C# has several advantages over other languages for developing desktop applications. It compiles to an intermediate language independently of the operating system, has automatic garbage collection, and does not require pointers, header files, or function declarations. C# also formalizes get/set methods, has a cleaner event model than C++ and Java, and supports value types, indexers, and conditional compilation. C# can be used to create various application types including Windows, console, web, and mobile applications.