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Burns Management
Presented by :
Dr (Maj) Rishi Raj Singh
Management of Burns
Burn care is typically categorized into three phases of care:-
1.Emergent / resuscitative phase -From onset of injury to
completion of fluid resuscitation.
2.Acute / intermediate phase -From beginning of diuresis to
near completion of wound closure.
3.Rehabilitative phase - From major wound closure to return
to individual’s optimal level of functioning.
Pre-Hospital Setting
• During and immediately after injury, burned patients must be
removed from the source and the burning process stopped.
• Next attention should be directed at initial resuscitation,
starting with the airway.
a) For those burned with flames, inhalation injury should
always be suspected and 100% oxygen given by
facemask.
• All rings, watches, jewellery, and belts should be removed
because they retain heat and can produce a tourniquet like
effect.
• Room temperature water should be copiously poured on the
wound within 3 hours of injury.
ADMISSION CRITERIA & CRITERIA FOR
REFERRAL
The American Burn Association and the American College of Surgeons
Committee on Trauma
1.100 or more bedded hospital or a burn centre
All major burns like:
• Partial thickness burns of >25% of TBSA in adults.
• >20% burns in children below 10 yrs and adults >50 yrs.
• Full thickness burns >10% TBSA.
• Burns of face, eyes, ears, and perineum.
• Chemical burns, electrical burns, inhalational injury, and underlying debilitating
illness.
2. 30-100 bedded community health centre hospital
• Moderate burns like burns >15% TBSA (excluding burns described above).
Initial Assessment
• It is divided into the primary and secondary survey.
• Exposure to heated gases and smoke often results in damage to the
upper respiratory tract which results in localized edema,
• In combination with generalized whole-body edema associated with
severe burn, may obstruct the airway over the course of hours.
• Airway injury must be suspected with
• Facial burns,
• Singed nasal hairs,
• Carbonaceous sputum
• Tachypnoea
• Respiratory status must be continually monitored to assess for airway
intervention and ventilatory support.
Initial management of a major burn: I—overview,Shehan Hettiaratchy, BMJ. 2004 Jun 26; 328(7455): 1555–1557. doi: 10.1136/bmj.328.7455.1555
Facial Burn Carbonaceous particles staining a patient's face after a burn in
an enclosed space
Initial Assessment
Perform an ABCDEF primary survey
A—Airway with cervical spine control
B—Breathing and ventilation
C—Circulation
D—Neurological disability
E—Exposure with environmental control
F—Fluid resuscitation
A—Airway with cervical spine control
INDICATIONS FOR EARLY INTUBATION
“Progressive hoarseness is a sign of impending airway obstruction, and
endotracheal intubation should be instituted early before oedema irretrievably
distorts the upper airway anatomy.”
• Extent of the burn (total body surface area burn > 40%-50%)
• Extensive and deep facial burns
• Burns inside the mouth
" Significant edema or risk for edema
• Difficulty swallowing
• Signs of respiratory compromise
• Decreased level of consciousness where airway protective reflexes are
impaired
• Anticipated patient transfer of large burn with airway issue without qualified
personnel to intubate en-route.
Definitive airways
OROPHARYNGEAL/
NASOPHARYNGEAL
SUPRAGLOTTIC
DEVICES-
LMA, IGEL, LTA
•Cuffed Tube below vocal cords.
•Inflated.
•Connected to 02 source.
•Supported with ventilation
Surgical airways
1.Needle cricothyroidotomy
2.Surgical cricothyroidotomy
3.Tracheostomy
B-Breathing and ventilation
• All burn patients should receive 100% oxygen through a humidified
non-rebreathing mask on presentation.
• Mechanical restriction of breathing—Deep dermal or full thickness
circumferential burns of the chest can limit chest excursion and
prevent adequate ventilation.
• Blast injury—If there has been an explosion, blast lung can complicate
ventilation. Penetrating injuries can cause tension pneumothoraxes,
and the blast itself can cause lung contusions and alveolar trauma and
lead to adult respiratory distress syndrome.
