Burns are one of the most serious injuries that can damage the skin and lead to complications. They are classified based on the percentage of total body surface area affected and depth of tissue damage. Common causes include scalds, flames, electricity, and chemicals. Proper management involves fluid resuscitation, wound care to prevent infection, and skin grafting for deep burns. Complications can be local, such as infection, contractures and scarring, or systemic like shock, organ failure and sepsis. Special consideration is needed for electrical or chemical burns.
The document defines burns and classifies them into first, second, and third degree burns based on the depth of skin damage. It describes methods to estimate burn extent using the "rule of nine" and factors that determine burn severity such as depth, size, location, and patient history. Signs and symptoms are explained for each degree of burn. Emergency management of burns is outlined in 17 steps along with complications that can occur.
Burn Injury classification and managementDr Alok Kumar
1. The document discusses various types of burn injuries including thermal burns from heat or flames, scalds from hot liquids, and non-thermal burns from electricity, chemicals, radiation, or cold.
2. It describes the pathology of burns including the severity and depth of tissue damage, vascular changes that can cause shock, and high risks of infection when the skin is destroyed.
3. The management of burns is outlined including treatment of shock, general wound care and infection prevention, skin grafting, and physiotherapy to prevent complications and aid rehabilitation.
This document provides information on burn injuries, including:
1. Defining burns and classifying them based on depth and extent of body surface area affected.
2. Describing the pathophysiology of burns and systemic effects such as fluid loss and circulatory changes.
3. Outlining the therapeutic management of burns, which involves resuscitation, wound care, pain management, and rehabilitation.
This document provides detailed information on burn injuries and burn rehabilitation. It begins by describing the different types and depths of burn wounds. It then discusses the pathophysiology and complications of burns, including infection, pulmonary issues, metabolic changes, cardiovascular effects, and scar formation. The document outlines burn assessment, wound zones, and total body surface area calculations. It explains the goals and components of burn rehabilitation, including examination, positioning, splinting, range of motion exercises, and conditioning. Skin grafting and the initial management of burn patients is also summarized.
This document provides information on the management of burn and polytraumatized patients. It defines burn as tissue damage due to heat change and describes the classification and complications of burns. The management of burns involves initially stopping the burning process, estimating the burned surface area, providing fluid resuscitation proportional to burn severity, treating for shock, and addressing infection risks. For polytraumatized patients, rapid assessment and stabilization of airway, breathing and circulation is critical both before and after hospital transport to prevent further harm.
1. The document provides guidance on first aid and management of burn injuries. It discusses stopping the burning process, cooling minor burns, and not removing clothing or applying creams/ointments for severe burns.
2. Hospitalization is necessary for optimal burn care. The acute management phase focuses on airway management, fluid resuscitation, wound care including debridement and dressings, and infection prevention.
3. During the intermediate recovery phase, ongoing treatment focuses on wound healing and avoiding complications through regular cleaning, topical antimicrobials like silver sulfadiazine, and treating any infections.
Burns are skin injuries caused by heat, flames, electricity, chemicals, friction, or sunlight. The severity depends on the depth of injury - first degree burns involve the outer layer of skin while third degree burns extend deeper. Proper burn care includes stopping the burning, removing clothing, ensuring an open airway, cooling the burn, treating for shock, preventing infection, managing pain, and addressing physical and emotional needs during recovery.
Burns are classified by depth and extent of injury. Superficial burns only affect the epidermis while deep burns damage the dermis. Full thickness burns destroy the entire dermis. Management involves fluid resuscitation, wound care, prevention of infection and complications. Local wound care includes cleaning, silver sulfadiazine cream and dressing changes. For deep burns, debridement and skin grafting may be needed. Monitoring of vitals, urine output and blood work is important. Escarotomy may be required for circumferential full thickness limb burns to prevent limb loss.
