The dermoepidermal junction is the interface between the lower epidermis and upper dermis. It consists of four layers - the cytoskeleton of basal keratinocytes, lamina lucida, lamina densa, and sublamina densa. Key components include hemidesmosomes, anchoring filaments containing laminin 332, type IV collagen lattice in lamina densa, and anchoring fibrils containing type VII collagen. Disorders can arise from autoimmune diseases targeting proteins like BPAG1e or type XVII collagen, or genetic defects in hemidesmosomal proteins like integrin β4 or laminin 332 causing forms of epidermolysis bullosa.
ned as the development of new radiculopathy or myelopathy of a motion segment adjacent to the site of a previous arthrodesis of the spine (either superior or inferior).1 Studies have shown that the prevalence of symptomatic ASD ranges from 9 to 17%, with an annual incidence be- tween 1.5% and 4% in patients who under- went anterior cervical diskectomy and fusion.24 Although there is controversy surrounding the origins of ASD and whether or not it is a function of surgery or a natural progression of disease, multiple biomechanical studies have suggested that arthrodesis leads to increased loading of adjacent segments, which in turn leads to disk degeneration.1
In terms of cervical alignment, it is postu- lated that kyphotic angulation could potentially cause a shift of cervical loading from the poste- rior columns to the anterior column, in turn leading to unnatural loading of adjacent seg- ments.1 Recently, a systematic review of the literature was completed examining a possible correlation between cervical sagittal imbalance and adjacent segment pathology. It was de- termined that five poorquality retrospective studies demonstrated level III evidence of a correlation between cervical sagittal malalign- ment and adjacent segme
This is a powerpoint presentation on the epidermal keratinization and its associated disorders, presented by Dr. Jerriton, Dermatology resident of SVMCH, Pondicherry.
ned as the development of new radiculopathy or myelopathy of a motion segment adjacent to the site of a previous arthrodesis of the spine (either superior or inferior).1 Studies have shown that the prevalence of symptomatic ASD ranges from 9 to 17%, with an annual incidence be- tween 1.5% and 4% in patients who under- went anterior cervical diskectomy and fusion.24 Although there is controversy surrounding the origins of ASD and whether or not it is a function of surgery or a natural progression of disease, multiple biomechanical studies have suggested that arthrodesis leads to increased loading of adjacent segments, which in turn leads to disk degeneration.1
In terms of cervical alignment, it is postu- lated that kyphotic angulation could potentially cause a shift of cervical loading from the poste- rior columns to the anterior column, in turn leading to unnatural loading of adjacent seg- ments.1 Recently, a systematic review of the literature was completed examining a possible correlation between cervical sagittal imbalance and adjacent segment pathology. It was de- termined that five poorquality retrospective studies demonstrated level III evidence of a correlation between cervical sagittal malalign- ment and adjacent segme
This is a powerpoint presentation on the epidermal keratinization and its associated disorders, presented by Dr. Jerriton, Dermatology resident of SVMCH, Pondicherry.
Dermoscopy or epiluminescence microscopy
A simple, noninvasive method to examine the subsurface features of the skin.
Structures seen
Epidermis
Dermoepidermal junction
Superficial dermis
3 types of dermoscope
1.Nonpolarized devices
2.Polarized devices
3.Hybrid devices
Dermoscopy is used in:
1.Evaluating pigmented skin lesions
2.Evaluating nonpigment skin lesions
3.Entomodermoscopy
4.Trichoscopy
5.Onychoscopy
different dermoscopic patterns are used to diagnose the dermatological diseases are
1. melanocytic patterns:
Pigmentary patterns: typical pigment pattern, atypical pigment patter, pseudonetwork
dots and globules
Blue white veil
star brust pattern
2, Non melanocytic pattern:
milia like cyst
comedo like opening
3. vascular patterns:
lacunae
arborizing vessels
comma like vessels
corkscrew vessel
red dots
glomerular vessels
linear vessels
etc
Definition, development, function & Site-specific of Melanocyte Definition, formation & function of Melanosomes, Definition & function of Melanin
Melanogenesis
he dermo-epidermal junction is a complex structure, composed of semidesmosomes (attachment plaque, cell membrane and junction plate) anchoring filaments, basal lamina, anchoring fibrils and elastic fibrils. A similar structure is seen in other epithelial and endothelial tissues, muscles and nerves. Among them, mucous epithelium is very like the epithelium of skin.
As observed under the light microscope, the PAS-positive basement membrane includes the basal lamina and anchoring fibrils. Elastic fibrils seem to be identical with oxytalan fibers and elastofibrils. Histochemical studies suggest that the junction consists of neutral mucopolysaccharides, collagenous protein, SO4-groups and lipids. However, no chemical analyses have been done.
