Curriculum Vitae-Lei Li-2015-7

CURRICULUM VITAE
Lei Li, PhD
CURRENT ADDRESS
Division of Molecular Embryonic Development,
State Key Laboratory of Stem Cell and Reproductive Biology,
Institute of Zoology/ Chinese Academy of Sciences,
1 Beichen West Road, Chaoyang District,
Beijing 100101, P.R.China
Tel:86-10-64807865
Email：lil@ioz.ac.cn
EDUCATION and DEGREES
Ph.D., Cell Physiology
Department of Cell Physiology, Institute for Molecular and Cellular
Regulation, Gunma University, Maebashi, Japan (1999-2002)
Advisor, Dr. Itaru Kojima.
BA., Animal Physiology and Biochemistry,
Department of Animal Physiology and Biochemistry, College of Biological
Sciences, China (Beijing) Agricultural University, Beijing, China (1990-1994)
PROFESSIONAL EXPERIENCE
State Key Laboratory of Stem Cell and Reproductive Biology, IOZ/ Chinese Academy of
Sciences, China, Professor (2009-present)
Laboratory of Cellular and Developmental Biology, NIDDK /National Institute of Health,
USA
Visiting/Research Fellow (2004-2009), Supervisor: Dr. Jurrien Dean
Laboratory of Clinical Investigation, NIA/National Institutes of Health, USA
Visiting Fellow (2003-2004), Supervisor: Dr. Josephine Egan
地址：北京市朝阳区北辰西路一号院 5 号邮编： 100101 网址：www.ioz.ac.cn 电子邮箱：ioz@ioz.ac.cn ADD:1 Beichen West
Road, Chaoyang District, Beijing 100101, P.R.Chian Http://www.ioz.ac.cn Email:ioz.@ioz.ac.cn 1

Department of Cell Physiology, IMCR/Gunma University, Japan
Postdoctoral Research Fellow (2002-2003), Supervisor: Dr. Itaru Kojima
Institute for Molecular and Cellular Regulation(IMCR), Gunma University, Japan,
Ph.D. Candidate (1999-2002), Mentor: Dr. Itaru Kojima
Department of Cell Physiology, IMCR/Gunma University, Japan,
Visiting Scholar (1998-1999), Supervisor: Dr. Itaru Kojima
Animal Physiology & Biochemistry, College of Biology, China Agricultural University, China
Research Associate (1994-1997), Supervisor: DR. Shunzhang Qi
SUPPORTING GRANTS
1) National Basic Research Program of China (2012CB944401, 2012-2016)
2) National Basic Research Program of China (2011CB944501, 2011-2015)
3) National Natural Science Foundation of China (31171382, 2012-2015)
4) National Natural Science Foundation of China (30971655, 2009-2012)
5) Hundred Talents Program of Chinese Academy of Sciences (2009-2013)
SELECTED PUBLICATIONS (* Corresponding author)
1) Zhao Z-A, Yu Y, Ma H-X, Wang X, Lu X, Zhai Y , Zhang X-X, Wang H, Li L*. The role
of ERAS during germ layer specification of mouse development. Open Biology.
2015 Aug; 5(8). pii: 150092. doi: 10.1098/rsob.150092
2) Zhao B, Zhang W, Duan Y, Lu Y, Cun Y, Li C, Guo K, Nie W, Li L, Zhang R, Zheng P.
Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards
Genomic Stability. Cell Stem Cell. 2015 Apr 29. pii: S1934-5909(15)00128-9. doi:
10.1016/j.stem. 2015.03.017.
3) Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J*, Li L*. Identification of a
human subcortical maternal complex. Molecular Human Reproduction. 2015 Apr;
21(4): 320-9. doi: 10.1093/molehr/gau116.
4) Yu X, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang Z, Zheng P, Zhu M,
Wang H, Sun QY, Dean J*, Li L*. The subcortical maternal complex controls

symmetric division of mouse zygotes by regulating F-actin dynamics. Nature
Communications. 2014 Sep 11; 5:4887.
5) Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang
S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li
B, Chen Q*, Duan E*, Wang H*. Uterine Rbpj is required for embryonic-uterine
orientation and decidual remodeling via Notch pathway-independent and
-dependent mechanisms. Cell Research. 2014 Aug; 24(8): 925-42.
6) Fu Z, Wang B, Wang S, Wu W, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z,
He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F*, Gao S*,
Wang H*. Integral proteomic analysis of blastocysts reveals key molecular
machinery governing embryonic diapause and reactivation for implantation in mice.
Biology of Reproduction. 2014 Mar; 90(3): 52, 1-11.
7) Li L*, Lu X and Dean J*. The maternal to zygotic transition in mammals. Molecular
Aspects of Medicine. 2013 Oct; 34(5): 919-38.
8) Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z, Hou N,
Cheng X, Sun Q, Li L, Yang X, Fan Z*. WASH inhibits autophagy through
suppression of Beclin 1 ubiquitination. The EMBO Journal. 2013 Oct; 32(20): 2685-
96.
9) Wang J, Xu M, Zhu K, Li L*, Liu X*. The N-terminus of FILIA forms an atypical KH
domain with a unique extension involved in interaction with RNA. PLoS ONE. 2012;
7(1): e30209.
10) Chen D, Zhang Y, Yi Q, Huang Y, Hou H, Zhang Y, Hao Q, Cooke HJ, Li L, Sun QY,
Shi Q*. Regulation of asymmetrical cytokinesis by cAMP during meiosis I in mouse
oocytes. PLoS ONE. 2012; 7(1): e29735.
11) Li L*, Zheng P and Dean J*. Maternal control of early mouse development.
Development. 2010 Mar; 137(6): 859-70.
12) Li L*, Baibakov B and Dean J. A subcortical maternal complex essential for pre-

