Cannabis and COVID-19 cytokine storm
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The document discusses the potential use of cannabinoids from Cannabis sativa to suppress the cytokine storm associated with COVID-19. It notes that COVID-19 causes an overactive immune response called a cytokine storm that can damage tissues and lead to death. Some cannabinoids have shown immunosuppressive effects in studies and may help regulate the immune system response and reduce the severity of cytokine storms. The author aims to systematically review evidence on cannabinoids that have demonstrated immunosuppressive activity against targets involved in cytokine storm pathobiology.
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![Cannabis and COVID-19 cytokine storm
Isaac Karimi
Department of Biology, Faculty of Science, Razi University 67149-67346, Kermanshah, Iran.
isaac_karimi2000@yahoo.com; karimiisaac@razi.ac.ir; http://orcid.org/0000-0001-7415-0472
Based on seminal reports, the immune system is over-activated in coronavirus disease 2019
(COVID-19) patients [1]. The straight consequences of this hyperinflammatory condition and
immune burst are symbolized as cytokine storm (CS) [2] which catalyses tissue destruction and
even leads to death. It seems to be rational to stop the noisy tumalt of immune cells and severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) through managing host response. The
overarching goal of using therapeutics is centered on antiviral drugs while it should be
hyperfocused on host defense. In this line, vaccination and drugs interacting with host protein
targets are far reaching goals to build healthier immune responses far away from excess statistical
skewness or kurtosis. Therefore, we should seek immunosuppressants to prohibit or to correct](https://image.slidesharecdn.com/cannabisandcovid-210313021027/85/Cannabis-and-COVID-19-cytokine-storm-1-320.jpg)
![immune system in CS, while the majorities of papers reported immunostimulating agents. In this
context, some botanical ingredients derived from various parts, mainly topflowers, of Cannabis
sativa L. (phytocannabinoids) possess immunosuppressive activities [3] eligble for vanishing CS.
In this orate, I will try to appreciate the attention of researchers to anti-CS activities of
phytocannabinoids reported in cannabis preparations like marijuana and hashish. Practically, I
pursue to describe the interactions of experimentally approved immunosupressive cannabinoids
and major targets involving in the pathobiology of CS by means of systematic review accompanied
with computational immunopharmacology.
Keywords: In silico drug discovery, cannabinoids, immunosuppression, cytokine storm,
hyperinflammation
References:
1. Kamla Prasad Mishra, Ajay Kumar Singh, Shashi Bala Singh. Hyperinflammation and
immune response generation in COVID-19. Neuroimmunomodulation. 2020;27:80–86
2. Quirch M, Lee J, Rehman S. Hazards of the cytokine storm and cytokine-targeted therapy
in patients with COVID-19: Review. J Med Internet Res. 2020 Aug 13;22(8):e20193.
3. Eisenstein TK, Meissler JJ. Effects of Cannabinoids on T-cell Function and Resistance to
Infection. J Neuroimmune Pharmacol. 2015 Jun;10(2):204-16.
Speaker Biography:
Dr. Isaac Karimi is an academic member in the Razi University from 2008. He received his Doctor
of Veterinary Medicine (DVM; 1998-2004) from Shahr-e-Kord University, Iran and Doctor of
Veterinary Sciences (DVSc; 2004-2008) in physiology from Urmia University, Iran. I.K. has an](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
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preprint Pdf book epidemiology and diffusion of some relevant virus latitude...
preprint Pdf book epidemiology and diffusion of some relevant virus latitude...M. Luisetto Pharm.D.Spec. Pharmacology
This document summarizes a book on the epidemiology and diffusion of viruses with a focus on the role of latitude, air pollutants, and humidity. It discusses several viruses including SARS, MERS, influenza, and COVID-19. It reviews literature finding associations between increased air pollutants like PM2.5 and higher risk of influenza-like illness. Some studies found temperature could impact COVID-19 transmission, with an optimal temperature range. Experiments with influenza in guinea pigs found that cold, dry conditions favor airborne transmission. The role of atmospheric conditions in the seasonality and spread of influenza over large geographic areas is discussed.Ijcmbt coronavirus covid-19 surface properties electrical charges status lu...
Ijcmbt coronavirus covid-19 surface properties electrical charges status lu...M. Luisetto Pharm.D.Spec. Pharmacology
This document discusses the electrical charge properties of the SARS-CoV-2 coronavirus surface and how it may impact viral transmission and infectivity.
Key points:
- The SARS-CoV-2 spike protein surface has a net negative charge, while the envelope, membrane, and nucleocapsid proteins have a net positive charge. Positively charged areas on the spike protein facilitate binding to negatively charged human cell receptors.
