This study retrospectively analyzed outcomes of 27 patients who underwent surgery for chondrosarcomas originating in the sacrum between 1992-2014. It found that en bloc resection was associated with longer hospital stays than intralesional surgery. En bloc resection also resulted in greater loss of motor, bowel and bladder function compared to intralesional surgery, though the results were not statistically significant. The 5-year and 10-year overall survival rates for the entire group were 53% and 37.8% respectively, with a higher rate seen for unilateral nerve root resection versus bilateral resection. The study aims to help assess functional outcomes and quality of life for patients with this rare type of cancer.
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Identified in 1921 by James Ewing
2nd most common bone tumor in children
Ewing’s Sarcoma Family of tumors:
Ewing’s sarcoma (Bone –87%)
Extraosseous Ewing’s sarcoma (8%)
Peripheral PNET(5%)
Askin’s tumor
Clinical presentation of osteosarcoma with relevant history and examination features.
epidemiology, sites of involvement, tumor classification, clinical presentation, investigation an management.
different modes of management with characteristic radiological features.
Objectives: To describe the pattern of clavicle fractures and to evaluate the results of surgical treatment for clavicle fractures. Patients and methods: This retrospective study included 38 cases of clavicle fractures who were treated by open reduction internal fi xation at Hanoi Medical University Hospital between January 2008 and June 2013.
Results: The ratio of male to female was 1.5/1. Average age was 42.0 years. Simple fractures (no intermediate fragments) are most common with 65.8% of patients. Middle third fractures accounted for
92.1% of patients. Bone union rate was 100%. The surgical results were excellent in 94.7% and good in 5.3% of cases according to Constant Score.
Identified in 1921 by James Ewing
2nd most common bone tumor in children
Ewing’s Sarcoma Family of tumors:
Ewing’s sarcoma (Bone –87%)
Extraosseous Ewing’s sarcoma (8%)
Peripheral PNET(5%)
Askin’s tumor
Clinical presentation of osteosarcoma with relevant history and examination features.
epidemiology, sites of involvement, tumor classification, clinical presentation, investigation an management.
different modes of management with characteristic radiological features.
Objectives: To describe the pattern of clavicle fractures and to evaluate the results of surgical treatment for clavicle fractures. Patients and methods: This retrospective study included 38 cases of clavicle fractures who were treated by open reduction internal fi xation at Hanoi Medical University Hospital between January 2008 and June 2013.
Results: The ratio of male to female was 1.5/1. Average age was 42.0 years. Simple fractures (no intermediate fragments) are most common with 65.8% of patients. Middle third fractures accounted for
92.1% of patients. Bone union rate was 100%. The surgical results were excellent in 94.7% and good in 5.3% of cases according to Constant Score.
Radiation-Induced Angiosarcoma of the Breast: Retrospective Analysis at a Reg...semualkaira
Radiation-induced angiosarcoma (RIA) of the breast is an uncommon but morbid complication after radiotherapy for breast cancer. This retrospective study analysed the treatment and outcome of breast RIA patients at Cambridge University Hospital (CUH), a regional treatment centre in the East of England.
Radiation-Induced Angiosarcoma of the Breast: Retrospective Analysis at a Reg...semualkaira
Radiation-induced angiosarcoma (RIA) of the breast is an uncommon but morbid complication after radiotherapy for breast cancer. This retrospective study analysed the treatment and outcome of breast RIA patients at Cambridge University Hospital (CUH), a regional treatment centre in the East of England.
Comparison of Clinical Efficacy of Surgical Approaches for Acetabular Fracturessemualkaira
To compare the different approaches and effects of pararectus approach, modified stoppa approach and ilioinguinal approach in the treatment of acetabular fractures.
Comparison of Clinical Efficacy of Surgical Approaches for Acetabular Fracturessemualkaira
: To compare the different approaches and effects
of pararectus approach, modified stoppa approach and ilioinguinal
approach in the treatment of acetabular fractures.
Comparison of Clinical Efficacy of Surgical Approaches for Acetabular Fracturessemualkaira
To compare the different approaches and effects
of pararectus approach, modified stoppa approach and ilioinguinal
approach in the treatment of acetabular fractures.