implantation mouse embryogenesis. Developmental Cell. 2008 Sep; 15(3): 416-25.
13) Ohsugi M, Zheng P, Baibakov B, Li L, Dean J*. Maternally derived FILIA-MATER
complex localizes asymmetrically in cleavage-stage mouse embryos.
Development. 2008 Jan; 135(2): 259-69.
14)Ogata T, Li L, Yamada S, Yamamoto Y, Tanaka Y, Takei I, Umezawa K and Kojima I*.
Promotion of β-Cell Differentiation by Conophylline in Fetal and Neonatal Rat
Pancreas, Diabetes. 2004 Oct; 53(10): 2596-2602.
15)Li L, Yi Z, Seno M, and Kojima I*. Activin A and Betacellulin: Effect on Regeneration
of Pancreatic β-Cells in Neonatal Streptozotocin-treated Rats, Diabetes. 2004 Mar;
53(3): 608-615.
16) Li L, Seno M, Yamada H, and Kojima I*. Betacellulin Improved Glucose Metabolism
by Promoting Conversion of Intra-islet Precursor Cells to-cells in Streptozotocin-
treated Diabetic Mice, Am J Physiol Endocrinol Metab. 2003 Sep; 285(3): E577-
83.
17) Li L, Seno M, Yamada H, and Kojima I* (2001). Promotion of β-cell Regeneration by
Betacellulin in 90% Pancreatectomized Rats. Endocrinology. 2001 Dec; 142(12):
5379-85.

AWARDS and FELLOWSHIPS
1) CAS“100 Talents”Program Recipient (Institute of Zoology/Chinese Academy of
Sciences, China), 2009
2) NIH Fellows Award for Research Excellence (NIH), 2007, 2008
3) NIDDK Nancy Nossal Fellowship Award (formerly NIDDK Scientific Director’s
Fellowship Awards, NIDDK/NIH) - Comparable to National Research Service Award,
2005
4) NIDDK Visiting Fellowship (NIDDK/NIH, USA), 7/2004-2008
5) NIA Visiting Fellowship (NIA/NIH, USA), 10/2003-6/2004
6) Postdoctoral Fellowship for Foreign Researchers (Japan Society for the Promotion of
Science, JSPS), 4/2002-9/2003
7) Yoneyama Doctor Course Scholarship (Rotary Yoneyama Memorial Foundation,
Japan), 4/2001-3/2002
INVITED ORAL PRESENTATIONS:
1) the EMBO Workshop on “Cell Biology of Early Mouse Development”Sept. 9-12, 2012
in Cambridge, UK : " The Subcortical Maternal Complex (SCMC) Requiring TLE6
and Critical for the Integrity of subcortex F-actin in Mouse Zygotes".
2) 2nd SKLRB Symposia on “Frontiers in Reproductive Biology”, May 6-11, 2012 in
Beijing, China: "The Function and Molecular Basis of Subcortical Maternal Complex
(SCMC)".
3) 1st SKLRB Symposia on “Frontiers in Reproductive Biology”, May May 8-12, 2010
in Beijing, China: "Maternal Control of Mouse Early Embryo Development".

4) 41st
Annual Meeting of the Society for the Study of Reproduction, May 27-30, 2008.
Kailua-Kona, Hawaii, USA: “Maternally Encoded FLOPED Complex Required for
Early Cleavage Stage of Mouse Embryogenesis".
5) 63rd
Annual Meeting of American Society for Reproductive Medicine, October 13-17,
2007. Washington, DC, USA: ”Novel Maternal Effect Gene Essential for Progression
beyond the Early Cleavage Stage of Mouse Embryogenesis”.
6) 46th
Annual Meeting of the Japan Diabetes Society. May 21-24, 2003. Toyama,
Japan: “Betacellulin Improves Glucose Metabolism by Promoting Conversion of
Precursor Cells to Beta-cells in Streptozotocin-treated Mice.”
7) 44th
Annual Meeting of the Japan Diabetes Society. April 16-18, 2001. Kyoto, Japan:
“Promotion of Beta-cell Regeneration by Betacellulin in Ninety Percent-
pancreatectomized Rats.”

Curriculum Vitae-Lei Li-2015-7

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