A case of chronic diarrhea secondary to Capillaria philippinensis in Occidental, Mindoro Philippines: a newly-diagnosed endemic area?
https://www.actamedicaphilippina.org/article/7208-a-case-of-chronic-diarrhea-secondary-to-capillaria-philippinensis-in-occidental-mindoro-possibly-a-newly-described-endemic-area
This document discusses diagnostic methods for intestinal nematodes, focusing on egg counting techniques and the Harada Mori filter paper strip culture technique. The Harada Mori technique involves smearing feces onto a filter paper strip, inserting it into a tube with water, and incubating for 10 days to allow nematode larvae to hatch and migrate up the strip. Examining the larvae allows identification of infections like hookworm, Strongyloides, or Trichostrongylus. While it can detect light infections, both pathogenic and non-pathogenic larvae may grow and require differentiation. Refrigerated samples cannot be used and handling requires caution to avoid infection.
This document discusses several nematode parasites that infect humans. It begins by providing background on the phylum Nematoda and describes the life cycle as including egg, larval and adult stages. It then classifies nematode parasites into those that infect the small intestine (Aphasmidia and Phasmidia classes) and those that infect the large intestine (Phasmidia class). Several key nematode species are described in detail, including Ascaris lumbricoides, Trichuris trichiura, hookworms (Necator americanus and Ancylostoma duodenale), Strongyloides stercoralis and Capillaria philippinensis. For each species, the
Rizal returned to the Philippines after five years abroad, despite warnings from friends about the controversy caused by his novel Noli Me Tangere. His reasons for returning included serving the Filipino people, observing the impact of his writings, operating on his mother's eyes, and inquiring about Leonor Rivera. Upon his return, he worked as a doctor in Calamba, where he treated patients for free or low fees. However, his novel remained banned and controversial, leading to investigations into his work and the agrarian system.
Rizal returned to the Philippines in 1887 after 5 years abroad to study medicine and serve his people. However, his novel Noli Me Tangere had angered the friars, so he was warned not to return. Nonetheless, he established a clinic in Calamba but faced threats due to his exposure of abuses on friar estates. He eventually left due to safety concerns for himself and his family, though it pained him to be away from serving his country.
The document summarizes information about the parasitic nematode Trichuris trichiura (whipworm) including its life cycle, morphology, pathology, treatment and distribution in humans. It causes whipworm infection in the large intestine. The adult worms penetrate the intestinal mucosa with their anterior ends and feed on blood. Heavy infections can cause hemorrhaging and prolapse of the rectum.
Schistosomiasis, also known as bilharzia or snail fever, is a disease caused by parasitic flatworms called blood flukes. It is a major public health problem in many parts of the developing world. Three main species infect humans - Schistosoma mansoni, S. haematobium, and S. japonicum. The parasites have complex life cycles involving freshwater snails and humans. Eggs produced by the parasites in human tissues cause inflammatory reactions that can damage organs. Symptoms depend on the infecting species but include abdominal pain, blood in urine or stool, and organ damage like liver fibrosis. Treatment involves praziquantel but prevention focuses on improving san
This document summarizes several important digenetic trematodes (flukes) that infect mammals in different organs. It describes the morphology, life cycles, pathology and epidemiology of liver flukes (Fasciola hepatica, Fascioloides magna), intestinal flukes (Fasciolopsis buski), lung flukes, and reproductive system flukes. Key details are provided for each fluke, including the definitive host, intermediate hosts, sites of infection, and symptoms caused.
This document discusses diagnostic methods for intestinal nematodes, focusing on egg counting techniques and the Harada Mori filter paper strip culture technique. The Harada Mori technique involves smearing feces onto a filter paper strip, inserting it into a tube with water, and incubating for 10 days to allow nematode larvae to hatch and migrate up the strip. Examining the larvae allows identification of infections like hookworm, Strongyloides, or Trichostrongylus. While it can detect light infections, both pathogenic and non-pathogenic larvae may grow and require differentiation. Refrigerated samples cannot be used and handling requires caution to avoid infection.
This document discusses several nematode parasites that infect humans. It begins by providing background on the phylum Nematoda and describes the life cycle as including egg, larval and adult stages. It then classifies nematode parasites into those that infect the small intestine (Aphasmidia and Phasmidia classes) and those that infect the large intestine (Phasmidia class). Several key nematode species are described in detail, including Ascaris lumbricoides, Trichuris trichiura, hookworms (Necator americanus and Ancylostoma duodenale), Strongyloides stercoralis and Capillaria philippinensis. For each species, the
Rizal returned to the Philippines after five years abroad, despite warnings from friends about the controversy caused by his novel Noli Me Tangere. His reasons for returning included serving the Filipino people, observing the impact of his writings, operating on his mother's eyes, and inquiring about Leonor Rivera. Upon his return, he worked as a doctor in Calamba, where he treated patients for free or low fees. However, his novel remained banned and controversial, leading to investigations into his work and the agrarian system.
Rizal returned to the Philippines in 1887 after 5 years abroad to study medicine and serve his people. However, his novel Noli Me Tangere had angered the friars, so he was warned not to return. Nonetheless, he established a clinic in Calamba but faced threats due to his exposure of abuses on friar estates. He eventually left due to safety concerns for himself and his family, though it pained him to be away from serving his country.
The document summarizes information about the parasitic nematode Trichuris trichiura (whipworm) including its life cycle, morphology, pathology, treatment and distribution in humans. It causes whipworm infection in the large intestine. The adult worms penetrate the intestinal mucosa with their anterior ends and feed on blood. Heavy infections can cause hemorrhaging and prolapse of the rectum.
Schistosomiasis, also known as bilharzia or snail fever, is a disease caused by parasitic flatworms called blood flukes. It is a major public health problem in many parts of the developing world. Three main species infect humans - Schistosoma mansoni, S. haematobium, and S. japonicum. The parasites have complex life cycles involving freshwater snails and humans. Eggs produced by the parasites in human tissues cause inflammatory reactions that can damage organs. Symptoms depend on the infecting species but include abdominal pain, blood in urine or stool, and organ damage like liver fibrosis. Treatment involves praziquantel but prevention focuses on improving san
This document summarizes several important digenetic trematodes (flukes) that infect mammals in different organs. It describes the morphology, life cycles, pathology and epidemiology of liver flukes (Fasciola hepatica, Fascioloides magna), intestinal flukes (Fasciolopsis buski), lung flukes, and reproductive system flukes. Key details are provided for each fluke, including the definitive host, intermediate hosts, sites of infection, and symptoms caused.
This document describes culture methods for cultivating various protozoan parasites. It discusses the purposes of culturing parasites, including for diagnostic, research, and teaching purposes. It provides examples of parasite species that can be cultured, such as Entamoeba histolytica, Giardia lamblia, and Plasmodium spp. The document outlines different types of culture media, including xenic, polyxenic, monoxenic, and axenic cultures. It also describes specific culture media and methods used for cultivating intestinal protozoa like amoebae, as well as haematozoan parasites including Leishmania and trypanosomes.
Stool Examination Abridged What A Medical Graduate Should KnowDr. Varughese George
The document provides information on stool examination for medical graduates. It discusses the advantages of stool examination in investigating gastrointestinal diseases such as detecting parasites, evaluating chronic diarrhea, dysentery, and identifying causative bacteria. It describes the collection and macroscopic examination of stool samples and preparation of slides for microscopic examination. The microscopic examination may reveal leukocytes, red blood cells, fat, meat fibers, and ova/cysts/trophozoites of parasites. Concentration techniques like sedimentation and floatation are used if parasites are present in low numbers. Common parasites like Entamoeba histolytica and Giardia intestinalis are also described.
Rizal returned to the Philippines in 1887 after studying in Europe for 5 years. He was warned not to return due to angering the friars with his novel Noli Me Tangere. In Calamba, he opened a medical clinic and school. However, the friars plotted against him due to his exposure of abuses on their estates. Amidst threats to his life, Rizal reluctantly left the Philippines again in 1888.
