CXR is a commonly performed imaging test that uses ionizing radiation to visualize the inside of the body. It is useful for diagnosing and treating conditions. A standard CXR involves exposing the chest to a small dose of radiation for less than half a second to produce images. It requires no special preparation and carries minimal risk when used appropriately. The CXR must be evaluated systematically by examining bones, the heart, lungs, mediastinum, diaphragm and soft tissues to identify any abnormalities.
Easy guide to Chest x-ray Interpretation & Case Studiesdevang ghanva
One of the easiest made approach for learning health care buddies about the Chest X-ray Interpretation with Case studies including the Radiological findings, Differential Diagnosis, Radiological Diagnosis, Causes & treatment of each Disease.
A talk for general practitioners on the role of CT coronary angiography in cardiology practice in Australia.
To see more from dr alistair begg visit his website at www.dralistairbegg.com or visit the cardiac dvd dvd website at www.whatswrongwithmyheart.com
Easy guide to Chest x-ray Interpretation & Case Studiesdevang ghanva
One of the easiest made approach for learning health care buddies about the Chest X-ray Interpretation with Case studies including the Radiological findings, Differential Diagnosis, Radiological Diagnosis, Causes & treatment of each Disease.
A talk for general practitioners on the role of CT coronary angiography in cardiology practice in Australia.
To see more from dr alistair begg visit his website at www.dralistairbegg.com or visit the cardiac dvd dvd website at www.whatswrongwithmyheart.com
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
5. IntroductionIntroduction
XR is a noninvasive test that helps Dx & RxXR is a noninvasive test that helps Dx & Rx
CXR is the most commonly done XRCXR is the most commonly done XR
XR involves exposing to a small dose of IR to make pix.XR involves exposing to a small dose of IR to make pix.
of the inside of bodyof the inside of body
It is the oldest imagingIt is the oldest imaging
XR: x-ray, IR: ionizing radiation, RT: resp. tract, BV: blood vessels, SoB: short ofXR: x-ray, IR: ionizing radiation, RT: resp. tract, BV: blood vessels, SoB: short of
breathing, F: fever, Ca: cancer, HD: heart d.breathing, F: fever, Ca: cancer, HD: heart d.
6. How is a CXR done?How is a CXR done?
In standing, sitting, or lying. PA, AP, side/angleIn standing, sitting, or lying. PA, AP, side/angle
Time of exposure is oftenTime of exposure is often <0.5 second!<0.5 second!
Medical XRs are only 15% of annual IR exposure!Medical XRs are only 15% of annual IR exposure!
Even with multiple & repeated XR;Even with multiple & repeated XR; total dose is still small!total dose is still small!
The more solid a structure is, the whiter it appears.The more solid a structure is, the whiter it appears.
Bones appear very white:Bones appear very white: (opaque)(opaque)
Muscle, blood, skin, fat: darkerMuscle, blood, skin, fat: darker (lucent)(lucent)
Expected benefits of XR must always outweigh riskExpected benefits of XR must always outweigh risk
7. Patient PreparationPatient Preparation
CXR requires no special preparationCXR requires no special preparation
May need to remove some/all clothesMay need to remove some/all clothes
Remove jewelry, dentures, eye glasses & metal objectsRemove jewelry, dentures, eye glasses & metal objects
that might interfere with XRthat might interfere with XR
Women must inform ifWomen must inform if pregnantpregnant; many imaging are; many imaging are
not donenot done
If XR is necessary, precautions will be takenIf XR is necessary, precautions will be taken
toto minimize exposure to the babyminimize exposure to the baby
8. 1.1. PA or AP viewPA or AP view
2.2. Inspiration or expirationInspiration or expiration
3.3. XRXR penetrationpenetration: Under- or Over-: Under- or Over-
4.4. Lateral (L/R)Lateral (L/R)
5.5. Oblique (R/L; posterior/anterior):Oblique (R/L; posterior/anterior): helpful to localizehelpful to localize
lesionslesions
6.6. Lateral decubitus (L/R): effusion or thickeningLateral decubitus (L/R): effusion or thickening
7.7. Lordotic: apical lesionLordotic: apical lesion
PositionPosition
9. PA vs AP viewsPA vs AP views
PA: XR tube is 40in from the pt.PA: XR tube is 40in from the pt.
AP: the XR tube is 40in from the pt.AP: the XR tube is 40in from the pt.
10. PA vs APPA vs AP
Usually an upright PA is done. AP is less useful & doneUsually an upright PA is done. AP is less useful & done
only if pt. can’t standonly if pt. can’t stand
Scapula is seen in peripheryScapula is seen in periphery
Clavicles project over lungsClavicles project over lungs
Posterior ribs are distinctPosterior ribs are distinct
Scapulae are over lung fieldsScapulae are over lung fields
Clavicles are above lung apexClavicles are above lung apex
Anterior ribs are distinctAnterior ribs are distinct
Broadened H & widening of M
11. Expiration:Expiration: can show a very abnormal chest. Loss of R heartcan show a very abnormal chest. Loss of R heart
border would lead to Dx of pn. On repeat exam. withborder would lead to Dx of pn. On repeat exam. with fullfull
inspiration,inspiration, the R heart border is normalthe R heart border is normal
Expiration vs InspirationExpiration vs Inspiration
12. InspirationInspiration
Full inspiration greatly helps to determineFull inspiration greatly helps to determine
lung abnormalities. Diaphragm should belung abnormalities. Diaphragm should be
found about the 8found about the 8thth
-10-10thth
posterior rib or 5posterior rib or 5thth
-6-6thth
anterior ribanterior rib
13. Correct exposure:Correct exposure: you should barely see IV discs through the heartyou should barely see IV discs through the heart
•If you see them very clearly, film is overpenetratedIf you see them very clearly, film is overpenetrated
•If you do not see them it is underpenetratedIf you do not see them it is underpenetrated
PenetrationPenetration
14. Good CXR: centered trachea, spine should be justGood CXR: centered trachea, spine should be just
transparent through H, full inspiration, anterior end of R 6transparent through H, full inspiration, anterior end of R 6thth
rib should pointrib should point
mid-way along the R hemidiaphragmmid-way along the R hemidiaphragm
17. Benefits vs. Risks of X-RaysBenefits vs. Risks of X-Rays
BenefitsBenefits
Non-invasive. Very fast & easy. PaNon-invasive. Very fast & easy. Particularly useful in ERrticularly useful in ER
No radiation remains in the body post XRNo radiation remains in the body post XR
Usually no SE in the diagnostic rangeUsually no SE in the diagnostic range
Equipment is cheap & widely availableEquipment is cheap & widely available
RisksRisks
Slight risk of CaSlight risk of Ca
Benefit of an accurate Dx far outweighs the riskBenefit of an accurate Dx far outweighs the risk
The effective radiation dose variesThe effective radiation dose varies
ER: emergency room. SE: side effectER: emergency room. SE: side effect
18. Radiation DoseRadiation Dose
CXR: very small (0.25 mRad)CXR: very small (0.25 mRad)
We all receive ~100 mRad/y from cosmic rays …We all receive ~100 mRad/y from cosmic rays …
But improperly used equipment can markedly increaseBut improperly used equipment can markedly increase
the radiation dosethe radiation dose
Minimizing IR DoseMinimizing IR Dose
Radiology protection councils update standardsRadiology protection councils update standards
Modern systems have tight control with significantModern systems have tight control with significant
filtration & dose controlfiltration & dose control
Parts of body not being imaged receive minimal doseParts of body not being imaged receive minimal dose
19. Accepted indications for CXRAccepted indications for CXR
Ac. resp./cardiac d.Ac. resp./cardiac d.