• Breathing concerns arise from three general causes:
1. Hypoxia
2. Carbon monoxide poisoning,
3. Smoke inhalation injury
Hypoxia-Hypoxia is a state in which
oxygen is not available in sufficient
amounts at the tissue level to
maintain adequate homeostasis.
It is common in
1.Smoke Inhalation Injury
2.Circumferential Chest Burns
3.Thoracic trauma unrelated to
thermal injury.
Investigation –
• Pulse oximetry
• ABG
Management-
Administer supplemental oxygen
with or without intubation.
CO POISONING-It inhibits aerobic
metabolism via inhibition of
complex IV of ETC (cytochrome c
oxidase).
It is common in
1. Motor exhaust.
2. Closed room with Gas heaters.
3. Burned in enclosed areas
Investigation-
• Normal PaO2.
• Elevated carboxyhemoglobin on
co-oximetry.
• Left shift in ODC-- Increase
affinity for O2 – decrease O2
unloading in tissues.
Management-
Administer 100% oxygen.
Hyperbaric oxygen if severe.
SMOKE INHALATIONAL INJURY
Caused by heat, particulates
(< 1 μm diameter), or irritants
(eg, NH3)
Criteria to diagnose
1.Exposure to the combustible
agent
2.Exposure of smoke to lower
airway below vocal cards - seen in
bronchoscopy.
Investigation -
• Chest x-ray and
• Arterial blood gas
determination.
Management -
Early airway management.
Avoid hypoxia.
“Mortality increases to double in
inhalational injury with burn as compare
to isolated burn”
C- Circulation
•BP, HR, color of unburnt skin
•2 large bore I.V.s in unburnt skin
•Draw bloodwork.
•Insert urinary catheter.
•Insert nasogastric tube, if necessary
•Doppler exam of circumferentially burnt extremities
D—Neurological disability
• All patients should be assessed for responsiveness with the Glasgow coma
scale; they may be confused because of hypoxia or hypovolaemia.
E—Exposure with environment control
• The whole of a patient should be examined (including the back) to get an
accurate estimate of the burn area and to check for any concomitant
injuries.
• Burn patients, especially children, easily become hypothermic. Patients
should be covered and warmed as soon as possible.
F—Fluid resuscitation
• Burns Resuscitation formulae
• Fluid of Choice-Hartmann’s solution or Ringer’s lactate is the most commonly used
crystalloid as it most closely replicates the osmolality of plasma.
• It is considerably less expensive than colloid and can maintain intravascular
volume.
• Lactated Ringer’s (RL)
NS can produce hyperchloremic acidosis
First 1⁄2 of total volume given in the first 8 hours
Remaining 1⁄2 of total volume given over following 16 hours
Source: Sabiston Textbook of Surgery
Revised ATLS Burn Resuscitation
•In children maintenance fuid must also be
given. This is normally dextrose–saline
given as follows:
Colloid Resuscitation
1.The most commonly used colloid is human albumin solution
2. Albumin should be preferably administered after the first 12 hours post burn as the
massive fluid shifts drive proteins out of the cells.
3.The most common colloid-based formula is the Muir and Barclay formula, which
estimates the amount of fuid that needs to be infused during the first 36 hours post
burn:
Six portions are given in total over 36 hours:
Give one infusion 4 hourly for 12 hours (three portions in total);
Then one infusion 6 hourly for 12 hours (two portions in total);
The final infusion to be given over 12 hours.
Basic formula is: TBSA% × weight (kg) × 0.5 = one portion
Adoption of rescue colloid during burn resuscitation decreases fluid administered and restores end-organ
perfusion lPaul Comish et al Burns,Volume 47, Issue 8, December 2021, Pages 1844-1850
Pain management
• Analgesia is a vital part of burns management.
