Treatment of Brain Metastases Using the Current Predictive Models: Is the Pro...CrimsonpublishersCancer
Brain metastases from solid tumours are the most common intracranial tumours [1] and it occur in 40% of patients with cancer [2]. The most common primary tumours that metastasize to the brain are lung(40%),breast (25%) and melanoma (20%) [3]. The incidence is expected to be on the increase, due to improved survival, with use of modern cytotoxic drugs, targeted therapy, immunotherapy and modern radiotherapy techniques, in addition to greater use of magnetic resonance imaging of the brain. Brain metastases are common in the elderly, defined as above 60 years [4], and the interval between diagnosis of the primary and the development of brain metastases is variable, however some reported an average of 19 months [5] and adenocarcinoma is the commonest histology that metastasizes to the brain [6].
Can brain atrophy measurement help us in monitoring MS progression in routine...MS Trust
This presentation by Dana Horáková, Department of Neurology and Centre of Clinical Neuroscience at the Charles University in Prague, looks at why and how we should measure brain atrophy.
It was presented at the MS Trust Annual Conference in November 2014.
Stereotactic Radiotherapy for the Treatment of Acoustic Neuromas Clinical Whi...Brainlab
Learn more: https://www.brainlab.com/radiosurgery-products/
Acoustic neuromas (AN) have an annual incidence of approximately one per 100,000 people and may account for up to 8% of all new tumors presenting to a neurosurgical referral practice. Acoustic neuromas are benign tumors arising from Schwann cells from the vestibular branch of the eighth cranial nerve. Nevertheless, they can pursue a potentially aggressive course, with uncontrolled local growth resulting in compression of the brainstem and fourth ventricle, cranial nerve and other neurological deficits.
Treatment of Brain Metastases Using the Current Predictive Models: Is the Pro...CrimsonpublishersCancer
Brain metastases from solid tumours are the most common intracranial tumours [1] and it occur in 40% of patients with cancer [2]. The most common primary tumours that metastasize to the brain are lung(40%),breast (25%) and melanoma (20%) [3]. The incidence is expected to be on the increase, due to improved survival, with use of modern cytotoxic drugs, targeted therapy, immunotherapy and modern radiotherapy techniques, in addition to greater use of magnetic resonance imaging of the brain. Brain metastases are common in the elderly, defined as above 60 years [4], and the interval between diagnosis of the primary and the development of brain metastases is variable, however some reported an average of 19 months [5] and adenocarcinoma is the commonest histology that metastasizes to the brain [6].
Can brain atrophy measurement help us in monitoring MS progression in routine...MS Trust
This presentation by Dana Horáková, Department of Neurology and Centre of Clinical Neuroscience at the Charles University in Prague, looks at why and how we should measure brain atrophy.
It was presented at the MS Trust Annual Conference in November 2014.
Stereotactic Radiotherapy for the Treatment of Acoustic Neuromas Clinical Whi...Brainlab
Learn more: https://www.brainlab.com/radiosurgery-products/
Acoustic neuromas (AN) have an annual incidence of approximately one per 100,000 people and may account for up to 8% of all new tumors presenting to a neurosurgical referral practice. Acoustic neuromas are benign tumors arising from Schwann cells from the vestibular branch of the eighth cranial nerve. Nevertheless, they can pursue a potentially aggressive course, with uncontrolled local growth resulting in compression of the brainstem and fourth ventricle, cranial nerve and other neurological deficits.
Annovis Bio is a clinical-stage, drug platform company addressing neurodegeneration, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Alzheimer’s in Down Syndrome (AD-DS). Annovis is believed to be the only company developing a drug for AD, PD and AD-DS that inhibits
more than one neurotoxic protein and improves the information highway of the nerve cell, known as axonal transport. When this information flow is impaired, the nerve cell gets sick and dies. The company expects its treatment to improve memory loss and dementia associated with AD and AD-DS, as well as body and brain function in PD. Annovis has an ongoing
Phase 2a study in AD patients and a second Phase 2a study in early PD and early AD patients.
