Genopole is a biotechnology park and cluster located near Paris, France. It was established in 1998 to promote the creation and development of biotech companies through providing: - Office and lab space across 83,000 square meters - Shared technical platforms and equipment across 15 facilities - Business support services and incubation programs - Connections to nearby academic and research institutions Genopole has supported the growth of over 80 companies and projects, generating over 1,000 jobs and €207 million in funding. It aims to further strengthen the regional biotech cluster through expanding facilities like GMP production centers.

1. Promoting the creation, relocation and development of biotechcompanies

2. Genopole® : From a Bio-Park to a Bio-Cluster ... Companies Hospital University Research A continuum dedicated to Biotechnology

3. Genopole® : a Biopark fully integrated in the Medicen Paris Region Bio-cluster Non-Profitable Organisation Incorporated in 1998 Creation & Development of a Bio-Park : Companies & Research Labs 30 Km

4. Building the most favorable environment to develop Biotech companies… International Network Shared Technical platforms Incubation and development Programs Versatile Real Estate Offers and Services Clinical Network International Scientific environment Biotech Companies Pre seed Fund

5. 20 research labs, incl. 3 national-scale centres more than 900 scientists From most National Research Institutes CNRS, CEA, INSERM, INRA, … Genopole ® : A stimulating Collaborative Scientific & Education Environment Research Evry University and 3 engineer schools more than 12 000 students (34 % in wet sciences and engineering) and 400 professors Ambitious Integrative Programs iStem : Institute for Stem Cells (2005) iSSB : Institute for Systems and Synthetic Biology (2009) Institute for Biomaterials (2010)

6. Our facilities include space from “plug ‘n play” offices for entrepreneurs to customisedtenant lab & office spaces for 50 to 300 m² wet lab & office suites Fully equipped with benches, sinks, deionised water, autoclave, freezers, rt-PCR, … Genopole ® : more than 83 000 m² dedicated to the development of life science companies Incubator with shared laboratory equipment Offices fully furnished, Meeting rooms, ... Real Estate Business Center (20-50 m²): customized spaces / specific demand and lay out for 300 to 2 000 m² and more wet lab, L2 & office suites

7. Our facilities include space from “plug ‘n play” offices for entrepreneurs to customized tenant lab & office space Genopole®: more than 80 000 m² dedicated to the development of life sciences Real Estate

8. A new hospital is build on Genopole® campus Genopole ® : a new hospital and a center for clinical and translational research Latest & Largest General Hospital build in France 1 000 beds Opening May 2011 Genopole coordinates the construction of a center for clinical and translational research Clinical 3 000 m² New Approaches Opening late 2011

9. Genopole ® : a team dedicated to foster creation and development of biotech companies Incubation MarketCompet. Bus Dev A Team of 6 multidisciplinary Project Managers Combining solid complementary backgrounds in pre-incubation, IP, finance, valuations, biz. dev., fund raising, licensing, … Finance Science(s) IP Team Clinic&Reg Scale up 6420 Finance Science(s) MarketCompet Bus Dev IP Team Clinic&Reg Scale up 6420

10. Genopole provides a whole list of services dedicated to young biotech companies Genopole®: a list of services to foster the development of Biotech companies Senior administrative officers, Accounting, quality assurance, onsite IT network support, human resources management, electronic libraries,… Genopole subsidises an European Grant Service dedicated to SMEs ... Brings support to preparation and application phases but also in the management of funded project Bureau Europe Genopole® Incubation

11. G1J - Genopole pre-seed Life Sciences Capital Fund Genopole®: with G1J IdF access to a pre-seed Fund Initial Capital: 2.1 M€ - 16 privateinvestors Investment/project: 50 000 – 100 000 € « From 1st day to 1st round of financing » Allowsaccess to the Oseogrant system and to National, Regional& EU grants Equity raise: 6 M€ brings G1J to the Proof of Concept Fund level Investment/project: 300 000 – 500 000 € Incubation G1J - Genopole Regional Life Sciences Capital Fund