Major chest trauma, hemoptysisMajor chest trauma, hemoptysis
Chr. SoB, interstitial lung d.Chr. SoB, interstitial lung d.
P. embolism, Pn., pl. effusion, PTX, Positive MTP. embolism, Pn., pl. effusion, PTX, Positive MT
Febrile neutropenia, immunosuppressedFebrile neutropenia, immunosuppressed
Persistent symptoms 6w post CAPPersistent symptoms 6w post CAP
Post tube & line insertion (not PPM or tracheostomy)Post tube & line insertion (not PPM or tracheostomy)
Suspected mass, LAP or metastasisSuspected mass, LAP or metastasis
Suspected elevated diaphragm.Suspected elevated diaphragm. Resp. distress in NBResp. distress in NB
PTX: pneumothorax, MT: Mantaux test, CAP: comm. acquired pn., SS:PTX: pneumothorax, MT: Mantaux test, CAP: comm. acquired pn., SS:
symptoms & signs, LAP: lymphadenopathy, PPM: permanent pacemaker. NB:symptoms & signs, LAP: lymphadenopathy, PPM: permanent pacemaker. NB:
newbornnewborn
20. NOTNOT considered indications for CXRconsidered indications for CXR
Asymptomatic pre-admn., asymptomatic pre-operativeAsymptomatic pre-admn., asymptomatic pre-operative
Daily routine in ICU without clinical changeDaily routine in ICU without clinical change
Routine pre-employment, minor chest trauma, URTIRoutine pre-employment, minor chest trauma, URTI
Uncomplicated ac. exacerbation of BA/COPDUncomplicated ac. exacerbation of BA/COPD
Classical bronchiolitisClassical bronchiolitis
Ac./chr. chest painAc./chr. chest pain
Pre-discharge Pn., nor a follow up CXR if SS are betterPre-discharge Pn., nor a follow up CXR if SS are better
except if at high risk of lung Ca (>50y), has chr. lungexcept if at high risk of lung Ca (>50y), has chr. lung
d. or is a smokerd. or is a smoker
Thoracic aneurysm follow up (CT is of choice)Thoracic aneurysm follow up (CT is of choice)
Screening for lung cancer in asymptomaticScreening for lung cancer in asymptomatic
21. Limitations of Chest RadiographyLimitations of Chest Radiography
As some d. of chest cannot be detected on a ordinaryAs some d. of chest cannot be detected on a ordinary
CXR, it cannot necessarily rule out all chest d.CXR, it cannot necessarily rule out all chest d.
Small cancers may not show upSmall cancers may not show up
P. embolism, cannot be seenP. embolism, cannot be seen
More imaging may be needed to clarify results of a CXRMore imaging may be needed to clarify results of a CXR
or to look for abnormalities not visible on CXRor to look for abnormalities not visible on CXR
27. Check List …Check List …
Lungs & pleura:Lungs & pleura:
hila: normal relationships, size, etc.hila: normal relationships, size, etc.
compare lung sizes, parenchymacompare lung sizes, parenchyma
BV pattern: compare upper to lower lobe, normalBV pattern: compare upper to lower lobe, normal
tapering to peripherytapering to periphery
pleura: fissures: major & minor - if seenpleura: fissures: major & minor - if seen
compare hemidiaphragmscompare hemidiaphragms
follow pleura around rib cagefollow pleura around rib cage
DiaphragmDiaphragm
Contour. Sharp costophrenic & cardiophrenic anglesContour. Sharp costophrenic & cardiophrenic angles
Right diaphragm is usually 1-2 cm higherRight diaphragm is usually 1-2 cm higher
Easy diagnosis:Easy diagnosis: Pn., Edema, TumorPn., Edema, Tumor
28. HeartHeart
PositionPosition
More central in young childrenMore central in young children
More on the L side in older childrenMore on the L side in older children
SizeSize
CARDIO-THORACIC RATIOCARDIO-THORACIC RATIO
Cardiac diameter:Cardiac diameter:
normal <15.5 cm in males; <14.5 cm in femalesnormal <15.5 cm in males; <14.5 cm in females
A change of >1.5 cm between 2 X-rays is significantA change of >1.5 cm between 2 X-rays is significant
Soft tissuesSoft tissues
Shadows: most commonly breast, nippleShadows: most commonly breast, nipple
abdo. for bowel gas, organ size, calcification, free airabdo. for bowel gas, organ size, calcification, free air
soft tissues & spine of necksoft tissues & spine of neck
Check List …Check List …
29. Cardio-thoracic ratioCardio-thoracic ratio
PA viewPA view onlyonly
>50% is abnormal in an adult:>50% is abnormal in an adult:
cardiac failurecardiac failure
pericardial effusionpericardial effusion
L/R ventriculomegalyL/R ventriculomegaly
>66% in a neonate>66% in a neonate
30.