• Small burns, especially superficial burns, respond well to
simple oral analgesia, paracetamol and non-steroidal anti-
inflammatory drugs.
• In patients with large burns, continuous analgesia is required,
beginning with infusions and continuing with oral tablets.
• Powerful, short-acting analgesia should be administered
before dressing changes.
Investigations for major burns
General
• Full blood count, packed cell volume, urea and electrolyte concentration, clotting screen
• Blood group, and save or crossmatch serum
Electrical injuries
• 12 lead electrocardiography
• Cardiac enzymes (for high tension injuries)
Inhalational injuries
• Chest x ray
• Arterial blood gas analysis
Can be useful in any burn, as the base excess is predictive of the amount of fluid resuscitation
required
Helpful for determining success of fluid resuscitation and essential with inhalational injuries
or exposure to carbon monoxide.
Secondary Survey
• This is a head to toe examination to
look for any concomitant injuries.
• History: This should aim at evaluating:
• Time of burn
• Possibility of being a medicolegal case.
• AMPLE history
Allergies
Medications
Past medical history
Last meal
Events and Environment of burn
injury.
B. Physical examination and evaluation of
burn wound.
• (i) Depth of burn
I Degree burns: Minor epithelial damage,
present as redness, clinically insignificant.
II Degree burns : Partial thickness burns &
scalds. These burns are painful
III Degree burns: Full thickness burns, usually
painless
• (ii) Calculation of Surface area of burn.
• Wallace's Rule of Nine is useful in adults. In
children, Lund & Brewder's Chart can be
used.
• A rough guide is - surface area of palm is
approximately equal to 1% of Total Body
Surface Area (TBSA).
I- Early Excision and wound debridement
• Early excision and grafting of the burn, noted as crucial during post-
burn days 2-12.
• When burn patients undergo early excision and grafting, there is a
decrease in the length of stay and faster healing time.
• Goal is to safely excise and debride the largest surface areas first, such
as the anterior or posterior trunk or large areas on the extremities.
• For cosmetic areas and functional areas, excision should be
performed at least within 7 to 14 days to improve outcomes.
Burn Debridement, Grafting, and ReconstructionJordan A. Browning; Renford Cindass. Copyright © 2023, StatPearls Publishing LLC.
• Surgical excision with the use of surgical knives such as the
Weck/Goulian knife and the Blair knife has been the mainstay for surgical
debridements.
• When encountering a blister, it is best to un-roof it. If left intact, the
blister becomes a potential source of infection, increases healing time,
and negatively affects patient comfort and mobility.
• Debridement techniques
1.Hydrosurgical debridement-Advantage Lowers operative cost
2. Autolytic/Enzymatic debridement- Disadvantage local redness raise
cosmetic concerns, increase pain.
3. Mechanical debridement- Disadvantage causes significant pain
4. Sterile maggots- limits real world application.
Burn Debridement, Grafting, and ReconstructionJordan A. Browning; Renford Cindass. Copyright © 2023, StatPearls Publishing LLC.
Versajet™ hydrosurgery system Nexobrid ™ enzymatic debridement
Pilling Weck Goulian Skin Graft Knife
Goulian Skin graft knife
Skin graft harvesting through the use of a
Blair's knife
II- Wound dressing
• Aims
1.To protect damaged epithelium
2.Minimize bacterial and fungal contamination
3.Occlusive dressing prevents evaporation.
1st Degree burn- Expose the wound
2nd Degree (Superficial)- Vaseline/paraffin gauze
- Collagen dressing (if not infected)
2nd Degree (Deep) - Collagen dressing (if not infected)
- Hydrocolloid dressing
Source: Sabiston Textbook of Surgery
Special Agents;Antimicrobials
• Available topical antibiotics can be divided into three classes: salves,
soaks, and antimicrobial dressings.
• Salves are generally applied directly to the wound with cotton
dressings placed over them.
• Soaks are solutions poured into cotton dressings on the wound,
• Antimicrobial dressings contain active agents to inhibit microbial
growth, generally some form of silver ion or other antibiotic.