The document defines burns and classifies them into first, second, and third degree burns based on the depth of skin damage. It describes methods to estimate burn extent using the "rule of nine" and factors that determine burn severity such as depth, size, location, and patient history. Signs and symptoms are explained for each degree of burn. Emergency management of burns is outlined in 17 steps along with complications that can occur.
Burn Injury classification and managementDr Alok Kumar
1. The document discusses various types of burn injuries including thermal burns from heat or flames, scalds from hot liquids, and non-thermal burns from electricity, chemicals, radiation, or cold.
2. It describes the pathology of burns including the severity and depth of tissue damage, vascular changes that can cause shock, and high risks of infection when the skin is destroyed.
3. The management of burns is outlined including treatment of shock, general wound care and infection prevention, skin grafting, and physiotherapy to prevent complications and aid rehabilitation.
This document provides information on burn injuries, including:
1. Defining burns and classifying them based on depth and extent of body surface area affected.
2. Describing the pathophysiology of burns and systemic effects such as fluid loss and circulatory changes.
3. Outlining the therapeutic management of burns, which involves resuscitation, wound care, pain management, and rehabilitation.
This document provides detailed information on burn injuries and burn rehabilitation. It begins by describing the different types and depths of burn wounds. It then discusses the pathophysiology and complications of burns, including infection, pulmonary issues, metabolic changes, cardiovascular effects, and scar formation. The document outlines burn assessment, wound zones, and total body surface area calculations. It explains the goals and components of burn rehabilitation, including examination, positioning, splinting, range of motion exercises, and conditioning. Skin grafting and the initial management of burn patients is also summarized.
This document provides information on the management of burn and polytraumatized patients. It defines burn as tissue damage due to heat change and describes the classification and complications of burns. The management of burns involves initially stopping the burning process, estimating the burned surface area, providing fluid resuscitation proportional to burn severity, treating for shock, and addressing infection risks. For polytraumatized patients, rapid assessment and stabilization of airway, breathing and circulation is critical both before and after hospital transport to prevent further harm.
1. The document provides guidance on first aid and management of burn injuries. It discusses stopping the burning process, cooling minor burns, and not removing clothing or applying creams/ointments for severe burns.
2. Hospitalization is necessary for optimal burn care. The acute management phase focuses on airway management, fluid resuscitation, wound care including debridement and dressings, and infection prevention.
3. During the intermediate recovery phase, ongoing treatment focuses on wound healing and avoiding complications through regular cleaning, topical antimicrobials like silver sulfadiazine, and treating any infections.
Burns are skin injuries caused by heat, flames, electricity, chemicals, friction, or sunlight. The severity depends on the depth of injury - first degree burns involve the outer layer of skin while third degree burns extend deeper. Proper burn care includes stopping the burning, removing clothing, ensuring an open airway, cooling the burn, treating for shock, preventing infection, managing pain, and addressing physical and emotional needs during recovery.
Burns are classified by depth and extent of injury. Superficial burns only affect the epidermis while deep burns damage the dermis. Full thickness burns destroy the entire dermis. Management involves fluid resuscitation, wound care, prevention of infection and complications. Local wound care includes cleaning, silver sulfadiazine cream and dressing changes. For deep burns, debridement and skin grafting may be needed. Monitoring of vitals, urine output and blood work is important. Escarotomy may be required for circumferential full thickness limb burns to prevent limb loss.
Peioperative Anaesthesia Management of Burn Patients.pptxRedwan38
This document discusses the perioperative anesthesia management of burn patients. It begins by describing burn depth classifications from first to fourth degree. It then discusses assessing burn severity using total body surface area calculations. Fluid resuscitation is discussed, noting formulas like Parkland that aim for specific urine outputs. The stages of thermal injuries from initial edema to diuresis are outlined. It details the localized and systemic effects of burns, involving many organ systems. Specific considerations for anesthetizing burn patients are provided, such as increased drug doses. Common burn-related operations and the importance of postoperative analgesia are also summarized.