Comparison of Clinical Efficacy of Surgical Approaches for Acetabular Fracturessemualkaira
Through regression sorting, 44 patients with acetabular fractures who were hospitalized in our unit from September 2012 to September 2017 were summarized. Three surgical methods were used, and the operation time, intraoperative blood loss, postoperative complications, fracture reduction satisfaction and hip function were recorded in the three groups.
Prognosis of Invasive Micropapillary Carcinoma of the Breast Analyzed by Usin...JohnJulie1
Invasive micropapillary carcinoma (IMPC) is a rare type of breast cancer with high frequency of regional lymph node metastasis. However, the prognosis of IMPC has remained controversial for decades. We aimed to compare the differences of prognosis between IMPC and Invasive ductal carcinoma(IDC) of the breast by utilizing Surveillance, Epidemiology, and End Results (SEER) database.
Prognosis of Invasive Micropapillary Carcinoma of the Breast Analyzed by Usin...NainaAnon
Invasive micropapillary carcinoma (IMPC) is a rare type of breast cancer with high frequency of regional lymph node metastasis. However, the prognosis of IMPC has remained controversial for decades. We aimed to compare the differences of prognosis between IMPC and Invasive ductal carcinoma(IDC) of the breast by utilizing Surveillance, Epidemiology, and End Results (SEER) database.
Upper Rectal Cancer: Benefit After Preoperative Chemoradiation Versus Upfront...daranisaha
Upper rectal cancer management is controversial. The present series reports the outcomes of treatment comparing neoadjuvant chemoradiation (NCRT) versus upfront surgery.
Upper Rectal Cancer: Benefit After Preoperative Chemoradiation Versus Upfront...JohnJulie1
Upper rectal cancer management is controversial. The present series reports the outcomes of treatment comparing neoadjuvant chemoradiation (NCRT) versus upfront surgery.
Upper Rectal Cancer: Benefit After Preoperative Chemoradiation Versus Upfront...
Chondrosarcoma
1. Introduction
Outcomes after surgery in Chondrosarcomas arising
from the sacrum
Digant Shah
The School of Biomedical Informatics | The University of Texas Health Science Center at Houston
Methods
Results
Discussion
References
Acknowledgements
Conclusion
Tables and Figures
Please contact the author via email:
digant.b.shah@uth.tmc.edu
Chondrosarcoma is the second most common primary malignant tumor of bone with a prevalence of 1 in
200,000 and accounts for approximately 25% of all bone sarcomas [1]. The overall 5-year and 10-year
survival rates are 74.0% and 54.4%, respectively [2].
The gold standard for treatment of these lesions has been surgical resection, which is determined by the
tumor size, proximity to vital structures, and risk of compromising axial stability [3], and is affected by the
stage, grade, and location. The en bloc approach used by most experienced surgeons is one of the best
treatment modality but is the most technically challenging as compared to the intralesional approach
which is generally undertaken by inexperienced surgeons thus affecting the recurrence.
The area of focus in most of the studies on chondrosarcomas has been on oncological outcomes [4], but
not on survivorship which is the quality of life (QOL) and functional outcomes. Also, in the current
literature, there is no distinguishing between pelvic and sacral chondrosarcomas, and both have often
been grouped with chordomas.
[1] F. Bertoni, P. Bacchini and P. Hogendoorn, "Chondrosarcoma," World Health Organisation Classification
of Tumours.Pathology and Genetics of Tumours of Soft Tissue and Bone.IARC Press, Lyon, pp. 247-251,
2002.
[2] E. Konishi, Y. Nakashima, M. Mano, Y. Tomita, I. Nagasaki, T. Kubo, N. Araki, H. Haga, J. Toguchida and T.
Ueda, "Primary central chondrosarcoma of long bone, limb girdle and trunk: Analysis of 174 cases by
numerical scoring on histology," Pathol. Int., vol. 65, pp. 468-475, 2015.