Source: Sabiston Textbook of Surgery
Salves Soaks
Agent Advantages Disadvantages
SSD (1%) Most commonly used,good
against pseudomonas and
gram negative bacteria
1.Frequent change of
dressing.
2.Does not penetrate Eschar
Silver nitrate Good action against
pseudomonas,
Little action against gram
negative
Mafenide acetate (5%) Penetrate Eschar 1.Painful application
2.Can induce Lactic Acidosis
or metabolic acidosis
Cerium nitrate Gram negative bacteria and
fungi.
Special Agents
Source: Sabiston Textbook of Surgery
• These CeO2 nanocoating's exhibit low toxicity, are easy to manufacture and
have a high level of antimicrobial properties even at very low
CeO2 concentrations. High-power ultrasonic treatment was used to coat the
surface of cotton fabric with CeO2 nanoparticles.
• Cerium Nitrate Treatment Provides Eschar Stabilization through Reduction
in Bioburden, DAMPs, and Inflammatory Cytokines.
https://pubmed.ncbi.nlm.nih.gov/31808807/
• Allografts- Skin allograft is obtained from a human donor (deceased or healthy) and used as a temporary
cover for burn wounds. It can be classified into the following:
1. Viable:
a. Fresh (freshly harvested from donor or refrigerated)
b. Cryopreserved
2. Nonviable:
a. Lyophilized (glycerol)
b. Irradiated (gamma irradiation)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676815/
III- Synthetic and Biological Dressing
• Full-thickness burn wounds should be excised and covered with split-
thickness autograft. However, autograft has limitation of donor-site
availability and morbidity. When autograft is not available, allograft can
be used.
Human Skin Allograft: Is it a Viable Option in Management of Burn Patients? Saurabh Gupta et al J Cutan
Aesthet Surg. 2019 Apr-Jun; 12(2): 132–135.
doi: 10.4103/JCAS.JCAS_83_18
Porcine xenografts vs. (cryopreserved) allografts
in the management of partial thickness burns: is
there a clinical difference?
• Both allografts and porcine
xenograft seem to perform equally
well clinically with regard to
healing related outcomes
• Clinical aspects being equal, other
aspects such as price and
availability should be used to
decide which material to use for
the management of partial
thickness burns.
By Michel H E Hermans Burns2014 May;40(3):408-15.doi: 10.1016/j.burns.2013.08.020. Epub 2013 Sep 6.
Synthetic and Biological Dressing
Acellular
• Biobrane
• Integra
• Matriderm
•
®
Renoskin
• Alloderm
• Various forms of
collagen (sheet/gel/flakes)
Cellular allogeneic
• Dermagraft
• Apligraft (Graftskin)
• Orcel
• Hyalomatrix
• TransCyte
Cellular autologous
• Cultured epidermal
autograft (CEA)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676815/
Smith & Nephew Biobrane 13 CM X 13 CM
INTEGRA™ Bilayer Matrix
Wound Dressing
Acellular Synthetic Dressing Material
Dermagraft®, a bioengineered
human dermal equivalent
Meat Band-Aids: Apligraf®
Cellular Synthetic Dressing Material
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676815/
Type Advantages Disadvantages
Allograft 1.Presence of a basement membrane
2.More intact and natural extracellular
matrix composition
3.Provides growth factors and cytokines
(helps in wound bed preparation)
4.Excellent reepithelialisation rate
5. Relatively less expensive
1 Antigenicity (rejection)
2. Risk of infection
3. Availability of donor
Synthetic skin substitutes 1.Controlled composition of scaffold
2.Growth factors and matrix components
can be added as required
3.Reduces pain
4.Less frequent dressing change
1.Lack of basement membrane
2.High cost
3.Antigenicity (foreign body reaction)
4.Reepithelialization and engraftment
rates are similar or less than allograft
(inconclusive evidence)
IV- Escharotomies
• When there is deep partial-thickness or full-thickness burns encompass the
circumference of an extremity, peripheral circulation to the limb can be
compromised.
