This document discusses the potential synergistic effects of hyperbaric oxygen therapy (HBOT) and cannabis in treating various medical conditions. It notes that HBOT at 2-3 atmospheres delivers 100% oxygen, which can boost energy production and methylation pathways involving MTHFR. Cannabinoids may reduce inflammation and activate the neuroprotective CB2 receptor on microglia cells. The combination of HBOT and cannabis could help address issues involving toxins, bacterial endotoxins, MTHFR dysfunction, low energy, inflammation and neurodegeneration. Safety is emphasized, recommending starting with low cannabis doses. Contact information is provided for further resources.