- The pH of the environment can impact the electrical charge distribution on the viral surface by altering the protonation states of amino acids. More acidic or basic conditions shift the surface charge.
- Positively charged electrostatic nanofiber filters show potential for highly efficient capture of aerosolHcbcm 20-004 regeneration abilities of vertebrates and invertebrates and rela...
Hcbcm 20-004 regeneration abilities of vertebrates and invertebrates and rela...M. Luisetto Pharm.D.Spec. Pharmacology
This document discusses regeneration abilities in vertebrates and invertebrates and their relationship to pharmacological research and cancer regulation. It notes that regeneration capacity varies between phyla and species, with invertebrates and some vertebrates like newts and zebrafish able to regenerate limbs and organs. In contrast, regeneration abilities are more limited in mammals like humans as they age. The aim is to take an evolutionary approach to understand similarities and differences in regeneration processes and how this relates to developing cancer therapies and regenerative medicine.Timeline
The document outlines the timeline of antibiotic resistance, beginning with the golden era of antibiotic development from the 1940s-1960s with the introduction of penicillin and other drugs. However, resistance emerged shortly after in the 1940s. While new antibiotics continued to be discovered, resistance increased sharply over time. Since the 1960s, development of new antibiotics has declined, with larger gaps in between, leaving many bacterial diseases increasingly difficult to treat due to multidrug resistant strains.
Future impacts of antibiotic resistance
This document discusses the future impacts of antibiotic resistance if it is not addressed. It notes that antibiotic resistance could lead to 10 million deaths per year by 2050 and cost the global economy billions. The world may enter a post-antibiotic era where common infections become difficult to treat again. Many drugs will become ineffective as resistance spreads, and new resistance mechanisms may emerge. Medical procedures could become more dangerous without effective antibiotics to treat associated infections. The costs of antibiotic resistance will be high both in terms of health and economic impacts. Urgent changes are needed in antibiotic use and development to address this growing threat.
Anti microbial resistance
Antimicrobial resistance (AMR) occurs when microorganisms become resistant to antimicrobial drugs that were previously able to treat infections. AMR arises through natural mutation and genetic transfer between microbes and is accelerated by misuse and overuse of antimicrobials. If not addressed, AMR could lead to increased mortality and healthcare costs as resistant organisms cause treatment failure. To combat AMR, proper antimicrobial use, hygiene, and surveillance are needed at the patient, clinical, agricultural, and policy levels. Education is also key to promoting appropriate antimicrobial usage.
COVID-19 immunology, MIS-C, and allergic diseases
COVID-19 immunology, MIS-C, and allergic diseases Chulalongkorn Allergy and Clinical Immunology Research Group
COVID-19 immunology, multisystem inflammatory syndrome in children, and allergic diseases
Presented by Rapisa Nantanee, MD.
June19, 2020Developing Covid-19 Vaccines at Pandemic Speed
This document summarizes the challenges of rapidly developing a vaccine for SARS-CoV-2 (Covid-19) during a pandemic. It discusses how previous epidemics like H1N1, Ebola, and Zika showed that vaccines often weren't available before the epidemics ended. New platforms like DNA, RNA, and recombinant protein vaccines may speed development but regulatory review and large-scale manufacturing are challenges. The pandemic requires overlapping and parallel development phases with high financial risk. Coordinated global efforts are needed to fund manufacturing at scale and establish a fair global allocation system for any successful vaccines.
E POSTER OF IMPACT OF IMMUNITY AS A PREVENTIVE MEASURE AGAINST COVID 19
This document discusses the role of immunity in preventing COVID-19 infections. It states that as there are currently no cures or treatments for COVID-19, prevention and management strategies are essential. Boosting immunity through proper nutrition and supplements can act as an effective preventive measure against the virus, as those with stronger immunity have lower risks of infection. Key immunity-boosting nutrients discussed include vitamins A, B, C, and E, as well as zinc and selenium.
IUPHAR Guide to IMMUNOPHARMACOLOGY
Poster on GtoImmuPdb presented at European Congress of Immunology (Amsterdam, Sep 2018). Overview of the main data types and features included in this extension to the IUPHAR/BPS Guide to PHARMACOLOGY
WHY THE ANTIBIOTICS ARE DANGEROUS TO OUR LIFE?
Antibiotics are commonly used but also contribute to growing antibiotic resistance, a major public health problem. When antibiotics become ineffective, infections are harder to treat and can lead to worse health outcomes like longer illnesses or death. Overuse and misuse of antibiotics, including taking incomplete courses or using them for viral infections, promotes the spread of resistant bacteria. Physicians should follow best practices like only prescribing antibiotics appropriately and narrowing treatment based on test results. Improving antibiotic stewardship through more responsible use can help reduce growing resistance and protect individuals as well as communities.
