This document summarizes the qualifications and experience of Shumei Ren, a biomedical research investigator specializing in oncological diseases. Ren has over 15 years of experience in molecular biology, pharmacology, and various techniques including flow cytometry, in vitro assays, and high throughput methods. Ren's professional experience includes positions at Thomas Jefferson University, Albany Medical College, and Hokkaido University investigating topics such as gastric cancer, prostate cancer, fibrosis, and hematopoietic malignancies.

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233 S 10th St
BLSB/ Rm424
Philadelphia, PA 19107
Shumei Ren, PhD Cell (518)727-5687
Specialist, Thomas Jefferson University shumeiren3@live.com
SUMMARY
Pioneering research investigator in biomedical science with expertise in oncological diseases, solid
background and hands-on-experience in molecular biology as well as pharmacology in study of gastric
cancer, prostate cancer, fibrotic disease; developed and optimized various in vitro assays, flow-cytometry
in assessing and investigating therapeutics; strong command of high throughput techniques; effective
problem-solving and excellent interpersonal skills; ample experience in project management and
mentoring students and associates.
Look for new opportunities in biotechnology or biopharmaceuticals
EDUCATION
PhD: Histology & Cytology, Hokkaido University, Japan
MS: Microbiology, Muroran Institute of Technology, Japan
Bachelor (MD equivalent): Medicine, North China University of Science and Technology, China
PROFESSIONAL EXPERIENCE
Research Fellow: Dermatology Department, Thomas Jefferson Univ 2013-current
Primary contributor in multiple projects including: 1) Establishment of patient-derived xenograft model
and cell lines from hematopoietic malignancies including AML, ALL, CML, 2) Epithelial Mesenchymal
Transition including lung fibrosis and cardiac fibrosis.
Research Assistant.: Translational Medicine, Thomas Jefferson Univ 2008-13
Key player in projects including: 1) Targets for Heart Failure Therapeutics, S100A1 gene therapy in
cardiac function after myocardial infarction, 2) Establish lentivirus-shRNA CCND1-tet/on stable cells, 3)
Establish CCND1 knock-down animal model
Postdoc: Center for Cell Biology & Cancer Research, Albany Medical College 2017-08
1). Investigating the effects of transcription activator p63 in association with activating transcription
factor 3 (ATF3) on cancer cell cycle arrest and apoptosis. 2). Investigating whether ATF 3 activates p53
by blocking E6-E6AP and p53 complexes in prostate cancer. 3). Screening anti-cancer drugs from over
2000 compounds by detecting p53 and MDM2 expression as well as cell viability using MTT assay.
Postdoc; Division of Molecular Oncology, , Hokkaido University, Japan, 2003-07
1). Study the oncogenic mechanisms of the helicobacter pylori CagA protein in relation to stomach
cancer, 2). Discovered multimerization of CagA plays a critical role in CagA signaling to SHP2 and FAK
and carcinogenesis
SKILLS AND EXPERTISE:
In vivo: over 15 years’ experience in handling mice, rat, breeding, dissection, cardiac puncture, tissue
isolation (Lung, heart, brain,bone marrow, spleen), Lung gavages, Intraperitoneal Injection (IP) in the
Mouse. Mouse lung fibrosis model: mice were exposed o silica using tongue-pull maneuver after
isoflurane-anesthesia.
DNA &RNA: DNA cloning, site directed multagenesis, cloning PCR, reverse transcription, quantitative real

2. time PCR.
Proteins: SDS-PAGE, Western blot, ELISA, immunoprecipitation.
Cell culture: Cell lines (NIH3T3, Hela, HEK293, HUVEC, etc.); Expertise in primary human
hematopoietic stem / progenitor and leukemic cell culture.
Stem cells: Mononuclear and CD34+ cells from normal bone marrow and cord blood.
Pathology: Tissue processing and sectioning; H&E, Masson’s trichrome, immunocytochemistry
including fluorescence and confocol microscopy, electron microscopy.
Computer skills: 1) Flow-cytometry data analysis using Flow-Jo. 2) Familiar with bioinformatics
software software (NCBI BLAST, NTI-Vector), imaging & analysis software (Adobe Photoshop,
Illustrator, GraphPad Prism.6) PC applications, MS office, MS DOS, paint.
PUBLICATIONS:
1. Joel Rosenbloom, Shumei Ren, New frontiers in fibrotic disease therapies: The focus of the Joan and
Joel Rosenbloom Center for Fibrotic Diseases at Thomas Jefferson University. Matrix Biology, 2015
2. Xiaoling J, Shumei Ren, Edward Macarak, and Joel Rosenbloom. Pathbiolgical mechanisms of
peritoneal adhesions: the mesenchymal transition of rat peritoneal methelial cells induced by TGF-β
and IL-6 requires activation of Erk1/2 and Smad2 linker region phosphorylation. Matrix Biology,
2015
3. Anagha Sen, Shumei Ren, Carolin Lerchenmuller, Jianxin Sun, Norbert Weiss, Patrick Most, Karsten
Peppel MicroRNA-138 Regulates Hypoxia-Induced Endothelial Cell Dysfunction By Targeting
S100A1. November 11, 2013. PLOS.
4. David Rohde, Henriette Brinks, Julia Ritterhoff, Gang Qui, Shumei Ren, Patrick Most S100A1 gene
therapy for heart failure: a novel strategy on the verge of clinical trials. J Mol Cell Cardiol. 2011 May;
50(5):777-84. Epub 2010 Aug 20
5. Wang H, Ma X, Ren S, Buolamwini JK, Yan C A small-molecule inhibitor of MDMX activates p53
and induces apoptosis Mol Cancer Ther. 2011 Jan;10(1):69-79. Epub 2010 Nov 12.
6. Peingli Mo, Hongbo Wang, Shumei Ren, Chunhong Yan, ATF3 activates p53 in human cervical
cancer cells by blocking E6-mediated degradation. Journal of Biological Chemistry J Biol Chem.
2010 Apr 23;285(17):13201-10. Epub 2010 Feb 18.
7. Shumei Ren, Hideaki Higashi, Masanori Hadakeyama The role of Helicobacter pylori CagA
multimerization in disturbing mammalian cell signal. Journal of Biological Chemistry. 27;
281(43):32344-52, 2006
8. Hideaki Higashi, Kazuyuki Yokoyama, Yumiko Fujii, Shumei Ren, Masanori Hatakeyama, EPIYA
motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells.
Journal of Biological Chemistry. 280, 23130～23137, 2005
9. Shumei Ren, Hiroko Takano, Kazuhiro Abe, Two types of bone resorption lacunae in the mouse
parietal bones as revealed by scanning electron microscopy and histochemistry. Archives of Histology
and Cytology, 68 (2) 2005
10. Shumei Ren, Observation of two types of bone resorption lacunae: a scanning electron microscopic
and histochemical study. The Hokkaido Medical Society, 78，2003
11. Kazuhiro Abe, Shumei Ren, Hiroko Takano, A morphological measurement of bone absorption,
especial a measurement of depth of bone resorption lacunae. Journal of Japanese Society of Bone
Morphomet, 10, 63-69, 2000
12. Shumei Ren, Tao Wang, Clinical observation of ventricular tachycardia by treatment of Nibentan.
Foreign medical sciences 5, 51～52, 5 1997