This document discusses Vibrio cholerae, the bacteria that causes cholera. It provides details on the identification and detection of virulence genes ctxA, tcpA, and OmpW in environmental V. cholerae strains isolated from a river in Iran that were non-O1 and non-O139. The study found that 4 out of 27 isolated V. cholerae strains contained the tcpA gene despite being non-toxigenic. It emphasizes the importance of identifying pathogenic strains and preventing the spread of cholera through proper water treatment and hygiene practices.
1. The document summarizes the order Cyclophyllidea, which includes medically important tapeworms. It describes key characteristics like hooks on the scolex and lateral genital pores.
2. It then discusses several tapeworm species that infect humans and other animals, including their life cycles and pathology. The beef tapeworm Taenia saginata and pork tapeworm T. solium can cause cysticercosis in humans.
3. The document also covers the hydatid tapeworms Echinococcus granulosus and E. multilocularis, which can form cysts in organs and cause hydatid disease in intermediate hosts like humans.
Mansonella perstans is a parasitic roundworm found primarily in tropical areas of Africa, South America, and the Caribbean. It lives in the body cavities of infected humans and is transmitted through the bites of Culicoides midges. The microscopic filarial worm causes the disease mansonellosis and typically does not cause severe symptoms, though some patients experience angioedema, fever, headaches or joint pain. Diagnosis involves examining blood samples under a microscope for the presence of microfilariae. Treatment options include albendazole, mebendazole, or combinations of diethylcarbamazine and mebendazole.
Rizal spent time in Biarritz, France in 1891 where he was warmly welcomed by the Boustead family who he was visiting. While there, he enjoyed the scenic beaches and spent time with Nelly Boustead, developing a romance. However, his marriage proposal to Nelly failed because he refused to convert from Catholicism to Protestantism as she demanded, and her mother also did not approve of Rizal. During his stay, Rizal finished writing the manuscript for his novel El Filibusterismo before departing for Paris.
This document summarizes the missing chapter "Elias and Salome" from Rizal's novel Noli Me Tangere. The chapter describes a conversation between Elias and his lover Salome, where Elias urges Salome to move away for her own safety since he is pursued by authorities. Though sad to leave their home, Salome agrees but asks Elias to remember her. The chapter provided background on minor characters and was removed by Rizal due to financial constraints in publishing costs.
Mansonella are filarial nematodes found in certain geographical areas. While usually not causing serious disease, they must be differentiated from other pathogenic microfilariae that occur in the same areas such as Wuchereria bancrofti, Loa loa, and Onchocerca volvulus. Mansonella streptocerca adults reside just under the skin and the microfilariae, which are unsheathed and non-periodic, can be found in the skin and blood. Manifestations of M. streptocerca can include pruritus, papular skin eruptions, and pigmentation changes with eosinophilia. Diagnosis is by identifying the microfilariae in skin sn
Special stains useful in Microbiology laboratory9925752690
This document provides information on various special stains used to identify microorganisms and cellular structures under the microscope. It discusses stains used for flagella, metachromatic granules, spirochetes, Chlamydia, rickettsia, and fungi. Specific stains covered include Wright's Giemsa, Gram, acid-fast, silver, toluidine blue, calcofluor white, acridine orange, auramine phenol, and lactophenol cotton blue. Procedures for each stain are provided along with what structures or organisms they help identify.
This document discusses procedures for staining tissue sections mounted on paraffin or celloidin slides. It outlines the general staining process which involves deparaffinization or clearing in xylene or alcohol, hydration in graded alcohols, and staining. Special considerations are given for staining celloidin sections which are soluble in alcohol. The process of collodionization is described as a way to reinforce sections mounted on paraffin ribbons that contain air bubbles, tears or inadequate infiltration.
Under Spanish colonial rule:
- The Spanish focused on Catholicism and expanding their Asian empire rather than practical economic development. As a result, the Philippines saw slow economic progress.
- Some economic changes introduced by Spain included a new land ownership system, tribute and forced labor policies, abolition of slavery, introduction of new crops and industries, and establishment of banks and trade networks.
- However, many Filipinos remained unhappy with Spanish taxation practices and oppression, which stunted greater economic growth and development under colonial rule.
RIZAL’S SECOND SOJOURN IN PARIS AND THE UNIVERSAL EXPOSITION OF 1889Claire Calli
Rizal spent his second sojourn in Paris during the Universal Exposition of 1889. Some key events included:
- The Exposition was held from May-October 1889 and attracted thousands of visitors to Paris.
- Rizal had difficulty finding affordable living quarters due to high demand.
- He participated in the International Art Competition but did not receive a prize, though his work was exhibited.
- Rizal founded three societies for Filipino students - Kidlat Club, Indios Bravos, and the mysterious R.D.L.M. Society.
- He continued writing for La Solidaridad and spent time with friends like the Venturas while studying languages.
Rizal moved to Madrid in 1890 to supervise legal cases against the Dominican landlords regarding the dispossession of his family's land in Calamba. He sought help from the Filipino colony and liberal Spanish newspapers, but the colonial government did nothing in response. Rizal had an aborted duel with Antonio Luna after Luna made disparaging remarks about Nellie Boustead. Leonor Rivera also informed Rizal of her upcoming marriage to an Englishman. Rivalry emerged between Rizal and Del Pilar as editor of La Solidaridad due to differing political views. After three days of voting, Rizal was elected as the Responsible leader to determine the newspaper's editorial policy.
Parasitology:
The Liver Flukes
Parasites: Fasciola species
Fasciola hepatica and Fasciola gigantica
Morphology Adult & Ova
Diagnostic Features
Diagnosis
Mode of Transmission
Disease Produced
Pathology and Symptomology
Incubation period
Life cycle
laboratory diagnosis
treatment
Prevention and control
Rizal visited the United States in 1888, arriving in San Francisco after a week-long quarantine for a cholera epidemic. He traveled across the American continent, impressed by its progress but critical of the lack of racial equality. Rizal then lived in London from 1888 to 1889, studying and annotating Morga's book on Philippine history. While in London, he received both good and bad news from the Philippines and grew as a leader of the Filipino community in Europe.
Rizal traveled extensively throughout East Asia, Europe, and the United States from 1888 to 1889. Some of the key places he visited included Hong Kong, Macao, Japan where he was impressed by Japanese culture, the United States where he was disturbed by racial discrimination, London where he lived for months, and Paris where he visited the 1889 World's Fair and the studio of his friend Juan Luna. Throughout his travels, Rizal keenly observed the people, culture, and politics of each place he visited and used his experiences to continue developing his ideas about reform and nationalism back in the Philippines.
Clonorchis sinensis, commonly known as the oriental liver fluke, is a parasite that infects the livers of humans. It is found primarily in Asia, where an estimated 30 million people are currently infected. People become infected by eating raw or undercooked freshwater fish that contain the parasite's larvae. The larvae hatch in the intestines and migrate to the bile ducts of the liver where they mature into adult flukes. Long-term infection can lead to liver inflammation, enlargement, and over time cirrhosis or cholangiocarcinoma if left untreated. Praziquantel is the drug of choice for treating infections.
A 41-year-old man from Occidental Mindoro, Philippines presented with chronic diarrhea lasting over a year. Stool analysis revealed multiple intestinal parasites including Capillaria philippinensis, Strongyloides stercoralis, Entamoeba histolytica, and Candida albicans. He was also diagnosed with pulmonary tuberculosis and tuberculosis colitis. Treatment with albendazole, metronidazole, diloxanide, fluconazole, and anti-tuberculosis drugs resolved his symptoms. This case highlights the need for repeated stool analysis when evaluating chronic diarrhea, as key parasites may only be detected after multiple tests. It also represents the first reported case of intestinal capillariasis from
This document describes the case of a 55-year-old man who experienced episodes of sweating, shortness of breath, and diarrhea for 10 months. Imaging showed a mass in his jejunum, which was resected and found to be a carcinoid tumor. Carcinoid tumors are often associated with heart lesions due to secretion of vasoactive substances. The expected heart lesion in this case would be carcinoid heart disease, characterized by plaque-like lesions in the heart valves.
