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Animal Science 434
Reproductive Cycles in the Female
Terminology
• Estrus is a noun.
– The cow is displaying estrus.
• Estrous is an adjective.
– The length of the estrous cycle is 21
days.
• Oestrus and Oestrous
– British and European spellings
• Estrus and Heat are synonymous
Terminology (cont.)
• Anestrus
– When the female is not having repeated
estrous cycles.
Types of Cyclicity
Polyestrus
Types of Cyclicity
Seasonally Polyestrus
Short day breeders
(Fall)
Long day breeders
(Spring)
Type of Cyclicity
Monoestrus
Dog Wolf Bear
Average Reproductive Cycles
Species Length of Length of Ovulation Length of
Estrous Cycle Estrus Pregnancy
cow 21 days 18 hr 11 hr after 282 days
polyestrus end estrus
ewe 17 days 29 hr near end 148 days
seasonal (fall) estrus
sow 21 days 48-72 hr 35-45 hr 115 days
polyestrus after start
estrus
mare 21 days 4-8 days 3-6 day of 335 days
seasonal (spring) estrus
polyestrus (1-2 days
before end of
estrus)
Variation in Cycle Types
Example Type of Follicular Ovulation & CL
Cycle Development CL Formation Function
Cow, ewe, Long Spontaneous Spontaneous Spontaneous
sow, mare
rats, mice, Short Spontaneous Spontaneous Induced
hamsters (4 days) (prolactin)
rabbit, cat, Induced Spontaneous Induced Induced
mink, ferret, (LH surge)
otter, alpaca
CA
Days Relative to the Gonadotropin Surge
0 1 2 3 4 5 6 7 8
-1
- 2
- 3
- 4
- 5
- 6
-7
LH
FSH
PGF
2a
Estradiol
Progesterone
Metestrus Diestrus
Proestrus
Diestrus Estrus
CL
Ovulation
CA
Days Relative to the Gonadotropin Surge
0 1 2 3 4 5 6 7 8
-1
- 2
- 3
- 4
- 5
- 6
-7
LH
FSH
PGF
2a
Estradiol
Progesterone
Metestrus Diestrus
Proestrus
Diestrus Estrus
CL
Ovulation
CA
Days Relative to the Gonadotropin Surge
0 1 2 3 4 5 6 7 8
-1
- 2
- 3
- 4
- 5
- 6
-7
LH
FSH
PGF
2a
Estradiol
Progesterone
Metestrus Diestrus
Proestrus
Diestrus Estrus
CL
Ovulation
Follicular Phase
Proestrus
• follicle enlarges
• estrogen increases
• vascularity of the
female reproductive
tract increases
• endometrial glands
begin to grow
• estrogen levels peak
CA
Days Relative to the Gonadotropin Surge
0 1 2 3 4 5 6 7 8
-1
- 2
- 3
- 4
- 5
- 6
-7
LH
FSH
PGF
2a
Estradiol
Progesterone
Metestrus Diestrus
Proestrus
Diestrus Estrus
CL
Ovulation
Estrus
• allows male to mount
• estrogen decreases
• LH surge occurs
• ovulation 24-48 hr after
surge of LH
• uterine motility high
with contractions
moving toward oviduct
• sperm transport is
optimal
• cervical mucus volume
increases
Follicular Phase
CA
Days Relative to the Gonadotropin Surge
0 1 2 3 4 5 6 7 8
-1
- 2
- 3
- 4
- 5
- 6
-7
LH
FSH
PGF
2a
Estradiol
Progesterone
Metestrus Diestrus
Proestrus
Diestrus Estrus
CL
Ovulation
Luteal Phase
Luteal Phase
Metestrus
• estrogen low
• ovulation in cow
• corpus hemorrhagicum
present
• uterus
contractions subside
endometrial glands
continue to grow and
become coiled
in cattle bleeding
occurs
• FSH increases
triggering growth of
follicles
CA
Days Relative to the Gonadotropin Surge
0 1 2 3 4 5 6 7 8
-1
- 2
- 3
- 4
- 5
- 6
-7
LH
FSH
PGF
2a
Estradiol
Progesterone
Metestrus Diestrus
Proestrus
Diestrus Estrus
CL
Ovulation
Luteal Phase
Luteal Phase
Diestrus
• progesterone high
• FSH
 Increases at some
point to cause
growth of ovulatory