This document provides information on burns, including definitions, assessment, wound care, complications, and management. It defines burns as tissue damage caused by heat, chemicals, electricity, or radiation. Burn severity is assessed using factors like size, depth, and patient age/health. Wound care involves cleaning and dressing burns, with deeper burns requiring skin grafts. Complications can be local, such as infection, or systemic like fluid loss and organ failure. Management follows ABCDE protocol - Airway, Breathing, Circulation, Disability, Exposure. It also covers tetanus shots, antibiotics, wound care, physiotherapy and more.
1. Burns are injuries to the skin caused by heat, chemicals, electricity, or radiation that result in damage to the skin layers and loss of fluids and electrolytes.
2. Burns are classified based on their depth and cause, with deeper burns affecting more skin layers and causing more severe damage.
3. Treatment of burns involves emergency care at the scene, fluid resuscitation, wound care, infection prevention, pain management, and rehabilitation to restore function.
1. Burns are injuries to the skin caused by heat, chemicals, electricity, or radiation that result in damage to the epidermis and dermis layers. They are classified based on etiology, depth, and percentage of total body surface area affected.
2. Treatment of burns involves emergency care at the scene, fluid resuscitation to prevent shock, wound care including cleaning and dressing changes, antibiotics to prevent infection, pain management, and nutritional support during healing.
3. Nursing management focuses on emergency response, monitoring for complications like fluid and electrolyte imbalances, preventing infection through sterile technique, managing pain, and supporting rehabilitation through physical therapy and psychosocial support.
This document provides information on nursing management of patients with burns. It discusses assessment of burns including determining burn depth, size, and severity. It outlines management of minor burns including cleaning, dressing, and ensuring analgesia. Management of major burns involves establishing airway, ensuring breathing and circulation, administering intravenous fluids, and transferring patients to a burn center for specialized care. Immediate steps include stopping the burning process, assessing for inhalation injuries, and providing fluid resuscitation.
This document discusses burn management and treatment. It defines burns and their causes, classifying them as physical (thermal, electrical) or chemical. Burn depth is classified in 4 degrees based on skin layer involvement. Extent of burn surface area is estimated using the Rule of Nines. Large burns can cause shock due to fluid loss, pain, or infection. Initial fluid resuscitation is crucial using formulas like Parkland to replace lost fluid volume over the first 24 hours. Wound care and infection control are also important for management.
The document provides details about a seminar on burns and management presented by nursing students. The objectives of the seminar were to provide in-depth knowledge about burns, classification of burns, clinical manifestations, diagnostic tests, and medical, surgical and nursing management of burns. The seminar also discussed complications and prevention of burns. Various topics covered included anatomy and physiology of skin, definition of burns, incidence of burns worldwide and in India, classification of burns based on mechanism and extent, and management of different degrees of burns.
Burns are injuries caused by heat, cold, electricity, chemicals, friction or radiation. There are different types of burns including thermal, chemical, electrical and radiation burns. Burns are classified by depth from superficial to full thickness. Management of burns involves three phases - emergent, intermediate and rehabilitative. The emergent phase focuses on fluid resuscitation while the intermediate phase involves wound care and the rehabilitative phase aims to return the patient to their normal activities. Nursing plays an important role in assessing burns, providing wound care, pain management and rehabilitation.
Burn Management is complex topic to learn and master during MS General Surgery courses.It is pet favorite questions during viva voice/practical exams.With this ppt it will help you to gain basic knowledge related to this Topic.If you like my work then do share your response by mailing me on officialdrrishi@outlook.com
The document discusses burns, including:
1. The structure of skin and how burns damage the epidermis and dermis layers.
2. The main causes of burns are thermal, chemical, inhalation, electric, and radiation burns.
3. Burn classification includes depth, extent, location, and patient risk factors which determine prognosis.
4. Burn management has three phases - emergent, acute, and rehabilitative - and the emergent phase focuses on airway management, IV fluids, wound care, drugs, and nutrition to stabilize the patient.