Annovis Bio is a clinical-stage, drug platform company addressing neurodegeneration, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Alzheimer’s in Down Syndrome (AD-DS). Annovis is believed to be the only company developing a drug for AD, PD and AD-DS that inhibits
more than one neurotoxic protein and improves the information highway of the nerve cell, known as axonal transport. When this information flow is impaired, the nerve cell gets sick and dies. The company expects its treatment to improve memory loss and dementia associated with AD and AD-DS, as well as body and brain function in PD. Annovis has an ongoing
Phase 2a study in AD patients and a second Phase 2a study in early PD and early AD patients.
The 2016 World Health Organization classification of tumors of the central nervous system broadly employs genetic alterations for diagnostic criteria including isocitrate dehydrogenase-1 (IDH1) mutation or IDH2 mutation, and 1p/19q codeletion,[1] with the goal of creating more homogeneous disease categories with greater prognostic value.[2-5] Molecular diagnostics is becoming an increasingly important aspect of clinical oncologic neuropathology practice.
Annovis Bio (NYSE American: ANVS) is a clinical-stage, drug platform company addressing neurodegeneration, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Alzheimer’s in Down Syndrome (AD-DS). Annovis is believed to be the only company developing a drug for AD, PD and AD-DS that inhibits more than one neurotoxic protein and improves the information highway of the nerve cell, known as axonal transport. When this information flow is impaired, the nerve cell gets sick and dies. The company expects its treatment to improve memory loss and dementia associated with AD and AD-DS, as well as body and brain function in PD. Annovis has an ongoing Phase 2a study in AD patients and plans to commence a second Phase 2a study in PD patients. Learn more at ANVSinfo.com.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Annovis Bio is a clinical-stage, drug platform company addressing neurodegeneration, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Alzheimer’s in Down Syndrome (AD-DS). Annovis is believed to be the only company developing a drug for AD, PD and AD-DS that inhibits
more than one neurotoxic protein and improves the information highway of the nerve cell, known as axonal transport. When this information flow is impaired, the nerve cell gets sick and dies. The company expects its treatment to improve memory loss and dementia associated with AD and AD-DS, as well as body and brain function in PD. Annovis has an ongoing
Phase 2a study in AD patients and a second Phase 2a study in early PD and early AD patients.
Annovis Bio is a clinical-stage, drug platform company addressing neurodegeneration, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Alzheimer’s in Down Syndrome (AD-DS). Annovis is believed to be the only company developing a drug for AD, PD and AD-DS that inhibits
more than one neurotoxic protein and improves the information highway of the nerve cell, known as axonal transport. When this information flow is impaired, the nerve cell gets sick and dies. The company expects its treatment to improve memory loss and dementia associated with AD and AD-DS, as well as body and brain function in PD. Annovis has an ongoing
Phase 2a study in AD patients and a second Phase 2a study in early PD and early AD patients.
The 2016 World Health Organization classification of tumors of the central nervous system broadly employs genetic alterations for diagnostic criteria including isocitrate dehydrogenase-1 (IDH1) mutation or IDH2 mutation, and 1p/19q codeletion,[1] with the goal of creating more homogeneous disease categories with greater prognostic value.[2-5] Molecular diagnostics is becoming an increasingly important aspect of clinical oncologic neuropathology practice.
Annovis Bio (NYSE American: ANVS) is a clinical-stage, drug platform company addressing neurodegeneration, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Alzheimer’s in Down Syndrome (AD-DS). Annovis is believed to be the only company developing a drug for AD, PD and AD-DS that inhibits more than one neurotoxic protein and improves the information highway of the nerve cell, known as axonal transport. When this information flow is impaired, the nerve cell gets sick and dies. The company expects its treatment to improve memory loss and dementia associated with AD and AD-DS, as well as body and brain function in PD. Annovis has an ongoing Phase 2a study in AD patients and plans to commence a second Phase 2a study in PD patients. Learn more at ANVSinfo.com.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...