follicle
• Uterus
 secrets fluid but
volume gradually
decreases
 contraction stop
 CL regresses at the
end of this period if
female is not
pregnant due to
PGF release
Characteristics of Estrous Cycles
Cow Ewe Sow Mare
Estrous cycle (days) 21 17 21 21
Proestrus (days) 3-4 2-3 3-4 2-3
Estrus 12-18 hr 24-36 hr 48-72 hr 4-8 days
Metestrus (days) 3-4 2-3 2-3 2-3
Diestrus (days) 10-14 10-12 11-13 10-12
Causes of
Anestrus
Pregnancy Presence of Offspring
Season
Stress
Pathology
Nutrition
Gestational Anestrus
Gestational Anestrus
• Progesterone during pregnancy
– negative feedback
• After parturition anestrus continues
– progesterone exposure during
pregnancy
– hypothalamus
• Lacks estradiol positive feedback
• allows time for uterine involution
Seasonal Anestrus
Horses are long day breeders!
Sheep are short day breeders!
Estradiol
Negative
Feedback
increases
Decreased
Negative
Feedback
Estradiol
Seasonal Anestrus
• just like entering puberty
• silent ovulation
+
+
Silent Ovulation
Anestrus Estrus
Lactational Anestrus
Suckling Effect on LH
Lactational Anestrus
• Suckling
• Other offspring factors
– visual encounter
– olfactory encounter
– auditory encounter
• Prolactin
– inhibits GnRH release
– major infertility problem in women who
are not lactating
Nutritional Anestrus
Menstrual Cycle
FSH
LH
Estradiol
Progesterone
Follicle
Ovulation
Corpus Luteum
Corpus
Albicans
2 4 6 8 10 14 16 18 20 22 24 26 28 2
12
Anterior
Pituitary
Hormones
Ovarian
Hormones
Ovary
Uterine
Endo-
metrium
Recruitment
Selection
Dominance
Recruitment
FSH
LH
Estradiol
Progesterone
Follicle
Ovulation
Corpus Luteum
2 4 6 8 10 14 16 18 20 22 24 26 28 2
12
Anterior
Pituitary
Hormones
Ovarian
Hormones
Ovary
Uterine
Endo-
metrium
Menses
Menses
5
days
5
days
Follicular
Phase
9 days
Luteal
Phase
14 days
Variation in Menstrual Cycle Length
35-day
cycle
Ovulation
14 days
Menses Foll. Phase Luteal Phase Menses
28-day
cycle Menses Luteal Phase Menses
Foll. Phase
25-day
cycle Menses Foll. Phase Menses
Luteal Phase
14 days
5 days
5 days
5 days
6 days
9 days
16 days 14 days
Breast
Tenderness
Menstural Cycle Length
• AGE
Length
 15 - 19 year olds 35 days
 30 year olds 30 days
 35 year olds 28 days
Variation
 More in teenagers
 Less in women in peak reproductive years
Rest are extra slides not used
in 2006
CA
Days Relative to the Gonadotropin Surge
0 1 2 3 4 5 6 7 8
-1
- 2
- 3
- 4
- 5
- 6
-7
Metestrus Diestrus
Proestrus
Diestrus Estrus
CL
Ovulation
CA
Days Relative to the Gonadotropin Surge
0 1 2 3 4 5 6 7 8
-1
- 2
- 3
- 4
- 5
- 6
-7
LH
FSH
Estradiol
Metestrus Diestrus
Proestrus
Diestrus Estrus
CL
Ovulation
CA
Days Relative to the Gonadotropin Surge
0 1 2 3 4 5 6 7 8
-1
- 2
- 3
- 4
- 5
- 6
-7
LH
FSH
PGF
2a
Estradiol
Progesterone
Metestrus Diestrus
Proestrus
Diestrus Estrus
CL
Ovulation

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Cycle.ppt

  • 1. Animal Science 434 Reproductive Cycles in the Female
  • 2. Terminology • Estrus is a noun. – The cow is displaying estrus. • Estrous is an adjective. – The length of the estrous cycle is 21 days. • Oestrus and Oestrous – British and European spellings • Estrus and Heat are synonymous
  • 3. Terminology (cont.) • Anestrus – When the female is not having repeated estrous cycles.
