3. MidAge Crisis ?
One explanation for the high divorce rate when women are in their 40s, 50s or 60s centers around
hormones(which usually happens in perimenopause)
Levels of oxytocin, which is a feel-good hormone that is attributed to feelings such as love for others
are seen to be significantly lower during Menopause
Some doctors claim that the lack of oxytocin changes a woman’s thinking from a “we” mindset to a
“me” mindset.
The ratio of women filing divorce to men filing divorce is 3:1! The surprising fact is that these divorces
are happening when the women are reaching the age of menopause
4. Menopause is affecting Productivity at work
Symptoms of the menopause usually last
between 4 and 8 years
Minimum Treatment Duration 4 years
The management of gender-specific health
issues other than pregnancy are rarely
discussed in the workplace
5. My mother went crazy
after menopause…
Mother Teacher
My teacher was very good before…
Lady Boss Boss Is Crazy
The majority of women are
unwilling to disclose menopause-
related health problems to line
managers…
7. Also known as Climacteric
Absence of Menstruation Permanently
Most common phenomenon amongst aged women
Occurs due to age related physiological changes in hormone levels
Perimenopause is a period of irregular bleeding but no
amenorrhoea
Post menopause is phase that occurs after menopause
What is
14. 90%
Women Present with
Severe Symptoms
during Menopause
75%
Of Menopausal
Women Present with
Hot Flashes
84%
Of Hot flashes symptoms
are Difficult to tolerate,
taken as very severe
The Most Troublesome symptom in Menopause
Menopause simply means the end of a woman’s menstrual periods. It is a significant hormonal
milestone that offers a good opportunity to assess your health and plan for the next phase of
your life.
15. Stages of
Menopause
Definition Symptoms
Perimenopause
It usually begins during a woman’s mid-40s
and can last for several years, even up to 10
years before menopause. It’s common to
experience irregular periods.
Menstrual changes, Hot flashes, weight
gain, Hair thinning,
Dry skin, decreased breast volume,
disrupted sleep, vaginal dryness and a
lowered sex drive.
Menopause
On average begins between the ages of
44-55. Once a woman has gone 12 full
months of not having a period she has
officially entered menopause
Weight gain, Night sweats, Vaginal
dryness, Mood swings, changes in
Urination, the risk of other diseases.
Postmenopause
The years following menopause. Increase
incidence of loss of estrogen., the average
postmenopausal age being 51 years old.
Stress incontinence Urinary tract
infections Insomnia, Severe Vaginal
dryness and itching, Vaginal discharge,
Weight gain
Stage wise Major Symptoms in Menopause
16. Hot Flashes Mood Swings Night Sweats
Early menopause occurs well before the usual age of Menopause. The
Common signs are the same as menopause, But the intensity of
symptoms may vary from Peri to Post…
According to the Women’s Mood and Hormone Clinic at the University
of California, the time that women experience the most symptoms is
during perimenopause. This is when estrogen and progesterone
fluctuate the most in the female brain.
Perimenopause
Mojor
Symptoms
17. Perimenopause – Preparing for a smooth transition
"My hot flashes are driving me
crazy!
Is there anything I can take to treat
my symptoms?
18. 3 Out of 4 Women experiencing menopause have
hot flashes
75% women have troublesome hot flushes ( Can be up to 90% in Oophorectomy)
For 10-15% it is unbearable
15-25% Indian Patients Visits Gynaecologists for their Hot Flashes
Hot Flashes Usually Resolved by 3-5 years
19. Hot Flashes are probably caused by
Hormonal Changes associated with
Menopause.
A decline in the function of the Ovaries causes
the Production of estrogen and Progesterone to
fluctuate, the fluctuate can be extreme
Internal Body Temperature Drops 1 Degree
Celsius during a hot flash
This condition is misinterpreted by brain
And it react abruptly
Hormonal Change
Hot Flashes and its effects
20. There are primarily 2 different types of testing:
vaginal pH swab and FSH (follicle-stimulating
hormone) levels
1.Vaginal pH Test: During reproductive years,
a vaginal pH is around 4.5. During menopause, it
rises to around 6.
2.Follicle-Stimulating Hormone (FSH): During
menopause, FSH rises and estrogen levels fall.
Healthcare providers may check both to assess
menopause. These levels may be measured more
than once over the course of perimenopause for
accuracy.
Common Perimenopause Tests
21. Current Management Options & their Limitations
• HRT
• Hormone replacement Therapy
(HT)
Breast Cancer
Endometrial Cancer
Thromboembolism
Ischemic Stroke
Myocardial Infarction
Should be used for lowest dose
with shortest time.
Only for post menopause.
• SERM
• Phytoestrogens
• Soy extract/Black cohosh
extract/Red clover extract
• No significant effects on Climacteric
Symptoms
• Black Cohosh Extracts comes with a
black box warning of Liver Damage.
• Majorly used for osteoprotective
activity; No role in symptoms of
menopause.
22. Sl
No.