12. Genopole®: More than 80 currently incorporated companies and active projects … LTK Pharma NanoBH GlobalBioEnergy Texcell GENOPOLE ® ENTREPRISES in 2008 69 biotechcompanies 1023 FTE 207.81 M€ fundraised 144.11 M€ sales / 30 companies 670 granted/penting patents 28 productsfrom IND to Phase III &market

13. Genopole ® : State of the art shared technical platforms and equipment Infrastructures 15 Platforms/Equipments end 2009 Management : 13 public labs, 1 private and 1 Genopole Genopole investments ~ 20 M€ Headcount : 68 persons Cumulated surface ~ 4200 m 2 5 obtained national quality label 2 ISO 9001 v 2000 certification & 2 planned in 2009 more than 300 scientific publications 8 patents/licences Sharing expertise, skills and resources

14. Genopole ® : State of the art shared technical platforms and equipment Infrastructures CERFE and CERFAP(Animal facility) Cell and Small Animal Irradiator Imaging and cytometryplatform Bioinformatic annotation DNA chips production Mass spectrometryplatform Evr@Platform(augmented reality and virtualenvironment) Plant DNA Microarrayplatform Biophotonics Platform Structural Biology Platform (NMR, AFM) Transmission electronmicroscopy DNA and cells Bank HTS Platform Cellsorting station Incubatorsharedequipements 15 Platforms

15. Genopole ® : GMP production centers for drugs of the future Infrastructures The Present & the Future A GMP compliantbiomanufacturingcenter for proteins frommammaliancells (biotherapy, monoclonal antibodies) A GMP compliant viral vector bioproduction center (Genethon) A production centre of enzymes and biocatalysis for industrial use. A GMP biomanufacturing centre using alternative techniques : bacteria , yeast , plants … An GMPoligonucleotides production center in partnership A Laboratory to develop and optimise the best expression systems A centre for filling, packaging and delivering productsunder GMP compliant

16. Genopole ® : State of the art shared technical platforms and equipment Infrastructures 65 % of the companies use the platforms network (25% use more than 3 platforms) For 25% of the companies, the decision of location in Genopole is closely linked to the presence of specific platforms Platforms have significantly promoted the development of 50% of the companies 25% local / 25% regional & national / 25% European / 25% international Local opening for technical facilities (proximity effect) Research programs at National / European and International level Level of opening depends on Technical & Scientific expertise Services (originality, quality,…) Capacity of partnering (platform business dev., users networks) Platforms : a major leverage for business Genopole platforms : Opening from local to international level

17. Genopole manages an international network Genopole ® : an international network oriented to biotech companies with international Cies, pharma laboratories, foreign bioincubators and international venture capital institutions, Genopole is member of several European consortium with European bioparks International BioLink (FP5) Oxford, Munich, Cagliari, Jerusalem, Cardiff Natibs (FP6) Berlin, Barcelona, Karolinska, Tallinn, Tel Aviv, Inno CEBR (FP6) Cambridge, Oxford, Berlin, Munich, Heidelberg, Barcelona, Uppsala, Tallinn, Lyon Bio-CT (FP7) Torino, Cambridge (CEBR), Barcelona, Berlin, Debrecen &Inno

18. Genopole ® : 135 M€ invested from 1998 to 2008

19. Genopole ® : 135 M€ invested from 1998 to 2008

20. GENOPOLE - 1998 GENSET UNIVERSITY National Sequencing Center (GENOSCOPE) Biofords Consultants AFM / GENETHON INCUBATOR Evry in 1998 Neurotech Biotech Companies Academic Research

23. 20research labs - 900 jobs- 69 biotech companies – 1 000 jobs- A comprehensive 83 000 m² real estate offer A team dedicated to development Services and a Europe Grant service 16platforms and equipments CorbeilEvry Hospital & Clinical and Translational Research Center GMP Biomanufacturing Center opening soon and 4 others biomanufacturing project running Our achievements ...

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