• Development of generalized edema beneath a nonyielding eschar impedes
venous outflow and eventually affects arterial inflow to the distal beds.
• This is recognized by numbness and tingling in the limb and increased pain in
the digits.
• General rules-
1.Extend the wound beyond the deep burn.
2.Diathermy any significant bleeding vessels
3.Apply haemostatic dressing and elevate the limb postoperatively
Bedside Escharotomies for Burns by Christine Yin et al Chapter First Online: 05 January 2019, Atlas of Critical
Care Procedures pp 251–254.
V- Fasciotomies
• Increase muscle compartment pressure
after escharotomies may indicate
fasciotomy.(tissue pressure >30 mmHg)
• Fasciotomy or fasciectomy is a surgical
procedure where the fascia is cut to
relieve tension or pressure in order to
treat the resulting loss of circulation to an
area of tissue or muscle. Fasciotomy is a
limb-saving procedure when used to treat
acute compartment syndrome.
Downloaded from https://academic.oup.com/jbcr/advance-article-abstract/doi/10.1093/jbcr/irz104/5518389 by guest on 13
September 2019
VI- Skin Grafting
• Langer’s Line-Skin tension line along
longitudinal axis of elliptical wounds on skin
of cadavers.
• Relaxed skin tension lines (RSTL)-Parallel to
wrinkles, perpendicular to underlying
muscle.
“Langer's lines have relevance to forensic
science and the development of surgical
techniques.”
Skin graft
STSG= Epidermis +
Variable amount of
dermis
(Thiersch)
Thin-0.15-0.3 mm
Intermediate-0.3-0.45 mm
Thick-0.45-0.6 mm
FTSG= Epidermis +
Entire dermis
(Wolfe)
• MC donor site-
Anteromedial thigh,
buttocks.
• No need for suture
• After Healing can be
reused
• MC donor site-Post
auricular skin,
supra/infraclavicular
fossa and groin skin
• Need for suture
• After Healing cannot be
reused
• Primary Contracture
Occurs at time of Harvest
• Elastin mediated
• Secondary Contracture
Occurs at time of Healing
• Myofibroblast mediated
Humby’s Knife to
raise STSG
Advantages of Meshing of Skin graft
1.Increases Surface area by 1.5 times
2.Prevents Hematoma collection beneath the grafts
Total full-thickness skin grafting for treating patients with extensive facial burn
injury: A 10-year experience
Author links open overlay panel Sergey B. Bogdanov et al, , Burns,Volume 47,
Issue 6, September 2021, Pages 1389-1398
Full Thickness Skin Grafts
Physiology of Graft Take
• Graft take is the incorporation of the new graft into implanted site and can be divided into four
main stages:
• Haemostasis – Normal physiological response to prevent excessive bleeding following grafting.
• Plasmatic imbibition – occurs around days 1-2, whereby initially fluid migrates into graft bed,
becoming oedematous but remains avascular.
• Inosculation – occurs around day 2-4, whereby a vascular network slowly begins to be
established.
• Neovascularisation – After 4 days , Angiogenesis established completely, Lymphatic channels
established, Oedema resolves, Graft appears pink, Collagen links formed between graft and bed.
• Cellular hyperplasia-After 1-2 weeks, Epidermis thickens 7-8 fold, Scaling and crusting returns to
normal by 4 weeks.
• Re-innervation – Begins 4-5 weeks after grafting completed by 12-24 months, pain returns first
than light touch and temperature later.
Causes of graft failure
1.Haematoma beneath the graft (MCC).
2.Infection
3.Movement or shearing force
4.Poor recipient bed
VII- Skin Flaps
• A skin flap is where tissue is transferred from a donor site to recipient
site along with its corresponding blood supply.
• Better cosmetic result and reduced chances of failure in comparison to
skin graft.