The document provides guidelines for the initial care of burn patients. It describes evaluating the patient's airway, breathing, and circulation as top priorities in the primary survey. It recommends establishing intravenous access and monitoring vital signs. The secondary survey involves a full head-to-toe examination to assess the extent and depth of burns and check for other injuries. Proper wound care includes cleaning and dressing burns, with topical antibiotics like silver sulfadiazine applied. Fluid resuscitation is also critical based on the percentage of total body surface area burned. Admission to a burn unit is recommended for deeper or more extensive burns.
This document provides information about burn injuries including:
1. Definitions of burn depth including first, second, and third degree burns. Common causes of burns are also listed.
2. The pathophysiology of burns is described affecting several body systems like hemodynamic changes, electrolyte imbalance, renal and pulmonary function, hematologic and GI systems, and decreasing immunity.
3. Burn severity is determined by depth, extent of total body surface area burned, age, and location of burns on the body. Common classifications of burns and methods to estimate burn extent are also summarized.
Thermal burns can damage the epidermis and dermis layers of skin and are classified as superficial, partial-thickness, or full-thickness based on depth of injury. Initial management of burns focuses on airway protection, fluid resuscitation to prevent shock, analgesia, and wound care. Extent of burns is estimated based on total body surface area involved. Hospital admission is recommended for burns over 10% TBSA in children or 15% in adults due to risk of complications like infection, low blood volume, breathing issues, and joint problems that require close monitoring.
Presentation.presentation for burns and complicationsPranavTrehan2
This document provides information on burns and their complications. It begins by defining a burn injury and discussing the epidemiology of burns. It then describes the anatomy of skin and classifies different types of burn injuries from epidermal burns to full thickness burns. The document outlines pathological changes that occur after burns and discusses clinical features, complications, determining burn extent, and medical and surgical management of burns including wound care, skin grafting, and physiotherapy.
This topic is oriented mainly on the Bailey & Love - 26th edition.
This will be of immense help for the MBBS - Students for the Theory as well as Clinical application.
Burns are wounds caused by heat, chemicals, electricity or radiation that damage the skin. They are classified based on depth and percentage of total body surface area affected. First degree burns involve only the outer layer of skin while deeper burns affect underlying tissues. Symptoms depend on depth but may include pain, blistering, and loss of sensation. Systemic effects can include increased metabolic demands and risk of infection. Treatment involves cooling the burn, fluid resuscitation, wound care, antibiotics and surgery. Complications may include scarring, contractures and infections if not properly managed.
This document provides information on burns, including causes, types, assessment, management, and treatment. It discusses:
- The different causes of burns, including thermal, electrical, chemical, and radiation burns.
- How to assess burn severity based on depth and extent of damage. Burns are typically classified as superficial, partial thickness, full thickness, or fourth degree.
- The signs and symptoms associated with different burn depths. More severe burns involve deeper tissue damage and have a poorer prognosis.
- The three phases of burn management: emergent/resuscitative, intermediate, and rehabilitative. The emergent phase focuses on initial first aid, ABCDE assessment, pain management and fluid resuscitation
This document provides an overview of physiotherapy for burn patients. It discusses the types, causes, and classifications of burns including superficial, partial thickness, and full thickness burns. It also covers burn wound zones, complications of burns like infection and metabolic issues, and the general management of burns including first aid, hospital referral, early hospital management, and fluid replacement. The goal of physiotherapy is to prevent contractures and aid in rehabilitation.
it consist definition, types of burn, its cause, scales to measure degree of burn, first aid management and supportive management along with rehabilitation therapy.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Peioperative Anaesthesia Management of Burn Patients.pptxRedwan38
This document discusses the perioperative anesthesia management of burn patients. It begins by describing burn depth classifications from first to fourth degree. It then discusses assessing burn severity using total body surface area calculations. Fluid resuscitation is discussed, noting formulas like Parkland that aim for specific urine outputs. The stages of thermal injuries from initial edema to diuresis are outlined. It details the localized and systemic effects of burns, involving many organ systems. Specific considerations for anesthetizing burn patients are provided, such as increased drug doses. Common burn-related operations and the importance of postoperative analgesia are also summarized.
