Civic engagement 1
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This document discusses ways to build up and motivate people through praise. It provides tips for praising employees, such as making praise specific and avoiding competition. Praise is more productive than punishment and face-to-face contact is important. The document also discusses goal setting, giving employees tools to succeed, and respecting everyone. Applying these principles to working with children, praise helps kids feel valued and loved while developing self-esteem. Respect is important with kids to gain their respect in return.
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6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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Civic engagement 1
- 1. Build Up Your People “Without inspiration the best powers of the mind remain dormant. There is a fuel in us which needs to be ignited with sparks.”Johann Gottfried Von Herder
- 2. Ways to Praise People: DON’T praise people, only, what they do Make praise as specific as possible Avoid phony praise Avoid praise that sets up competition Nate
- 3. The Office Video Clip Season 2, Episode 1, “The Dundies” http://www.cucirca.com/2008/06/17/the-office-season-2-episode-1-the-dundies/ “Recognition gives employees the extra push they need to do their jobs just a little bit better.” –Adrian Gostick Brittany
- 4. Main Points from Article Praise is more PRODUCTIVE than punishment. Face-to-Face Contact is VERY important. Don’t get lost in the digital world. Be open and available for your employees. Make new employees feel welcome. Elizabeth
- 5. Managing Others: Goal Setting Giving people the tools to succeed Everyone deserves respect Benfold Today:http://www.benfold.navy.mil/
- 6. The Carrot PrincipleBy: Adrian Gostick Increase Bottom Line=Praise Employees Employees who feel valued are more productive. Managers who can’t be trusted are ineffective. Employees hunger for “carrots” (Praise and Incentives) more than money. Brittany
- 7. Application to Pond Gap Brittany Kids need praise. They need to feel valued and loved. Children need to develop strong self-esteem through encouragement. Kids need people to be open with and adults to trust. Children thrive to learn. Give respect to get respect, even with kids.
- 8. Elizabeth
- 9. Additional Research On This Topic: “Employee Motivation Techniques” http://www.buzzle.com/articles/employee-motivation-techniques.html “Learning to Compliment Effectively” http://www.managementsite.com/507/Learning-to-compliment-effectively-.aspx “20 Ways to Motivate Your Employees Without Raising Their Pay” http://www.biztrain.com/motivation/stories/20ways.htm “The Carrot Principle” Abstract http://leadersacademy2011.com/carrot_principle_getabstract.pdf Elizabeth