The revelations of the Snowden Leaks and other events in modern internet times have resulted in a need for developers and security professionals working on start-up companies to rethink not just security policies and procedures but overall architecture more broadly. Cryptographic systems in communications systems have seen the largest architectural changes. However, changes are also required in data storage architecture and even networking architecture. This talk will discuss means and methodologies for building secure, robust, and resilient start-up computing architectures. Common attacks that impact startups, data compromises, and DDoS attacks will be discussed. The impact of the required adaptations in infrastructure and software design on existing common business models, like AdRev, will be touched on.