COMEXANE BRAIN RELAXATION.pptx
1. Estrategias de Relajación
Cerebral en pacientes
neurocríticos
Cristhian Camilo Bastidas
Neuroanestesiología
Instituto Nacional de Neurología
y Neurocirugía
Universidad Nacional Autónoma
de México
3. TABLA DE CONTENIDO
Neuromonitoreo aplicado
INTERVENCIÓN
04
Farmacológica y no
Farmacológica
FACTORES DE
RIESGO
DEFINICIÓN Y
CONCEPTOS
ACTUALES
01
02
Bases fisiológicas
Diagnóstico y Clasificación.
¿SE PUEDE
MEDIR LA BR ?
03
CONCLUSION
ES
05
4. Relación equilibrada que existe entre
el volumen cerebral y la capacidad
craneal una vez que se ha realizado
la craniectomía.
Implicaciones anestésicas,
quirúrgicas, fisiológicas y pronosticas
RELAJACIÓN
CEREBRAL
J. Li1, A. W. Gelb2, A. M. Flexman3, Et al, Definition, evaluation, and management of brain relaxation during craniotomy , British Journal of Anaesthesia, 116 (6): 759–69 (2016)
5. RELAJACIÓN CEREBRAL
• Volumen del contenido
intracraneal es igual o
menor a la capacidad
del espacio
intracraneal.
J. Li1, A. W. Gelb2, A. M. Flexman3, Et al, Definition, evaluation, and management of brain relaxation during craniotomy , British Journal of Anaesthesia, 116 (6): 759–69 (2016)
6. RELAJACIÓN CEREBRAL vs ICP
J. Li1, A. W. Gelb2, A. M. Flexman3, Et al, Definition, evaluation, and management of brain relaxation during craniotomy , British Journal of Anaesthesia, 116 (6): 759–69 (2016)
7. RELAJACIÓN CEREBRAL vs ICP
J. Li1, A. W. Gelb2, A. M. Flexman3, Et al, Definition, evaluation, and management of brain relaxation during craniotomy , British Journal of Anaesthesia, 116 (6): 759–69 (2016)
8. RELAJACIÓN CEREBRAL
J. Li1, A. W. Gelb2, A. M. Flexman3, Et al, Definition, evaluation, and management of brain relaxation during craniotomy , British Journal of Anaesthesia, 116 (6): 759–69 (20
9. RELAJACIÓN CEREBRAL
Niels A. Lassen, Cerebral Blood Flow and Oxygen Consumption in Man, Physiological Reviews, The American Physiological Society, April 1959
10. Pérez de Arriba N, Antuña Ramos A, Martin Fernandez V, et al. (May 31, 2022) Risk Factors Associated With Inadequate Brain Relaxation in Craniotomy for Surgery of Supratentorial Tumors.
Cureus 14(5): e25544. DOI 10.7759/cureus.25544
11. Factores de riesgo
Pérez de Arriba N, Antuña Ramos A, Martin Fernandez V, et al. (May 31, 2022) Risk Factors Associated With Inadequate Brain Relaxation in Craniotomy for Surgery of Supratentorial Tumors.
Cureus 14(5): e25544. DOI 10.7759/cureus.25544
• Estudio prospectivo
observacional single center.
• Sept 2017 – Dic 2020
• 325 pacientes contemplados
• 273 excluidos
• 52 pacientes
Dexametasona 12 mg antes de incisión en
piel,
Propofol TCI Schnider Ce 2 ug/ml BIS 40 -
60
Remifentanil Minto Ce 2 - 3 ng/ml
Rocuronio 0.6 a 1.2 mg/kg TOF 1
Línea arterial con Zero en foramen de
Monro
Sonda vesical, Termómetro esofágico
Manitol al 20% y líquidos con Plasmalite
12. Factores de riesgo
Pérez de Arriba N, Antuña Ramos A, Martin Fernandez V, et al. (May 31, 2022) Risk Factors Associated With Inadequate Brain Relaxation in Craniotomy for Surgery of Supratentorial Tumors.
Cureus 14(5): e25544. DOI 10.7759/cureus.25544
13. Pérez de Arriba N, Antuña Ramos A, Martin Fernandez V, et al. (May 31, 2022) Risk Factors Associated With Inadequate Brain Relaxation in Craniotomy for Surgery of Supratentorial Tumors.