• One type is Random Flap-Randomly rotated and based on subdermal
plexus
• Limited – 3:1 (L:B)
3
1
Z plasty V-Y plasty
Nutrition in burn patient
• Aggressive nutritional support to counterbalance the effect of Hypermetabolism
and Protein catabolism following Burns
• ENTERAL feeding is preferred over PARENTERAL feeding
• NG tube if >15% BSA.
• Basal energy expenditure in
• Normal = 1 (20 Kcal/kg/day)
• Mild/Moderate sepsis = 1.4
• Severe sepsis or shock = 1.8
• Severe burns – 2 (40 Kcal/kg/day).
• Maximum nitrogen loss occurs between Day 5 – Day 10.Therefore 20% of all
calories should come from protein.
Davies formula- Children 3gm/kg+1 g x % TBSA
Adults 1gm/kg+3g x %TBSA
Source: Sabiston Textbook of Surgery
• Burns patient is hypercatabolic – up to 150- 200% above baseline.
• Burn patient caloric requirement 3000- 5000calories per day.
• Butter milk diet 1cal/cc
• 4 Eggs, 4 Bananas, 4tbs Sugar, 1 litre Curd and mixed with water to 1600cc.
Predicting energy expenditures in burned patients,W W Turner Jr et al,PMID: 3965733,DOI: 10.1097/00005373-198501000-00002J Trauma,1985 Jan;25(1):11-6.doi:
10.1097/00005373-198501000-00002.
Curreri formula: Age 16-59 years= (25)W + (40) TBSA
Age >60 years=(20) W + (65) TBSA
Sutherland formula: Children = 60 Kcal/kg + 35 Kcal x %TBSA
Adults = 20 Kcal/kg + 70 Kcal x %TBSA
Efficacy of CMC supplementary burns feed (SBF) in burns patients: A retrospective study Ashish Kumar Gupta et al
Burns Open,Volume 4, Issue 1, January 2020, Pages 10-15
Rehabilitation: An Important Step in Recovering
From a Burn Injury
• When a person experiences a serious
burn, their life can be turned upside
down. While initial treatment is
focused on healing the burn itself, it's
also important to begin the process
of rehabilitation as soon as possible
so the patient can regain a sense of
normalcy.
Rehabilitation
• The rehabilitation phase is defined as beginning when the patient’s burn wounds
are covered or healed and the patient is able to resume a level of self-care activity
• Complications
– Skin and joint contractures
– Hypertrophic scarring
• Both patient and family actively learn how to care for healing wounds
• Role of exercise is emphasized
• Constant encouragement and reassurance
• Address spiritual and cultural needs
• Maintain a high-calorie, high-protein diet
• Occupational therapy – in order to meet the goals to develop, recover and
improve skills needed for daily living and working.
Zhou YQ, Zhou JY, Luo GX, Tan JL. Effects of early rehabilitation in improvement of paediatric burnt hands
function. World J Clin Cases 2021; 9(32): 9741-9751 [PMID: 34877313 DOI: 10.12998/wjcc.v9.i32.9741]
Scar massage by the
rehabilitation therapist
Active ROM exercise with grip
Static orthoses used in an
antideformity position
Compression therapy with pressure garment
Burn battle Survivor - Turia Pitt (36 yrs)
• Pitt was competing in a 100 km ultramarathon through Western
Australia's Kimberley region, when she was caught in a large
bush fire.
• Pitt sustained burns to 65 percent of her body. It was several
hours before medical help arrived and she was air-lifted out.
• As a result of her injuries in the fire, she was placed in a
medically-induced coma for a month.
• All the fingers of her right hand and two fingers on her left had
to be amputated.
• She endured six months in the hospital, underwent over 200
operations and spent two years in recovery.
• During that time, she was required to wear a full-body
compression suit and mask and only remove it for an hour daily.
• The mask was needed to help smooth out the scars on her face
and body.