  • 5. Types of Cyclicity Seasonally Polyestrus Short day breeders (Fall) Long day breeders (Spring)
  • 7. Average Reproductive Cycles Species Length of Length of Ovulation Length of Estrous Cycle Estrus Pregnancy cow 21 days 18 hr 11 hr after 282 days polyestrus end estrus ewe 17 days 29 hr near end 148 days seasonal (fall) estrus sow 21 days 48-72 hr 35-45 hr 115 days polyestrus after start estrus mare 21 days 4-8 days 3-6 day of 335 days seasonal (spring) estrus polyestrus (1-2 days before end of estrus)
  • 8. Variation in Cycle Types Example Type of Follicular Ovulation & CL Cycle Development CL Formation Function Cow, ewe, Long Spontaneous Spontaneous Spontaneous sow, mare rats, mice, Short Spontaneous Spontaneous Induced hamsters (4 days) (prolactin) rabbit, cat, Induced Spontaneous Induced Induced mink, ferret, (LH surge) otter, alpaca
  • 9. CA Days Relative to the Gonadotropin Surge 0 1 2 3 4 5 6 7 8 -1 - 2 - 3 - 4 - 5 - 6 -7 LH FSH PGF 2a Estradiol Progesterone Metestrus Diestrus Proestrus Diestrus Estrus CL Ovulation
  • 10. CA Days Relative to the Gonadotropin Surge 0 1 2 3 4 5 6 7 8 -1 - 2 - 3 - 4 - 5 - 6 -7 LH FSH PGF 2a Estradiol Progesterone Metestrus Diestrus Proestrus Diestrus Estrus CL Ovulation
  • 11. CA Days Relative to the Gonadotropin Surge 0 1 2 3 4 5 6 7 8 -1 - 2 - 3 - 4 - 5 - 6 -7 LH FSH PGF 2a Estradiol Progesterone Metestrus Diestrus Proestrus Diestrus Estrus CL Ovulation
  • 12. Follicular Phase Proestrus • follicle enlarges • estrogen increases • vascularity of the female reproductive tract increases • endometrial glands begin to grow • estrogen levels peak
  • 13. CA Days Relative to the Gonadotropin Surge 0 1 2 3 4 5 6 7 8 -1 - 2 - 3 - 4 - 5 - 6 -7 LH FSH PGF 2a Estradiol Progesterone Metestrus Diestrus Proestrus Diestrus Estrus CL Ovulation
  • 14. Estrus • allows male to mount • estrogen decreases • LH surge occurs • ovulation 24-48 hr after surge of LH • uterine motility high with contractions moving toward oviduct • sperm transport is optimal • cervical mucus volume increases Follicular Phase
  • 15. CA Days Relative to the Gonadotropin Surge 0 1 2 3 4 5 6 7 8 -1 - 2 - 3 - 4 - 5 - 6 -7 LH FSH PGF 2a Estradiol Progesterone Metestrus Diestrus Proestrus Diestrus Estrus CL Ovulation
  • 16. Luteal Phase Luteal Phase Metestrus • estrogen low • ovulation in cow • corpus hemorrhagicum present • uterus contractions subside endometrial glands continue to grow and become coiled in cattle bleeding occurs • FSH increases triggering growth of follicles
  • 17. CA Days Relative to the Gonadotropin Surge 0 1 2 3 4 5 6 7 8 -1 - 2 - 3 - 4 - 5 - 6 -7 LH FSH PGF 2a Estradiol Progesterone Metestrus Diestrus Proestrus Diestrus Estrus CL Ovulation