This document provides information on burns, including definitions, assessment, wound care, complications, and management. It defines burns as tissue damage caused by heat, chemicals, electricity, or radiation. Burn severity is assessed using factors like size, depth, and patient age/health. Wound care involves cleaning and dressing burns, with deeper burns requiring skin grafts. Complications can be local, such as infection, or systemic like fluid loss and organ failure. Management follows ABCDE protocol - Airway, Breathing, Circulation, Disability, Exposure. It also covers tetanus shots, antibiotics, wound care, physiotherapy and more.
1. Burns are injuries to the skin caused by heat, chemicals, electricity, or radiation that result in damage to the skin layers and loss of fluids and electrolytes.
2. Burns are classified based on their depth and cause, with deeper burns affecting more skin layers and causing more severe damage.
3. Treatment of burns involves emergency care at the scene, fluid resuscitation, wound care, infection prevention, pain management, and rehabilitation to restore function.
1. Burns are injuries to the skin caused by heat, chemicals, electricity, or radiation that result in damage to the epidermis and dermis layers. They are classified based on etiology, depth, and percentage of total body surface area affected.
2. Treatment of burns involves emergency care at the scene, fluid resuscitation to prevent shock, wound care including cleaning and dressing changes, antibiotics to prevent infection, pain management, and nutritional support during healing.
3. Nursing management focuses on emergency response, monitoring for complications like fluid and electrolyte imbalances, preventing infection through sterile technique, managing pain, and supporting rehabilitation through physical therapy and psychosocial support.
This document provides information on nursing management of patients with burns. It discusses assessment of burns including determining burn depth, size, and severity. It outlines management of minor burns including cleaning, dressing, and ensuring analgesia. Management of major burns involves establishing airway, ensuring breathing and circulation, administering intravenous fluids, and transferring patients to a burn center for specialized care. Immediate steps include stopping the burning process, assessing for inhalation injuries, and providing fluid resuscitation.
This document discusses burn management and treatment. It defines burns and their causes, classifying them as physical (thermal, electrical) or chemical. Burn depth is classified in 4 degrees based on skin layer involvement. Extent of burn surface area is estimated using the Rule of Nines. Large burns can cause shock due to fluid loss, pain, or infection. Initial fluid resuscitation is crucial using formulas like Parkland to replace lost fluid volume over the first 24 hours. Wound care and infection control are also important for management.
The document provides details about a seminar on burns and management presented by nursing students. The objectives of the seminar were to provide in-depth knowledge about burns, classification of burns, clinical manifestations, diagnostic tests, and medical, surgical and nursing management of burns. The seminar also discussed complications and prevention of burns. Various topics covered included anatomy and physiology of skin, definition of burns, incidence of burns worldwide and in India, classification of burns based on mechanism and extent, and management of different degrees of burns.
Burns are injuries caused by heat, cold, electricity, chemicals, friction or radiation. There are different types of burns including thermal, chemical, electrical and radiation burns. Burns are classified by depth from superficial to full thickness. Management of burns involves three phases - emergent, intermediate and rehabilitative. The emergent phase focuses on fluid resuscitation while the intermediate phase involves wound care and the rehabilitative phase aims to return the patient to their normal activities. Nursing plays an important role in assessing burns, providing wound care, pain management and rehabilitation.
Burn Management is complex topic to learn and master during MS General Surgery courses.It is pet favorite questions during viva voice/practical exams.With this ppt it will help you to gain basic knowledge related to this Topic.If you like my work then do share your response by mailing me on officialdrrishi@outlook.com
The document discusses burns, including:
1. The structure of skin and how burns damage the epidermis and dermis layers.
2. The main causes of burns are thermal, chemical, inhalation, electric, and radiation burns.
3. Burn classification includes depth, extent, location, and patient risk factors which determine prognosis.
4. Burn management has three phases - emergent, acute, and rehabilitative - and the emergent phase focuses on airway management, IV fluids, wound care, drugs, and nutrition to stabilize the patient.