[3] P. Bergh, B. Gunterberg, J. M. Meis‐Kindblom and L. Kindblom, "Prognostic factors and outcome of
pelvic, sacral, and spinal chondrosarcomas," Cancer, vol. 91, pp. 1201-1212, 2001.
[4] D. Andreou, S. Ruppin, S. Fehlberg, D. Pink, M. Werner and P. Tunn, "Survival and prognostic factors in
chondrosarcoma: results in 115 patients with long-term follow-up," Acta Orthopaedica, vol. 82, pp. 749-
755, 2011.
[5] Biagini, R., P. Ruggieri, M. Mercuri, R. Capanna, A. Briccoli, S. Perin, U. Orsini, S. Demitri, and S.
Arlecchini. "Neurologic deficit after resection of the sacrum." La Chirurgia degli organi di movimento 82,
no. 4: 357-372, 1996.
[6] A. W. Silberman, "Surgical debulking of tumors," Surg. Gynecol. Obstet., vol. 155, pp. 577-585, Oct,
1982.
[7] S. Canbay, A. E. Hasturk, I. Ustun, C. Bayram and G. Dilek, "Giant Sacral Chordoma: Radiographic
Features and Management," Neurosurgery Quarterly, vol. 22, pp. 12-15, 2012.
Patients with chondrosarcomas arising from the sacrum being treated at UT MD Anderson, Houston,
Texas between January 1, 1992, and March 1, 2014, were considered. A retrospective review of medical
records, imaging studies, pathology reports and clinical follow-up data was performed. Conventional
chondrosarcomas were graded using a three-tiered system (Grades 1 – Low grade, Grade 2 –
Intermediate grade, Grade 3 – High grade). Dedifferentiated chondrosarcomas and mesenchymal
chondrosarcomas were all categorized as Grade 4 tumors. Information on patient demographics, hospital
days, survival, local recurrences, metastases, and complication were obtained in all cases.
0 12 24 36 48 60 72 84 96 108 132 156 180
0.0
0.2
0.4
0.6
0.8
1.0
P-value= 0.369
Bilateral ( E / N = 4 / 5 )
Unilateral ( E / N = 10 / 17 )
Overall Survival by Nerve Root Scrificed Section
Time (months)
Probability
Overall Survival
Time (Months)
Probability
0 12 36 60 84 108 132 156 180
0.0
0.2
0.4
0.6
0.8
1.0
Statistical Analysis
1. Univariate analysis using Kaplan-Meier method with log-rank assessment to assess the prognostic
significance of individual risk factors.
2. Cox proportional hazards multivariate analysis to determine time-related to factors that affected
disease-free survival.
3. The long-term outcome determined by survival rate after treatment of local recurrence.
All statistical analyses were carried out using Statistical software SAS 9.3 (SAS, Cary, NC) and S-Plus 8.2
(TIBCO Software Inc., Palo Alto, CA). All tests were 2-sided and A p-value of less than 0.05 was considered
significant.
Table 1 provides a summary of the patient demographics and surgical details.
The analysis of the results shows that there was a significant effect of the type of surgery on the length of stay (p-
value = 0.0315), as seen in Table 2.
It was seen that there was a considerable amount of loss of motor, bowel, and bladder when an en bloc excision
was performed as compared an intralesional approach(Table 3), the results were not statistically significant.
The overall survival rates of the entire group at 5 and 10 years were 53% and 37.8%, respectively (Figure 1). It was
also seen that the overall survival rate was higher for a patient treated with unilateral nerve root resection as
compared to bilateral nerve root resection (Figure 2). However the results were not statistically significant.
