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Methods for Monoclonal Antibody Sequencing1
Advantages of Sequencing by DASS2
© 2007 - 2019 Creative-Biolabs All Rights Reserved Email: info@creative-biolabs.com Tel: 1-631-381-2994
Resolve N-terminally blocked
protein
Identify new protein
100% coverage of VJ and
VDJ regions
Accurately distinguish
leucine from isoleucine
ANTIBODY
SEQUENCING SERVICE
Creative Biolabs
Antibody
Sequencing
Services
Biosimilar Monoclonal Antibody
Sequencing Service
Single Domain Antibody
Sequencing Service
Rabbit Antibody Sequencing
Service
Chicken IgYs Sequencing Service
TCR (T Cell Receptor) Sequencing
Service
Human/Humanized Antibody
Sequencing Service
Rodent Antibody Sequencing
Service
Hybridoma Sequencing Service
WHAT WE DO:
Monoclonal antibody sequenc
-ing plays a significant role in
enhancing antibody affinity
and humanization through
obtaining the first-order
antibody sequence, which acts
as the basis and prerequisite
in the research and develop-
ment of antibody generic
drugs. Direct sequencing
analysis of existing antibody
products on the market is a
shortcut to developing
antibody drugs, antibody
diagnostic reagents and other
antibody products. Therefore,
a highly efficient and more
accurate sequencing technol-
ogy is needed by all the
researchers in the relevant
field, which would also signifi-
cantly enhance the precision
medicine accordingly.
The R&D team of Creative
Biolabs has achieved an
unparalleled breakthrough
based on the proprietary
Database Assisted Shotgun
Sequencing (DASS) technolo-
gy, which enable the precise
identification of leucine and
isoleucine, determining the
antibody sequences with
100% accuracy. This valuable
breakthrough helps to better
carry out functional analysis
and verification, and to lay a
good foundation for down-
stream application in a
cost-effective way.
Edman
Degradation
Traditional Mass
Spectrometry
Sequencing
by DASS
De Novo
De Novo
De Novo
DE NOVO
De Novo De Novo
De Novo
De Novo
De Novo
De Novo
De Novo
100% accuracy in determining
the antibody sequences
High-throughput compatibility

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De novo antibody seuqencing

  • 1. Methods for Monoclonal Antibody Sequencing1 Advantages of Sequencing by DASS2 © 2007 - 2019 Creative-Biolabs All Rights Reserved Email: info@creative-biolabs.com Tel: 1-631-381-2994 Resolve N-terminally blocked protein Identify new protein 100% coverage of VJ and VDJ regions Accurately distinguish leucine from isoleucine ANTIBODY SEQUENCING SERVICE Creative Biolabs Antibody Sequencing Services Biosimilar Monoclonal Antibody Sequencing Service Single Domain Antibody Sequencing Service Rabbit Antibody Sequencing Service Chicken IgYs Sequencing Service TCR (T Cell Receptor) Sequencing Service Human/Humanized Antibody Sequencing Service Rodent Antibody Sequencing Service Hybridoma Sequencing Service WHAT WE DO: Monoclonal antibody sequenc -ing plays a significant role in enhancing antibody affinity and humanization through obtaining the first-order antibody sequence, which acts as the basis and prerequisite in the research and develop- ment of antibody generic drugs. Direct sequencing analysis of existing antibody products on the market is a shortcut to developing antibody drugs, antibody diagnostic reagents and other antibody products. Therefore, a highly efficient and more accurate sequencing technol- ogy is needed by all the researchers in the relevant field, which would also signifi- cantly enhance the precision medicine accordingly. The R&D team of Creative Biolabs has achieved an unparalleled breakthrough based on the proprietary Database Assisted Shotgun Sequencing (DASS) technolo- gy, which enable the precise identification of leucine and isoleucine, determining the antibody sequences with 100% accuracy. This valuable breakthrough helps to better carry out functional analysis and verification, and to lay a good foundation for down- stream application in a cost-effective way. Edman Degradation Traditional Mass Spectrometry Sequencing by DASS De Novo De Novo De Novo DE NOVO De Novo De Novo De Novo De Novo De Novo De Novo De Novo 100% accuracy in determining the antibody sequences High-throughput compatibility