This document discusses electric circuits and their components. It describes the basics of series and parallel circuits. A closed loop through which current can flow is called an electric circuit. Components of a circuit include a voltage source to maintain current, conducting wires to allow current to pass through, switches to control current flow, and loads that convert electrical energy. Series circuits have one path for current and if interrupted anywhere will not function. Parallel circuits have multiple loops so if one is interrupted current can still flow in others. The document compares properties, advantages, and disadvantages of series and parallel circuits.
In a series circuit, the sum of the voltages consumed by each individual resistance is equal to the source voltage. ... In a parallel circuit, the voltage across each of the components is the same, and the total current is the sum of the currents flowing through each component.
In this presentation I defined the series and parallel circuit's and their behaviour how to these circuit works and their advantages and disadvantages it may be help you to understand their use.
In a series circuit, the sum of the voltages consumed by each individual resistance is equal to the source voltage. ... In a parallel circuit, the voltage across each of the components is the same, and the total current is the sum of the currents flowing through each component.
In this presentation I defined the series and parallel circuit's and their behaviour how to these circuit works and their advantages and disadvantages it may be help you to understand their use.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
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What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
2. Electric Circuit
A closed loop through which current can flow
is called an electric circuit. For a continuous
flow of electrons, there must be a complete
circuit with no gaps.
BASICS SERIES PARALLEL
3. Components of Electric Circuit
Voltage source is a device that maintains a
constant amount of voltage. Common voltage
sources used at home are battery, generator,
wall socket, and electric outlet.
BASICS SERIES PARALLEL
4. Components of Electric Circuit
Conducting wires are special kind of
conductors where current can pass through
easily. There is a corresponding safe amount
of current that can pass through for every
size, thickness, or cross-sectional area of
conducting wire.
BASICS SERIES PARALLEL
5. Components of Electric Circuit
Electrical switch is a device that can control
the entrance of current. When it is on, the
circuit is closed, then current can pass
through. When it is off, the circuit is open,
and current cannot pass through.
BASICS SERIES PARALLEL
6. Components of Electric Circuit
Electrical load is an electrical device that
converts electrical energy to heat like in the
case of electric iron, and to light and heat like
in the case of a light bulb.
BASICS SERIES PARALLEL
7. Series Circuit
A circuit that consists of one loop is called a
series circuit. If a series circuit is interrupted
at any point in its single loop, no current can
flow through the circuit and no loads in the
circuit will work.
BASICS SERIES PARALLEL
8. Series Circuit
A circuit that consists of one loop is called a
series circuit. If a series circuit is interrupted
at any point in its single loop, no current can
flow through the circuit and no loads in the
circuit will work.
BASICS SERIES PARALLEL
10. Properties
1. The total resistance of a series circuit is
the sum of all resistances in the circuit. Total
resistance is always greater than the
individual resistances in a series circuit.
2. The voltage source is equal to the sum of
all voltages in each load in a circuit.
3. The current is constant across each load.
BASICS SERIES PARALLEL
11. Advantages
1. A series connection does not overheat
easily.
2. In a series circuit, there is the only one
path for the current to flow from the voltage
source to the different loads. It would be easy
to connect and disconnect new load.
3. Since series circuit is less likely to
overheat, there is no need to use expensive,
BASICS SERIES PARALLEL
12. Disadvantages
1. If one of the light bulbs is damaged or
removed in a series connection, all other light
bulbs in the circuit will not light too.
2. The addition of more light bulbs in series
circuit causes a decrease in the brightness of
the bulbs.
BASICS SERIES PARALLEL
13. Disadvantages
3. The loads in a series circuit are difficult to
control individually. When the switch is off,
all loads in the circuit will not function
anymore.
4. It is difficult to identify the damaged bulb
in the circuit.
BASICS SERIES PARALLEL
14. Parallel Circuit
A circuit that has two or more loops is called
a parallel circuit. it. If one loop is
interrupted, the current can still flow
through the other loop. In the parallel circuit,
if one light bulb burns out, the other light
bulb will still work because current can still
flow through it.
BASICS SERIES PARALLEL
16. Properties
1. The reciprocal of the total resistance in a
parallel circuit is the sum of the reciprocal of
all resistances in the circuit. Total resistance
is always less than the smallest resistance in
the circuit.
2. There is only one voltage which is equal to
a voltage source.
3. The total current is equal to the sum of all
BASICS SERIES PARALLEL
17. Advantages
1. All loads in parallel connection are directly
connected to the voltage source. Even the
resistances vary, all light bulbs can still have
their maximum brightness.
2. In a parallel circuit, even if one of the light
bulbs is damaged, all other light bulbs will
still function since the flow of current is not
entirely interrupted.
BASICS SERIES PARALLEL
18. Advantages
3. Individual load in a parallel circuit is easy
to control. Each load has a connecting wire
for the current to flow, and each may have its
own switch. Even if you switch off one bulb,
other bulbs are not affected.
4. All light bulbs and appliances at home are
connected in parallel. Switching off some
appliances does not affect other appliances.
BASICS SERIES PARALLEL
19. Disadvantages
1. Overloading may happen if appliances are
simultaneously used at home.
2. A parallel connection is difficult to install,
maintain, and repair since large volume of
conducting wires is needed.
3. It requires the use of several conducting
wires of varying sizes.
BASICS SERIES PARALLEL