The document provides guidelines for the initial care of burn patients. It describes evaluating the patient's airway, breathing, and circulation as top priorities in the primary survey. It recommends establishing intravenous access and monitoring vital signs. The secondary survey involves a full head-to-toe examination to assess the extent and depth of burns and check for other injuries. Proper wound care includes cleaning and dressing burns, with topical antibiotics like silver sulfadiazine applied. Fluid resuscitation is also critical based on the percentage of total body surface area burned. Admission to a burn unit is recommended for deeper or more extensive burns.
This document provides information about burn injuries including:
1. Definitions of burn depth including first, second, and third degree burns. Common causes of burns are also listed.
2. The pathophysiology of burns is described affecting several body systems like hemodynamic changes, electrolyte imbalance, renal and pulmonary function, hematologic and GI systems, and decreasing immunity.
3. Burn severity is determined by depth, extent of total body surface area burned, age, and location of burns on the body. Common classifications of burns and methods to estimate burn extent are also summarized.
Thermal burns can damage the epidermis and dermis layers of skin and are classified as superficial, partial-thickness, or full-thickness based on depth of injury. Initial management of burns focuses on airway protection, fluid resuscitation to prevent shock, analgesia, and wound care. Extent of burns is estimated based on total body surface area involved. Hospital admission is recommended for burns over 10% TBSA in children or 15% in adults due to risk of complications like infection, low blood volume, breathing issues, and joint problems that require close monitoring.
Presentation.presentation for burns and complicationsPranavTrehan2
This document provides information on burns and their complications. It begins by defining a burn injury and discussing the epidemiology of burns. It then describes the anatomy of skin and classifies different types of burn injuries from epidermal burns to full thickness burns. The document outlines pathological changes that occur after burns and discusses clinical features, complications, determining burn extent, and medical and surgical management of burns including wound care, skin grafting, and physiotherapy.
This topic is oriented mainly on the Bailey & Love - 26th edition.
This will be of immense help for the MBBS - Students for the Theory as well as Clinical application.
Burns are wounds caused by heat, chemicals, electricity or radiation that damage the skin. They are classified based on depth and percentage of total body surface area affected. First degree burns involve only the outer layer of skin while deeper burns affect underlying tissues. Symptoms depend on depth but may include pain, blistering, and loss of sensation. Systemic effects can include increased metabolic demands and risk of infection. Treatment involves cooling the burn, fluid resuscitation, wound care, antibiotics and surgery. Complications may include scarring, contractures and infections if not properly managed.
This document provides information on burns, including causes, types, assessment, management, and treatment. It discusses:
- The different causes of burns, including thermal, electrical, chemical, and radiation burns.
- How to assess burn severity based on depth and extent of damage. Burns are typically classified as superficial, partial thickness, full thickness, or fourth degree.
- The signs and symptoms associated with different burn depths. More severe burns involve deeper tissue damage and have a poorer prognosis.
- The three phases of burn management: emergent/resuscitative, intermediate, and rehabilitative. The emergent phase focuses on initial first aid, ABCDE assessment, pain management and fluid resuscitation
This document provides an overview of physiotherapy for burn patients. It discusses the types, causes, and classifications of burns including superficial, partial thickness, and full thickness burns. It also covers burn wound zones, complications of burns like infection and metabolic issues, and the general management of burns including first aid, hospital referral, early hospital management, and fluid replacement. The goal of physiotherapy is to prevent contractures and aid in rehabilitation.
it consist definition, types of burn, its cause, scales to measure degree of burn, first aid management and supportive management along with rehabilitation therapy.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
DECLARATION OF HELSINKI - History and principlesanaghabharat01
This SlideShare presentation provides a comprehensive overview of the Declaration of Helsinki, a foundational document outlining ethical guidelines for conducting medical research involving human subjects.
