This document summarizes information about neuroscience and behavior. It discusses how neuroscience studies the principles regulating routine activities and their relationship to biochemistry, anatomy, physiology and pathophysiology, as well as therapeutic methodology in seeking balance. It then provides information on the effects of stress on cortisol levels and health outcomes in children, including those born after 9/11 and children of Holocaust survivors. Stress is described as a leading health problem worldwide and major cause of illness, linked to leading causes of death. Job stress is a large economic burden due to accidents, absenteeism and other impacts.

1. Neurociencia do
comportamento
Dr. Efrain Olszewer
FAPES

2. NEUROCIENCIA DO
COMPORTAMENTO
 ESTUDA OS PRINCIPIOS QUE
REGULAM AS ATIVIDADES
ROTINEIRAS, E SUA RELAÇÃO COM A
BIOQUIMICA, ANATOMIA,
FISIOLOGIA E FISIOPÁTOLOGIA,
ASSIM COMO A METODOLOGIA
TERAPEUTICA NA PROCURA DO
EQUILIBRIO.

3. Powerful Solutions for
Stress Management
World s #1 Health Problem

4. 1983
2004
2002

5. Crianças nascidas após WTC  09/01

Cortisol menor na saliva  Stress das mães
Sobreviventes do Holocausto  Menor
cortisol

Por conviver com pais deprimidos ou
ansiosos

6. JOURNAL OF CLINICAL
ENDOCRINOLOGY AND METABOLISM
2004
ESCOLA DE MEDICINA MOUNT SINAI
(NY) E UNIVERSIDADE DE
EDIMBURGO
Filhos de 187 mulheres grávidas após 11/09/01

Diminuíram peso e nível de cortisol baixo em
saliva

7. Stress Is Everywhere
http://www.stress.org/problem.htm
 43% of all adults suffer from stress
 75-90% of all visits to primary care physicians
are for stress-related complaints or disorders
 Stress has been linked to all the leading causes
of death:
– CVD, cancer, lung ailments, accidents, cirrhosis and
suicide
 Stress levels have escalated in children,
teenagers, college students and the elderly
 Depression affects about 12.4 million women in
the United States each year
 In America alone, over 6 million men have
depression each year

8. The price of job stress is
estimated at over $300 billion annually
 Job stress - leading source of
stress for adults
– Accidents
– Absenteeism
– Employee turnover
– Diminished productivity
– Direct medical, legal and insurance
costs
 41% adults reported at least
one substantial stress symptom
post-9.11 and continue to worry
about homeland security
 Violence - an increasingly
serious problem
Fed. Agency: National Institute for
Occupational Safety and Health (NIOSH)
http://www.cdc.gov/niosh/stresswk.html

9. How Can Stress Cause So
Much Illness?
Selye’s General Adaptation Syndrome
The 3 Stages of Stress
 Arousal
– Rapid increases in catecholamines
– Slower increases of corticosteroids
 Adaptation
– Characterized by sustained increased levels of
corticosteroids and alarm molecules
– Altered glucose tolerance, blood pressure,
thyroid hormone and sex hormone metabolism
 Exhaustion
– Degenerative diseases characterized by the
adverse influence of corticosteroids and alarm
molecules"Without stress, there would be no life" - Hans Selye

10. COLESTEROL
METABOLISMO ESTERÓIDES
Progesterona
17 OH Progesterona
Androsterona Testosterona
Estrona Estradiol
Estriol
Pregnenolona
17 OH
Pregnenolona
DHEA
Boro
Cortisol