Cureus 14(5): e25544. DOI 10.7759/cureus.25544
Factores de riesgo
14. Pérez de Arriba N, Antuña Ramos A, Martin Fernandez V, et al. (May 31, 2022) Risk Factors Associated With Inadequate Brain Relaxation in Craniotomy for Surgery of Supratentorial Tumors.
Cureus 14(5): e25544. DOI 10.7759/cureus.25544
M 0.25 y 0.5 g/ kg
no concluyente
Factores de riesgo
15. MADS RASMUSSEN, M.D., PH.D., Et al. Craniotomy for supratentorial brain tumors: risk factors for brain swelling after opening the dura mater J Neurosurg 101:621–626, 2004
Factores de riesgo
16. MADS RASMUSSEN, M.D., PH.D., Et al. Craniotomy for supratentorial brain tumors: risk factors for brain swelling after opening the dura mater J Neurosurg 101:621–626, 2004
• Estudio prospectivo observacional single
center.
• Marzo 1994 - Enero 2003
• 975 pacientes contemplados
• 692 pacientes.
• Dx Histopatológico, Radiología, Anestesia,
Medición de la ICP por catéter subdural.
Esquemas Anestésicos:
Isofluorane/ Fentanil 1.5 MAC
(tiopental, atracurio, Fentanil 2-3
ug/Kg/hr. Lidocaina)
Sevofluorane/ Fentanil 1.5 MAC
(Propofol, lidocaína, atracurio,
Fentanil 2-3 ug/Kg/hr)
Propofol/ Fentanil 6 -10 mg/kg/hr
propofol, Fentanil 2-3 ug/Kg/hr
Propofol/ Remifentanil Propofol
4-8 mg/kg/hr, Remi 0.2 – 0.5
ug/kg/min
Factores de riesgo
17. MADS RASMUSSEN, M.D., PH.D., Et al. Craniotomy for supratentorial brain tumors: risk factors for brain swelling after opening the dura mater J Neurosurg 101:621–626, 2004
18. MADS RASMUSSEN, M.D., PH.D., Et al. Craniotomy for supratentorial brain tumors: risk factors for brain swelling after opening the dura mater J Neurosurg 101:621–626, 2004
19.
20. INTERVENCIONES
•NO FARMACOLÓGICA
1. Posicionamiento de la cabeza
2. Ventilación
a)Hiperoxemia?
b)Hipocapnia?
3. Drenaje de LCR.
FARMACOLÓGICA
Terapia Hiperosmolar
Manitol
SH
Anestésicos
Volátiles
Propofol
Diuréticos
Esteroides
22. Sarhan KA, Emad R, Mahmoud D, Hasanin A, Hosny O, Al-Sonbaty M, Abo El-Ela A, Othman S. The effect of hyperventilation versus normoventilation on cerebral
oxygenation using near infrared spectroscopy in children undergoing posterior fossa tumor resection: A randomized controlled cross-over trial. Anaesth Crit Care
Pain Med. 2023 Jun;42(3):101190. doi: 10.1016/j.accpm.2022.101190. Epub 2022 Dec 21. PMID: 36565745.
23. Sarhan KA, Emad R, Mahmoud D, Hasanin A, Hosny O, Al-Sonbaty M, Abo El-Ela A, Othman S. The effect of hyperventilation versus normoventilation on cerebral
oxygenation using near infrared spectroscopy in children undergoing posterior fossa tumor resection: A randomized controlled cross-over trial. Anaesth Crit Care
Pain Med. 2023 Jun;42(3):101190. doi: 10.1016/j.accpm.2022.101190. Epub 2022 Dec 21. PMID: 36565745.
24. Sarhan KA, Emad R, Mahmoud D, Hasanin A, Hosny O, Al-Sonbaty M, Abo El-Ela A, Othman S. The effect of hyperventilation versus normoventilation on cerebral
oxygenation using near infrared spectroscopy in children undergoing posterior fossa tumor resection: A randomized controlled cross-over trial. Anaesth Crit Care
El análisis de regresión lineal
reveló que cada disminución
de 1 mmHg en ETCO2
disminuiría los valores NIRS
izquierdos en un 1,4 % [0,66–
2,2] y los valores NIRS
derechos en un 1,38 % [0,45–
2,3].
