The document outlines the Partnership for Aflatoxin Control in Africa's (PACA) strategy to address the aflatoxin challenge in Africa. PACA works at the continental, regional, and country levels. At the continental level, PACA focuses on knowledge management, convening stakeholders, and mainstreaming aflatoxin control into frameworks. At the regional level, PACA collaborates with Regional Economic Communities to harmonize regulations and support country planning. At the country level, PACA helps develop evidence-based country plans to build government capacity for implementation and monitoring over multiple years. PACA takes a phased approach starting with pilot countries to systematically address the complex issue of aflatoxin contamination across Africa.