The lymphatic system drains interstitial fluid from tissues, transports it through lymphatic vessels, and carries out immune responses. It consists of lymph nodes that filter interstitial fluid and contain B and T cells. The thymus produces T cells, lymph nodes filter pathogens from lymph, and the spleen destroys pathogens and stores platelets and blood cells. Barrier defenses include skin and mucous membranes, while internal defenses include interferon that stops virus replication and the complement system that helps destroy pathogens. Inflammation isolates and destroys pathogens at the injury site and fever increases immune response effectiveness. Lymphocytes have antigen receptors and mediate either cell-mediated or antibody-mediated immune responses.

1. Chapter 17 The Immune System
Note-taking Guide
http://www.slideshare.net/hohlert/chapter-4517-notes
Lymphatic System
• Drain ___________________________________.
• Transport __________________________________.
• Carry out _____________________________________.
• Consistof_____________________________________ similartobloodvessels.
• Contain_________________________________________ to filterinterstitial fluid.
Lymphatic Organs and Tissues
• Thymus- two-lobedorgan,locatedmedial tothe lungsandsuperiortothe heart,
______________________________________________________________________________
• Lymphnodes- 600 beanshapednodes,
______________________________________________________________________________
______________________________________________________________________________
• Spleen- betweenstomachand
diaphragm,_______________________________________________________, macrophages
destroypathogens,storage of platelets, productionof fetal bloodcells,BandT cellscarryout
immune responses
• Lymphaticnodulesare eggshaped,tonsils

2. • 5 tonsils
• Pharyngeal,adenoid,twopalatine tonsils(obviousones) 2lingual tonsilsatthe base of the
tongue.
Barrier Defenses-Non- specificimmune response
• External barrierspreventpathogensfromenteringthe body:
•
•
•
•
•
•
•
•
Internal Defenses
• Interferon- ________________________________________________________________
• Complementsystem-_______________________________________________________
• Natural killercells- _________________________________________________________
• Phagocytes- ______________________________________________________
• Macrophages- _______________________________________________________

3. Inflammationand FeverResponse
• Helps preventthe _____________________________________________________________
• Allowsmore ________________________________ to flow tothe injurysite.
• ___________________________________________________________________.
• Carries _________________________________________________ to the site faster
• Feveriscausedby ______________________________________.
• Elevatedbodytemperatureincreasesthe effectsof
__________________________________________, and speedsupbodilyreactionsandrepair.
Lymphocytes-specificimmune response
• ______________________________________________________.
• Containantigenreceptors.
• Cell-mediatedresponse- ________________________________________
• Antibodymediatedresponse- _____________________________________________________.
Antigensand Antibodies
• An antigencausesthe bodyto _____________________________________________________.
• Specific______________________________________ will reacttocertainproteinsandtoxins.
• ______________________________________________ (majorhistocompatibilitycomplex)-
unique proteinsthatidentifyyoutohelpT cellsrecognize foreigninvaders.

4. • Major roadblockto ______________________________________________.
• Antigensinduce plasmacellsto ___________________________________________ called
antibodies againstthem.
• The antibodyfitsagainstthe ______________________________________________ on the
surface of the microbe.
• Antibodiesbelongtoa groupof proteinscalled
______________________________________________________.
• Each has a distinctfunction andchemical structure.
T Cells
• The presence of ____________________________ informthe T cellstobeginattackbut it only
becomes________________________ once the foreignantigenbindswithit.
• _______________________________________ must ingestaforeignantigen,processitand
presentitto a T cell for recognition.
________________________________________________________________can do this.
• T cellsalsoneeda secondstimulatortopreventfalsealarms. ______________________ does
this.
• Once activated,the T cell _______________________ itself intoanarmy.
• Causesswollen_____________________.
3 Typesof T-cells
• HelperT cells __________________________________ ______________

5. • CytotoxicTcells __________________________________________ withprecision using
_____________________.
• MemoryT cells _________________________________________________.
B Cells
• Usuallystayin the __________________________.
• Secrete ______________________ once activatedbyT cellsandinterleukins.
• Can receive _____________________________ antigensbutrespondfastertoprocessedones
• Can become _______________ to respondtothe same antigeninthe future
AcquiredImmunity
• NaturallyAcquired
Active_________________________________________________________________________
______________________________________________________________________________.
• NaturallyAcquiredPassive-
______________________________________________________________________________
_________________________________________________________________________.
• ArtificiallyAcquiredActive-
______________________________________________________________________________
_________________________________________________________________________.

6. • ArtificiallyAcquiredPassive-
______________________________________________________________________________
_________________________________________________________________________.