CBCT is useful for maxillofacial diagnosis as it allows observation of cross-sectional changes with no geometric distortion and overcomes anatomical noise. It provides an accurate 3D representation of lesion extent, involvement of adjacent structures, and internal structures. CBCT has a sensitivity of 91% for bone carcinoma diagnosis, similar to MRI. It is optimal for diagnosing benign lesions due to its better spatial resolution, lower cost, and lower radiation dose compared to other imaging modalities. CBCT should be ordered after clinical examination if additional information is needed to aid diagnosis, and the appropriate scan volume and voxel resolution should be selected.