This document examines the effects of adenosine on septal coronary artery (SCA) blood flow velocity using Doppler echocardiography. It finds that adenosine increases SCA diastolic and systolic blood flow velocity in a dose-dependent manner. The systolic to diastolic velocity ratio and coronary flow velocity reserve - a measure of blood flow changes from baseline to hyperemia - also increase with higher adenosine doses.

2. SCA: Septal Coronary Artery
Diastolic
Phase
Systolic
Phase
PW Doppler signals of the SCA flow velocity
BL
0.4 mg/kg Adenosine
0.7 mg/kg Adenosine
5min Post-0.7 mg/kg Adenosine
SCA
Modified PLAX b-mode
SCA
Color Doppler Modified PLAX
Color Doppler Echocardiography
LV
LV
RV
RV

3. 0
50
100
150
200
250
300
350
400
450
500
BL
(n=6)
0.4mg/kg Adenosine
(n=6)
0.7mg/kg Adenosine
(n=5)
5-min post 0.7mg/kg
Adenosine
(n=4)
Coronary
Artery
Vmax
at
Systole
(m/s)
Systolic Vmax
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
BL
(n=6)
0.4mg/kg Adenosine
(n=6)
0.7mg/kg Adenosine
(n=6)
5-min post 0.7mg/kg
Adenosine
(n=4)
Systolic/Diastolic
Ratio
Systolic/Diastolic ratio
0
200
400
600
800
1000
1200
1400
1600
BL
(n=6)
0.4mg/kg Adenosine
(n=6)
0.7mg/kg Adenosine
(n=6)
5-min post 0.7mg/kg
Adenosine
(n=4)
Coronary
Artery
Vmax
at
Diastole
(m/s)
Diastolic Vmax
CFVR: Coronary Flow Velocity Reserve
Each value represents mean±SD CFVR = Hyperemic Vmax/ BL Vmax
0.0
0.5
1.0
1.5
2.0
2.5
0.4mg/kg Adenosine
(n=6)
0.7mg/kg Adenosine
(n=6)
5-min post 0.7mg/kg Adenosine
(n=4)
CFVR
Coronary Flow Velocity Reserve