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Colorectal cancer
Presented by
ANU RV
Senior Lecturer .
DEFINITION
 Colorectal cancer is a disease in which
cancer cells grow either colon or in rectum..
 The colon are the parts of digestive system
,normally the cells of colon and rectum divide
in a regular manner .If cells keep on dividing a
mass of tissue forms calledtumor, that may
be benign or malignant.(medical
encyclopedia)
Colorectal cancer commonly known as colon
cancer or bowel cancer ;which is a cancer
from uncontrolled cell growth in the colon or
rectum ,genetic analysis shown that
essentially colon and rectum tumors are the
same type of carcinomas..national cancer
institute)
Etiology
 1.inflammatory bowel disease
 2.genetic mutations
 3.polyps
Risk factors
1.Dietary factors
2.Environmental factors
3.Lynch syndrome
4.Familial adenomatous polyposis
Cancer distribution
15%
5%
9%
20%
50%
Classifications(duke’s )
 DukeA:the tumor penetrates into the mucosa of
bowel wall no further
 DukeB :B1:tumor penetrates into but not through
the muscular layer
 B2;tumor penetrates into through the
muscular layer
 Duke C:C1:tumor penetrates into but not through
the muscular layer there is pathogenic evidence
of colon cancer in the lymph nodes

C2;tumor penetrates into the muscular layer with
pathological evidence of colon cancer in the lymph
nodes
Modified duke D:the tumor spread beyond the
confines ..metastasis to other organs
TNM
STAGING T;TUMOR
 T1:tumor invades submucosa
 T2:tumor invades muscular layer
 T3:tumor invades to muscular and peri rectal
tissues
 T4:tumor perforates the organ and other
structures
Node (N)
 N0: No regional lymph node metastasis
 N1:metastasis to 1 to 3 regional lymph nodes
 N2: Metastasis in 4 or more regional lymph nodes
 Metastasis (m)
 M0:no metastasis
 M1 :distant metastasis
Stages
 Stage1:T1N0M0;T2N0M0(cancer hasbegun
to spread but still in the inner linig
 Stage2:T3N0M0 ,T4N0M0(cancer hasspread
to other organs near colon and rectum
 Stage3:T4N1 M0 (cancer has spread to lymph
nodes .
 Stage 4(cancer spread through lymph nodes
to other distant parts of the body
pathophysiology
Clinical features
Right side
 1.abdominal pain
 2.bleeding
 3.weakness
 4. Fatigue
 5. Palpable
abdominal mass
 6.Malena
 7.Bowel
obstruction
Left side
 1.coliky pain
 2.bleeding
 3.obstruction
 4.weakness and
fatigue
 5 ribbon like stools
 6.nausea and
vomitting
Rectum
1.Pain
2.Rectal bleeding
3.Bloody stools
4. Altered bowel pattern
5.Perineal and buttok
pain
Management
Medical management
1.chemotherapy
2.Bilogic or targeted therapy
3.Radiation therapy
Surgical management
 1.colectomy (right hemicolectomy-asending colon
 Left hemi colectomy(decending colon)
 Extended hemicolectomy(transeverse colon)
 Sigmoidectomy
 Tottal colectomy
 Subtottal colectomy
 Colostomy
Colostomy
 A colostomy is a surgical procedure in which a
stoma is formed by drawing the healthy end of
the large intestine though the abdominal wall
and suturing in to place (medical encyclopedia)
 Colostomy is a surgical procedure that allows
intestinal contents to pass from the bowel
through an opening is called STOMA .the stoma
created when the intestine is brought through
the abdominal wall and sutured to the
skin.(colostomy nursing care)
Types of ostomies
 End stoma
Loop stoma
Double-barreled stoma
Knock pouch
Colostomy care
 Emotional support as the patient cope with a
radical body change
 Patient teaching about stoma care