The normal junction can be separated by physical, chemical or enzymatic methods. Suction is a unique technique for dermo-epidermal separation. Its formation is studied in embryonic skin, cultivated skin and wound healing. The junction is initiated by an increased density of basal cell membrane and is laid down on the surface of the dermis.
The junction binds the epidermis firmly to the corium and controls the passage of material from the dermis to the epidermis or vice versa.
Dermoscopy or epiluminescence microscopy
A simple, noninvasive method to examine the subsurface features of the skin.
Structures seen
Epidermis
Dermoepidermal junction
Superficial dermis
3 types of dermoscope
1.Nonpolarized devices
2.Polarized devices
3.Hybrid devices
Dermoscopy is used in:
1.Evaluating pigmented skin lesions
2.Evaluating nonpigment skin lesions
3.Entomodermoscopy
4.Trichoscopy
5.Onychoscopy
different dermoscopic patterns are used to diagnose the dermatological diseases are
1. melanocytic patterns:
Pigmentary patterns: typical pigment pattern, atypical pigment patter, pseudonetwork
dots and globules
Blue white veil
star brust pattern
2, Non melanocytic pattern:
milia like cyst
comedo like opening
3. vascular patterns:
lacunae
arborizing vessels
comma like vessels
corkscrew vessel
red dots
glomerular vessels
linear vessels
etc
Definition, development, function & Site-specific of Melanocyte Definition, formation & function of Melanosomes, Definition & function of Melanin
Melanogenesis
he dermo-epidermal junction is a complex structure, composed of semidesmosomes (attachment plaque, cell membrane and junction plate) anchoring filaments, basal lamina, anchoring fibrils and elastic fibrils. A similar structure is seen in other epithelial and endothelial tissues, muscles and nerves. Among them, mucous epithelium is very like the epithelium of skin.
As observed under the light microscope, the PAS-positive basement membrane includes the basal lamina and anchoring fibrils. Elastic fibrils seem to be identical with oxytalan fibers and elastofibrils. Histochemical studies suggest that the junction consists of neutral mucopolysaccharides, collagenous protein, SO4-groups and lipids. However, no chemical analyses have been done.
The normal junction can be separated by physical, chemical or enzymatic methods. Suction is a unique technique for dermo-epidermal separation. Its formation is studied in embryonic skin, cultivated skin and wound healing. The junction is initiated by an increased density of basal cell membrane and is laid down on the surface of the dermis.
The junction binds the epidermis firmly to the corium and controls the passage of material from the dermis to the epidermis or vice versa.
The Biology of the Basement Membrane Zone Ibrahim Farag
It is a critical interface between the epidermis and dermis and is a highly specialized structure that allows for communication between different cell types.
Examination of BMZ/Structure of BMZ/Origin of BMZ/Function of BMZ/Examples of Some diseases affecting BMZ
Structure of Skin | Layers of Skin |Function of Skin
https://www.youtube.com/watch?v=IytTVigBQrI&t=172s
Dr. Nagendra Kr Meena
PG Resident
Hindu Rao Hospital,New Delhi
Keratinized tissue, also known as keratinized mucosa, refers to the band of tissue surrounding your teeth at the point where they meet the gums. The word "keratinized" is used to describe cells that produce large amounts of a protein called keratin, making them strong and better at forming barriers. Local irritation interferes with keratinization, and healthy gingiva is more keratinized than diseased, irritated gingiva. Nonepithelial cells are also present in the oral gingival epithelium. These include melanocytes, and Langerhans cells in the stratum spinosum. In the oral cavity, keratinized mucosa is found in the gingiva and palate mucosa, whereas the non-keratinized mucosa is found in the buccal mucosa.
Lack of K140 immunoreactivity in junctional epidermolysis bulls skin and keratinocytes associates with misfolded laminin epidermal growth factor-like motif 2 of the B3 short arm
Collagen /certified fixed orthodontic courses by Indian dental academy Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
Collagen / /certified fixed orthodontic courses by Indian dental academy Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
for beginners, providing thorough training in areas such as SEO, digital communication marketing, and PPC training in Noida. After finishing the program, students receive the certifications recognised by top different universitie, setting a strong foundation for a successful career in digital marketing.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
DEJ and Applied aspects.pptx
1. DERMOEPIDERMAL JUNCTION AND ITS APPLIED
ASPECTS
PRESENTED BY – DR.ADYASA BASA
JUNIOR RESIDENT
SCB MCH
MODERATED BY-DR.SIDDHARTHA DASH
ASSISTANT PROFESSOR
SCB MCH
2. INTRODUCTION
● The interface between lower part of epidermis and the top layer
of dermis is dermo-epidermal junction.
● It is a basement membrane zone which is recognised
histologically by positive staining with PAS.
● It is not visible in haematoxylin eosin stained section.
3. ● At dermo-epidermal junction, finger like upward
projections called the ‘dermal papilla’ and downward
projections into dermis called ‘epidermal rete ridges’
are seen.