31. An area of more density within lung, must be result of:An area of more density within lung, must be result of:
1.1. Consolidation:Consolidation: filling of alveoli with fluid, pus, blood, cells (also tumor cells)filling of alveoli with fluid, pus, blood, cells (also tumor cells)
2.2. InterstitialInterstitial: fine or coarse reticular opacities or small nodules: fine or coarse reticular opacities or small nodules
3.3. Nodule or mass:Nodule or mass: any space occupying lesion either solitary or multipleany space occupying lesion either solitary or multiple
4.4. Atelectasis:Atelectasis: loss of air in the alveoli (volume loss & increased density)loss of air in the alveoli (volume loss & increased density)
32.
33. LungsLungs
Start at the top.Start at the top.
Compare R & L.Compare R & L.
Trachea is centralTrachea is central
Lung parenchymaLung parenchyma
becomes lighter asbecomes lighter as
you go down lung.you go down lung.
If not, it may indicateIf not, it may indicate
pleural effusionpleural effusion
37. MEDIASTINUM …MEDIASTINUM …
SUPERIORSUPERIOR MEDIASTINUMMEDIASTINUM
Begins -Begins - rootroot of the neck &of the neck &
Ends - line drawnEnds - line drawn T-4 vertebraeT-4 vertebrae ------ sternomanubrialsternomanubrial junctionjunction..
this line skims the top of the aortic arch. Tthis line skims the top of the aortic arch. T
(INFERIOR) MEDIASTINUM(INFERIOR) MEDIASTINUM
Below this line to diaphragm. Further divided intoBelow this line to diaphragm. Further divided into
Anterior (Anterior (everything anterior to H)everything anterior to H)
Middle (Middle (H & pericardium)H & pericardium)
Posterior (Posterior (posterior to H to the spine)posterior to H to the spine)
38. The M can be divided into anterior,The M can be divided into anterior,
middle & posterior compartments.middle & posterior compartments.
But there isBut there is no tissue plane separatingno tissue plane separating
them.them.
On the lateral XR by 2 imaginaryOn the lateral XR by 2 imaginary lines:lines:
1.1.anterior to the trachea & posteriorly to the inferior VC.anterior to the trachea & posteriorly to the inferior VC.
2.2.passing 1 cm posteriorly to the anterior border of vertebraepassing 1 cm posteriorly to the anterior border of vertebrae
This helps to make a more narrow DDThis helps to make a more narrow DD
39. Pitfalls to CXR InterpretationPitfalls to CXR Interpretation
Poor inspiration:Poor inspiration: high diaphragms & crowding of normalhigh diaphragms & crowding of normal
lung markingslung markings
Over/under penetrationOver/under penetration of rays: obliterate/exaggerateof rays: obliterate/exaggerate
imp. findings. Properly-penetrated PA CXR: one canimp. findings. Properly-penetrated PA CXR: one can
just make out thoracic vertebrae overlying thejust make out thoracic vertebrae overlying the
image of the heartimage of the heart
RotationRotation distorts normal structuresdistorts normal structures
Forgetting the path of the x-ray beamForgetting the path of the x-ray beam
40. CONSOLIDATIONCONSOLIDATION
Lobar/segmental DensityLobar/segmental Density
Air BronchogramAir Bronchogram
No Loss of Lung VolumeNo Loss of Lung Volume
No shift of mediastinumNo shift of mediastinum
Here, loss of L heart silhouette,Here, loss of L heart silhouette,
diaphragmatic silhouette intact,diaphragmatic silhouette intact,
blunting of costophrenic angleblunting of costophrenic angle
41. Pneumococcal pn. Is thePneumococcal pn. Is the
commonest c/of lobarcommonest c/of lobar
consolidation.consolidation.
Architecture is intact.Architecture is intact.
Airway is patent.Airway is patent.
1. a density1. a density
corresponding to acorresponding to a
segment or lobesegment or lobe
2. air bronchogram2. air bronchogram
3. no loss of lung vol.3. no loss of lung vol.
42. (LOBAR) CONSOLIDATION …(LOBAR) CONSOLIDATION …
RUL densityRUL density
Loss of ascending aortaLoss of ascending aorta
silhouettesilhouette
No shift of mediastinumNo shift of mediastinum
Transverse fissure notTransverse fissure not
significantly shiftedsignificantly shifted
Air bronchogramAir bronchogram
No loss of lung volumeNo loss of lung volume
43. Extensive RUL consolidation, withExtensive RUL consolidation, with
bulging of minor fissurebulging of minor fissure
44. Staph. Pn.: RML consolidation withStaph. Pn.: RML consolidation with
cavitation & air bronchogram. There iscavitation & air bronchogram. There is
a small R p. effusion. The remaining thea small R p. effusion. The remaining the
lung fields are ok.lung fields are ok.
45. PLEURAL EFFUSIONPLEURAL EFFUSION
Radiological criteriaRadiological criteria::
homogenoushomogenous opacityopacity
in dependent portionin dependent portion
costophrenic &costophrenic &
cardiophrenic angles lostcardiophrenic angles lost
loss of diaphragm silhouetteloss of diaphragm silhouette
A. shows fluid layering in the R pleural cavity. BA. shows fluid layering in the R pleural cavity. B
shows the normal width of the lungshows the normal width of the lung
50. SIGNS OF ATELECTASISSIGNS OF ATELECTASIS (loss of volume)(loss of volume)
Shift of M, elevation of diaphragmShift of M, elevation of diaphragm
Drooping of shoulder, crowding of ribsDrooping of shoulder, crowding of ribs
Movement of Fissures on lateral viewMovement of Fissures on lateral view
Movement of Hilum:Movement of Hilum: R hilum is normally slightly lower
Compensatory hyperinflation: more lucency & splayingCompensatory hyperinflation: more lucency & splaying
of BV seen in normal areasof BV seen in normal areas
Alterations in proportion of Lt. & Rt.Alterations in proportion of Lt. & Rt. (55%)(55%) LungLung
Hemithorax asymmetryHemithorax asymmetry
M: mediastinum. D: diaphragmM: mediastinum. D: diaphragm
51. Right upper lobe collapseRight upper lobe collapse
Movement of the Fissures, a
DIRECT sign of volume loss
Elevation of
diaphragm
Tracheal shift
Hilum displaced
52. Types of Atelectasis:Types of Atelectasis:
Resorptive:Resorptive: airways are obstructed; air gets absorbedairways are obstructed; air gets absorbed
Relaxation (passive):Relaxation (passive): lung is held to chest wall by -velung is held to chest wall by -ve
pressure; if it is lost (PTX & p. effusion) lung recoils.pressure; if it is lost (PTX & p. effusion) lung recoils.