Antibiotic therapy in_patients_with_septic_shock
1) Empirical antibiotic therapy is initiated prior to determining the specific infecting microorganism in patients with septic shock. Inappropriate empirical therapy is associated with increased mortality.
2) Therapies should be broad-spectrum and cover likely pathogens based on infection site and patient risk factors. They should be reassessed and narrowed once culture results are available.
3) Antibiotics should be administered within 1 hour of recognizing septic shock, as delays in treatment are associated with increased mortality. Prompt administration of appropriate empirical therapy improves survival in septic shock.
Covid new latest
Researchers have found that bats can carry coronaviruses like MERS and SARS-CoV-2 without getting sick due to a "super immunity". Bats have unique immune systems that allow coronaviruses to enter a long-term relationship without killing bat cells. However, stresses on bats can disrupt this balance and allow viruses to multiply, potentially spilling over to other species. The research sheds light on how coronaviruses adapt to infect bats without harming them, and could help predict future pandemics.
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Molecular mechanism prediction analysis of compound Kushen injection in the t...
Molecular mechanism prediction analysis of compound Kushen injection in the t...
The Potential Neurological Side Effect of The Covid-19
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Role of Corticosteroid in the Management of Covid 19
Meta-Analysis Identifies Type I Interferon Response as Top Pathway Associated...
Meta-Analysis Identifies Type I Interferon Response as Top Pathway Associated...
Treatment of COVID-19; old tricks for new challenges
Treatment of COVID-19; old tricks for new challenges
preprint Pdf book epidemiology and diffusion of some relevant virus latitude...
preprint Pdf book epidemiology and diffusion of some relevant virus latitude...
Ijcmbt coronavirus covid-19 surface properties electrical charges status lu...
Ijcmbt coronavirus covid-19 surface properties electrical charges status lu...
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Hcbcm 20-004 regeneration abilities of vertebrates and invertebrates and rela...
E POSTER OF IMPACT OF IMMUNITY AS A PREVENTIVE MEASURE AGAINST COVID 19
E POSTER OF IMPACT OF IMMUNITY AS A PREVENTIVE MEASURE AGAINST COVID 19
Similar to Cannabis and COVID-19 cytokine storm
A broad perspective on COVID-19: a global pandemic and a focus on preventive ...
Abstract Coronavirus 2019 has become a highly infectious disease caused by severe acute respiratory syndrome coronavirus-2, a strain of novel coronavirus, which challenges millions of global healthcare facilities. Coronavirus are sub-microscopic, single stranded positive sense RNA viruses that leads to multi organ dysfunction syndrome, severe acute and chronic respiratory distress syndrome and pneumonia. The spike glycoprotein structure of the virus causes the viral protein to bind with the receptors on the lung and gut through angiotensin-converting enzyme 2. In some cases, the infected patients become hyper to the immune system because of the uncontrolled production of cytokines resulting in “cytokine storm”, a devastating consequence of coronavirus disease 2019. Due to the rapid mutant strain and infective nature of severe acute respiratory syndrome coronavirus-2, discovering a drug or developing a vaccine remains a global challenge. However, some anti-viral agents, certain protease inhibitor drugs, non-steroidal inflammatory drugs and convalescent plasma treatment were suggested. The containment and social distancing measures only aim at reducing the rate of new infections. In this view, we suggest certain traditional herbs and complementary and alternative medicine as a supporting public healthcare measure to boost the immune system and also may provide some lead to treat and prevent this infection.
Vaccination
The word "vaccine" originates from the Latin word “vacca”, meaning “cow” a virus (cowpox) which manly effect the cow. which Edward Jenner demonstrated in 1798 could prevent smallpox in humans.
Covid-19 (SARS-CoV-2) from Pathophysiology to Vaccine Development.
SARS-CoV-2 from Pathophysiology to Vaccine Development. In this PPT, I have tried to give a brief overview of the ongoing pandemic.