• She removed it for the first time on the 60 Minutes program
revealing her face to the world on TV.
French Polynesian born athlete, motivational
speaker, author and mining engineer.
Thank You

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Burns.pptx

  • 1. Burns Management Presented by : Dr (Maj) Rishi Raj Singh
  • 2. Management of Burns Burn care is typically categorized into three phases of care:- 1.Emergent / resuscitative phase -From onset of injury to completion of fluid resuscitation. 2.Acute / intermediate phase -From beginning of diuresis to near completion of wound closure. 3.Rehabilitative phase - From major wound closure to return to individual’s optimal level of functioning.
  • 3. Pre-Hospital Setting • During and immediately after injury, burned patients must be removed from the source and the burning process stopped. • Next attention should be directed at initial resuscitation, starting with the airway. a) For those burned with flames, inhalation injury should always be suspected and 100% oxygen given by facemask. • All rings, watches, jewellery, and belts should be removed because they retain heat and can produce a tourniquet like effect. • Room temperature water should be copiously poured on the wound within 3 hours of injury.
  • 4. ADMISSION CRITERIA & CRITERIA FOR REFERRAL The American Burn Association and the American College of Surgeons Committee on Trauma 1.100 or more bedded hospital or a burn centre All major burns like: • Partial thickness burns of >25% of TBSA in adults. • >20% burns in children below 10 yrs and adults >50 yrs. • Full thickness burns >10% TBSA. • Burns of face, eyes, ears, and perineum. • Chemical burns, electrical burns, inhalational injury, and underlying debilitating illness. 2. 30-100 bedded community health centre hospital • Moderate burns like burns >15% TBSA (excluding burns described above).
  • 5. Initial Assessment • It is divided into the primary and secondary survey. • Exposure to heated gases and smoke often results in damage to the upper respiratory tract which results in localized edema, • In combination with generalized whole-body edema associated with severe burn, may obstruct the airway over the course of hours. • Airway injury must be suspected with • Facial burns, • Singed nasal hairs, • Carbonaceous sputum • Tachypnoea • Respiratory status must be continually monitored to assess for airway intervention and ventilatory support. Initial management of a major burn: I—overview,Shehan Hettiaratchy, BMJ. 2004 Jun 26; 328(7455): 1555–1557. doi: 10.1136/bmj.328.7455.1555
  • 6. Facial Burn Carbonaceous particles staining a patient's face after a burn in an enclosed space
  • 7. Initial Assessment Perform an ABCDEF primary survey A—Airway with cervical spine control B—Breathing and ventilation C—Circulation D—Neurological disability E—Exposure with environmental control F—Fluid resuscitation
  • 8. A—Airway with cervical spine control INDICATIONS FOR EARLY INTUBATION “Progressive hoarseness is a sign of impending airway obstruction, and endotracheal intubation should be instituted early before oedema irretrievably distorts the upper airway anatomy.” • Extent of the burn (total body surface area burn > 40%-50%) • Extensive and deep facial burns • Burns inside the mouth " Significant edema or risk for edema • Difficulty swallowing • Signs of respiratory compromise • Decreased level of consciousness where airway protective reflexes are impaired • Anticipated patient transfer of large burn with airway issue without qualified personnel to intubate en-route.