● By transmission electron microscopy the laminated
model of the dermoepidermal juction is studied.
4. PAS staining showing the basement
membrane.
Electron microscopy shoeing ultra
structure of DEJ.
6. FUNCTIONS OF DEJ
Dermo epidermal junction acts as:
● Substrate for attachment of cells.
● Template for tissue repair.
● Matrix for cell migration.
● Substrate to influence differentiation and morphogenesis.
● Permeability barrier for cells and macromolecules.
7. LAMINATED MODEL OF DEJ
● This model divides the DEJ ultrastructurally into 4 subregions:
I. The cytoskeleton,hemidesmosomal plaque and plasma
membrane of basal keratinocyte
II. Lamina lucida
III. Lamina densa
IV. Sublamina densa
8.
9.
10. HEMIDESMOSOMES
● Hemidesmosomes is the structure of 1st layer of BMZ.
● The number of hemidesmosomes is constant in each indivisual.
● Hemidesmosomes extend from intracellular component of basal
keratinocytes to lamina lucida in upper portion of dermal-
epidermal basement membrane.
11. ● The most cytoplasmic portion
is called the inner plaque .
● The portion of
hemidesmosome closely
attached with the basal
plasma membrane is called
the outer plaque.
12. ● The inner plaque is attached to the tonofilaments which
are composed of keratin 14 and keratin 5.
● The outer plaque is connected to anchoring filaments in
the lamina lucida.
● The hemidesmosomes consists of
Transmembrane protein-integrin α6β4,BP180,CD151.
Cytoplasmic protein - plectin and BPAG1.
13.
14. ● Major components of hemidesmosomes are HD1(500),
HD2(230), HD3(200), HD4(180) and HD5(120).
● HD2 and HD4 bullous pemphigoid antigen 1 and 2 respectively.
● HD3 and HD5 corresponds to β4 and α6 integrins respectively.
● HD1 corresponds to plectin-intracytoplasmic adhesion molecule.
15. BPAG1
● It is a high molecular weight protein of plakin family of
cytoskeletal linkers which is localised to cytoplasmic
plaque of HD.
● It has a tripartite structure:
1)Amino terminal - globular domain:- cytoplasmic domain of BPAG2 and
β4 subunit of α6β4 integrin and ERBIN.
2)central coiled rod
3)carboxy terminal-intermediate filament binding domain.
16. ● Erbin protein interacts with transmembrane tyrosine kinase
receptor Erb-B2.
● There are many isoforms of BPAG1
○ BPAG1e present in skin.
○ BPAG1n present in neurons.
● Therefore mutation in BPAG1 also results in dystonia and
ataxia.
17.
18.
19. Plectins
● Intracellular protein present in cytoplasmic domain of
hemidesmosomes
● It stabilises BMZ by binding both intermediate filaments
and outer plaque components.
20. ● Carboxy terminus binds to
keratin intermediate
filaments.
● Amino terminal binds to the
cytoplasmic tail of β4 of α6β4
integrin.
21.
22. BPAG2 (collagen XVII)
● Transmembrane protein of collagen family associated
with HD-anchoring filament complex.
● 2 divisions of this protein are:-
○ Intra cytoplsmic domain appears as globular head
○ Extra cytoplasmic domain as a central rod (coll 15) with flexible
tail.
23. ● The cytoplasmic domain of
BPAG2 associates with
BPAG1e, integrin subunit
β4 and plectin.
● The extra cellular domain
of binds to the integrin
subunit α6 and laminin
332.
24. Integrins
● These are heterodimeric transmembrane receptors that
promote cell-cell and cell-matrix interactions.
● These modulate cell adhesion,signal transduction,gene
expression,growth and other fundamental biologic
processes.
● The 2 types of integrins found in epidermal BMZ:
○ α6β4 :- laminin binding
○ α3β1:-collagen binding
25. ● Cytoplasmic domain of integrin interact with the actin
cytoskeleton.
● The extracellular domain forms the ligand binding site.
● In basal keratinocytes kindilin 1 and kindilin 2 form a part of
signalling complex of intergrins.
● Mutation in FERMT1 Gene encoding kindilin 1 are responsible
for KINDLER SYNDROME.
27. ● Hemidesmosome associated integrin is α6β4.
● The cytoplsmic portion of β4 is associates with plectin.
● The distal carboxy terminal region binds to BPAG2.
● The proximal extra cellular domain of α6 binds to NC16A
donain of BPAG2.
● Cytoplasmic tail of β4 contains seqences required for
hemidesmosome assembly.
28.
29.
30. LAMINA LUCIDA
● Lamina lucida is electron lucent region of BMZ(20-
40nm)
● Lamina lucida connects hemidesmosomes above to
lamina densa below.
● The major constituents of lamina lucida are laminin 5 ,
α6β4 integrin and ecto domain of BP180.