CURCUMET CAPSULES: A Natural Immunomodulator Helps to Prevent Covid-19 Infection
CURCUMET CAPSULES: A Natural Immunomodulator Helps to Prevent Covid-19 InfectionAssociate Professor in VSB Coimbatore
The whole world is suffering from the corona virus, a global pandemic, which has captured world attention to the immune system. As the world scrambles to find a cure for Covid-19, health experts have suggested boosting the body’s immunity. Immune system defense against bacteria, virus and other organisms may help minimize the effects and hasten the recovery from the disease. Covid-19 still has a troublingly high mortality rate. A person with a strong immune system and good body health should be able to recover from severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infections without any complications because the immune system produced antibodies. Immunity will be “our savior” against the virus. The idea is that if you don’t have a potent weapon to combat the enemy, a strong and effective shield is the best bet to protect yourself. There are still millions of people in the world at risk due to old age, weak immune system and pre-existing medical issue. Turmeric plays a major role to boost the immune system and a potent immunomodulatory agent that can help the population to prevent the covid-19 infection. Based on these facts A Natural immunomodulatory agent CURCUMET CAPSULES has been Developed by R&D Centre, Lactonova Nutripharm (P) Ltd, HYDERABAD. The present paper Reviews the Role of CURCUMET CAPSULES, A Natural immunomodulatory agent helps to prevent covid-19 infection.Confirmation of Safety of COVID 19 mRNA Vaccination for Cancer Patients
Patients in the active phase of treatment for cancer are a population at risk of coronavirus disease 19 COVID 19 with poor prognosis. While a majority of patients treated for cancer expressed their will to be vaccinated as early as December 2020 in a French survey, no data were available in terms of vaccine efficacy and tolerance, because they were excluded from initial registration trials. Several clinical facilities aimed to assess the safety and immunogenicity of the BNT162b2 Pfizer–BioNTech vaccine in patients with cancer. In patients with cancer, one dose of the BNT162b2 vaccine yields poor efficacy. Immunogenicity increased significantly in patients with solid cancer within 2 weeks of a vaccine boost at day 21 after the first dose. However, the anti SARS CoV 2 immune response was lower in patients with solid tumors who were vaccinated a second dose of BNT162b2 vaccine than in healthy individuals. These data support prioritization of patients with cancer for an early day 21 second dose of the BNT162b2 vaccine. Takuma Hayashi | Nobuo Yaegashi | Ikuo Konishi "Confirmation of Safety of COVID-19 mRNA Vaccination for Cancer Patients" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd42563.pdf Paper URL: https://www.ijtsrd.commedicine/other/42563/confirmation-of-safety-of-covid19-mrna-vaccination-for-cancer-patients/takuma-hayashi
Indian Medicinal Herbs’ Pharmacological Interventions in the Management of CO...
Indian Medicinal Herbs’ Pharmacological Interventions in the Management of CO...BRNSSPublicationHubI
The document discusses the potential use of Indian medicinal herbs in managing COVID-19. It notes that while no current treatments exist for SARS-CoV-2, medicinal plants may offer antiviral compounds that could target the viral life cycle. The review highlights several phytochemicals isolated from medicinal plants that have demonstrated antiviral effects against coronaviruses. It argues that numerous aromatic herbs and phytochemicals found in plants await further assessment for their therapeutic potential against COVID-19 and other viral illnesses.Computational Prediction for Antibiotics Resistance Through Machine Learning ...
Computational Prediction for Antibiotics Resistance Through Machine Learning ...CrimsonpublishersCJMI
Computational Prediction for Antibiotics
Resistance Through Machine Learning and Pk/Pd
Analysis by Hyunjo Kim in Cohesive Journal of Microbiology & Infectious DiseaseDr vijay pneumococcal disease prevention in older adults 2020
The document provides details about Dr. Vijay K. Agrawal including his credentials and positions held. It also includes two disclosure statements indicating that Dr. Agrawal does not have any financial interests or arrangements that could be perceived as a conflict of interest. The rest of the document appears to be a slide presentation on pneumococcal disease.
Bacteriological_Profile_Surgical_Site_Infections_Antibiotic_Pattern.pdf
Bacteriological_Profile_Surgical_Site_Infections_Antibiotic_Pattern.pdfSSR Institute of International Journal of Life Sciences
Bacteriological Profile of Surgical Site Infections and their Antibiotic Susceptibility Pattern
http://dx.doi.org/10.21276/SSR-IIJLS.2019.5.2.4
Ijms 22-05992-v3
Autophagy, Unfolded Protein Response, and Neuropilin‐1
Cross‐Talk in SARS‐CoV‐2 Infection: What Can Be Learned
from Other Coronaviruses
Prospects and Problems of Development of Candidate Vaccine against COVID 19
There is an urgent need to develop a vaccine against coronavirus disease 2019 COVID 19 , which is caused by a new coronavirus, severe acute respiratory syndrome coronavirus type 2 SARS CoV 2 infection. Although vaccine development typically requires 3 to 5 years, there is a possibility that the vaccine developed for either severe acute respiratory syndrome SARS or the middle east respiratory syndrome MERS could be used against COVID 19 as well. Therefore, a vaccine against COVID 19 is expected to be commercialized within 1 to 2 years. If so, it will be the fastest vaccine development in human history.In this review, we have summarized the information released as of April 10, 2020. Takuma Hayashi | Yasuaki Amano | Takashi Ura | Ikuo Konishi "Prospects and Problems of Development of Candidate Vaccine against COVID-19" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, URL: https://www.ijtsrd.com/papers/ijtsrd38521.pdf Paper Url: https://www.ijtsrd.com/medicine/other/38521/prospects-and-problems-of-development-of-candidate-vaccine-against-covid19/takuma-hayashi
Jama sanders covid-19
This document reviews potential pharmacologic treatments for COVID-19. It summarizes the virology of SARS-CoV-2 and potential drug targets. It reviews the in vitro activity and clinical experiences of repurposed drugs including chloroquine/hydroxychloroquine, lopinavir/ritonavir, and umifenovir. It also discusses investigational agents such as remdesivir. Over 300 clinical trials are evaluating potential COVID-19 treatments but currently no therapies have proven effective based on randomized clinical trial data.