This document describes culture methods for cultivating various protozoan parasites. It discusses the purposes of culturing parasites, including for diagnostic, research, and teaching purposes. It provides examples of parasite species that can be cultured, such as Entamoeba histolytica, Giardia lamblia, and Plasmodium spp. The document outlines different types of culture media, including xenic, polyxenic, monoxenic, and axenic cultures. It also describes specific culture media and methods used for cultivating intestinal protozoa like amoebae, as well as haematozoan parasites including Leishmania and trypanosomes.
Stool Examination Abridged What A Medical Graduate Should KnowDr. Varughese George
The document provides information on stool examination for medical graduates. It discusses the advantages of stool examination in investigating gastrointestinal diseases such as detecting parasites, evaluating chronic diarrhea, dysentery, and identifying causative bacteria. It describes the collection and macroscopic examination of stool samples and preparation of slides for microscopic examination. The microscopic examination may reveal leukocytes, red blood cells, fat, meat fibers, and ova/cysts/trophozoites of parasites. Concentration techniques like sedimentation and floatation are used if parasites are present in low numbers. Common parasites like Entamoeba histolytica and Giardia intestinalis are also described.
Rizal returned to the Philippines in 1887 after studying in Europe for 5 years. He was warned not to return due to angering the friars with his novel Noli Me Tangere. In Calamba, he opened a medical clinic and school. However, the friars plotted against him due to his exposure of abuses on their estates. Amidst threats to his life, Rizal reluctantly left the Philippines again in 1888.
This document discusses Vibrio cholerae, the bacteria that causes cholera. It provides details on the identification and detection of virulence genes ctxA, tcpA, and OmpW in environmental V. cholerae strains isolated from a river in Iran that were non-O1 and non-O139. The study found that 4 out of 27 isolated V. cholerae strains contained the tcpA gene despite being non-toxigenic. It emphasizes the importance of identifying pathogenic strains and preventing the spread of cholera through proper water treatment and hygiene practices.
1. The document summarizes the order Cyclophyllidea, which includes medically important tapeworms. It describes key characteristics like hooks on the scolex and lateral genital pores.
2. It then discusses several tapeworm species that infect humans and other animals, including their life cycles and pathology. The beef tapeworm Taenia saginata and pork tapeworm T. solium can cause cysticercosis in humans.
3. The document also covers the hydatid tapeworms Echinococcus granulosus and E. multilocularis, which can form cysts in organs and cause hydatid disease in intermediate hosts like humans.
Mansonella perstans is a parasitic roundworm found primarily in tropical areas of Africa, South America, and the Caribbean. It lives in the body cavities of infected humans and is transmitted through the bites of Culicoides midges. The microscopic filarial worm causes the disease mansonellosis and typically does not cause severe symptoms, though some patients experience angioedema, fever, headaches or joint pain. Diagnosis involves examining blood samples under a microscope for the presence of microfilariae. Treatment options include albendazole, mebendazole, or combinations of diethylcarbamazine and mebendazole.
Rizal spent time in Biarritz, France in 1891 where he was warmly welcomed by the Boustead family who he was visiting. While there, he enjoyed the scenic beaches and spent time with Nelly Boustead, developing a romance. However, his marriage proposal to Nelly failed because he refused to convert from Catholicism to Protestantism as she demanded, and her mother also did not approve of Rizal. During his stay, Rizal finished writing the manuscript for his novel El Filibusterismo before departing for Paris.
This document summarizes the missing chapter "Elias and Salome" from Rizal's novel Noli Me Tangere. The chapter describes a conversation between Elias and his lover Salome, where Elias urges Salome to move away for her own safety since he is pursued by authorities. Though sad to leave their home, Salome agrees but asks Elias to remember her. The chapter provided background on minor characters and was removed by Rizal due to financial constraints in publishing costs.
Mansonella are filarial nematodes found in certain geographical areas. While usually not causing serious disease, they must be differentiated from other pathogenic microfilariae that occur in the same areas such as Wuchereria bancrofti, Loa loa, and Onchocerca volvulus. Mansonella streptocerca adults reside just under the skin and the microfilariae, which are unsheathed and non-periodic, can be found in the skin and blood. Manifestations of M. streptocerca can include pruritus, papular skin eruptions, and pigmentation changes with eosinophilia. Diagnosis is by identifying the microfilariae in skin sn
Special stains useful in Microbiology laboratory9925752690
This document provides information on various special stains used to identify microorganisms and cellular structures under the microscope. It discusses stains used for flagella, metachromatic granules, spirochetes, Chlamydia, rickettsia, and fungi. Specific stains covered include Wright's Giemsa, Gram, acid-fast, silver, toluidine blue, calcofluor white, acridine orange, auramine phenol, and lactophenol cotton blue. Procedures for each stain are provided along with what structures or organisms they help identify.
This document discusses procedures for staining tissue sections mounted on paraffin or celloidin slides. It outlines the general staining process which involves deparaffinization or clearing in xylene or alcohol, hydration in graded alcohols, and staining. Special considerations are given for staining celloidin sections which are soluble in alcohol. The process of collodionization is described as a way to reinforce sections mounted on paraffin ribbons that contain air bubbles, tears or inadequate infiltration.
Under Spanish colonial rule:
- The Spanish focused on Catholicism and expanding their Asian empire rather than practical economic development. As a result, the Philippines saw slow economic progress.
- Some economic changes introduced by Spain included a new land ownership system, tribute and forced labor policies, abolition of slavery, introduction of new crops and industries, and establishment of banks and trade networks.
- However, many Filipinos remained unhappy with Spanish taxation practices and oppression, which stunted greater economic growth and development under colonial rule.
RIZAL’S SECOND SOJOURN IN PARIS AND THE UNIVERSAL EXPOSITION OF 1889Claire Calli
Rizal spent his second sojourn in Paris during the Universal Exposition of 1889. Some key events included:
- The Exposition was held from May-October 1889 and attracted thousands of visitors to Paris.
- Rizal had difficulty finding affordable living quarters due to high demand.
- He participated in the International Art Competition but did not receive a prize, though his work was exhibited.
- Rizal founded three societies for Filipino students - Kidlat Club, Indios Bravos, and the mysterious R.D.L.M. Society.
- He continued writing for La Solidaridad and spent time with friends like the Venturas while studying languages.
Rizal moved to Madrid in 1890 to supervise legal cases against the Dominican landlords regarding the dispossession of his family's land in Calamba. He sought help from the Filipino colony and liberal Spanish newspapers, but the colonial government did nothing in response. Rizal had an aborted duel with Antonio Luna after Luna made disparaging remarks about Nellie Boustead. Leonor Rivera also informed Rizal of her upcoming marriage to an Englishman. Rivalry emerged between Rizal and Del Pilar as editor of La Solidaridad due to differing political views. After three days of voting, Rizal was elected as the Responsible leader to determine the newspaper's editorial policy.
Parasitology:
The Liver Flukes
Parasites: Fasciola species
Fasciola hepatica and Fasciola gigantica
Morphology Adult & Ova
Diagnostic Features
Diagnosis
Mode of Transmission
Disease Produced
Pathology and Symptomology
Incubation period
Life cycle
laboratory diagnosis
treatment
Prevention and control
Rizal visited the United States in 1888, arriving in San Francisco after a week-long quarantine for a cholera epidemic. He traveled across the American continent, impressed by its progress but critical of the lack of racial equality. Rizal then lived in London from 1888 to 1889, studying and annotating Morga's book on Philippine history. While in London, he received both good and bad news from the Philippines and grew as a leader of the Filipino community in Europe.