2. Is one of the most serious injuries to the body.
They cause dramatic damage of the
physiological functions of the skin which lead
to serious local or systemic complications.
By size and weight the skin is the second
largest organ in the body next only to the
muscles.
3. Aetiology
1. Scalds caused by boiled liquids.
2. Flame burns
3. Electric burns
4. Chemical burns are due to either acids or
alkalis.
5. Inhalation burns due to exposure to hot
gases and may affect the upper and lower
airway.
4. Classification
A. Classification according to the
percentage surface area involved:
This follow the rule of 9.
In children he rule of 9 needs some modification
due to the large size of the head in comparison to
the rest of the body.
5.
6. Burns are classified into:
1 Major burn Involves more than 30% of the body surface
area.
2 Intermediate
burn
Involves 15-30% in adults & Between 10-30% in
child.
3 Minor burn than 15% in adult & 10% in children.
7. B. Classification according to the depth of
the burnt tissues:
1. First degree burns:
as in sunburns
Only the epidermis is damaged causing
erythema of the skin.
They heal rapidly.
8. 2. Second degree burns:
The epidermis & portion of dermis are damaged
If no infection occurs epithelial regeneration can
occur from the remnants of hair follicles and sweat
glands in dermis and the burn will heal in 3 weeks.
If infection occurs these epithelial elements are
destroyed and the case will be changed to a full
thickness burn.
9. This degree if further subdivided into:
a) Superficial partial thickness burn: only
epidermis is damaged causing erythema
of the skin and heal rapidly.
b) Deep partial thickness burns: the
epidermis and portion of the dermis are
damaged.
10.
11.
12. 3. Full thickness burn:
These is complete destruction of epidermis and
dermis.
After separation of the eschar by the 3rd week, the
patient should be prepared for skin grafting.
The differentiation of partial thickness from full
thickness burn sometimes difficult and even in the
same area.
13. Both pattern may intermingle together, how ever
the following may help to differentiate:
Partial thickness burn Full thickness burn
1. Mottled red White or black eschar
2. Moist due to exudation of
plasma
Dry
3. Show blisters surrounded by
erythema
Possible visible thrombosed
subcutaneous vessels.
4.Very painful & sensitive to air
(pin pick test)
Painless due to loss of the terminal
nerve ending.
5. Heal within 3 weeks Granulation tissue formation and
eschar separation starts to occur
after 3 weeks.
14.
15.
16.
17. Epilation test:
Useful test is to pull on a hair, if the hair pulls
easily & painlessly the burn is deep one.
18.
19.
20.
21.
22.
23.
24.
25.
26. Pathophysiology
1. Increased capillary permeability lead to the
loss of enormous amount of fluids & protein
in the damaged area. It maximum in the first
8 hrs. and continue for 48 hrs.
2. Excessive loss of water by evaporation with
loss of calories.
3. The burnt area will be colonized by bacteria.
27. Complication
A. Systemic complication:
1. Inhalation injury:
Asphyxia may occur immediately from
inhalation oh heat or gases.
Atelectasis, pneumonia, emphysema and
pulmonary oedema may follow.
Finally respiratory failure may occur with
systemic sepsis.
28. 2. Neurogenic & hypovolemic shock
3. Renal failure: acute renal failure can occur
after prolonged uncorrected hypovolemia.
4. Gastro intestinal complications:
a. Acute peptic ulcer (Curling’s ulcer).
b. Ileus usually occurs during the early post burn
period.
c. Acute ulcerations of the colon.
d. Multiple organ failure (MOF) often follow sepsis
(the outcome is poor).
29. B. Local complication:
a) Early local complication:
1. Infection:
Is the primary cause of death
May lead to development of septicaemia and septic shock
It usually occurs between 4-7 days post burn.