Common misconception:Common misconception: a. is due to compressiona. is due to compression
Adhesive atelectasisAdhesive atelectasis:: surfactant loss: collapse (ARDS,surfactant loss: collapse (ARDS,
p. embolism)p. embolism)
Cicatricial (fibrotic) a.:Cicatricial (fibrotic) a.:
Alveoli gets trapped in scar (in fibrotic d.)Alveoli gets trapped in scar (in fibrotic d.)
Round a.:Round a.:
Lung gets trapped by pleural d. & is devoid of air.Lung gets trapped by pleural d. & is devoid of air.
Classically seen in asbestosisClassically seen in asbestosis
PTX: pneumothorax. BF: blood flow. D.: disease/disorder/defectPTX: pneumothorax. BF: blood flow. D.: disease/disorder/defect
53. RUL atelectasisRUL atelectasis
1.1. triangular densitytriangular density
2.2. elevated right hiluselevated right hilus
3.3. tenting R diaphragm (blue arrow)tenting R diaphragm (blue arrow)
4.4. obliteration of the retrosternal clear spaceobliteration of the retrosternal clear space (arrow)(arrow)
54. RML atelectasisRML atelectasis
1.1. Blurring of H border. 2. Triangular density on lateral view.Blurring of H border. 2. Triangular density on lateral view. Usually itUsually it
does not cause noticeable rise of D. Adoes not cause noticeable rise of D. A pectus excavatumpectus excavatum can mimick acan mimick a
RML a. on a frontal view, but the lateral view should solve this problemRML a. on a frontal view, but the lateral view should solve this problem
55. RLL atelectasisRLL atelectasis
Fall from stairs with severe pain on R flank. Look some loculatedFall from stairs with severe pain on R flank. Look some loculated
fluid posterolateral (hematothorax). Afluid posterolateral (hematothorax). Abnormal R border of H. Rightbnormal R border of H. Right
interlobar artery is not visible, as is surrounded by collapsed RLL,interlobar artery is not visible, as is surrounded by collapsed RLL,
which is adjacent to RAwhich is adjacent to RA
On aOn a FU filmFU film the a. has resolved (mucus plug). Note the R interlobarthe a. has resolved (mucus plug). Note the R interlobar
arteryartery (red arrow)(red arrow) & the normal R heart border& the normal R heart border (blue arrow)(blue arrow)
56. LUL atelectasisLUL atelectasis
• Minimal vol. loss with rise of D.Minimal vol. loss with rise of D. Large density with loss of H. borderLarge density with loss of H. border
• Band of increased density in the retrosternal spaceBand of increased density in the retrosternal space
• Abnormal L hilum, i.e. possible obstructing massAbnormal L hilum, i.e. possible obstructing mass
Apical region is dark (c/by overinflation), which causes the superiorApical region is dark (c/by overinflation), which causes the superior
segment to creep all the way up to the apical region; called thesegment to creep all the way up to the apical region; called the luftluft
57. Left LL atelectasisLeft LL atelectasis
Triangular density over H; must be located posterior to H. This is confirmed on LV.Triangular density over H; must be located posterior to H. This is confirmed on LV.
The contour of left D is lost when you go from anterior to posterior. We cannot seeThe contour of left D is lost when you go from anterior to posterior. We cannot see
the LL vessels, as they are surrounded by the atelectatic lobe. Normally when youthe LL vessels, as they are surrounded by the atelectatic lobe. Normally when you
follow the thoracic spine from top to bottom, the lower region becomes lessfollow the thoracic spine from top to bottom, the lower region becomes less
opaque. Here we have the opposite (blue arrow). Left hilum is pulled downopaque. Here we have the opposite (blue arrow). Left hilum is pulled down
58. Total atelectasisTotal atelectasis
RL: due to mucus plugging. Shifting of M. Re-aeration on FURL: due to mucus plugging. Shifting of M. Re-aeration on FU
CXR after suction. A common c/of total a. of a lung is aCXR after suction. A common c/of total a. of a lung is a
ventilation tube positioned too deep & thus obstructing oneventilation tube positioned too deep & thus obstructing one
of the main bronchiof the main bronchi
59. TOTAL ATELECTASIS …TOTAL ATELECTASIS …
Homogenous density RHomogenous density R
hemithoraxhemithorax
M shift to RM shift to R
R hemithorax smallerR hemithorax smaller
R heart & D silhouetteR heart & D silhouette
are not identifiableare not identifiable
R: right, D: diaphragm, M: mediastinumR: right, D: diaphragm, M: mediastinum
60. This pt. had widespread Br.Pn. & was on ventilation.This pt. had widespread Br.Pn. & was on ventilation.
During FU a white out on the left was seen. This was c/by aDuring FU a white out on the left was seen. This was c/by a
large mucus plug. After suction L lung was re-aeratedlarge mucus plug. After suction L lung was re-aerated
BrPn: bronchopneumonia. c/by: caused by. FU: follow upBrPn: bronchopneumonia. c/by: caused by. FU: follow up
TOTAL ATELECTASIS …TOTAL ATELECTASIS …
61. Cicacitration atelectasisCicacitration atelectasis
Can be the result of fibrosis of lung; seen after radiotherapy & in chr.Can be the result of fibrosis of lung; seen after radiotherapy & in chr.
inf, esp. TB. This pt. got radiotherapyinf, esp. TB. This pt. got radiotherapy
62. FIBROSISFIBROSIS
Diffuse hazinessDiffuse haziness
Apical cap thickeningApical cap thickening
Blunting of costophrenic angleBlunting of costophrenic angle
No shift of fluid in lateral decubitusNo shift of fluid in lateral decubitus
Loss of lung volumeLoss of lung volume
Lines not corresponding to fissuresLines not corresponding to fissures
63.
64. MAS. Radiograph obtained shortly after birth shows ill-defined, predominantlyMAS. Radiograph obtained shortly after birth shows ill-defined, predominantly
perihilar opacities in the lungs; these are more severe on the right. The lungs areperihilar opacities in the lungs; these are more severe on the right. The lungs are
hyperexpanded. Heart size is normal.hyperexpanded. Heart size is normal.