2005 Plague and anthrax JI Ania
In 3 sentences or less:
The document analyzes how anthrax and plague biowarfare vaccines interact with human dendritic cells. It finds that while the plague vaccine strongly induces dendritic cell maturation and stimulates immune responses, the anthrax vaccine is a poor stimulator of dendritic cell maturation and cytokine production. However, the anthrax vaccine can stimulate T cell responses when combined with an adjuvant like pertussis, supporting the use of adjuvants to enhance the immune response to suboptimal vaccines.
Coronavirus disease 2019
This document reviews potential treatment options for COVID-19 that are supported by early evidence. It summarizes in vitro and clinical evidence for remdesivir, chloroquine/hydroxychloroquine, and lopinavir/ritonavir. Remdesivir shows potent activity against SARS-CoV-2 and other coronaviruses in vitro and clinical benefit in animal studies of MERS and Ebola. Early clinical data in COVID-19 patients treated with remdesivir showed improvement. Chloroquine also has in vitro activity against SARS-CoV-2 and is supported by some clinical case studies from China. However, the efficacy of these agents specifically for COVID-19 treatment requires further evaluation in controlled
Choose one of the psychological disorders discusse
This document describes the development of a single-dilution enzyme-linked immunosorbent assay (ELISA) to detect SARS-CoV-2 antibodies in human serum samples. The assay uses a recombinant SARS-CoV-2 spike protein to capture IgG and IgA antibodies. Testing on a large number of convalescent and control serum samples identified optimal single dilutions that provided reliable qualitative detection of antibodies with high sensitivity and specificity. The assay can detect both IgG and IgA antibodies from a single serum sample measurement, making it suitable for high-throughput clinical use during the COVID-19 pandemic.
mr tee 1.pptx
The immune system fights viral infections through both innate and adaptive immune responses. When a virus like SARS-CoV-2 infects the body, the innate immune system responds first through pattern recognition receptors that activate immune cells. This limits viral spread and induces inflammation. The adaptive immune system then mounts a specific response through T cells that kill infected cells and B cells that produce antibodies against the virus. Together these immune responses aim to eliminate the virus and prevent reinfection, but overactivation can also cause immunopathology.
The Efficacy and Safety of Convalescent Plasma for COVID-19 Patients: A Meta-...
Convalescent plasma (CP) was demonstrated
promising benefit for clinical practice involved in efficacy and
safety in previous coronavirus pandemics, however, the efficacy of
CP from COVID-19 sufferers are still controversial and unascertainable based on current randomized controlled trials (RCTs). The
urgent needs for affirmative replies on the efficacy and safety of
CP for COVID-19 patients must be developed as soon as possible.
Farmacologia COVID Jama sanders 2020_rv_200005 Dr. Freddy Flores Malpartida
This document reviews potential pharmacologic treatments for COVID-19. It summarizes the virology of SARS-CoV-2 and potential drug targets, including viral entry proteins and immune pathways. Several repurposed drugs are discussed, including chloroquine/hydroxychloroquine which may inhibit viral entry and immune responses. Over 300 clinical trials are investigating potential COVID-19 treatments but currently no therapies have proven effective. The most promising is remdesivir, which has strong antiviral activity but requires further clinical trial evaluation.
Jama sanders 2020 tto
This document reviews potential pharmacologic treatments for COVID-19. It summarizes the virology of SARS-CoV-2 and potential drug targets. Currently, there are no proven effective therapies but remdesivir shows promise based on in vitro activity. Over 300 clinical trials are investigating potential treatments including repurposed drugs like chloroquine/hydroxychloroquine and lopinavir/ritonavir. The review summarizes the mechanisms and pharmacology of select proposed treatments and provides an overview of ongoing clinical trials.
