This document discusses differentiating instruction to meet the needs of all learners. It defines differentiation as identifying the most effective strategies for achieving learning goals for each student. The document outlines ways teachers can differentiate the process, product, content, and grouping based on students' readiness, interests, and learning styles. Teachers are encouraged to use assessments to understand students' prior knowledge and tailor instruction accordingly. Examples of differentiation strategies include varying activities, resources, support, tasks, and outcomes. The benefits and challenges of differentiation are discussed.