65. PLEURAL FIBROSISPLEURAL FIBROSIS
Smaller R hemithoraxSmaller R hemithorax
Diffuse hazinessDiffuse haziness
Tracheal shift to RTracheal shift to R
Blunted costophrenicBlunted costophrenic
angleangle
Lines not corresponding toLines not corresponding to
fissuresfissures
71. PNEUMOTHORAXPNEUMOTHORAX
Air (black) in R. pleural spaceAir (black) in R. pleural space
No lung markingsNo lung markings
No vascular markings ..No vascular markings ..
Atelectatic (lung margin) ..Atelectatic (lung margin) ..
Larger R hemithoraxLarger R hemithorax
Opposite lung:Opposite lung: vascular marksvascular marks
prominentprominent
No shift of MNo shift of M
Deep sulcus signDeep sulcus sign
More haziness on left: diversionMore haziness on left: diversion
of entire cardiac outputof entire cardiac output
Small fluid level near CP angle:Small fluid level near CP angle:
hydro PTXhydro PTX
72. LeftLeft
PTXPTX.. Lucency atLucency at
left CP angleleft CP angle
(red arrow)(red arrow)
which projectswhich projects
well below thewell below the
CP angle on RCP angle on R
(white arrow)(white arrow)
is theis the "Deep"Deep
sulcus sign"sulcus sign"
indicating PTXindicating PTX
on a supineon a supine
CXRCXR
73. TENSION PNEUMOTHORAXTENSION PNEUMOTHORAX
Atelectatic R lungAtelectatic R lung
No vascular markingsNo vascular markings
Shift of MShift of M
Deep sulcus signDeep sulcus sign
Increased haziness onIncreased haziness on
L: diversion ofL: diversion of
entire cardiac OPentire cardiac OP
74. Tension PTX with M shift. Failure to place a R chest tube immediately couldTension PTX with M shift. Failure to place a R chest tube immediately could
diminishdiminish venous return & lead to deathvenous return & lead to death
75.
76. HYDROPNEUMOTHORAXHYDROPNEUMOTHORAX
Air in pleural cavityAir in pleural cavity
Lung margin visibleLung margin visible
Bilateral fluid level:Bilateral fluid level:
Any time; a horizontalAny time; a horizontal
fluid level means air &fluid level means air &
fluid in the spacefluid in the space
86. LUNG MASSLUNG MASS
MassMass
Round or ovalRound or oval
Sharp marginSharp margin
HomogenousHomogenous
No respect forNo respect for
anatomyanatomy
Lung Ca.: large cellLung Ca.: large cell
91. Unilateral Pulmonary EdemaUnilateral Pulmonary Edema
AspirationAspiration
Disease in other lung,Disease in other lung,
e.g. COPDe.g. COPD
PosturalPostural
Rapid expansion ofRapid expansion of
PTXPTX
100. MCQMCQ
CXR is most commonly done XRCXR is most commonly done XR
Most CXR done are normalMost CXR done are normal
Deep sulcus sign is seen in PTX on supine CXRDeep sulcus sign is seen in PTX on supine CXR
onlyonly
Commonest c/of pl. effusion in BD is pneumoniaCommonest c/of pl. effusion in BD is pneumonia
PTB causes specific changes in CXRPTB causes specific changes in CXR
Editor's Notes
Ionizing radiation carries enough energy to knock electrons from atoms/molecules, thereby
ionizing them. IR is made up of energetic subatomic particles, ions or atoms moving at high speeds (usually &gt;1% of the speed of light), & EMW on the high-energy end of the EM spectrum.
Gamma rays, X-rays, & the higher UV part of the EM spectrum are ionizing, whereas the lower
UV part of EMS & all the spectrum below UV, including visible light (including nearly all types of laser light), infrared, microwaves, & radio waves are non-IR. The boundary between ionizing & non-ionizing EM radiation that occurs in the UV is not sharply defined, since different molecules & atoms ionize at different energies. Conventional definition places the boundary at a photon energy between 10 eVand 33 eV in the UV.
Typical ionizing subatomic particles from radioactivity include alpha particles, beta particles & neutrons. Almost all products of radioactive decay are ionizing because the energy of radioactive decay is typically far higher than that required to ionize. Other subatomic ionizing particles which occur naturally are muons, mesons, positrons, & other particles that constitute the secondary cosmic rays that are produced after primary cosmic rays interact with Earth&apos;s atmosphere.
Cosmic rays are generated by stars & certain explosions. These may also produce radioisotopes on Earth (e.g., carbon-14), which in turn decay & produce IR. Cosmic rays & the decay of radioactive isotopes are the primary sources of natural IR on Earth referred to as background radiation. IR can also be generated artificially by X-ray tubes, particle accelerators, & any of the various methods that produce radioisotopes artificially.
IR is not detectable by our senses, so radiation detection instruments are used. But, high intensities can cause emission of visible light upon interaction with matter, such as in Cherenkov radiation & radioluminescence.
IR is used in variety of fields like medicine, nuclear power, research, manufacturing, construction, & many other areas, but presents a health hazard. IR causes damage to living tissue, & can cause radiation burns, cell damage, radiation sickness, Ca, & death
Natural radiation exposure comes from cosmic radiation from the sun, terrestrial radiation from rocks & soil, & internal radiation within our own bodies from things we have eaten such as milk or water.
The radiation in food & drink comes from water, plants & animals, which receive radiation from the earth or cosmic radiation from the sun.
Annual background radiation at sea level is one-half the radiation in Denver, Colorado. Denver is at high altitude & the earth&apos;s atmosphere filters cosmic rays so that the higher one goes above sea level, the greater cosmic radiation level.
Despite the variation in background radiation, there is no increase in cancer or congenital abnormalities detected in these areas
PA vs AP
The PA (posterioranterior) film is obtained with the patient facing the cassette & the x-ray tube 6 feet away. This distance diminishes the effect of beam divergence & magnification of structures closer to the x-ray tube. On the film below the exam was obtained in an AP or anteroposterior position. Note that the chest has a difference appearance. The heart shadow is magnified because it is an anterior structure. The pulmonary vasculature is also altered when patients are examined in the supine position. On the AP supine film there is more equalization of the pulmonary vasculature when the size of the lower lobe vessels are compared to the upper.
