This chapter discusses stress and health, including: 1) Stress is the process of perceiving and responding to threatening or challenging events, and can be appraised as a threat or challenge. 2) Prolonged stress can lead to exhaustion through stages of alarm reaction, resistance, and exhaustion as described in the general adaptation syndrome. 3) Stressful life events like catastrophes, life changes, and daily hassles can impact health. 4) Stress can influence health through behaviors, emotions, and physiological responses.