BRAND Company
Sum of MAT
VAL
Sum of MAT
UNIT
UNIT
GR %
1 MENOPACE ISO MEYER ORGANICS PVT. LTD 9.3 404 9
2 MENOHELP MANKIND PHARMACEUTICALS LTD. 8.2 763 35
3 PALMIGES LARENON 6.6 391
4 ESTROG- 100 SHIELD 6.2 183 -13
5 ISOFLAV RAPTAKOS BRETT & CO. LTD. 4.4 270 10
6 NEW MENOEASE PHARMED LTD 4.1 314 -25
7 MENOJOY MACLEODS PHARMACEUTICALS PVT.LTD 3.9 169 54
8 MENOREG MACLEODS PHARMACEUTICALS PVT.LTD 2.7 251 10
9 MENO-PRO BRITISH BIOLOGICAL 2.5 106 -1
10 MENOSAN HIMALAYA DRUG COMPANY 1.8 221 -11
Grand Total 52.7 3311 19
Phyto Estrogen Market at a Glance
26. Sexual Function During Menopause
• Distressing Sexual Problems can be more common in Menopause, Peak at ages 45-64
• Testosterone level declines gradually after menopause( Vs. Abrupt Decline in Estrogen)
• Changes in vaginal wall due to low estrogen leads to painful intercourse, a frequent cause of Sexual
Dysfunction after menopause
27. Weight Gain
• Weight Gain during menopause –mainly related to aging and lifestyle, average weight gain 5 lbs
• Changes in body composition and fat distribution ( Independent of Age)
• Increase in Fat in abdominal region
• Decrease in lean body mass
• Increase in visceral abdominal fat
• Decrease in Energy expenditure
28. What do woman value During Menopause
• Managing Symptoms
• Short & Long-term Health
• Metal wellbeing
• Healthy Sex Life
• Maintain weight and appearance
• Increased Confidence
• Still Raising Families
• Caring for Husbend aswell as other
aging parents
• Value Strong Social Networks of
Famies
Looking Good Nurturing Friends & Family
30. Err 731 gave me my life back
• MULTIPLE SHORT AND LONG-TERM STUDIES WITH MORE THAN 400 PERI- AND POST-
MENOPAUSAL WOMEN
31. Significant Reduction in Daily Hot Flash Frequency*
Efficacy comparable to hormone therapies*
Err 731
Efficacy & Safety
ERr 731 has a long-term history*
Recommended by healthcare professionals in Germany since 1993
Unlike hormone therapies, ERr 731 does not contain estrogen
ERr 731 demonstrates selective affinity for ERβ, in endometrial tissue,
32. "Estrovera(Err 731) is a life changer for patients as well as doctors."
~ R. Gulati, MD
"The majority of people notice a difference in their menopausal symptoms within two
weeks to a month on Estrovera(Err 731) . Some people's symptoms diminish to the point
where they aren't bothered by them anymore, and other's see complete relief from all
their symptoms. Estrovera(Err 731) is a win-win situation because it works and because
there are no side effects associated with it. This product sells because it works!"
~ J. Cochran, ND
"Estrovera(Err 731) is easy, inexpensive, and safe, and there is heavy anecdotal
evidence that shows that it works for a lot of people, so it's effective, too. I believe
introducing lifestyle changes and optimizing health is something that needs to be done
first before exploring riskier options like hormone replacement. As a physician, I would
rather be a soundboard or an advocate for optimizing a patient's lifestyle with foods
and safe remedies that can either ease their symptoms or almost eliminate them. With
Estrovera(Err 731), you don't have to be a salesman or consistently encourage people
to use it—they will come to you and keep asking for it because it works!"
~ R. Lazarus, DC
Err 731
Doctors Testimonials
c
33. "This product WORKS!! Even with a bio-identical creme treatment, my hot flashes
were debilitating, exhausting and totally embarrassing. Three months on Estrovera
and the hot flashes are occasional instead of always occurring; mild instead of major'
tolerable instead of torture. I recently experimented with taking them every other day
but rapidly discovered I have no desire to return to that land of torment."
~ G. Lungle
I have had almost no hot flashes since beginning this product!”
~ C. Babson
Without Estrovera I would be living in the Arctic or spending most the day and night with
my head in the freezer! I am so not kidding! About 5 weeks ago I started Estrovera as
recommended by my naturopath as a natural approach to hot flashes. I had been
seriously struggling for about 5 months and the hot flashes had just become unbearable
and happened about every hour day or night. My heart would race and I couldn't sleep
and I was just exhausted. I "get" that after 44 years of periods, my body is confused and
needs time to sort this all out, but I was so tired and felt unwell and weak and ready to
give up and go the HRT route. This is going to sound like an infomercial, but Estrovera
has helped me so much. My hot flashes have probably been reduced so that I only have
one about every couple of hours and the intensity is reduced by about 50% as well. I am
also taking other vitamins to support my changing body, eating healthy and avoiding a
lot of triggers. I can honestly say that without Estrovera, I would be on HRT. I am so
very grateful for this natural support! I am looking forward to even more improvement
over the next couple of months."