Tumor related deaths
57% - sacrum (4/7)
25% - spine (3/12)
25% - pelvis (11/43)
ChondrosarcomaChordoma
Table 1 - Patient Demographics and
surgery details (n=27)
Age (Mean, 1st surgery) 46.04 years
Male
Female
18 (67%)
9 (33%)
Length of stay 40.23 days
Grade
1
2
3
4
1 (3.85%)
11 (42.31%)
10 (38.46%)
4 (15.38%)
Chemotherapy
Pre
Post
• 1 cycle
• 2 cycle
2 (7.41%)
5 (18.52%)
1 (3.7%)
XRT
Pre
Post
2 (7.69%)
3 (11.54%)
Alive
Dead
11 (40.74%)
16 (59.26%)
Metastasis 7 (25.93%)
Surgery Sequelae
Intralesional
En bloc
6 (22.22%)
21 (77.78%)
Reconstruction
Flap
VAG
Instrumentation
5 (33.35%)
8 (53.36%)
2 (13.34%)
Margins:
Negative
Positive
15 (15.56%)
12 (44.44%)
Recurrence 13 (50%)
Nerve Resection:
Unilateral
Bilateral
17 (77.27%)
5 (22.73%)
The purpose of this retrospective study is to assess the outcomes after surgery for chondrosarcomas
arising from the sacrum.
Objective
Grade: 1 – Low Grade, 2 – Intermediate Grade, 3 –
High Grade, 4 – Dedifferentiated/Mesenchymal,
VAG – Vascularized Auto Graph
Treatment course
Table 3 - Functional Outcomes (n = 27) [5]
Intralesional
(4)
HS
(2)
HSwHP
(17)
HSwEHP
(4)
Motor function 0 = 4 0 = 2 0 = 4, I = 10, II = 3 II = 4
Bowel function 0 = 4 0 = 2 0 = 9, I = 5, II = 3 0 = 2, I = 1, II = 1
Bladder function 0 = 4 0 = 2 0 = 10, I = 4, II = 3 0 = 1, II = 3
HS – Hemisectomy, HSwHP – Hemisectomy with Hemipelvectomy, HSwEHP – Hemisectomy with
External Hemipelvectomy,
In all tumors, the goal is to achieve full clearance of the cancerous growth which is achieved by en-
Bloc resection. However, at times, the tumor is too big or entwined with vital structures such as
major blood vessels or the axial skeleton that complete removal of the tumor would result in
immediate compromise of patient survival. In these cases, the surgeon compromises on clearance by
using the intralesional approach. This practice is called debulking and, is also called intralesional [6]
since much of the perimeter of resection is with the tumor, rather than outside the borders of the
tumor as seen in en-bloc. The reason why there seems to be a correlation between length of stay
and type of surgery is because the intralesional surgery is much less extensive/aggressive than an en-
bloc resection.
Another important consideration in this study has been the focus on chondrosarcomas and not
chordomas. Both are clinically and radiographically similar in nature, but are histologically and
immunohistologicaly different. Both chordomas and chondrosarcomas appear as a large expansile
mass in the sacrococcygeal region and present with symptoms such as pain, numbness, constipation,
weakness, and incontinence. Often vital structures such as the rectum, bladder, uterus, and adnexa
are displaced or completely surrounded by the tumor. Although chordomas tend to hemorrhage,
chondrosarcomas typically do not. However, Chondrosarcomas arise off midline and they consist of
both mineralized and non-mineralized Chondroid matrix [7]
Chondrosarcoma is a malignancy of bone that can present within the sacrum. The effective diagnosis
plays an essential role in the disease treatment. Currently, there is a huge gap in the literature on
chondrosarcomas arising from the sacrum. Focused studies on these lesions are required, which will
help to assess the functional outcomes and in turn help in improving patient quality of care and
outcome.
Table 2 – Type of Surgery vs Length of stay
Surgery type N Mean StD Min Q1 Median Q3 Max P-value
Intralesional 5 17 12.17 3 8 18 22 34 0.0315
En bloc 21 45.76 28.07 10 22 33 71 113
1. It is a retrospective analysis of patients treated over 22 years, diagnostic approaches and surgical
technical skills have changed.
2. Data was obtained from medical charts, which may not completely accurate.
3. Lack of patients due to rarity of the condition.
4. No information on the size of the lesion in the clinical notes.
Limitations
Figure 2 - Overall survival rate based on nerve root
sacrificed
Figure 1 -Overall survival rate
We thank Dr. Justin Bird for mentoring and supervising the project. Lei Feng for assisting in analyzing
the data and Sarah Rizvi for her contribution in writing the research protocol.