  • 18. Luteal Phase Luteal Phase Diestrus • progesterone high • FSH  Increases at some point to cause growth of ovulatory follicle • Uterus  secrets fluid but volume gradually decreases  contraction stop  CL regresses at the end of this period if female is not pregnant due to PGF release
  • 19. Characteristics of Estrous Cycles Cow Ewe Sow Mare Estrous cycle (days) 21 17 21 21 Proestrus (days) 3-4 2-3 3-4 2-3 Estrus 12-18 hr 24-36 hr 48-72 hr 4-8 days Metestrus (days) 3-4 2-3 2-3 2-3 Diestrus (days) 10-14 10-12 11-13 10-12
  • 20. Causes of Anestrus Pregnancy Presence of Offspring Season Stress Pathology Nutrition
  • 22. Gestational Anestrus • Progesterone during pregnancy – negative feedback • After parturition anestrus continues – progesterone exposure during pregnancy – hypothalamus • Lacks estradiol positive feedback • allows time for uterine involution
  • 23. Seasonal Anestrus Horses are long day breeders!
  • 24. Sheep are short day breeders!
  • 28. Seasonal Anestrus • just like entering puberty • silent ovulation
  • 29. + +
  • 33.
  • 34. Lactational Anestrus • Suckling • Other offspring factors – visual encounter – olfactory encounter – auditory encounter • Prolactin – inhibits GnRH release – major infertility problem in women who are not lactating
  • 37. FSH LH Estradiol Progesterone Follicle Ovulation Corpus Luteum Corpus Albicans 2 4 6 8 10 14 16 18 20 22 24 26 28 2 12 Anterior Pituitary Hormones Ovarian Hormones Ovary Uterine Endo- metrium Recruitment Selection Dominance Recruitment
  • 38. FSH LH Estradiol Progesterone Follicle Ovulation Corpus Luteum 2 4 6 8 10 14 16 18 20 22 24 26 28 2 12 Anterior Pituitary Hormones Ovarian Hormones Ovary Uterine Endo- metrium Menses Menses 5 days 5 days Follicular Phase 9 days Luteal Phase 14 days
  • 39. Variation in Menstrual Cycle Length 35-day cycle Ovulation 14 days Menses Foll. Phase Luteal Phase Menses 28-day cycle Menses Luteal Phase Menses Foll. Phase 25-day cycle Menses Foll. Phase Menses Luteal Phase 14 days 5 days 5 days 5 days 6 days 9 days 16 days 14 days Breast Tenderness
  • 40. Menstural Cycle Length • AGE Length  15 - 19 year olds 35 days  30 year olds 30 days  35 year olds 28 days Variation  More in teenagers  Less in women in peak reproductive years
  • 41. Rest are extra slides not used in 2006
  • 42.
  • 43. CA Days Relative to the Gonadotropin Surge 0 1 2 3 4 5 6 7 8 -1 - 2 - 3 - 4 - 5 - 6 -7 Metestrus Diestrus Proestrus Diestrus Estrus CL Ovulation
  • 44. CA Days Relative to the Gonadotropin Surge 0 1 2 3 4 5 6 7 8 -1 - 2 - 3 - 4 - 5 - 6 -7 LH FSH Estradiol Metestrus Diestrus Proestrus Diestrus Estrus CL Ovulation
  • 45. CA Days Relative to the Gonadotropin Surge 0 1 2 3 4 5 6 7 8 -1 - 2 - 3 - 4 - 5 - 6 -7 LH FSH PGF 2a Estradiol Progesterone Metestrus Diestrus Proestrus Diestrus Estrus CL Ovulation