~ P. Sheasby
Err 731
Patient Testimonials
C
34. Prior to Estrovera, I had major hot
flashes and extreme sweating every
45 minutes, all day and all night. My
shirt would be wet, my hair would be
wet, and I wasn't able to get any
sleep. After the first two weeks of
taking Estrovera, I was able to sleep
six hours straight! Estrovera makes
my life so much simpler, and I feel so
much cleaner now that I'm not
sweating and drenching constantly. It
has changed my hot flashes and my
life and allows me to finally get a
good night’s sleep."
~ R. Hale, patient
I would classify myself as
perimenopausal—I have irregular cycles,
mood fluctuations and night sweats, which
prohibited me from being able to sleep. I
began seeing relief from my symptoms in
about two weeks after taking Estrovera.
Now I am able to sleep through the night
and my temperament is much more
moderate. Estrovera is a product that
women in all stages of menopause can
benefit from because it is healthy and it is a
simple solution with great, positive
outcomes."
~ D. Joy, patient
"Best product for menopause that I have
taken and I have taken many. I know it
works because I ran out and symptoms
came back. While taking the Estrovera
there were no symptoms and I was a
happy woman. Thanks Estrovera you are
the BEST!"
~ M. Hills, patientC CC C
Err 731
Patient Testimonials
35. "Estrovera has been like a miracle for me. I was so miserable with frequent
hot flashes, night sweats, mood swings, anxiety, etc. that I sought medical
assistance. I didn't want to do hormone replacement therapy so I spoke with a
Naturopathic doctor who recommended Estrovera. He told me he'd read the
studies and researched the ingredients and he felt that this was the safest and
most effective treatment available for menopause. I ordered a bottle and after
only a few days I started noticing the symptoms getting less and less frequent.
I realized one day that I couldn't even remember the last time I had
experienced any of those symptoms because it had been so long. Another
thing that convinced me this was working was that I forgot to take it for 2
consecutive days and I starting getting hot flashes on the second day. Thank
you for discovering this treatment. I finally feel like myself again."
~Lynn Q., patient
I've had hot flashes and night sweats for the last 10 years. I've tried several
products and nothing seemed to give me the relief I was looking for. My night
sweats were becoming unbearable. I was told about Estrovera by my holistic
physician. Although skeptical I decided to give it a try. So happy I did. My
symptoms have certainly decreased and I experience maybe 1 night sweat a
night and I've only been on Estrovera for a week. I will continue to use
Estrovera and hopefully have my life completely back! Thank you for such a
great product."
~S. Rosenmeier, patient
CC
CC
Err 731
Patient Testimonials
36. If ED is for Male Vs. Menopause…
During Menopause loss of libido due to disrupted Sex hormones & Loss Veginal dryness can
cause Loss of Sex Drive
ED Menopause
37. Menopause,
a Blue Ocean in the World Of Gynaecology
Menopause
An Noble Action beyond
business and work for a Good
Cause
39. Prevalence of Menopause in India
1,354,051,854
11% Women Population aged between 40-60 Years
73,115,988
Indian Population
48.19% women out of Indian Population –
652,517,588
Ref : Indian Journal of Orthopaedics( Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017174/)
• Epidemiology of knee osteoarthritis in India and Related Factors Chandra Prakash Pal, Pulkesh Singh,1 Sanjay Chaturvedi,2 Kaushal Kumar Pruthi, and Ashok Vij3
Huge Scope for Peri, Menopause & Post Menopause
72% Rural
28% Urban
Global: According to Hill (1995) the number of postmenopausal women in the world will rise from 467 million in
1990 to 1.2 billion by 2030. Most of the increase in number will occur in developing countries.
India: According to the 2016 census of India, there were about 120 million women aged 45 yr and above and this
number is expected to increase to 401 million in 2026
42. Surge in emergency contraceptive pill sales rings alarm bell
sale of ECP in last five years has increased almost four times, from 4.9 million in 2008 to 16.4 million in 2013.
According to recently released data from Euromonitor
International, India’s market for emergency
contraceptives jumped 88% to $104.4 million (Rs 667
crore) between 2009 and 2014, ranking the country third
in the world after the US and China.
46. Ahealthy Seed of Idea that can Germinate in
to a Strong Division
47. 72% Rural
28% Urban
Total Indian
Population:1,354,051,854
Women Population in
India(48.19%):652,517,588
Women
Aged between 40-60 Yrs.
(11%):73,115,988
Urban Woman Population
(28%):2,04,47,664
Patient expected to Visit Doctor
( 2%) :4,00,000
Hypothesis: MRP:60 INR
NRV:43 INR
One Rx with 1 year Adherence
1 Rx Val.: 15,000/- INR
First year: 628cr.
48. Err 731 Prelaunch Meeting
Round Table Meeting with Indian Menopause Society
Consensus Building & Fit Err in treatment protocol
49. Err 731 Prelaunch Meeting
International Speaker in National Conference
Clinical Trial with Indian Menopause Society
51. Err 731 Launch Meeting
Top KOL from Indian Menopause Society
SBU Heads, Marketing & BD team of TOP 10 Gynac companies
SDN Probio Team & Team from Finzelberg, AG
Theme: German Innovation
Free Pickup & Drop only by Mercedes