No se encontró correlación
entre la PaCO2 al final de la
fase 1 y la puntuación de
relajación cerebral (r = 0,06,
p = 0,66).
25. Lane BC, Scranton R, Cohen-Gadol AA. Risk of Brain Herniation After Craniotomy With Preoperative Lumbar Spinal Drainage: A Single-Surgeon Experience of 365
Patients Among 3000 Major Cranial Cases. Oper Neurosurg (Hagerstown). 2021 Jan 13;20(2):E77-E82. doi: 10.1093/ons/opaa262. PMID: 32823289.
26. Lane BC, Scranton R, Cohen-Gadol AA. Risk of Brain Herniation After Craniotomy With Preoperative Lumbar Spinal Drainage: A Single-Surgeon Experience of 365
Patients Among 3000 Major Cranial Cases. Oper Neurosurg (Hagerstown). 2021 Jan 13;20(2):E77-E82. doi: 10.1093/ons/opaa262. PMID: 32823289.
27. Drenaje entre 40 a 60 ml al momento
de apertura de la duramadre.
Seguimiento a 30 días.
No se demostró fistula del LCR
mRankin favorable
Descompresión temprana
Rápido acceso a la base del cráneo
Herniación?
Lane BC, Scranton R, Cohen-Gadol AA. Risk of Brain Herniation After Craniotomy With Preoperative Lumbar Spinal Drainage: A Single-Surgeon Experience of 365
Patients Among 3000 Major Cranial Cases. Oper Neurosurg (Hagerstown). 2021 Jan 13;20(2):E77-E82. doi: 10.1093/ons/opaa262. PMID: 32823289.
28. •Hernández-Palazón J, et al. Comparison of 20% mannitol and 3% hypertonic saline for intra- operative brain relaxation during
supratentorial brain tumour craniotomy in patients with a midline shift. Neurocirugia. 2023.
https://doi.org/10.1016/j.neucie.2022.10.003
29. •Hernández-Palazón J, et al. Comparison of 20% mannitol and 3% hypertonic saline for intra- operative brain relaxation during supratentorial brain tumour craniotomy in patients with a midline
shift. Neurocirugia. 2023. https://doi.org/10.1016/j.neucie.2022.10.003
30. No hubo diferencias
estadísticas
No hubo diferencias
estadísticas
Manitol 1 g/kg vs SH 3%
Prospectivo, aleatorizado doble ciego
60 Pcts entre Enero y Octubre 2020
Hemodinamia
BRS
No hubo diferencias
estadísticas
*** uresis.
Complicaciones y
estancia hospitalaria
Hernández-Palazón J, et al. Comparison of 20% mannitol and 3% hypertonic saline for intra- operative brain relaxation during supratentorial brain tumour craniotomy in patients with a midline shift. Neurocirugia. 202
https://doi.org/10.1016/j.neucie.2022.10.0
31. • Joaquín Hernández-Palazón, Et al. (2016) A comparison of equivolume, equiosmolar solutions of hypertonic saline and mannitol for brain relaxation during elective supratentorial craniotomy, British Journal of
Neurosurgery, 30:1, 70-75, DOI: 10.3109/02688697.2015.1109061
32. • Joaquín Hernández-Palazón, Et al. (2016) A comparison of equivolume, equiosmolar solutions of hypertonic saline and mannitol for brain relaxation during elective supratentorial craniotomy, British Journal of
Neurosurgery, 30:1, 70-75, DOI: 10.3109/02688697.2015.1109061
33. • Joaquín Hernández-Palazón, Diego Fuentes-García, Paloma Doménech- Asensi, Sebastián Burguillos-López, Joaquín García-Ferreira, Luis Falcón-Araña & Claudio Piqueras-Pérez (2018)
A dose-response relationship study of hypertonic saline on brain relaxation during supratentorial brain tumour craniotomy, British Journal of Neurosurgery, 32:6, 619-627, DOI:
10.1080/02688697.2018.1508640
34. Joaquín Hernández-Palazón, Diego Fuentes-García, Paloma Doménech- Asensi, Sebastián Burguillos-López, Joaquín García-Ferreira, Luis Falcón-Araña & Claudio Piqueras-Pérez (2018) A
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35. • Ze Jiang†, Youxuan Wu†, Fa Liang, Minyu Jian, Haiyang Liu, Hongxun Mei and Ruquan Han*, Brain relaxation using desflurane anesthesia and total intravenous anesthesia in patients undergoing craniotomy
for supratentorial tumors: a randomized controlled study 2023, https://doi.org/10.1186/s12871-023-01970-z
36. Ze Jiang†, Youxuan Wu†, Fa Liang, Minyu Jian, Haiyang Liu, Hongxun Mei and Ruquan Han*, Brain relaxation using desflurane anesthesia and total intravenous anesthesia in patients undergoing craniotomy for
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37. Curr Opin Anaesthesiol. 2015 October ; 28(5): 532–536. doi:10.1097/ACO.0000000000000232.
