CURSO INTENSIVO DE NUTRIGENOMICA Y MEDICINA ORTOMOLECULAR CURSO II - AGOSTO 2017

1. Neurociencia do
comportamento
Dr. Efrain Olszewer
FAPES

2. NEUROCIENCIA DO
COMPORTAMENTO
 ESTUDA OS PRINCIPIOS QUE
REGULAM AS ATIVIDADES
ROTINEIRAS, E SUA RELAÇÃO COM A
BIOQUIMICA, ANATOMIA,
FISIOLOGIA E FISIOPÁTOLOGIA,
ASSIM COMO A METODOLOGIA
TERAPEUTICA NA PROCURA DO
EQUILIBRIO.

3. Powerful Solutions for
Stress Management
World s #1 Health Problem

4. 1983
2004
2002

5. Crianças nascidas após WTC  09/01

Cortisol menor na saliva  Stress das mães
Sobreviventes do Holocausto  Menor
cortisol

Por conviver com pais deprimidos ou
ansiosos

6. JOURNAL OF CLINICAL
ENDOCRINOLOGY AND METABOLISM
2004
ESCOLA DE MEDICINA MOUNT SINAI
(NY) E UNIVERSIDADE DE
EDIMBURGO
Filhos de 187 mulheres grávidas após 11/09/01

Diminuíram peso e nível de cortisol baixo em
saliva

7. Stress Is Everywhere
http://www.stress.org/problem.htm
 43% of all adults suffer from stress
 75-90% of all visits to primary care physicians
are for stress-related complaints or disorders
 Stress has been linked to all the leading causes
of death:
– CVD, cancer, lung ailments, accidents, cirrhosis and
suicide
 Stress levels have escalated in children,
teenagers, college students and the elderly
 Depression affects about 12.4 million women in
the United States each year
 In America alone, over 6 million men have
depression each year

8. The price of job stress is
estimated at over $300 billion annually
 Job stress - leading source of
stress for adults
– Accidents
– Absenteeism
– Employee turnover
– Diminished productivity
– Direct medical, legal and insurance
costs
 41% adults reported at least
one substantial stress symptom
post-9.11 and continue to worry
about homeland security
 Violence - an increasingly
serious problem
Fed. Agency: National Institute for
Occupational Safety and Health (NIOSH)
http://www.cdc.gov/niosh/stresswk.html

9. How Can Stress Cause So
Much Illness?
Selye’s General Adaptation Syndrome
The 3 Stages of Stress
 Arousal
– Rapid increases in catecholamines
– Slower increases of corticosteroids
 Adaptation
– Characterized by sustained increased levels of
corticosteroids and alarm molecules
– Altered glucose tolerance, blood pressure,
thyroid hormone and sex hormone metabolism
 Exhaustion
– Degenerative diseases characterized by the
adverse influence of corticosteroids and alarm
molecules"Without stress, there would be no life" - Hans Selye

10. COLESTEROL
METABOLISMO ESTERÓIDES
Progesterona
17 OH Progesterona
Androsterona Testosterona
Estrona Estradiol
Estriol
Pregnenolona
17 OH
Pregnenolona
DHEA
Boro
Cortisol