● Spanning the lamina lucida and connecting lamina densa
to HD are the anchoring filaments.
31.
32. Anchoring Filaments
● Anchoring filaments are thread like structures 3-4 nm in
diameter.
● Laminin 332 is the major component of these anchoring
filament;others being α6β4 integrin ,XVII collagen and laminin
311.
● They are derived from basal keratinocytes.
33. LAMININS
● Each laminin molecule
consists of 3 polypeptide
units,α, β and γ which forms
a cruciform structure with 3
short arms and 1 long arm.
● The major laminin in the
cutaneous basement
membrane zone is laminin
332.
34. ● Functions of laminins:
○ Interaction with hemidesmodomal components and type VII collagen
○ Cell attachment and spreading
○ Neurite outgrowth and cellular differentiation.
● Mutation in any of the three polypeptide subunit of laminin
332 results in junctional forms of EB.
35. LAMINA DENSA
● Lamina densa is the third layer of basement membrane
zone(40-60 nm).
.
● Lamina densa is connected to epidermis by anchoring
filaments and to dermis by anchoring fibrils.
● Type IV collagen is the major component of lamina
densa others being HSPGs and Nidogen.
36.
37. TYPE IV COLLAGEN
● It is synthesized in rough endoplasmic reticulum and
secreted via golgi apparatus into basement membrane.
● Type 4 collagen molecule consists of 3 polypeptide
chains known as alpha α chains which assemble into
triple helical structure giving it a ‘hockey stick
appearance’
38.
39. ● The composition of alpha chain varies with tissue
location of basement membrane zone.
● In cutaneous basement membrane zone, type 4 collagen
is made mainly of α1 and α2 chains.
● The individual collagen molecules in case of type 4
collagen form
○ dimers tetramers assembles in a lattice like structure
laterally in a complex hexagonal arrangement.
40. ● Such kind of arrangement allows BMZ to be highly flexible.
42. Collagen fibrils showing a characteristic banding pattern after treatment and staining with uranyl acetate
and lead citrate for transmission electron microscopy.
43. HEPARAN SULPHATE PROTEOGLYCANS
● It is a diverse group of macromolecules that are ubiquitous
components of basement membranes.
● They consist of a core protein with covalently attached
heparan and sulphate chains in a ‘bottle brush’
configuration.
● Heparan sulphate proteoglycans are also found on the
surface of epithelial cells and mediate cell-matrix.
interactions.
44. ● The best characterised basement membrane HSPG is perlecan .
● Perlecan spot welds the laminin and collagen IV containing
networks together.
● The high sulphate content of HSPGs confer an overall negative
charge to basement membrane and thereby restricts their
permeability.
45. NIDOGENS
● Nidogen is a 150 kDa glycoprotein present in lamina
densa.
● It has 3 globular domains resembling a dumbell like
structure
○ G3 binds to laminin 311
○ G2 binds to collagen IV
● Nidogen laminin complexes bind to heparan sulfate
proteogylcan and stabilise the basement membrane.
46.
47.
48. SUBLAMINA DENSA
● Beneath the lamina densa, lies
the sublamina densa layer
composed of anchoring fibrils.
● Anchoring fibrils binds the
lamina densa to superficial
dermis.
49. ANCHORING FIBRILS
● Major component of anchoring fibril is type 7 collagen.
● Type VII collagen consists of three identical α chains.
● Amino terminus – NC1
● Carboxy terminus- NC2
● Type VII collagen molecules become organized into
anchoring fibrils through the formation of antiparallel
dimers linked through their carboxy‐terminal ends.
50. ● Globular NC1 domain binds the lamina densa at one end and
either loop back into lamina densa or connect to electron dense
elements in sublamina densa known as anchoring plaques.
● Anchoring plaques are portions of lamina densa that have
dropped out and fallen into sublamina densa region.
● The large amino‐terminal interact with type IV collagen and
laminin 332.
56. Reference:-
● Kim B. Yancy. The Biology of Basement Membrane. In:Jean L. Bolognia, Julie V.
Schaffer, Lorenzo Cirroni, editor. Dermatology, fourth ed. China: Elsevir;2018 p.483-
493.
● John A.McGrath, Jouni Uttio. Structure and function of skin. In: Christopher E.M.
Griffiths,Jonathan Barker, Tanya Bleiker,Robert Calmer, Daniel Creamer. Rook’s
Textbook of Dermatology, ninth ed. West sussex:John Wiley and sons Ltd;2016.
p.2.1-2.48.
● Devinder Mohan Thappa, Deepti Konda. Structure and Function of Skin.In:
S.Sacchidanand, Chetan Obroi, Arun C.Inamdar. IADVL Textbook of Dermatology,
fourth ed. Mumbai: Bhelani Publishing House; 2022p.27-29.