Normal stoma
Equipments
Pouching system
Gloves
Bed pan
Plastic bags
Tissue paper
Wash cloth
Cleansing solution
clamp
Explain the procedure to the
patient
Screen the patient
Hand wasing
Wear gloves
Arrange all the article near to
the patient
Remove contents from the
pouch
Remove all the content to a bed pan by
opening the clamp ,after procedure
return the clamp and remove the pouch
from the skin wipe the stoma with wash
cloth.if physian approves cleansing
solution use that.dry the area
Select flange size 1or 2cm larger than
the stoma,trace the size.make the strter
hole.attach the pouch on skin
barrier.remove pouch when it is 1/3rd
filled
colostomy irrigation
Gather Necessary Materials Needed -Youwill
need the following materials: a colostomy
irrigation water bag with tubing and cone .
This is good because it has a very
handy temperature indicator to preventany
stomach cramping and has a flowmeter to
control water flow.Another thingis
your Irrigation drainage bag with belt (ask
about the variant from hollister 7724) this is a
reusable bag which comes very handy.Ofcourse
you also need your paper towels.
Irrigation kit
Cone with
sleeve
Fill the colostomy irrigation bag -
can always use mineral water. Just make sure the
temperature is a variant of your body temperature
and not on any extremes.(normal body temp is 37.5
degree celsius).The amount of water still varies per
individual; some use 750ml and some use 1.5 Liters
of water. can start with 750mL (again, your doctor's
advise is important)
Attach irrigation sleeve - your irrigation drainage
bag can now be attached using your belt placing
your stoma on the middle of the ring.
Insert the cone of the irrigation water bag to
stoma - . Just make sure you insert the cone
firm enough to avoid water leaks.
Infuse the water to your stoma - Start at a
slower rate and gradually increase water flow.
The infusion will last from 3-5 minutes.Youdont
have to fill in the whole 1,000mL in. (Remember:
if you encounter any discomfort at this stage,
stop the water infusing, remove the cone for a
while, then continue again and start at a slower
rate of infusion)
Let the stool exit -After infused, remove the
cone and let the stool exit to the sleeve or the
collection bag with belt that you have attached
earlier.This process will take around 45 to 60
minutes. . If you see enough stool has collectedin
the bag, go back to the bathroom, deposit the
contents to the bowl and close the sleeveagain.
Repeat this process until everythinghas
evacuated from the bowel.
Remove the sleeves and Put on regular
pouching system - After the bowel isempty,
remove the sleeves, wash it with soap and
water, rinse and dry them.Youmay way to
use disinfectant to make it odorfree and
clean.After this, you can now freely use a
patch or your regular pouching system.
Nursing management
 Accute pain related to inflammatory process
 Deficient fluid volume related to vomiting
 Imbalanced nutrition less than body
requirement related to dietary restriction
 Disturbed body image related to fecal
diversion
 Anxiety related to the loss of bowel control
 Risk for impaired skin integrity related to
discharge in the peristomal area
Complication
 Liver cancer
 Lung cancer
 Intestinal obstruction
 Intestinal perforation
Prevention
 Colonoscopy
 Polyps removal
 NSAID
ADVANCEME
NTS
NANOTECHNOLOGY
 DMFO..CELECOXIBANDCOMBINATION
OF SULINADAC ,DIFLUROETHYL
LORNITHINE REDUCE RISKOF POLYPS
DEVELOPMENT