Assessment of adequacy of inspiratory effort
Ensuring an adequate inspiratory effort is imp for CXR. It is a simple process. It is ascertained by counting either the number of visible anterior or posterior ribs. If six complete anterior or ten posterior ribs are visible then it is an adequate inspiratory effort.
If a poor inspiratory effort is made or if the CXR is taken in expiration, then several potentially spurious findings can result:
apparent cardiomegaly
apparent hilar abnormalities
apparent mediastinal contour abnormalities
the lung parenchyma tends to appear of increased density, i.e. ‘white lung’
Assessment of exposure quality
Is the film penetrated enough? On a HQ XR, vertebrae should just be seen through the H. If they are not visible, then an insufficient XR have passed through. The film will look ‘whiter’ leading to potential ‘overcalling’ of pathology. Similarly, if the film looks too ‘black’, then too much XR have gone. This causes lesions less conspicuous & may lead to ‘undercalling’
X-rays are taken only on the recommendation of a physician who balances benefits against risk. Routine surveillance of equipment & fulfilling all regulations are mandated. Annual inspections of the equipment & review of departmental procedures are always in compliance.
Also, physicians involved in performing X-ray procedures undergo specific training to reduce radiation exposure & use techniques that decrease exposure. Technologists who are familiar in dealing with children are particularly good at obtaining quality images on the first try. This reduces the need for repeated radiation exposure
Febrile neutropenia is fever, often with other s/of inf., in neutropenia aka neutropenic sepsis. In 50% of cases, an inf. is detectable; bacteremia is present in 20% only.
FN is a serious complication of chemo- that can lead to delays in Rx and necessary dose reductions, which compromise Rx efficacy. 1% of pts with chemo develop FN, which contributes to MM.Neutropenia is low counts, usually within 7-12d following chemo. It is Dx by ANC of &lt;500 following chemo, or by an ANC expected to decrease to &lt;500 within 48 hours. Due to reduced neutrophils, pts. with neutropenia may have an impaired ability to fight inf. Hence, even a minor inf may become very serious. It is crucial to monitor for SS of inf, which may present as fever, chills, or sweats. Neutropenia may be a/by F originating from an underlying inf. F may be the sole indicator of an underlying inf in chemo-induced neutropenia; other SS of inflam may be absent. Neutropenia must be assessed for risk of severe inf immediately at presentation of F. FN is defined by an oral &gt;101ºF from a single reading or at least 100.4ºF sustained over a 1-h period or reported from 2 consecutive readings in a 2-h.Risk of an inf-related complication must be determined so that appropriate early management can begin. FN may have minimal or absent symptoms, so close exam of the most commonly infected sites. FN are initially investigated for inf on sites of previous procedures or catheters, as well as on or in the skin, GIT, oropharynx, lungs, GUT, and RS. CXR may be indicated if SS of respiratory inf. Pn can progress rapidly in FNDetailed Hx should be evaluated, including new site-specific symptoms, recent ABT, surgical history, and underlying comorbidities. Hx should be analyzed for past positive microbiology records, specifically of AB-resistance or bacteremia. Cultures should be obtained from suspected sites. Urinalysis and sputum and stool cultures may be necessary.Labs, including CBC with DC and platelet are needed. At least 2 sets of blood CS are recommended, 1 from a central venous catheter and 1 from a peripheral vein. Renal and LFT are routine, electrolytes.FN undergo initial risk assessment for serious complications, including mortality, to determine appropriate Rx. IDSA, National Comprehensive Cancer Network (NCCN), and European Society of Medical Oncology (ESMO) outline the classification of risk for patients with FN. Depending on the level of risk determined, management of patients may vary in the administration of treatment (oral or intravenous), duration of therapy, and Rx setting (outpatient or hospital).Patients are classified into risk categories based on clinical criteria, including the duration of neutropenia, ANC measure, presence of comorbidities, renal and hepatic insufficiencies, medication usage, and history of FN. The Multinational Association of Supportive Care in Cancer (MASCC) index is a formal method for defining risk stratification, which is incorporated into the initial risk evaluation. The MASCC index assigns values to patient age, history, outpatient or inpatient status, clinical signs, severity of fever and neutropenia, and presence of medical comorbidities; the summation of those values determines risk classification.Patients with FN are characterized as having a low risk of complications if the patient has good performance status and few medical comorbid conditions, presents with adequate hepatic function and renal function, and the neutropenia’s duration is expected to be less than 7 days. Patients are stratified into a low-risk category with an MASCC Risk Index score of at least 21. Low-risk patients are initially treated with oral or intravenous empiric therapy.4,5Patients with FN are classified as having a high risk of complications if they present with profound neutropenia marked by an ANC less than 100 cells per microliter following chemotherapy, and if the duration of neutropenia is anticipated to last longer than 7 days. In addition, high-risk patients may have clinically relevant comorbidities such as hypotension, pneumonia, new onset of abdominal pain, renal or hepatic insufficiency, or neurological changes. Patients are also stratified into the high-risk category if they present with a MASCC Risk Index score of less than 21. Patients with FN at high risk of serious complications are treated with intravenous empiric antibiotic therapy in the inpatient setting.1,4,5Evidence-based guidelines for the management of patients with FN in clinical practice have been developed by the IDSA, NCCN, and ESMO.Patients with FN with high risk of complications should be initiated with empiric antibiotics administered intravenously in the hospital setting. Clinical practice guidelines from the IDSA recommend initial antibiotic monotherapy including an antipseudomonal beta-lactam (ie, cefepime), a carbapenem (ie, meropenem, imipenem, or cilastatin), or piperacillin-tazobactam. Patients who are afebrile and develop signs and symptoms of infection should also be treated empirically with the same regimen as high-risk patients. Initial treatment with vancomycin and other antibiotics effective against gram-positive cocci are not recommended as standard empirical antibiotic treatment for patients with FN. However, these agents may be considered in modifications of initial treatment as additional therapy for patient-based needs, such as suspicion of catheter-related infection, skin or soft-tissue infection, pneumonia, hemostatic instability, or antibiotic resistance.4,5The IDSA guidelines recommend therapy modifications for patients with a positive blood culture with a risk of infection with antibiotic-resistant organisms. If methicillin-resistant Staphylococcus aureus is suspected, the initial antibiotic regimen can be modified to include vancomycin, daptomycin, or linezolid. Suspicion of vancomycin-resistant enterococcus calls for the addition of linezolid or daptomycin. If extended-spectrum beta-lactamase–producing