Rizal traveled extensively throughout East Asia, Europe, and the United States from 1888 to 1889. Some of the key places he visited included Hong Kong, Macao, Japan where he was impressed by Japanese culture, the United States where he was disturbed by racial discrimination, London where he lived for months, and Paris where he visited the 1889 World's Fair and the studio of his friend Juan Luna. Throughout his travels, Rizal keenly observed the people, culture, and politics of each place he visited and used his experiences to continue developing his ideas about reform and nationalism back in the Philippines.
Clonorchis sinensis, commonly known as the oriental liver fluke, is a parasite that infects the livers of humans. It is found primarily in Asia, where an estimated 30 million people are currently infected. People become infected by eating raw or undercooked freshwater fish that contain the parasite's larvae. The larvae hatch in the intestines and migrate to the bile ducts of the liver where they mature into adult flukes. Long-term infection can lead to liver inflammation, enlargement, and over time cirrhosis or cholangiocarcinoma if left untreated. Praziquantel is the drug of choice for treating infections.
A 41-year-old man from Occidental Mindoro, Philippines presented with chronic diarrhea lasting over a year. Stool analysis revealed multiple intestinal parasites including Capillaria philippinensis, Strongyloides stercoralis, Entamoeba histolytica, and Candida albicans. He was also diagnosed with pulmonary tuberculosis and tuberculosis colitis. Treatment with albendazole, metronidazole, diloxanide, fluconazole, and anti-tuberculosis drugs resolved his symptoms. This case highlights the need for repeated stool analysis when evaluating chronic diarrhea, as key parasites may only be detected after multiple tests. It also represents the first reported case of intestinal capillariasis from
This document describes the case of a 55-year-old man who experienced episodes of sweating, shortness of breath, and diarrhea for 10 months. Imaging showed a mass in his jejunum, which was resected and found to be a carcinoid tumor. Carcinoid tumors are often associated with heart lesions due to secretion of vasoactive substances. The expected heart lesion in this case would be carcinoid heart disease, characterized by plaque-like lesions in the heart valves.
The document discusses two conditions: paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). PNH is a complement-mediated hemolytic anemia treated with the drug eculizumab, a C5a inhibitor. aHUS is a complement-mediated thrombotic microangiopathy that can cause stroke, heart attack, and kidney failure, and is also treated with eculizumab. The document asks the reader to identify PNH, aHUS, and the mode of action of eculizumab.
Challenges in management of peripartum cardiomyopathy with diuretic resistanc...iosrphr_editor
presentation: In this report we present a 30 years old female patient, Para 1 living 1, who was admitted one month ago with complaints of abdominal distension, lower limb swelling and difficulty in breathing that started worsening two weeks prior.12-lead ECG showed sinus tachycardia (100beats/min), low voltage and non-specific T inversion and flattening.Echocardiography showed dilated left ventricle (5.8cm) and left atrium (4.4cm), global hypokinesia with ejection fraction of 36% by biplane. Grade 1 diastolic dysfunction, no thrombus seenand Mild pericardial effusion.
Challenges in management of peripartum cardiomyopathy with diuretic resistanc...iosrphr_editor
Background: Peri-partum cardiomyopathy is an idiopathic cardiomyopathy that presents with heart failure secondary to left ventricle systolic dysfunction towards the end of pregnancy or in the months after delivery, in the absence of any other cause of heart failure.Approximately 75% of cases are diagnosed within the first month peri-partum, and 45% present in the first week. Case
The document summarizes several case studies of patients presenting with uncommon manifestations of common diseases:
1. A man with fatigue, rash and anal fistula was diagnosed with syphilis based on a positive RPR test.
2. A man with weight loss, cough and fever was initially treated for pneumonia but was ultimately diagnosed with acute pancreatitis based on elevated amylase and lipase levels.
3. A man with syncope was initially suspected to have seizures but autopsy revealed pulmonary embolisms, consistent with factor V Leiden deficiency found post-mortem.
4. A woman with Parkinson-like symptoms visiting from Paris after using ecstasy was found to have a meningi
- The 77-year old female patient was admitted to the hospital for vomiting blood and abdominal pain. She suffered from multiple comorbidities and underwent several surgeries previously.
- During her 13-day hospital stay, she developed several complications including ileus, sepsis, pneumonia, and small bowel obstruction. Her condition continued to decline despite treatment.
- She passed away after being placed on comfort care measures only. Her complex medical history and multiple postoperative complications ultimately led to her death.
Hypokalemic Periodic Paralysis A Case Reportijtsrd
"Hypokalemic periodic paralysis HPP is a medical emergency with prevalence of 1 in 100,000 . Rapid management is very important since, very low potassium levels can lead to cardiac complications . In this case, a twenty four year old female without a similar history in the family, having hypokalemia periodic paralysis attack is presented. This case report study has been presented for the consideration of the rare HPP in patients presenting with sudden muscle weakness. Blessy Rachal Boban | Cillamol K. J | Elena Cheruvil | Sheffin Thomas | Tony Abraham ""Hypokalemic Periodic Paralysis: A Case Report"" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-3 , April 2019, URL: https://www.ijtsrd.com/papers/ijtsrd21658.pdf
Paper URL: https://www.ijtsrd.com/pharmacy/pharmacy-practice/21658/hypokalemic-periodic-paralysis-a-case-report/blessy-rachal-boban"
1. The patient is exhibiting signs and symptoms consistent with Kawasaki disease, including prolonged fever, oral ulcers, conjunctivitis, rash, lymphadenopathy, and extremity changes.
2. Kawasaki disease does occur in Egypt, with an estimated 280 cases diagnosed annually.
3. Treatment for Kawasaki disease involves intravenous immunoglobulin and aspirin to prevent coronary artery aneurysms, which develop in around 25% of untreated patients.
A 25-year-old female presented with abdominal pain, repeated fits and profuse vaginal bleeding after delivering a dead baby at home. She was diagnosed with HELLP syndrome based on her symptoms and lab results. She was treated aggressively in the intensive care unit with magnesium sulfate to control seizures, blood transfusions, evacuation of retained placenta, antihypertensives, and hemodialysis. Her condition improved over several days and she was discharged after 10 days on oral medications. The case illustrates the importance of early detection and rapid treatment by a multidisciplinary team for successful management of HELLP syndrome.
Case presentation on AUTOIMMUNE HEP final.pptxZairaHussain6
This document describes a case of an 11-year-old female child presenting with abdominal distension and blood in stool. Various tests were performed and findings were consistent with cirrhosis of the liver with portal hypertension. Further workup revealed positive ANA and ASMA antibodies, consistent with a diagnosis of autoimmune hepatitis. Autoimmune hepatitis is a chronic disease of unknown cause characterized by liver inflammation and necrosis that can progress to cirrhosis. It has two main types and is diagnosed based on elevated enzymes, antibodies, and histopathology. Treatment involves immunosuppression with steroids and medications, with the goal of achieving remission though relapse is common.
Except in association with molar or hydropic degeneration of the placenta, with or without a coexistent fetus, eclampsia before 20 weeks of gestation is rare and only few cases have been described. The case reported was that of a 24 year old primipara who had tonic-clonic seizures at 19 weeks gestation without prior Preeclampsia. She remained stable and was managed closely up to 36 weeks gestation. She had spontaneous vaginal delivery of a live baby at 38 weeks with good outcome. Atypical eclampsia may develop before 20 weeks of gestation and could pose serious management challenges. Such patients if carefully selected and closely monitored may have satisfactory outcome. This case deserves reporting because of its rare nature as several literature search did not reveal any reported case of eclampsia before 20 weeks that was successfully managed to term.
A 74-year-old male was admitted to the hospital after suffering an acute cerebral vascular accident (stroke). He has a history of depression, prior strokes, and his daughter is in hospice care. Upon admission, diagnostic testing revealed evidence of old strokes and significant intracranial atherosclerotic disease. The patient's nursing care plan focuses on improving mobility to prevent complications, addressing feelings of hopelessness through communication and support, and helping with communication challenges due to his stroke through slow, clear speech and allowing time to respond.