Jcavi aid1007 rbd targeted covid vaccine and full lenght spike-protein vaccin...
Jcavi aid1007 rbd targeted covid vaccine and full lenght spike-protein vaccin...M. Luisetto Pharm.D.Spec. Pharmacology
The document discusses the relationship between COVID-19 vaccines that target the full-length spike protein versus just the receptor-binding domain (RBD), and their potential relationship to procoagulant effects and rare blood clotting issues. Some key points:
- Vaccines like AstraZeneca use the full-length spike protein in viral vectors, while others just target the RBD region.
- The spike protein plays a role in viral entry and interacts with host cell receptors like ACE2. It also has glycans that help disguise the virus.
- Studies found the AstraZeneca vaccine induces cell spikes similar to SARS-CoV-2, eliciting an immune response.
-Similar to Cannabis and COVID-19 cytokine storm (20)
A broad perspective on COVID-19: a global pandemic and a focus on preventive ...
A broad perspective on COVID-19: a global pandemic and a focus on preventive ...
Covid-19 (SARS-CoV-2) from Pathophysiology to Vaccine Development.
Covid-19 (SARS-CoV-2) from Pathophysiology to Vaccine Development.
CURCUMET CAPSULES: A Natural Immunomodulator Helps to Prevent Covid-19 Infection
CURCUMET CAPSULES: A Natural Immunomodulator Helps to Prevent Covid-19 Infection
Confirmation of Safety of COVID 19 mRNA Vaccination for Cancer Patients
Confirmation of Safety of COVID 19 mRNA Vaccination for Cancer Patients
Indian Medicinal Herbs’ Pharmacological Interventions in the Management of CO...
Indian Medicinal Herbs’ Pharmacological Interventions in the Management of CO...
Computational Prediction for Antibiotics Resistance Through Machine Learning ...
Computational Prediction for Antibiotics Resistance Through Machine Learning ...
Dr vijay pneumococcal disease prevention in older adults 2020
Dr vijay pneumococcal disease prevention in older adults 2020
Bacteriological_Profile_Surgical_Site_Infections_Antibiotic_Pattern.pdf
Bacteriological_Profile_Surgical_Site_Infections_Antibiotic_Pattern.pdf
Prospects and Problems of Development of Candidate Vaccine against COVID 19
Prospects and Problems of Development of Candidate Vaccine against COVID 19
Choose one of the psychological disorders discusse
Choose one of the psychological disorders discusse
The Efficacy and Safety of Convalescent Plasma for COVID-19 Patients: A Meta-...
The Efficacy and Safety of Convalescent Plasma for COVID-19 Patients: A Meta-...
Farmacologia COVID Jama sanders 2020_rv_200005 Dr. Freddy Flores Malpartida
Farmacologia COVID Jama sanders 2020_rv_200005 Dr. Freddy Flores Malpartida
Jcavi aid1007 rbd targeted covid vaccine and full lenght spike-protein vaccin...
Jcavi aid1007 rbd targeted covid vaccine and full lenght spike-protein vaccin...
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5成品做好拍照或者视频给您确认；
6快递给客户（国内顺丰国外DHLUPS等快读邮寄）。
7完成交易删除客户资料
高精端提供以下服务：
一：渥太华大学渥太华大学毕业证文凭证书全套材料从防伪到印刷水印底纹到钢印烫金
二：真实使馆认证（留学人员回国证明）使馆存档
三：真实教育部认证教育部存档教育部留服网站可查
四：留信认证留学生信息网站可查
五：与学校颁发的相关证件1:1纸质尺寸制定（定期向各大院校毕业生购买最新版本毕,业证成绩单保证您拿到的是鲁昂大学内部最新版本毕业证成绩单微信95270640）
A.为什么留学生需要操作留信认证?
留信认证全称全国留学生信息服务网认证,隶属于北京中科院。①留信认证门槛条件更低,费用更美丽,并且包过,完单周期短,效率高②留信认证虽然不能去国企,但是一般的公司都没有问题,因为国内很多公司连基本的留学生学历认证都不了解。这对于留学生来说,这就比自己光拿一个证书更有说服力,因为留学学历可以在留信网站上进行查询!
