1) Strontium ranelate and sodium fluoride were studied for their effects on bone remodeling after tooth extraction and integration of dental implants. 2) Female rats had lower molars extracted and immediately received dental implants under anesthesia. They were given strontium ranelate, sodium fluoride, or a combination of the two to study their effects. 3) Results showed strontium ranelate increased bone density and improved healing after extraction compared to the control. The combination of strontium ranelate and sodium fluoride led to more rapid maturation of new bone tissue forming around the implants. Therefore, the combination of strontium and fluoride may help with integration of dental implants.

1. STRONTIUM RANELATE AND SODIUM
FLUORIDE IN THE MANAGEMENT OF
IMPLANT OSSEOINTEGRATION
By : W. Jaber (KWT), N. Hassanzadeh (IRN)
Scientific mentor– Ye. Vazhnichaya, D.M., professor
Poltava, 2012

2. Intorodoction:
 Dental Implants:
is an artificial tooth root that a periodontist places into
your jaw to hold a replacement tooth or bridge.

3.  Osteoporosis:
it’s condition in which the bones become fragile and brittle,
leading to a higher risk of fractures than in normal bone.
Bone Mineral Density (BMD)
by Dual energy X-ray
Absorptiometry.

4.  Research purpose:
is to study the influence of strontium ranelate and its co-
administration with sodium fluoride on the re-modeling of
bone tissue after the tooth extraction and the
osseointegration of dental implants.

5.  Research methods:
15 female Wistar rats of 200 g of body weight were used in the
experiments which were permitted by Bioethics commission of the
Ukrainian Medical Stomatological Academy. Low molar was
extracted in control and experimental rats and dental implantation
was carried out immediately after the tooth extraction under the
general anesthesia by ether for narcosis.

6.  Why low molar is extracted ?

7.  Medication used in the Experiment :
1) Strontium Ranelate:
o used as water suspension
containing 10 mg of
strontium salt in 1 ml of liquid.
o In dose 30 mg/kg body weigh (0,6 ml) orally once a
day .
(Strontium Ranelate) REDUCES bone Resorption ,
& INCREASES bone Formation.

8. 2) Sodium Fluoride :
o as 0,012% aqueous solution, orally, in
Average dose 0,6 mg/kg.
( Sodium Fluoride )
# improve the integration
of dental implants into jaw
bone.
# enhance the strength of teeth by the formation of
Fluorapatite .

9.  Research results:
o Molar extraction without pharmacological
correction :
- Alveolus are
fuzzy & rough.
- Compact plate
wells traced not
all over.
- Development
of new bone
tissue in the site of tooth extraction is poor.

10. o Molar extraction + strontium ranelate :
- hypertrophy of bone
tissue which is dense at
the top of extracted
tooth.
- density of this surplus tissue on
the level of the gum
is less.
- Compact plate wells in a clear zone of osteosclerosis.
- Spongy alveolar bone has clear smooth trabeculars sections
without degradation.
- Cortical plate of the alveolar process was normal.

11.  Molar extraction + strontium ranelate+ sodium
fluoride:
- Alveolus is not viewed.
(it’s filling by bone tissue
faster)
- Compact plate wells as
a clear zone of
osteosclerosis.
- No signs of inflammation or hypertrophy.
- Sponge alveolar bone is with clear smooth beams and
without signs of degradation.
- Cortical plate of the alveolar process is normal.

12.  Dental implant :
- Bone tissue around
implant has signs
of inflammation.
- Sponge alveolar
bone is with clear
smooth beams and
without signs of
degradation.
- Cortical plate of the alveolar process is normal.

13.  Dental implant + strontium ranelate:
- There is dense
secondary bone
tissue around it.
- Formation of granulating
periodontium at the top
is observed.
- no signs of degradation.
- Hypertrophy of bone tissue of alveolar process is registered.
- Cortical plate of the alveolar process is without pathology.

14.  Dental implant+ strontium ranelate+ sodium
fluoride:
- It’s similar to treatment
With Strontium ranelate
BUT without
hypertrophy of bone
tissue.
- Around the implant the
bone tissue has clear
trabecular structure.
- No signs of degradation.
- Cortical plate of the alveolar process is in the good
condition.

15.  Conclusion:
Thus, it is shown that strontium ranelate increases the
density of bone tissue and improves reparative
processes in the site of tooth extraction and dental
implantation in comparison with control rats without
pharmacotherapy. Addition of sodium fluoride to this
therapy is characterized by more intensive maturation
of young bone tissue around implants as compared to
previous group. The data obtained show that
combination of strontium and fluoride is perspective
for pharmacological management of dental implants
osseointegration.

16. Thank you for attention!