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Capillaria philippinensis in Occidental Mindoro, Philippines
1. Chronic Diarrhea from Capillaria philippinensis in Mindoro
81VOL. 46 NO. 3 2012 ACTA MEDICA PHILIPPINAVol. 43 N0. 4 2009 ACTA MEDICA PHIlIPPINA 13
Heart Failure and Short Stature in a 43 year-old male
transferred to the intensive care unit (ICU) for ventilatory
supportandclosermonitoring.onbedsidecardiacultrasound,
there was a finding of eccentric left ventricular hypertrophy,
global hypokinesia with depressed overall systolic function
withconcomitantspontaneousechocontrastonleftventricular
(lV) cavity suggestive of rheologic stasis, the ejection fraction
was 25%, with moderate mitral regurgitation, moderate
aortic regurgitation with aortic sclerosis, severe tricuspid
regurgitation with mild pulmonary hypertension, pulmonary
regurgitation, and minimal pericardial effusion or pericardial
fat pad. Cardiac enzymes were not consistent with an acute
coronary event (Table 3), however, intravenous (IV) heparin
(overlapping with oral warfarin) was still given to cover for
the presence of a possible lV thrombus as demonstrated
by rheologic stasis on cardiac ultrasound. Medications
were shifted to IV diuretics and inotropes; oral digoxin was
started. IV antibiotics were given for possible pulmonary
infection. The patient later on showed improvement, and was
eventually weaned off from ventilatory support, extubated,
Table 1. Initial laboratory Results
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
RDW
PlT
RETIC
SEG
lYMPH
MoNo
Eo
BASo
BlAST
CBC
Reference
Value
5-10
4-6
120-150
0.38-0.48
80-100 Fl
27-31 PG
320-360 G/l
11.5-15.5%
200-400
0.005-0.015
50-70%
20-44%
2-9%
0-4%
0-2%
0%
Result
4.5
90
0.27
Inc
48
50
2
0
0
0
RBS
HGBA1C
BUN
CREA
AlB
TAG
HDl
lDl
ToTAl CHol
AST
AlT
Alk po4
NA
K
Cl
CA++
P
MG++
Reference
Value
3.9-6.1
4.27-6.07
2.6-6.4
53-115
34-50
0.34-1.7
0.91-1.56
1.1-3.8
4.2-5.2
15-37
30-65
140-148
3.6-5.2
100-108
2.12-2.52
0.74-1
Result
6.3
6.4
5.0
123
32
0.82
0.67
4.21
5.25
95
91
184
136.9
3.35
86
2.37
2.27
0.83
Blood chem.
Color
Transp
Sp Gravity
pH
Sugar
Protein
RBC
WBC
Cast
Epith cell
Bacteria
Mucus th
Crystals
Am urates
straw
Clear
1.010
8.0
NEG
NEG
0-1
0-2
Rare
occ’l
Rare
Rare
Urinalysis
pH
pCo2
po2
HCo3
o2 sat
Fio2
Temp
7.408
49.1
70
31.3
93.6
21%
36.9
ABG
PBS
Slight poikilocytosis,
acanthocytes, ovalocytes,
slight toxic granulation,
slight anisocytosis
Table 2. Thyroid Function Tests
Free T4
TSH
(0.8-2.0)
(0.4-6.0)
0.02 ng/dl
24.75 Uiu/ml
Reference Value Result
Figure 1. Electrocardiogram upon admission
Table 3. Cardiac Enzymes
Qualitative
Troponin I
CK-MB
CK-ToTAl
0-6.0
21-232
PoSITIVE
1.14
543
Reference Range (mmoL) Result
Figure 2. Chest radiograph on admission
_______________
Corresponding author: Mary Ondinee U. Manalo, MD
Department of Medicine
Philippine General Hospital
University of the Philippines Manila
Taft Avenue, Ermita, Manila 1000 Philippines
Telephone: +632 8062209 / 0923 6503548
Email: marymanalo_md@yahoo.com
A Case of Chronic Diarrhea Secondary to Capillaria philippinensis in
Occidental Mindoro: Possibly a Newly-Described Endemic Area?
Mary Ondinee U. Manalo,1 Virgilio P. Bañez2 and Vicente Y. Belizario, Jr.3,4
1Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila
2Section of Gastroenterology, Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila
3National Institutes of Health, University of the Philippines Manila
4Department of Parasitology, College of Public Health, University of the Philippines Manila
Introduction
Intestinal capillariasis or capillariasis philippinensis is
caused by a small nematode known as Capillaria
philippinensis. Symptoms of this illness are diarrhea,
borborygmi, and abdominal pain. This helminthic infection
was virtually unknown until 1963 when Chitwood reported
the first case, a schoolteacher from Bacarra, Ilocos Norte. He
had a history of intractable diarrhea for 3 weeks with ascites,
emaciation and cachexia and later died at the Philippine
General Hospital in Manila.1,2
In the 1960s, a capillariasis outbreak occurred in
Tagudin, Ilocos Sur where almost a hundred died.3 Another
epidemic was recorded in Southern Leyte in the Philippines
in the early 1980s.4 In the recent past, this parasite was also
isolated in Compostela Valley Province2 and Zamboanga del
Norte in Western Mindanao.5
We present a case of chronic diarrhea secondary to
multiple enteric pathogens, including Capillaria philippinensis
in Occidental Mindoro, a possible newly-described endemic
area.
Case
A 41-year-old male from the town of Alacaak, Sta. Cruz,
Occidental Mindoro presented with a one-year history of
colicky abdominal pain and watery diarrhea. Multiple
consults were done in their region that revealed
“unremarkable fecalyses”. He was given various antibiotics
but this did not resolve his symptoms.
Six months prior to admission, four men in their
barangay died from chronic diarrhea and this prompted the
patient to seek consult in Manila. He was admitted in a
private hospital for work-up where fecalysis again was
“unremarkable”, abdominal CT that revealed no masses,
and colonoscopy with biopsy that revealed mild nonspecific
colitis. During this time, the patient had lost more than a
third of his weight and developed bipedal edema. Patient
was repeatedly readmitted but no definite diagnosis was
established. He was never febrile.
The patient had a history of pulmonary tuberculosis
treated for only a week. He was fond of eating dogs and
kilawin. He knew the four people who died in their locality.
He admitted to having been in a drinking binge with at least
one of them and ate kilawin during their binges. He worked
as a farmer, as a fisherman, and as a tricycle driver. He
would catch fish in Pagbahan River, but would sometimes
buy from the local market. No other family member
presented with diarrhea. He had no history of travel.
The patient presented at the Emergency Room of the
Philippine General Hospital severely emaciated, unable to
ambulate and with palpatory BP (Figure 1). He weighed 42
kilograms (BMI=16), with bronchovesicular breath sounds,
normal cardiac rate and regular rhythm, scaphoid abdomen
which was normoactive, grade 2 bipedal non-pitting edema,
and unremarkable digital rectal exam. Neurologic findings
were normal. He was hydrated and started on inotropes.
Initial investigations revealed the following: severe
hypoalbuminemia (2g/L) with no proteinuria, hemoglobin
142g/L, wbc 7.4 x 109/L (neut 0.64 lymph 0.32 eos 0.013), and
low electrolytes (sodium, potassium, calcium, magnesium,
and phosphorus). He had normal creatinine, bilirubins, and
liver enzymes. His ECG had low voltage complexes. His
initial stool examination showed abundant white blood
cells, without any RBC, fat globules, ova, or parasites. Fecal
CASE REPORT
2. Chronic Diarrhea from Capillaria philippinensis in Mindoro
82 VOL. 46 NO. 3 2012ACTA MEDICA PHILIPPINA Vol. 43 N0. 4 200912 ACTA MEDICA PHIlIPPINA
Heart Failure and Short Stature in a 43 year-old male
Katerina T. leyritana1
, Ma. Czarlota M. Acelajado-Valdenor1
, Amado o. Tandoc III2
and Agnes D. Mejia1
1
Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila
2
Department of Pathology, College of Medicine, University of the Philippines Manila
CASE REPORT
Corresponding author: Ma. Czarlota Acelajado-Valdenor, M.D.