gram-negative bacteria is suspected, patients may benefit from the early use of carbapenem. The addition of polymyxin-colistin or tigecycline to the early treatment is appropriate if the presence of Klebsiella pneumoniae carbapenemase-producing bacteria is suspected. Patients allergic to penicillin may be given cephalosporin, but either ciprofloxacin and clindamycin or aztreonam and vancomycin are recommended in cases of immediate hypersensitivity.4Patients with FN at low risk of complications may be initially treated with empirical antibiotics administered orally or intravenously in the inpatient setting. Patients meeting select criteria of clinical stability and adequate gastrointestinal absorption may be eligible for treatment switch from intravenous to oral administration of antibiotics. Recommended treatment for low-risk patients includes combination oral antibiotic therapy with ciprofloxacin and amoxicillin-clavulanate. Other orally administered regimens commonly used in clinical practice are monotherapy with levofloxacin or ciprofloxacin and combination with ciprofloxacin and clindamycin. If a patient is being treated for FN with fluoroquinolone prophylaxis, a fluoroquinolone cannot be used as an initial empiric therapy. Additionally, selected patients who are at low risk for complications and have family support and appropriate culture status may be eligible for transitioning treatment with intravenous or oral empiric therapy to the outpatient setting. Patients who continue to present with fever and worsening signs and symptoms of infection are to remain in hospital rather than being discharged.1,4,5Empiric antifungal therapy is not recommended for routine use in low-risk patients. Initiation of empiric antifungal therapy is recommended for patients who continue to have persistent fever of unidentified cause following 4 to 7 days of antibiotic treatment, and who present with neutropenia that is expected to last more than 7 days. In patients with FN who are already receiving anti-mold prophylaxis, the switch to an agent in a different antifungal class should be considered. However, there are insufficient data to determine which antifungal agent is most appropriate.4Assessment of Therapeutic Response The assessment of response and duration of therapy outlined by clinical practice guidelines for the management of FN recommend daily patient reviews following administration of empiric therapy to determine needs for subsequent management. Daily assessments include laboratory tests and cultures for infection, fever trends, and toxicity of treatment.
Treatment is necessary until the patient is afebrile for at least 48 hours, clinically stable with resolution of neutropenia (ANC of at least 500 cells per microliter), and has negative blood cultures.4,5 For patients with documented » infections, the duration of treatment is decided by the organism and site of infection, and treatment should continue until resolution of neutropenia.4If a patient is clinically unstable, such as if they present with persistent fever, signs of infection, or positive blood cultures, a broad-coverage antibiotic therapy should be considered. Patients with persistent fever are at a high risk of developing complications and need prompt consultation from an infectious diseases physician. If high fever persists for more than 4 to 6 days, then empiric antifungal therapy may be necessary. Treatment with antibiotics can be discontinued in patients with an ANC of less than 500 cells per microliter who have maintained an afebrile state for 5 to 7 days without any complications. High-risk patients, such as those with acute leukemia and those who have recently had high-dose cytotoxic chemotherapy, may require treatment with antibiotics for up to 10 days or until the resolution of neutropenia.1,4,5Prophylaxis for FNThe recommended initial treatment for patients who are considered high risk for complications of FN, and who are expected to have an extended period of profound neutropenia lasting longer than 7 days defined by no more than 100 cells per microliter, is fluoroquinolone prophylaxis. Both ciprofloxacin and levofloxacin are recommended to treat patients at high risk for FN; however, levofloxacin is the preferred agent for patients with an increased risk of Streptococcus-mediated oral mucositis.4,5 The IDSA guidelines do not recommend treatment with prophylaxis in low-risk patients, nor do they recommend the addition of an antibiotic against gram-positive infections with prophylaxis.4,5Patients who are considered high risk for invasive fungal infection, such as candidiasis from allogeneic hematopoietic stem cell transplant or from intensive remission induction or salvage-induction chemotherapy for acute leukemia, are strongly recommended to be initiated on antifungal prophylaxis with fluconazole, itraconazole, voriconazole, posaconazole, micafungin, or caspofungin. Patients who are considered high risk for aspergillus are aged 13 years or older, and/or are undergoing intensive chemotherapy for acute myeloid leukemia or myelodysplastic syndrome are strongly recommended to initiate posaconazole for prophylaxis. Low-risk patients are not required to have antifungal prophylaxis.4Prophylaxis with Granulocyte Colony-Stimulating FactorGranulocyte colony-stimulating factor (G-CSF)—filgrastim, filgrastim-sndz, tbo-filgrastim, or pegfilgrastim—is indicated for the prevention of chemotherapy-induced neutropenia in patients with nonmyeloid malignancies.5 As a prophylactic treatment, G-CSF is used to reduce infection in patients with nonmyeloid malignancies who are undergoing myelosuppressive chemotherapy associated with severe FN. Treatment with a G-CSF reduces the time to neutrophil recovery and decreases the duration of FN.6The NCCN recommends that patients with solid and nonmyeloid malignancies are evaluated for risk factors of chemotherapy-induced FN prior to the first cycle of chemotherapy.7 The intensity of the chemotherapy regimen administered is associated with the severity of neutropenia. Patients are assessed for factors including disease type, chemotherapy regimen, treatment intent, and patient risk factors that may lead to the development of FN (Table 37).1,7Patients who are at low risk of developing FN (&lt;10%) and patients who do not present with risk factors should not initiate prophylaxis with G-CSF. Patients with intermediate risk for FN (10%-20%) need to be evaluated for additional patient risk factors, which are summarized in Table 3.7 After assessment, patients who present with at least 1 of these risk factors for FN is recommended for treatment with a G-CSF. Prophylaxis with G-CSF is initiated in patients who are at high risk for FN (&gt;20%) to reduce the risks of FN, hospitalization, and intravenous antibiotic use during the course of treatment.7ConclusionAs cytotoxic chemotherapy-induced FN may lead to serious complications of infection and mortality, initiating antimicrobial therapy is recommended for this patient population. Before initiating antibiotic therapy, it is crucial to perform a risk assessment to determine whether the therapy should be oral or intravenous, inpatient or outpatient, and patient needs for the duration of therapy. Risk assessment also plays a key role in determining whether G-CSF should be initiated for primary prophylaxis. Guidelines suggest that G-CSF may be needed to boost the immune system of high-risk patients, but G-CSF should initially be avoided in low-risk patients. In cases of intermediate risk, additional patient risk factors need to be weighed.
