The document describes the Toscana Life Sciences Foundation, which was established in Siena, Italy to support life sciences research and foster technology and industry development in the Tuscan region. The Foundation operates a bio-incubator facility that provides lab and office space, equipment, services and consulting to startup companies. The bio-incubator has selected and supported several early-stage life sciences companies conducting research in areas such as oncology, neuroscience and infectious diseases.

1. www.toscanalifesciences.org

2. TLS Foundation Toscana Life Sciences Foundation was established in Siena two years ago by different public and private subjects, with the aim of supporting research activities in the field of life Sciences and, in particular, fostering the development of projects from basic research to industrial application in the field of Life Sciences The TLS final mission is to trigger the technological and industrial development and improve job and wealth creation in the Tuscan Region

3. TLS mission Toscana Life Sciences Regional Universities Public Administration Local Financial Institutions Strengthening the value of research Territory Industrial development

4. Founders

5. Germano Carganico General Manager Andrea Paolini Administration Ilaria Niccolai Administrative Assistant Francesco Refi Infrastructures/ IT Francesco Maria Senatore Business Development Letizia Sensini Comunication Cristina Tinti Scientific Affairs Laura Salvini Technology Facilities TLS Foundation boards and staff Founders Board Executive Board Scientific Advisory Board

7. TLS project chronology December 2007 Other two companies move in December 2004 September 2005 December 2005 February 2006 July 2006 November 2006 March 2007 TLS foundation’s establishment TLS operations begin 1° Call for Incubation Restructuring of Bio-incubator starts First project selection The Bio-incubator is inaugurated First two companies start operations

9. TLS bio-incubator

18. First round financing

19. Second round financing Z- Cube

21. 19 Tuscany Cluster The cluster is home to: 19 Biotech companies,10 of which born since 2000 14 Global Biotech & Pharma research centers active in clinical trials 55 Biotech/Pharma locations of Manufacturing, Research and Administration 3 Universities areas (more than 7.600 graduates in technical e scientific fields in 2004) 78 Hospitals involved in clinical trial (with an average of 23 trials per organization) 1.029 Clinical trials (excluding phase I) conducted in the period 2000-2004 Total = 19 Number of Biotech Companies by Sector 2004 Tuscany: a strategic research location From “Invest in Tuscany – Biotechnology Report 2006” Territory : • Inhabitants: 3,6 millions • Population density: (163 inhabitants/ sq.km) • Surface 2.992 Km

24. The deal -flow International Call for Application Scouting Tight relationship with the TTO of the Tuscan universities project selection (quality as guiding criterion) Finding start up financing Business plan submission TLS Executive Board approval Incubation

27. TLS science park companies Externautics AxaPharm