Department of Medicine
Philippine General Hospital
Taft Avenue, Manila, 1000 Philippines
Telephone: +632 554-8488
Email: czarlota@yahoo.com
Presentation of the case
This is a case of a 43-year-old male presenting with short
stature and heart failure. The patient was admitted at the
medicine ward of the Philippine General Hospital (PGH)
for dyspnea. This paper will investigate several issues:
differentiating congenital from acquired hypothyroidism,
the relationship between hypothyroidism and the
cardiomyopathies, and the therapeutic options in patients
with cardiomyopathy secondary to hypothyroidism.
The patient had been born full term to a then 31-year-
old Gravida 4 Para 3 (G4P3), the 4th
of 9 siblings, with an
apparently unremarkable delivery at home facilitated by
a traditional birth attendant. He was noted to be normal
at birth. The patient was allegedly at par with age both
physically and mentally until eight years old when he was
said to have stopped growing in height. He was brought to
a private doctor, whose diagnosis was undisclosed, and he
was given medications to increase height, which the patient
took for only one month with no improvement. Through the
years, the patient was apparently well, although still of short
stature, with thick lips, coarse facial features and dry skin.
He was notably slow in ambulation. He was said to have
bronchial asthma at age 15 years, and since then he had been
taking salbutamol tablets occasionally for bouts of dyspnea
occurring one to two times annually.
The patient’s symptoms started in 2001 when he was
reported to have sudden loss of consciousness. During this
time, the patient did not have any symptoms of heart failure;
no prior seizures, cyanotic episodes, chest pain, headache, or
blurring of vision. He regained consciousness shortly after and
was brought to a private physician, whose assessment was a
“heart problem”. He was prescribed unrecalled medications
taken for a few months and eventually discontinued when
the syncopal episode did not recur.
In the next four years, the patient would develop
intermittent, progressive exertional dyspnea and bipedal
edema. later on this would be accompanied by generalized
body weakness, anorexia, and constipation, severe enough to
require regular laxative use. There was also a report of two
more syncopal episodes. He was brought to another doctor
in a private hospital where the assessment was still a “heart
problem”. The patient was again prescribed unrecalled
medications and again was lost to follow-up. This time,
however, symptoms were persistent. He later consulted at
another local hospital, where he was admitted and managed
as a case of anemia and bronchial asthma. He was discharged
slightly improved after four days, only to have recurrent heart
failure symptoms, prompting admission at PGH.
Upon admission the patient was in mild respiratory
distress, with stable vital signs and no note of fever. Pertinent
physical exam findings included short stature, thick lips, non-
pitting periorbital edema, dry skin, a displaced apical impulse,
crackles on both lung fields, and bilateral non-pitting bipedal
edema. There was also a 3 cm x 3 cm reducible umbilical
hernia. However, there was no pallor, no neck vein distention,
no apparent congenital malformations, no cardiac murmurs
and no clubbing. There was also no note of an anterior neck
mass.
laboratoryworkupshowedcardiomegalywithpulmonary
congestion,thoracicdextroscoliosis,andatheromatousaortaby
chest radiograph, and left ventricular hypertrophy by 12-lead
electrocardiogram (12-l ECG) (Figures 1 and 2), normocytic
normochromic anemia (Hgb 90 mg/dl), dyslipidemia, and
pre-renal azotemia (serum creatinine 123 mmol). Electrolytes
on admission showed slight hyponatremia, hypokalemia,
and hypochloremia (serum Na 136, K 3.35, Cl 86). Blood gases
revealed partially compensated metabolic alkalosis with mild
hypoxemia. The patient was noted to be hypothyroid based
on elevated serum thyroid-stimulating hormone (TSH) and
markedly decreased serum free thyroxine (FT4). The exact
values are shown in Tables 1 and 2.
Upon admission to the wards, the patient was managed
as having congestive heart failure from cardiomyopathy
secondary to acquired hypothyroidism. oral loop diuretics,
angiotensin-converting enzyme (ACE) inhibitors, beta-
blockers, statins, and levothyroxine were started. Electrolyte
correction was instituted. The sections of Endocrinology
and Cardiovascular Diseases were co-managing the patient
together with the General Medicine service.
He soon developed respiratory failure, upon which the
considerations were acute pulmonary congestion, nosocomial
pneumonia, to rule out an acute coronary event. He was later
occult blood was likewise negative. Investigations for
pulmonary tuberculosis including a chest film and sputum
AFB were normal. No enteric pathogen was isolated on
initial stool culture. Stool was sent to the College of Public
Health for FECT which revealed no parasites. A 2D-echo
was requested to rule out a cardiogenic cause for the shock
and it revealed a small pericardial effusion with an ejection
fraction of 33%.
Figure 1. Appearance of the patient prior to treatment
(BMI=16 kg/m2).
Since no enteric pathogen was initially isolated, the
investigator initially pursued work-up for non-infectious
causes like malabsorption syndromes, irritable bowel
disease, malignancy, adrenal insufficiency,
hyperthyroidism, and carcinoid. Infectious causes were
likewise pursued. Cortisol (560 pmol/L) and thyroid
function tests were both normal. Irritable bowel disease and
malignancy were ruled out because of the CT scan and the
colonoscopy findings. Another stool culture was done and
this revealed growth of Candida species. Salmonella IgG/IgM
were non-reactive. HIV screening was negative. Stool AFB
was +1 on day 1 and day 2. However, the investigator was
not entirely convinced that this was just TB and stool was
sent almost every day for fecalysis.
The patient was on inotropes and colloids during the
first week of his admission. He was placed on nothing per
orem, except medications, to allow time for the patient’s
intestinal villi to regenerate. Gastroenterology consult was
sought and the patient was treated as if he had short gut
syndrome. He was started on ranitidine, loperamide, and
racecadotril. Fluconazole and Category I TB treatment were
started as well. He was placed on total parenteral nutrition.
By the end of the second week, patient was off inotropes
and was started on clear liquids. When this was tolerated,
he was started on elemental feeding.
However, diarrhea persisted. By the third week, serial
fecalyses revealed the presence of the following: Entamoeba
histolytica cysts, Strongyloides stercoralis adult and
rhabditiform larvae. First line treatment for strongyloidiasis
is Ivermectin but this was not available in the Philippines.
Second line drug is albendazole 400 mg bid x 5 days every 2
weeks x 2 cycles and this was started on the patient the
same day. Since the patient had been treated multiple times
for amoebiasis, diloxanide furoate, a luminal agent, was
added on top of metronidazole.
The next stool sample had suspected Capillaria
philippinensis ova, which were atypical because they did not
possess bipolar plugs. Another stool sample was sent the
following day and the diagnosis of capillariasis was
established when it revealed typical Capillaria ova with
bipolar plugs (Figure 2). The patient was then treated with
the following drugs: albendazole 400 mg bid x 10 days then
repeated after 2 weeks (this covered for both C. philippinensis
and S. stercoralis); metronidazole 500 mg tabs q6 x 14 days;
diloxanide furoate 500 mg tab tid x 14 days; fluconazole 200
mg cap x 10 days; and quadruple anti-Koch’s. By this time,
the chronic diarrhea of the patient was attributed to: 1.) TB
colitis, 2.) C. philippinensis, 3.) S. stercoralis, 4.) E. histolytica,
and 5.) C. albicans.
Figure 2. C. philippinensis ova recovered from the stool of the
patient.
Three days after being given those drugs, diarrhea
resolved. A repeat 2D-Echo showed an improved ejection
fraction of 72%, consistent with nutritional cardiomyopathy.