Pulmonary trunk. the short, wide vessel that conveys venous blood from the RV to the lungs. It is 5cm long & 3cm wide, & it ascends obliquely, dividing into R & L PA
The anterior M contains thymus, LN, ascending aorta, pulmonary artery, phrenic nerves and thyroid.The most common lesions in this will either be of thymic or LN origin. Even the germ cell T arise from the pluripotent cells of the thymus.Before you want to biopsy an anterior M mass, do not forget that some of these lesions can be vascular in origin.
The four T&apos;s for anterior M masses:: Thymus, Teratoma (germ cell), Thyroid, Terrible Lymphoma
Lobar consolidation:
Alveoli filled with inflam. exudate
Interstitium & architecture remain intact
The airway is patent
K pneumoniae is G-ve that usually affects people with alcoholism or chr debilitating d (similar to other gram -ve pn). Consolidation is lobar & resembles S. pneumonia. Bulging of minor fissure here is less common nowadays with modern ABT. Also, this is not specific. A helpful feature which may help to DD from pneumococcal pn is that K pneumoniae develops cavitation in 30-50%. This occurs early & progresses quickly. Massive necrosis is a recognised complication. Cavitation is rare in pneumococcal pn.
MRSA pn most commonly occurs post influenza in young & previously healthy pts. It is a/with a high mortality & should be suspected in prodrome of flu like symptoms, haemoptysis, HGF, multilobar infiltrates with cavitation or a h/of IVDU. MRSA pn is frequently bilateral.
MRSA pn were previously predominantly nosocomial inf. Since 1990s MRSA has emerged as a community acquired pathogen. It most commonly causes skin and soft tissue inf.
Meigs syn is the triad of benign ovarian T, ascites & pleural effusion that resolves after resection of T. Ovarian fibromas constitute the majority in MS. MS, however, is a Dx of exclusion, only after ovarian Ca is ruled out.
Pseudo-MS consists of p effusion, ascites, & benign T of the ovary other than fibromas. These include those of the fallopian tube or uterus & mature teratomas, struma ovarii, and ovarian leiomyomas. This terminology sometimes also includes ovarian or metastatic GI malignancies
Alterations in Proportion of L & R Lung can be a clue to recognition of a.
Hemithorax asymmetry: normally, R & L hemithorax are equal in size. The hemithorax will be smaller on the side of a.
In many cases atelectasis is the first sign of a lung cancer.Evidently it is very important to recognize the various presentations of atelectasis, since some of them can be easily misinterpretated.
The key-findings on the X-ray are:
Sharply-defined opacity obscuring vessels without air-bronchogram
Volume loss resulting in displacement of diafragm, fissures, hili or mediastinum
A common finding in a. of the RUL is &apos;tenting&apos; of D (blue arrow, lower pic). He had a centrally located lung Ca with mets. in both lungs (red arrows)
Pulmonary fibrosis leads to serious breathing problems. Scar formation leads to thickening of the walls, and causes reduced oxygen supply. As a consequence patients suffer from perpetual SoB. In some patients the specific cause can be diagnosed, but in others cannot (idiopathic pulmonary fibrosis). No known cure
Pleural fibrosis & calcification are thickening & stiffening occurring due to inflam or exposure to asbestos. People may not have symptoms, or, if a large area of the pleura is affected, they may have SoB (fibrosis prevents lungs from expanding). Dx is CXR & sometimes CT. Sometimes surgery is needed to remove the pleura. Usually, the pleura is very thin & flexible, but sometimes it becomes thick. Asbestos sometimes affects only a small area of the pleura. The fibrotic pleura can be calcified
Pleural thickening can cause SoB & adversely affect the lungs&apos; ability to function. It is not malignant & is not necessarily a s/of asbestos lung d.
ADA is a protein produced by cells throughout the body & is a/with the activation of lymphocytes. M tb may increase ADA at sites. ADA in pleural fluid helps Dx of TB of the pleurae Small pleural fluid is continuously produced to lubricate. A variety of d, including inf, can cause pleuritis & can lead to pleural effusion. Detecting mycobacteria in pleural fluid can be difficult as there may be very few bacteria. Though the ADA not specific & does not replace the culture , it may be positive even when bacteria are very low & can be used as an adjunct test to help determine whether TB is likely.
Deep sulcus sign on a supine CXR raises suspicion of a PTX. On a supine CXR (common in ICU or as part of a trauma radiograph series), it may be the only suggestion of a pneumothorax because air collects anteriorly & basally, within the pleural space, as opposed to the apex when upright. The CP angle is abnormally deepened when the pleural air collects laterally
Abscess Characteristics
Cavitating infective consolidation. Single or multiple. Bacterial (Staph, Klebsiella, Proteus, Pseudomonas, TB & anaerobes) or fungi are the most common.
‘Primary’ lung abscess – large solitary abscess w/out underlying lung disease is usually due to anaerobic bacteria. A/with aspiration and/or impaired local or systemic immune response (elderly, epileptics, diabetics, alcoholics & the immunosuppressed)
Clinical features: often a predisposing risk factor, e.g. antecedent h/of aspiration or symptoms developing in an immunocompromised. Cough with purulent sputum. Swinging F. Consider in chest infections that fail to respond to AB. It can run an indolent course with persistent & sometimes mild symptoms. These are a/with weight loss & anorexia mimicking pulmonary neoplasm or TB.
XR: Most commonly occur in the apicoposterior aspect of the UL or the apical segment of the LL. CXR may be normal in the first 72 h. CXR – a cavitating essentially spherical area of consolidation usually &gt;2 cm in diameter, but can measure up to 12cm. There is usually an air-fluid level present. Characteristically the dimensions of the abscess are equal when measured in the frontal & lateral projections. CT is important in characterising the lesion & discriminating from other differential lesions. The abscess wall is thick & irregular & may contain locules of free gas. Abscesses abutting the pleura form acute angles. There is no compression of the surrounding lung. The abscess does not cross fissures. It is imp to make sure no directcommunication with the bronchial tree is present (bronchopleural fistula).