B.为什么我们提供的毕业证成绩单具有使用价值？
查询留服认证是国内鉴别留学生海外学历的唯一途径但认证只是个体行为不是所有留学生都操作所以没有办理认证的留学生的学历在国内也是查询不到的他们也仅仅只有一张文凭。所以这时候我们提供的和学校颁发的一模一样的毕业证成绩单就有了使用价值。只硕大的蛇皮袋手里拎着长铁钩正站在门口朝黑色的屋内张望不好坏人小偷山娃一怔却也灵机一动立马仰起头双手拢在嘴边朝楼上大喊：“爸爸爸——有人找——那人一听朝山娃尴尬地笑笑悻悻地走了山娃立马“嘭的一声将铁门锁死心却咚咚地乱跳当山娃跟父亲说起这事时父亲很吃惊抚摸着山娃的头说还好醒得及时要不家早被人掏空了到时连电视也没得看啰不过父亲还是夸山娃能临危不乱随机应变有胆有谋山娃笑笑说那都是书上学的看童话和小说时多
一比一原版(爱大毕业证书)爱丁堡大学毕业证如何办理
毕业原版【微信:41543339】【(爱大毕业证书)爱丁堡大学毕业证】【微信:41543339】成绩单、外壳、offer、留信学历认证（永久存档真实可查）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【我们承诺采用的是学校原版纸张（纸质、底色、纹路），我们拥有全套进口原装设备，特殊工艺都是采用不同机器制作，仿真度基本可以达到100%，所有工艺效果都可提前给客户展示，不满意可以根据客户要求进行调整，直到满意为止！】
【业务选择办理准则】
一、工作未确定，回国需先给父母、亲戚朋友看下文凭的情况，办理一份就读学校的毕业证【微信41543339】文凭即可
二、回国进私企、外企、自己做生意的情况，这些单位是不查询毕业证真伪的，而且国内没有渠道去查询国外文凭的真假，也不需要提供真实教育部认证。鉴于此，办理一份毕业证【微信41543339】即可
三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
留信网服务项目：
1、留学生专业人才库服务（留信分析）
2、国（境）学习人员提供就业推荐信服务
3、留学人员区块链存储服务
→ 【关于价格问题（保证一手价格）】
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
选择实体注册公司办理，更放心，更安全！我们的承诺：客户在留信官方认证查询网站查询到认证通过结果后付款，不成功不收费！
一比一原版(UCSF文凭证书)旧金山分校毕业证如何办理
毕业原版【微信:176555708】【(UCSF毕业证书)旧金山分校毕业证】【微信:176555708】成绩单、外壳、offer、留信学历认证（永久存档真实可查）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【我们承诺采用的是学校原版纸张（纸质、底色、纹路），我们拥有全套进口原装设备，特殊工艺都是采用不同机器制作，仿真度基本可以达到100%，所有工艺效果都可提前给客户展示，不满意可以根据客户要求进行调整，直到满意为止！】
【业务选择办理准则】
一、工作未确定，回国需先给父母、亲戚朋友看下文凭的情况，办理一份就读学校的毕业证【微信176555708】文凭即可
二、回国进私企、外企、自己做生意的情况，这些单位是不查询毕业证真伪的，而且国内没有渠道去查询国外文凭的真假，也不需要提供真实教育部认证。鉴于此，办理一份毕业证【微信176555708】即可
三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
留信网服务项目：
1、留学生专业人才库服务（留信分析）
2、国（境）学习人员提供就业推荐信服务
3、留学人员区块链存储服务
→ 【关于价格问题（保证一手价格）】
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
选择实体注册公司办理，更放心，更安全！我们的承诺：客户在留信官方认证查询网站查询到认证通过结果后付款，不成功不收费！
Analysis insight about a Flyball dog competition team's performance
Insight of my analysis about a Flyball dog competition team's last year performance. Find more: https://github.com/rolandnagy-ds/flyball_race_analysis/tree/main
Beyond the Basics of A/B Tests: Highly Innovative Experimentation Tactics You...
This webinar will explore cutting-edge, less familiar but powerful experimentation methodologies which address well-known limitations of standard A/B Testing. Designed for data and product leaders, this session aims to inspire the embrace of innovative approaches and provide insights into the frontiers of experimentation!
Predictably Improve Your B2B Tech Company's Performance by Leveraging Data
Harness the power of AI-backed reports, benchmarking and data analysis to predict trends and detect anomalies in your marketing efforts.
Peter Caputa, CEO at Databox, reveals how you can discover the strategies and tools to increase your growth rate (and margins!).
From metrics to track to data habits to pick up, enhance your reporting for powerful insights to improve your B2B tech company's marketing.
- - -
This is the webinar recording from the June 2024 HubSpot User Group (HUG) for B2B Technology USA.