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colorectal cancer

  • 1. Colorectal cancer Presented by ANU RV Senior Lecturer .
  • 2. DEFINITION  Colorectal cancer is a disease in which cancer cells grow either colon or in rectum..  The colon are the parts of digestive system ,normally the cells of colon and rectum divide in a regular manner .If cells keep on dividing a mass of tissue forms calledtumor, that may be benign or malignant.(medical encyclopedia)
  • 3. Colorectal cancer commonly known as colon cancer or bowel cancer ;which is a cancer from uncontrolled cell growth in the colon or rectum ,genetic analysis shown that essentially colon and rectum tumors are the same type of carcinomas..national cancer institute)
  • 4. Etiology  1.inflammatory bowel disease  2.genetic mutations  3.polyps Risk factors 1.Dietary factors 2.Environmental factors 3.Lynch syndrome 4.Familial adenomatous polyposis
  • 6. Classifications(duke’s )  DukeA:the tumor penetrates into the mucosa of bowel wall no further  DukeB :B1:tumor penetrates into but not through the muscular layer  B2;tumor penetrates into through the muscular layer  Duke C:C1:tumor penetrates into but not through the muscular layer there is pathogenic evidence of colon cancer in the lymph nodes 
  • 7. C2;tumor penetrates into the muscular layer with pathological evidence of colon cancer in the lymph nodes Modified duke D:the tumor spread beyond the confines ..metastasis to other organs
  • 8. TNM STAGING T;TUMOR  T1:tumor invades submucosa  T2:tumor invades muscular layer  T3:tumor invades to muscular and peri rectal tissues  T4:tumor perforates the organ and other structures
  • 9. Node (N)  N0: No regional lymph node metastasis  N1:metastasis to 1 to 3 regional lymph nodes  N2: Metastasis in 4 or more regional lymph nodes  Metastasis (m)  M0:no metastasis  M1 :distant metastasis
  • 10. Stages  Stage1:T1N0M0;T2N0M0(cancer hasbegun to spread but still in the inner linig  Stage2:T3N0M0 ,T4N0M0(cancer hasspread to other organs near colon and rectum  Stage3:T4N1 M0 (cancer has spread to lymph nodes .  Stage 4(cancer spread through lymph nodes to other distant parts of the body
  • 12. Clinical features Right side  1.abdominal pain  2.bleeding  3.weakness  4. Fatigue  5. Palpable abdominal mass  6.Malena  7.Bowel obstruction Left side  1.coliky pain  2.bleeding  3.obstruction  4.weakness and fatigue  5 ribbon like stools  6.nausea and vomitting
  • 13. Rectum 1.Pain 2.Rectal bleeding 3.Bloody stools 4. Altered bowel pattern 5.Perineal and buttok pain
  • 14. Management Medical management 1.chemotherapy 2.Bilogic or targeted therapy 3.Radiation therapy
  • 15. Surgical management  1.colectomy (right hemicolectomy-asending colon  Left hemi colectomy(decending colon)  Extended hemicolectomy(transeverse colon)  Sigmoidectomy  Tottal colectomy  Subtottal colectomy  Colostomy
  • 16. Colostomy  A colostomy is a surgical procedure in which a stoma is formed by drawing the healthy end of the large intestine though the abdominal wall and suturing in to place (medical encyclopedia)  Colostomy is a surgical procedure that allows intestinal contents to pass from the bowel through an opening is called STOMA .the stoma created when the intestine is brought through the abdominal wall and sutured to the skin.(colostomy nursing care)
  • 17.
  • 20.
  • 23.
  • 24. Colostomy care  Emotional support as the patient cope with a radical body change  Patient teaching about stoma care
  • 26. Equipments Pouching system Gloves Bed pan Plastic bags Tissue paper Wash cloth Cleansing solution clamp
  • 27. Explain the procedure to the patient Screen the patient Hand wasing Wear gloves Arrange all the article near to the patient
  • 28. Remove contents from the pouch
  • 29.
  • 30. Remove all the content to a bed pan by opening the clamp ,after procedure return the clamp and remove the pouch from the skin wipe the stoma with wash cloth.if physian approves cleansing solution use that.dry the area Select flange size 1or 2cm larger than the stoma,trace the size.make the strter hole.attach the pouch on skin barrier.remove pouch when it is 1/3rd filled
  • 31.
  • 32. colostomy irrigation Gather Necessary Materials Needed -Youwill need the following materials: a colostomy irrigation water bag with tubing and cone . This is good because it has a very handy temperature indicator to preventany stomach cramping and has a flowmeter to control water flow.Another thingis your Irrigation drainage bag with belt (ask about the variant from hollister 7724) this is a reusable bag which comes very handy.Ofcourse you also need your paper towels.
  • 35. Fill the colostomy irrigation bag - can always use mineral water. Just make sure the temperature is a variant of your body temperature and not on any extremes.(normal body temp is 37.5 degree celsius).The amount of water still varies per individual; some use 750ml and some use 1.5 Liters of water. can start with 750mL (again, your doctor's advise is important) Attach irrigation sleeve - your irrigation drainage bag can now be attached using your belt placing your stoma on the middle of the ring.
  • 36. Insert the cone of the irrigation water bag to stoma - . Just make sure you insert the cone firm enough to avoid water leaks. Infuse the water to your stoma - Start at a slower rate and gradually increase water flow. The infusion will last from 3-5 minutes.Youdont have to fill in the whole 1,000mL in. (Remember: if you encounter any discomfort at this stage, stop the water infusing, remove the cone for a while, then continue again and start at a slower rate of infusion)
  • 37. Let the stool exit -After infused, remove the cone and let the stool exit to the sleeve or the collection bag with belt that you have attached earlier.This process will take around 45 to 60 minutes. . If you see enough stool has collectedin the bag, go back to the bathroom, deposit the contents to the bowl and close the sleeveagain. Repeat this process until everythinghas evacuated from the bowel.
  • 38. Remove the sleeves and Put on regular pouching system - After the bowel isempty, remove the sleeves, wash it with soap and water, rinse and dry them.Youmay way to use disinfectant to make it odorfree and clean.After this, you can now freely use a patch or your regular pouching system.
  • 39. Nursing management  Accute pain related to inflammatory process  Deficient fluid volume related to vomiting  Imbalanced nutrition less than body requirement related to dietary restriction  Disturbed body image related to fecal diversion  Anxiety related to the loss of bowel control  Risk for impaired skin integrity related to discharge in the peristomal area
  • 40. Complication  Liver cancer  Lung cancer  Intestinal obstruction  Intestinal perforation Prevention  Colonoscopy  Polyps removal  NSAID
  • 41. ADVANCEME NTS NANOTECHNOLOGY  DMFO..CELECOXIBANDCOMBINATION OF SULINADAC ,DIFLUROETHYL LORNITHINE REDUCE RISKOF POLYPS DEVELOPMENT

Editor's Notes

  1. Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is a type of inherited cancer syndrome associated with a genetic predisposition to different cancer types. This means people with Lynch syndrome have a higher risk of certain types of cancer.