After another week, the patient was discharged wheelchair-
borne. He was educated on how he acquired his illness.
Avoidance of eating raw fish and walking barefooted was
emphasized. A month after, the patient followed up
weighing 49 kg (Figure 3). He was already ambulant and
had good appetite. Albumin improved from 2 g/L to 24 g/L
after just one month. Repeat FECT revealed no organisms.
By the time he completed his 6 months of anti-Koch’s, he
was already back in Occidental Mindoro where he now
drives his tricycle for a living.
3. Chronic Diarrhea from Capillaria philippinensis in Mindoro
83VOL. 46 NO. 3 2012 ACTA MEDICA PHILIPPINAVol. 43 N0. 4 2009 ACTA MEDICA PHIlIPPINA 13
Heart Failure and Short Stature in a 43 year-old male
transferred to the intensive care unit (ICU) for ventilatory
supportandclosermonitoring.onbedsidecardiacultrasound,
there was a finding of eccentric left ventricular hypertrophy,
global hypokinesia with depressed overall systolic function
withconcomitantspontaneousechocontrastonleftventricular
(lV) cavity suggestive of rheologic stasis, the ejection fraction
was 25%, with moderate mitral regurgitation, moderate
aortic regurgitation with aortic sclerosis, severe tricuspid
regurgitation with mild pulmonary hypertension, pulmonary
regurgitation, and minimal pericardial effusion or pericardial
fat pad. Cardiac enzymes were not consistent with an acute
coronary event (Table 3), however, intravenous (IV) heparin
(overlapping with oral warfarin) was still given to cover for
the presence of a possible lV thrombus as demonstrated
by rheologic stasis on cardiac ultrasound. Medications
were shifted to IV diuretics and inotropes; oral digoxin was
started. IV antibiotics were given for possible pulmonary
infection. The patient later on showed improvement, and was
eventually weaned off from ventilatory support, extubated,
Table 1. Initial laboratory Results
WBC
RBC
HGB
HCT
MCV
MCH
MCHC
RDW
PlT
RETIC
SEG
lYMPH
MoNo
Eo
BASo
BlAST
CBC
Reference
Value
5-10
4-6
120-150
0.38-0.48
80-100 Fl
27-31 PG
320-360 G/l
11.5-15.5%
200-400
0.005-0.015
50-70%
20-44%
2-9%
0-4%
0-2%
0%
Result
4.5
90
0.27
Inc
48
50
2
0
0
0
RBS
HGBA1C
BUN
CREA
AlB
TAG
HDl
lDl
ToTAl CHol
AST
AlT
Alk po4
NA
K
Cl
CA++
P
MG++
Reference
Value
3.9-6.1
4.27-6.07
2.6-6.4
53-115
34-50
0.34-1.7
0.91-1.56
1.1-3.8
4.2-5.2
15-37
30-65
140-148
3.6-5.2
100-108
2.12-2.52
0.74-1
Result
6.3
6.4
5.0
123
32
0.82
0.67
4.21
5.25
95
91
184
136.9
3.35
86
2.37
2.27
0.83
Blood chem.
Color
Transp
Sp Gravity
pH
Sugar
Protein
RBC
WBC
Cast
Epith cell
Bacteria
Mucus th
Crystals
Am urates
straw
Clear
1.010
8.0
NEG
NEG
0-1
0-2
Rare
occ’l
Rare
Rare
Urinalysis
pH
pCo2
po2
HCo3
o2 sat
Fio2
Temp
7.408
49.1
70
31.3
93.6
21%
36.9
ABG
PBS
Slight poikilocytosis,
acanthocytes, ovalocytes,
slight toxic granulation,
slight anisocytosis
Table 2. Thyroid Function Tests
Free T4
TSH
(0.8-2.0)
(0.4-6.0)
0.02 ng/dl
24.75 Uiu/ml
Reference Value Result
Figure 1. Electrocardiogram upon admission
Table 3. Cardiac Enzymes
Qualitative
Troponin I
CK-MB
CK-ToTAl
0-6.0
21-232
PoSITIVE
1.14
543
Reference Range (mmoL) Result
Figure 2. Chest radiograph on admission
Figure 3. The patient after treatment (BMI=20 kg/m2).
Discussion
Capillariasis is a parasitic disease caused by infection
with any of the four Capillaria species found to infect
humans: Capillaria hepatica, C. aerophila, C. plica, and C.
philippinensis.3 Capillaria philippinensis inhabits the small
bowel of humans, causing mostly diarrhea and
malabsorption. The life cycle is incompletely understood,
although freshwater fish contain larvae infectious for
humans and birds. The latter is an important reservoir host,
especially migratory birds that could drop their feces in any
body of water. Laboratory examinations document the
typical findings of protein-losing enteropathy,
malabsorption, and electrolyte loss. The diagnosis is
established by detecting characteristic ova or larvae in the
stool. In untreated patients, mortality rate is 33%, but
specific anti-helminthic therapy is effective and life-saving.
Infection is prevented by eating only properly cooked
freshwater fish.6
C. philippinensis was first reported in 1963 in Bacarra,
Ilocos Norte Province and has been endemic in that area
ever since, particularly in Pudoc Lake where it was isolated.1
Since then, additional endemic foci of C. philippinensis have
been identified in Southern Leyte,3 in Compostela Valley, in
Southern Mindanao,2 and in Zamboanga del Norte, Western
Mindanao.5
To date, this is the first reported case of intestinal
capillariasis from Occidental Mindoro, an island bounded
by the Mindoro Strait and the Mamburao reef (Figure 4).
There are 11 barangays in Sta. Cruz, and in Alacaak, where
the patient resides, there is a freshwater reservoir called the
Pagbahan River where he sometimes catches fish. People
here are fond of eating kilawin, which is raw fish soaked in
vinegar and seasoning.
The lacustrine goby or dulong (Gobiopterus lacustris)
and the Philippine anchovy or bolinaw (Encrasicholina
oligobranchus) are the two most common species eaten raw
in their locality because they are cheap. In fact, they are
sometimes called the “poorman’s fish”. However, when
there is a festivity, they would sometimes use chopped
and pounded milkfish (Chanos chanos) or tanigue
(Acanthocybium solandri) in their kilawin. Any of these species
of fishes could have been harboring the infective larvae and
could have been ingested by migratory birds as the
definitive host or by men as the accidental host.
Figure 4. The Municipality of Sta. Cruz, Occidental Mindoro
(Source: www.wikipilipinas.org, reproduced with
permission).
According to the patient, people living here have water-
sealed toilets, although he is aware of some families using
pit privies. He also attested that some people in their locality
resort to open and indiscriminate defecation. Children
sometimes defecate near the shoreline when they are
playing and swimming.
In this case, we believe that the patient may be an
“indigenous case” in that he acquired his infection from his
locality (rather than an “imported case”, where a patient got
the infection from an already established endemic area). He
had no history of travel, and there were already 4 deaths in
their area attributed to diarrhea secondary to an
undetermined cause. Since migratory birds are in part
responsible for dissemination, the bodies of water
surrounding Sta. Cruz may have been part of their usual
stops. The cycle of fish eating infected feces, then man eating
infected fish could have easily been perpetuated in this area
because eating raw fish is a common practice. Furthermore,
since open and indiscriminate defecation has been described
by the patient, fish eating not just infected bird feces, but
infected human feces as well, could have been part of the
cycle.
This case presented with diagnostic difficulties since the
patient presented with almost a year of “unremarkable”
4. Chronic Diarrhea from Capillaria philippinensis in Mindoro
84 VOL. 46 NO. 3 2012ACTA MEDICA PHILIPPINA Vol. 43 N0. 4 200912 ACTA MEDICA PHIlIPPINA
Heart Failure and Short Stature in a 43 year-old male
Katerina T. leyritana1
, Ma. Czarlota M. Acelajado-Valdenor1
, Amado o. Tandoc III2
and Agnes D. Mejia1
1
Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila
2
Department of Pathology, College of Medicine, University of the Philippines Manila
CASE REPORT
Corresponding author: Ma. Czarlota Acelajado-Valdenor, M.D.