• Dosis de Remifentanil
• Uso de Sulfato de
magnesio perioperatorio
• Terapia endovascular
Técnica anestésica
• Brote de supresión en
Cirugía vascular HSA.
38. Brian L. Hoh, MD, MBA, FAHA, Chair; Nerissa U. Ko, MD, MAS, Vice Chair; Sepideh AminHanjani, MD, FAHA*; 2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American
Heart Association/ American Stroke Association Stroke. 2023;54:e00–e00. DOI: 10.1161/STR.0000000000000436
39. Brian L. Hoh, MD, MBA, FAHA, Chair; Nerissa U. Ko, MD, MAS, Vice Chair; Sepideh AminHanjani, MD, FAHA*; 2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart
Association/ American Stroke Association Stroke. 2023;54:e00–e00. DOI: 10.1161/STR.0000000000000436
40. Hagihira S (2017) Brain Mechanisms during Course of Anesthesia: What We Know from EEG Changes during Induction and Recovery. Front. Syst. Neurosci. 11:39. doi: 10.3389/fnsys.2017.00039
MONITORIZACIÓN
Protección neuronal y sueño
fisiológico.
41. Li, R.; Yang, D.; Fang, F.; Hong, K.-S.; Reiss, A.L.; Zhang, Y. Concurrent fNIRS and EEG for Brain Function Investigation: A Systematic, Methodology-Focused Review. Sensors2022,22,5865. https://
doi.org/10.3390/s22155865
MONITORIZACIÓN
42. Li, R.; Yang, D.; Fang, F.; Hong, K.-S.; Reiss, A.L.; Zhang, Y. Concurrent fNIRS and EEG for Brain Function Investigation: A Systematic, Methodology-Focused Review. Sensors2022,22,5865. https:// doi.org/10.3390/s22155865
MONITORIZACIÓN
43. Couture, E.J., Deschamps, A. & Denault, A.Y. Patient management algorithm combining processed electroencephalographic monitoring with cerebral and somatic near-infrared spectroscopy: a case
series. Can J Anesth/J Can Anesth 66, 532–539 (2019). https://doi.org/10.1007/s12630-019-01305-y
MONITORIZACIÓN
44. World Neurosurg. (2021) 151:23-28. https://doi.org/10.1016/j.wneu.2021.04.054
MONITORIZACIÓN
45. CONCLUSIONES
1. La relajación cerebral se debe alcanzar en todos los
escenarios de paciente neurocrítico: Tumoración
cerebral, HSA, Stroke, Traumatismo craneal severo.
2. El manejo anestésico no solo se limita a la correcta
elección del agente a utilizar.
3. Es imperativo mantener y preservar los parámetros
fisiológicos durante el trans anestésico.
4. El monitoreo neurológico puede ser una estimación
del grado de relajación cerebral.
5. El brote de supresión temporal esta teniendo mayor
interés en la cirugía vascular neurológica.
