
⚫ DiaBeen Cream is a natural formula with an excellent
safety profile.
⚫ DiaBeen Cream is considered as a cost effective brand
16. 16
DiaBeen® Cream use … Diabetic foot
ulcers grades:
Diabetic foot ulcer grade Grade Features Diabeen Cream (Possibility
of usage)
0 Cellulites (No open lesion) ✓
1 Superficial diabetic ulcer ✓
2 Ulcer reaches ligament, tendon,
joint capsule without
osteomyelitis
✓ (In combination)
3 Deep ulcer with abscess and
osteomyelitis
✓ (In combination)
4 Localized gangrene
5 Extensive gangrene
17. 17
DiaBeen® Cream … Scientific – Based
formula:
There are a lot of studies and articles approve the high
efficacy and the safety of DiaBeen® Cream formula:
18. 18
DiaBeen® Cream … References:
There are a lot of studies and articles approve the high
efficacy and the safety of DiaBeen® Cream formula:
19. 19
DiaBeen® Cream … References:
Triterpenoid saponin – rich fraction of centella asiatica
decrease IL-1Beta and NF-KB and augments tissues
regeneration and excision wound repair (Turk Biol – 2016).
Evaluation of the topical spray containing centella asiatica
extract and its efficacy on excision wounds in rats. (Acta
pharma – 2016).
Multiple biological actions of curcumin in the management
of diabetic foot ulcer complications (Trop Med Surg – 2015).
Indian spices for management of diabetic foot
complications (Chitragan et al, Angiol – 2013).
The effect of kiwifruit therapeutics in the treatment of
diabetic foot ulcers (The international journal of lower
extremity wounds).
20. 20
DiaBeen® Cream … References:
Effects of topical kiwifruit on healing of neuropathic
diabetic foot ulcer (Journal of research in medical sciences –
2014).
Effects of topical kiwifruit on healing of chronic Bedsores
(Indian J Surg. – 2015).
Wound healing and the use of medicinal plants (Evidence –
Based CAM – 2019).
Plactranthus amboinicus and centella asiatica cream for the
treatment of diabetic foot ulcers (Evidence – Based CAM –
2012) .
Wound healing and antibacterial efficacy of Rheum and its
different extracts on excisional wounds (Journal of entomology
studies – 2018).