Treatment: by prevention through proper local burn wound
care and systemic antibiotic therapy.
2. Constricting eschars: may form in deep circumferential
burns of the limbs and chest and should be treated by urgent
escharotomy (release).
3. Oedema: in burn of the face & neck, may lead to suffocation
and urgent tracheostomy may be needed.
30. B. Delayed complications:
1. Contracture across joint
2. Scar formation (hypertrophic or keloid)
3. Malignant transformation ( Marjolin ulcer)
31. Management of burns
A. First aid management:
1. Patent airway should be assured.
2. Strong analgesic as 50 mg Pethidine I.V
3. Tetanus prophylaxis
4. Saline or tap water at room temperature
for 15 minutes to decrease oedema and
relieve the pain.
32. B. Minor burns:
Can treated as outpatient & treatment as
1. Dressing using proper local chemotherapeutic
2. Analgesia
C. All majors and most moderate burns (except very
superficial ones) should be admitted to the burn unit:
1. A wide bore I.V. cannula is inserted
2. Foley’s catheter to check the urine output
3. Treatment essentially consist of :
33. I. Resuscitative fluid therapy:
The amount & rate of fluid replacement:
Depend on the patient’s weight and the % of total body
surface area injured.
Must be given for the first 48 hrs. and after that
The amount infused during the first 24 hrs. is 2 ml/ percent
surface area burn / kg body weight. Half the amount
calculated is given over the first 8 hrs. and other half over
next 16 hrs. Also half the calculated is given over the
second day.
34. The types:
1. Evan’s formula:
1st day: 1 ml/kg/ % burn normal saline + 1 ml /kg/ %burn colloid
(dextran) + 200 ml glucose.
2nd day: ½ ml /kg/ %burn normal saline + 0.5ml/ kg / %burn
colloid + 200 ml glucose.
1. Parkland’s formula:
4 ml / kg / %burn RL / day
½ the amount is given in the first 8 hrs. , ¼ in the second 8hrs. ,
and ¼ in the third 8 hrs.
3. Modified Brook’s formula:
1st day: 2-3 ml/kg/ %burn LR + 2000 ml glucose.
2nd day: 1 ml/kg/ %burn RL + 0.5 ml/kg/ %burn colloid +2000ml
glucose.
35. N.B:
In all formulae, the maximum percentage of
burn calculated is 50% , otherwise serious over
infusion may occur.
Administration of blood can be started after
48hrs. guided by haematocrit value.
Oral intake is avoided during the first 48hrs. to
avoid gastrointestinal complication then started
gradually after that.
36. II. Local burn wound care: (after
resuscitation):
Constricting eschars (in the limbs and chest) have to
be released immediately. Urgent fasciotomy in
deeper burns may be limb saving.
The aim of the local wound care is to avoid infection.
After cleansing & conservative debridement, topical
antibiotics should be applied.
37. The wound is managed by either:
A. The exposure method
B. Bulky occlusive dressing (the occlusive
method)
38. Open method Closed method
Indication
1. Burns of face, neck,
perineum.
2. Burns involving one side
of trunk.
1. Circumferential
burns.
2. Limbs (to prevent
stiffness &
adhesions.
Advantages
1. More comfortable to
patients.
2. Avoid repeated
dressing.
3. Decrease anaerobic
bacterial growth.
1. Decrease cross
infection.
2. Decrease fluid loss
by evaporation.
3. Decrease pain by
covering exposed
nerves
4. Decrease oedema of
tissue by
compression.
39. Special types of burns
A. Electrical burns:
Severity of the burn is divided into high and low tension
injuries according to the voltage.
Tissue damage is due to the passage of the electric current
through blood and bones.
B. Chemical burns:
Severity of burn is determined by the strength of the agent,
amount, duration of skin contact and its mechanism of
action.
Management:
a. Systemic control >> by antidote
b. Locally the agent should be thoroughly cleaned.