2. CorDynamics introduces telemetry that records respiratory
parameters along with blood pressure and ECG in large animals
Multiple options
1) blood pressure, ECG, and respiratory parameters
- simultaneous and continuous recording
- combines two ICH S7 assessments in one study
2) can be used in multiple species
- rabbit, dog, pig, NHP
Pharmacological validation
- bethanechol (cholinergic agonist)
3. Effects of bethanechol on heart rate
Effect of Bethanechol (subcutaneous) on Heart Rate
in the Conscious, Telemetrized Rabbit
350
300
250
200
HR (bpm)
150
100
Vehicle (n=4)
50
10 mg/kg (n=4)
0
-70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490
Time (minutes)
4. Effects of bethanechol on tidal volume
Effect of Bethanechol (subcutaneous) on Tidal Volume
in the Conscious, Telemetrized Rabbit
30
25
20
TV (ml)
15
10
5 Vehicle (n=4)
10 mg/kg (n=4)
0
-70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490
Time (minutes)
5. Effects of bethanechol on minute volume
Effect of Bethanechol (subcutaneous) on Minute Volume
in the Conscious, Telemetrized Rabbit
3500
Vehicle (n=4)
3000
10 mg/kg (n=4)
2500
MV (ml)
2000
1500
1000
500
0
-70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490
Time (minutes)
6. Effects of bethanechol on respiratory rate
Effect of Bethanechol (subcutaneous) on Respiratory Rate
in the Conscious, Telemetrized Rabbit
300
Vehicle (n=4)
250
10 mg/kg (n=4)
200
Rf (breaths/min)
150
100
50
0
-70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490
Time (minutes)
