First RCE Thematic Conference: Towards Achieving the SDGs 5-7 December 2017 Okayama, Japan

1. Towards further
multi-stakeholder partnerships
between
industry and academia for the SDGs.
Dean
Graduate School of Medicine,
Dentistry and Pharmaceutical Sciences
Okayama University
Yasutomo Nasu, M.D., Ph.D.
Challenges from Medical Fields

2. Okayama University Hospital

3. History of Okayama University…
Medical Training Place Sponsored by the Lord Okayama
Onchi School
The Third
Senior High School
Medical Faculty
The Sixth Higher School
Okayama Medical
College
Okayama Normal
School
Ohara Institute for Agricultural Research
Okayama Youth Normal School
Okayama
Agricultural College
Okayama University
1870
1874
1894
1900
1914
1922
1943
1944
1946
1949
National University Cooperation Okayama University2004
Okayama University (OU) Outlook
3

4. Okayama University
Graduate School
Since 1870
岡山大学病院
1921
Present
1884
Hospital Med. School

5. Departments
34 Clinical Departments
12 Dental Departments
Hospital Pharmacy
Department of Nursing
Department of Medical Technology
44 Central Clinical facilities

6. Staff & Hospital beds
Total
Psychiatric hospital bed 34
Infectious disease hospital beds 2
Beds for general patients 813
Total 849
【 Beds 】【 Staff 】
（as of April, 2016）
Administrative
staff
410
Dentist
199
Nurses
1054
Medical
Engineering staff
308
Doctor
589

8. Top five among national university hospital
Number of Operation (FY 2014)
Kyoto
Osaka
Kyushu

9. Top 10 University for Clinical Medicine
Oct 2015
Tokyo
Kyoto
Osaka
Tohoku
Keio
Tokyo M,D
Nagoya
Kyushu
Hokkaido

10. “Center of Excellence for Innovative Medical Technology”
Top Global University Project
Promotion to strengthen research universities
Acceleration of a translational research network
Creation of Innovative Medical Device as Japan Brands
Promotion of Clinical Study Core Hospital
Basic
research
Translational
Clinical
research
Okayama University was selected for the following 5 core national
projects and functions as a research institution which seamlessly links
basic research to clinical research.
Okayama University Hospital

12. Mid-West Japan area
(Chugoku & Shikoku)

13. Tottori
Shimane
Hiroshima
Ehime
Kagawa
Kochi
Hyogo Kyoto
Okayama
Clinical Research Network
（84 Affiliated Hospital with more than 250 beds）
Mid-West Japan Clinical Study Consortium
Yamaguchi

14. Chugoku-Shikoku Medical Network
OkayamaOkayama
Academic network among medical school

15. Tokyo Medical Univ.
Tohoku Univ.
Jikeikai Univ.
Kobe Univ.
Kitasato Univ.
Achievements of Okayama Univ. in Gene Therapy in Japan
The only institution that has completed multiple clinical protocols
p53
J Clin Oncol. 24:1689, 2006 Mol Ther.15:834, 2007
p53, lung ca. （First in Japan） HSV-tk, prostate ca. （First in Japan）
Okayama Univ. , with it’s management skills and revolutionary seeds, is the
leading institution in the field of cancer gene therapy and related TR in Japan
HSV-tk
March, 2001
March, 1999
Protocol planning
Application support
Share in the trials
Publications

16. Gene therapy protocols in Japan and Positioning of Okayama Univ.
6
11
50
5
0 (not done)
2
0 (Canceled)
5
22
9
10
3
5
4
0
1
No. of cases
RenalTokyo Univ. Hp.
1998
Arteriosclerosis Obliterans (ASO)Kyushu Univ. Hp.2005
Arteriosclerosis Obliterans (ASO)Anges-Mg
2003
Arteriosclerosis Obliterans (ASO)Osaka Univ. Hp.2001
2007
Advanced Parkinson diseaseJichi medical Univ. Hp.2006
Maligant melanomaShinshu Univ. Hp.
X-SCIDTohoku Univ. Hp.
ADA deficiency diseaseHokkaido Univ. Hp.
NeuroblastomaTokyo Univ. Hp.
Recurrent leukemia, prevent GVHD progressionTsukuba Univ. Hp.
2002
Advanced esophageal cancerChiba Univ. Hp.
Breast cancer, prevent myelosuppressionNational Cancer institute Hp.
Malignant gliomaNagoya Univ. Hp.2000
AIDS1997
ADA deficiency diseaseHokkaido Univ. Hp.1995
CompletionDiseaseInstitution
Takara-bio Recurrence Leukemia 1
2009
Tokyo Univ. Hp. Glioblastoma
National Cancer Center Hematopoietic malignancy
In practice
In practice
Mie Univ. Hp. Esophageal cancer In practice
Kyoto prefecture Univ. Hp Renal cell carcinoma
carcinoma
In practice
Tohoku Univ. Hp.
Tokyo Jikeikai Univ. Hp
Midori-Juji.
Okayama Univ. Hp.
○
9
3
1
2
Tokyo Med. Univ. Hp.
○
Prostate cancer Ad-HSV-tk
Okayama Univ. Hp. ○
×
×
○Kobe Univ. Hp. Prostate cancer Ad-HSV-tk 6
○
○
○
Kitasato Univ. Hp Prostate cancer Ad-HSV-tk 3
Okayama Univ. Hp. 10Advanced prostate cancer Ad-IL122008
Okayama Univ.Hp.
Advanced prostate cancer
Prostate cancer (Neoadjuvant) Jan.25 2011 On Going2011 Ad-REIC
Head and neck cancer Telomelysin (Oncolytic Adv)
Malignant Mesothelioma
Okayama Univ.Hp.
apvd IRB
apvd IRB
Most Active
Institution
In Japan
Asian Center
for Cancer
Gene
Therapy
Non small cell lung cancer Ad-p53 ○
Ad-REIC
Supported
by Okayama
Prostate cancer Ad-HSV-tk
Ad-HSV-tk
Ad-HSV-tk
×

18. Pre-IND meeting WashingtonD.C Nov.10.2009
Members from FDA
R.Rowenthal
TOMO
Simon J. Hall
Urology
Mt Sinai NY
Masami

19. REIC gene therapy trial in USA

20. Application of Ad-REIC against various solid tumors
Ad-SGE-
REIC
REICREIC
supported by MHLW
“Health Labour Sciences
Research Grant” (2011～)
Ad-SGE-REIC
Intratumoral Inj.
Evaluation system
for cancer vaccine
Advanced
Ad-REIC Vector
Malignant
Glioma
Liver Cancer,
Pancreatic
Cancer
Lung Cancer,
Malignant
Mesothelioma
Renal
Cancer
Prostate
Cancer

28. Okayama University Hospital Biobank
• Founded on Apr 2015
• Collecting fresh & high quality biospecimen
• Wealth of longitudinal clinical information with biospecimen
• Providing biospecimen to industry as well as academia

29. • For networking and sharing experience
• Began with 4 clinical biobanks
• First symposium on Oct 2015
• Many interests from industry, academia, and government
Clinical Biobank Study Group