Department of Medicine
Philippine General Hospital
Taft Avenue, Manila, 1000 Philippines
Telephone: +632 554-8488
Email: czarlota@yahoo.com
Presentation of the case
This is a case of a 43-year-old male presenting with short
stature and heart failure. The patient was admitted at the
medicine ward of the Philippine General Hospital (PGH)
for dyspnea. This paper will investigate several issues:
differentiating congenital from acquired hypothyroidism,
the relationship between hypothyroidism and the
cardiomyopathies, and the therapeutic options in patients
with cardiomyopathy secondary to hypothyroidism.
The patient had been born full term to a then 31-year-
old Gravida 4 Para 3 (G4P3), the 4th
of 9 siblings, with an
apparently unremarkable delivery at home facilitated by
a traditional birth attendant. He was noted to be normal
at birth. The patient was allegedly at par with age both
physically and mentally until eight years old when he was
said to have stopped growing in height. He was brought to
a private doctor, whose diagnosis was undisclosed, and he
was given medications to increase height, which the patient
took for only one month with no improvement. Through the
years, the patient was apparently well, although still of short
stature, with thick lips, coarse facial features and dry skin.
He was notably slow in ambulation. He was said to have
bronchial asthma at age 15 years, and since then he had been
taking salbutamol tablets occasionally for bouts of dyspnea
occurring one to two times annually.
The patient’s symptoms started in 2001 when he was
reported to have sudden loss of consciousness. During this
time, the patient did not have any symptoms of heart failure;
no prior seizures, cyanotic episodes, chest pain, headache, or
blurring of vision. He regained consciousness shortly after and
was brought to a private physician, whose assessment was a
“heart problem”. He was prescribed unrecalled medications
taken for a few months and eventually discontinued when
the syncopal episode did not recur.
In the next four years, the patient would develop
intermittent, progressive exertional dyspnea and bipedal
edema. later on this would be accompanied by generalized
body weakness, anorexia, and constipation, severe enough to
require regular laxative use. There was also a report of two
more syncopal episodes. He was brought to another doctor
in a private hospital where the assessment was still a “heart
problem”. The patient was again prescribed unrecalled
medications and again was lost to follow-up. This time,
however, symptoms were persistent. He later consulted at
another local hospital, where he was admitted and managed
as a case of anemia and bronchial asthma. He was discharged
slightly improved after four days, only to have recurrent heart
failure symptoms, prompting admission at PGH.
Upon admission the patient was in mild respiratory
distress, with stable vital signs and no note of fever. Pertinent
physical exam findings included short stature, thick lips, non-
pitting periorbital edema, dry skin, a displaced apical impulse,
crackles on both lung fields, and bilateral non-pitting bipedal
edema. There was also a 3 cm x 3 cm reducible umbilical
hernia. However, there was no pallor, no neck vein distention,
no apparent congenital malformations, no cardiac murmurs
and no clubbing. There was also no note of an anterior neck
mass.
laboratoryworkupshowedcardiomegalywithpulmonary
congestion,thoracicdextroscoliosis,andatheromatousaortaby
chest radiograph, and left ventricular hypertrophy by 12-lead
electrocardiogram (12-l ECG) (Figures 1 and 2), normocytic
normochromic anemia (Hgb 90 mg/dl), dyslipidemia, and
pre-renal azotemia (serum creatinine 123 mmol). Electrolytes
on admission showed slight hyponatremia, hypokalemia,
and hypochloremia (serum Na 136, K 3.35, Cl 86). Blood gases
revealed partially compensated metabolic alkalosis with mild
hypoxemia. The patient was noted to be hypothyroid based
on elevated serum thyroid-stimulating hormone (TSH) and
markedly decreased serum free thyroxine (FT4). The exact
values are shown in Tables 1 and 2.
Upon admission to the wards, the patient was managed
as having congestive heart failure from cardiomyopathy
secondary to acquired hypothyroidism. oral loop diuretics,
angiotensin-converting enzyme (ACE) inhibitors, beta-
blockers, statins, and levothyroxine were started. Electrolyte
correction was instituted. The sections of Endocrinology
and Cardiovascular Diseases were co-managing the patient
together with the General Medicine service.
He soon developed respiratory failure, upon which the
considerations were acute pulmonary congestion, nosocomial
pneumonia, to rule out an acute coronary event. He was later
laboratory results. Capillariasis could possibly be endemic
in this barangay for quite some time now, but was left
undiagnosed. In Compostela Valley, there have been 12
deaths before the diagnosis of capillariasis was established.
This was attributed to the lack of proficiency of the local
health staff in laboratory diagnosis and a general lack of
awareness of this potentially fatal parasitic infection.2 An
inexperienced observer may confuse the eggs with those of
Trichiuris trichiura, which are larger (50 to 54 by 22 to 23 m)
and barrel-shaped, with more prominent mucoid bipolar
plugs.3
According to a study by Belizario et al., 54.7% of
patients examined at Compostela Valley were infected with
≥1 organism, including C. philippinensis. Most of the patients
were co-infected with hookworms, Endolimax nana,
Entamoeba histolytica, Entamoeba coli, and Heterphyes sp.2 This
is called polyparasitism, and the study done in Mindanao
reflected the same problem in Thailand where it is a
common practice to eat koi pla (chopped raw fish mixed with
lemon juice, finely cut red onion and chili) and tab kaab
(pounded raw whole fish mixed with lemon juice, finely cut
red onion and chili). C. philippinensis has been identified in
25 provinces in Thailand and majority of infected patients
also harbored hookworms.7,8 In addition, cases of
polyparasitism with C. philippinensis have also been reported
in Taiwan,9 Lao Republic,10 Egypt,11-12 Iran,13 Southern
Brazil14 and Africa.15
In our patient, the chronic diarrhea could have easily
been caused by C. philippinensis, S. stercoralis, and E.
histolytica. All these organisms are related to poor
environmental sanitation, possibly stemming from
indiscriminate defecation. Our patient was unique because
the Capillaria eggs only surfaced after more than 10 serial
fecalyses done at our Institution. This is odd, since Capillaria
infections are usually prolific. Eggs, larvae, and adults
appear in great numbers in stool specimens.3 This is in
contrast to S. stercoralis wherein worm load is low. In these
cases, chances of finding the parasite is proportional to the
number of occasions in which the stool is examined, or if
available, stool should be analyzed using concentration
techniques. It is also important to note that occurrence of
autoinfection, or the ability of a parasite to multiply and
complete one’s life cycle inside humans, is recognized only
in Strongyloides stercoralis and to a lesser extent, in Capillaria
philippinensis infections.16 In these two infections, complete
eradication of the parasite is necessary for cure.
The patient also had TB colitis, which is permissive for
infection with C. philippinensis and S. stercoralis.16 Parasitic
overgrowth rendered him susceptible to Candida as well. In
these cases of polyparasitism, morbidity becomes additive
and mortality subsequently is higher. The key then to the
cure of our patient was clinching the correct diagnosis that
facilitated correct treatment.
Conclusion
In summary, we have presented a case of intestinal
capillariasis from Occidental Mindoro, left undiagnosed for
more than a year in different institutions. Although
capillariasis contributed to his disease, polyparasitism with
Strongyloides stercoralis and Entamoeba histolytica could
account for the patient’s overall condition. Presently, there is
still a need to identify the possible occurrence of intestinal
capillariasis in other unrecognized foci and to define its
geographic distribution here and abroad.
Recommendations
This case was reported to the Department of Health to
pursue this site as a potential area for epidemiologic
investigation. Accurate diagnosis will result in the
appropriate treatment and provide information and
evidence as basis for the control and prevention of this
potentially fatal disease in the community.
__________
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