Talk presented to the TE Jamboree group on April 22nd 2022 about the history of transposable element nomenclature and ways of naming transposable elements.
Talk presented to the TE Jamboree group on April 22nd 2022 about the history of transposable element nomenclature and ways of naming transposable elements.
Phasmids as Pests of Agriculture and ForestryEdward Baker
Introductory presentation on stick insects (Insecta: Phasmida) as pests of agriculture and forestry, with examples from the USA, Australia, Fiji and China.
Cite as:
Baker, Edward (2015): Phasmids as Pests of Agriculture and Forestry. figshare.
http://dx.doi.org/10.6084/m9.figshare.1472902
Measuring Impact: Towards a data citation metricEdward Baker
How the ViBRANT and eMonocot projects are building tools, including a modified implementation of Bourne and Fink's 'Scholar Factor', the Biodiversity Data Journal, and Scratchpad's user metrics and statistics modules.
New tools for monitoring biodiversity and environmentsEdward Baker
How do we do science when the computer of 15 years ago now fits in your pocket and costs less than the battery you need to run it? Should biodiversity scientists work with the hacker and maker community? Should we forge links with engineering departments? Should hardware become a standard tool of the biodiversity informatician?
Phasmids as Pests of Agriculture and ForestryEdward Baker
Introductory presentation on stick insects (Insecta: Phasmida) as pests of agriculture and forestry, with examples from the USA, Australia, Fiji and China.
Cite as:
Baker, Edward (2015): Phasmids as Pests of Agriculture and Forestry. figshare.
http://dx.doi.org/10.6084/m9.figshare.1472902
Measuring Impact: Towards a data citation metricEdward Baker
How the ViBRANT and eMonocot projects are building tools, including a modified implementation of Bourne and Fink's 'Scholar Factor', the Biodiversity Data Journal, and Scratchpad's user metrics and statistics modules.
New tools for monitoring biodiversity and environmentsEdward Baker
How do we do science when the computer of 15 years ago now fits in your pocket and costs less than the battery you need to run it? Should biodiversity scientists work with the hacker and maker community? Should we forge links with engineering departments? Should hardware become a standard tool of the biodiversity informatician?
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
2. SOME BIG QUESTIONS
• What is this sound?
• Where and when does this sound occur?
• What sounds like this?
• How is sound effected by X?
Sound as a proxy for taxa, rainfall, traffic, Dave, UFOs,…
6. TYPES OF SEARCH
• Discovery of datasets
• Discovery of metadata
• Discovery within files
7. OTHER EXAMPLES (BIODIVERSITY)
• GBIF
• GloBI
• Traitbank
Small pieces… loosely joined
Data managed and published in
many places
Aggregated centrally using TDWG
standards
8. WHY AREN’T WE THERE?
• Searching inside sounds is a bit hard
• But as a community we’re bad at some basic
aspects of open science
9. FAIR PRINCIPLES
• Findable
• Accessible
• Interoperable
• Reusable
Baker E, Vincent S (2019) A deafening silence: a lack of data and reproducibility in
published bioacoustics research? Biodiversity Data Journal 7:
e36783. https://doi.org/10.3897/BDJ.7.e36783
10. WHAT DOES A SYSTEM NEED?
• Publication of data and metadata
• Standards for aggregation
• An aggregator
11. WHAT DOES A SYSTEM NEED?
• Publication of data and metadata – we need to do better
• Standards for aggregation – AudubonCore for metadata
• An aggregator – working on it…
12. WHAT SHOULD WE AGGREGATE?
• Metadata of recordings
• Annotated regions (ann-o-mate – coming soon)
• Other analyses for search
13. SEARCHING INSIDE ‘ALL THE AUDIO’
• There’s so much data if we aggregate it all!
• Analysis IS compression (think of extreme form of MP3 that
only keeps what you are looking for)
• Outputs of analysis are small (labels, vectors, numbers) and
easy to query
14. WHAT’S USEFUL?
• Indices – maybe?
• Labels – yes, particularly with some taxonomic categorization, but also think rain,
traffic noise, etc
• Feature vectors – just ask Sarab
• What about a combination? Potentially very interesting
15. CAN ANSWER MORE COMPLEX QUESTIONS
• Does this species sing just after it rains?
• How does aircraft noise effect the vocalization of this family of birds?
• What habitat in North America sounds most like this bog just outside York?
• Many others… just from sound analysis
• But can integrate further…. E.g. correlate with organism traits (TraitBank)
16. WHAT’S NEXT?
• I am moving back to NHM to spend some time (in part)
prototyping an aggregator (audioBlast).
• A basic version should be functional soon
• Comments/ideas/contributions/complaints –
edward.baker@nhm.ac.uk