Watch the video recording at https://youtu.be/5vjwGfPN9lw
Sign up for future HUG events at https://events.hubspot.com/b2b-technology-usa/
University of New South Wales degree offer diploma Transcript
澳洲UNSW毕业证书制作新南威尔士大学假文凭定制Q微168899991做UNSW留信网教留服认证海牙认证改UNSW成绩单GPA做UNSW假学位证假文凭高仿毕业证申请新南威尔士大学University of New South Wales degree offer diploma Transcript
一比一原版(Chester毕业证书)切斯特大学毕业证如何办理
毕业原版【微信:41543339】【(Chester毕业证书)切斯特大学毕业证】【微信:41543339】成绩单、外壳、offer、留信学历认证（永久存档真实可查）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【我们承诺采用的是学校原版纸张（纸质、底色、纹路），我们拥有全套进口原装设备，特殊工艺都是采用不同机器制作，仿真度基本可以达到100%，所有工艺效果都可提前给客户展示，不满意可以根据客户要求进行调整，直到满意为止！】
【业务选择办理准则】
一、工作未确定，回国需先给父母、亲戚朋友看下文凭的情况，办理一份就读学校的毕业证【微信41543339】文凭即可
二、回国进私企、外企、自己做生意的情况，这些单位是不查询毕业证真伪的，而且国内没有渠道去查询国外文凭的真假，也不需要提供真实教育部认证。鉴于此，办理一份毕业证【微信41543339】即可
三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
留信网服务项目：
1、留学生专业人才库服务（留信分析）
2、国（境）学习人员提供就业推荐信服务
3、留学人员区块链存储服务
→ 【关于价格问题（保证一手价格）】
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
选择实体注册公司办理，更放心，更安全！我们的承诺：客户在留信官方认证查询网站查询到认证通过结果后付款，不成功不收费！
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Cannabis and COVID-19 cytokine storm
- 1. Cannabis and COVID-19 cytokine storm Isaac Karimi Department of Biology, Faculty of Science, Razi University 67149-67346, Kermanshah, Iran. isaac_karimi2000@yahoo.com; karimiisaac@razi.ac.ir; http://orcid.org/0000-0001-7415-0472 Based on seminal reports, the immune system is over-activated in coronavirus disease 2019 (COVID-19) patients [1]. The straight consequences of this hyperinflammatory condition and immune burst are symbolized as cytokine storm (CS) [2] which catalyses tissue destruction and even leads to death. It seems to be rational to stop the noisy tumalt of immune cells and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) through managing host response. The overarching goal of using therapeutics is centered on antiviral drugs while it should be hyperfocused on host defense. In this line, vaccination and drugs interacting with host protein targets are far reaching goals to build healthier immune responses far away from excess statistical skewness or kurtosis. Therefore, we should seek immunosuppressants to prohibit or to correct
- 2. immune system in CS, while the majorities of papers reported immunostimulating agents. In this context, some botanical ingredients derived from various parts, mainly topflowers, of Cannabis sativa L. (phytocannabinoids) possess immunosuppressive activities [3] eligble for vanishing CS. In this orate, I will try to appreciate the attention of researchers to anti-CS activities of phytocannabinoids reported in cannabis preparations like marijuana and hashish. Practically, I pursue to describe the interactions of experimentally approved immunosupressive cannabinoids and major targets involving in the pathobiology of CS by means of systematic review accompanied with computational immunopharmacology. Keywords: In silico drug discovery, cannabinoids, immunosuppression, cytokine storm, hyperinflammation References: 1. Kamla Prasad Mishra, Ajay Kumar Singh, Shashi Bala Singh. Hyperinflammation and immune response generation in COVID-19. Neuroimmunomodulation. 2020;27:80–86 2. Quirch M, Lee J, Rehman S. Hazards of the cytokine storm and cytokine-targeted therapy in patients with COVID-19: Review. J Med Internet Res. 2020 Aug 13;22(8):e20193. 3. Eisenstein TK, Meissler JJ. Effects of Cannabinoids on T-cell Function and Resistance to Infection. J Neuroimmune Pharmacol. 2015 Jun;10(2):204-16. Speaker Biography: Dr. Isaac Karimi is an academic member in the Razi University from 2008. He received his Doctor of Veterinary Medicine (DVM; 1998-2004) from Shahr-e-Kord University, Iran and Doctor of Veterinary Sciences (DVSc; 2004-2008) in physiology from Urmia University, Iran. I.K. has an
- 3. interdisciplinary view, however he is concentrated on ethnopharmacology, translational research, nanotoxicology, computational biology and biomathematics. I.K. (co)authored 130 research papers and book chapters and served as member of editorial board of many peer-reviewed journals. Speaker Name: ISAAC KARIMI Email Id: isaac_karimi2000@yahoo.com; karimiisaac@razi.ac.ir Conference Name: The 2nd International Pharma Conference which has been scheduled for the month of April 22-23, 2021 on an online platform Session Name: Abstract Category: Ph. No-+989129480462