  • 9. Definitive airways OROPHARYNGEAL/ NASOPHARYNGEAL SUPRAGLOTTIC DEVICES- LMA, IGEL, LTA •Cuffed Tube below vocal cords. •Inflated. •Connected to 02 source. •Supported with ventilation Surgical airways 1.Needle cricothyroidotomy 2.Surgical cricothyroidotomy 3.Tracheostomy
  • 10. B-Breathing and ventilation • All burn patients should receive 100% oxygen through a humidified non-rebreathing mask on presentation. • Mechanical restriction of breathing—Deep dermal or full thickness circumferential burns of the chest can limit chest excursion and prevent adequate ventilation. • Blast injury—If there has been an explosion, blast lung can complicate ventilation. Penetrating injuries can cause tension pneumothoraxes, and the blast itself can cause lung contusions and alveolar trauma and lead to adult respiratory distress syndrome. • Breathing concerns arise from three general causes: 1. Hypoxia 2. Carbon monoxide poisoning, 3. Smoke inhalation injury
  • 11. Hypoxia-Hypoxia is a state in which oxygen is not available in sufficient amounts at the tissue level to maintain adequate homeostasis. It is common in 1.Smoke Inhalation Injury 2.Circumferential Chest Burns 3.Thoracic trauma unrelated to thermal injury. Investigation – • Pulse oximetry • ABG Management- Administer supplemental oxygen with or without intubation. CO POISONING-It inhibits aerobic metabolism via inhibition of complex IV of ETC (cytochrome c oxidase). It is common in 1. Motor exhaust. 2. Closed room with Gas heaters. 3. Burned in enclosed areas Investigation- • Normal PaO2. • Elevated carboxyhemoglobin on co-oximetry. • Left shift in ODC-- Increase affinity for O2 – decrease O2 unloading in tissues. Management- Administer 100% oxygen. Hyperbaric oxygen if severe. SMOKE INHALATIONAL INJURY Caused by heat, particulates (< 1 μm diameter), or irritants (eg, NH3) Criteria to diagnose 1.Exposure to the combustible agent 2.Exposure of smoke to lower airway below vocal cards - seen in bronchoscopy. Investigation - • Chest x-ray and • Arterial blood gas determination. Management - Early airway management. Avoid hypoxia. “Mortality increases to double in inhalational injury with burn as compare to isolated burn”
  • 12. C- Circulation •BP, HR, color of unburnt skin •2 large bore I.V.s in unburnt skin •Draw bloodwork. •Insert urinary catheter. •Insert nasogastric tube, if necessary •Doppler exam of circumferentially burnt extremities
  • 13. D—Neurological disability • All patients should be assessed for responsiveness with the Glasgow coma scale; they may be confused because of hypoxia or hypovolaemia. E—Exposure with environment control • The whole of a patient should be examined (including the back) to get an accurate estimate of the burn area and to check for any concomitant injuries. • Burn patients, especially children, easily become hypothermic. Patients should be covered and warmed as soon as possible.
  • 14. F—Fluid resuscitation • Burns Resuscitation formulae • Fluid of Choice-Hartmann’s solution or Ringer’s lactate is the most commonly used crystalloid as it most closely replicates the osmolality of plasma. • It is considerably less expensive than colloid and can maintain intravascular volume. • Lactated Ringer’s (RL) NS can produce hyperchloremic acidosis First 1⁄2 of total volume given in the first 8 hours Remaining 1⁄2 of total volume given over following 16 hours Source: Sabiston Textbook of Surgery
  • 15. Revised ATLS Burn Resuscitation
  • 16. •In children maintenance fuid must also be given. This is normally dextrose–saline given as follows:
  • 17. Colloid Resuscitation 1.The most commonly used colloid is human albumin solution 2. Albumin should be preferably administered after the first 12 hours post burn as the massive fluid shifts drive proteins out of the cells. 3.The most common colloid-based formula is the Muir and Barclay formula, which estimates the amount of fuid that needs to be infused during the first 36 hours post burn: Six portions are given in total over 36 hours: Give one infusion 4 hourly for 12 hours (three portions in total); Then one infusion 6 hourly for 12 hours (two portions in total); The final infusion to be given over 12 hours. Basic formula is: TBSA% × weight (kg) × 0.5 = one portion Adoption of rescue colloid during burn resuscitation decreases fluid administered and restores end-organ perfusion lPaul Comish et al Burns,Volume 47, Issue 8, December 2021, Pages 1844-1850
  • 18. Pain management • Analgesia is a vital part of burns management. • Small burns, especially superficial burns, respond well to simple oral analgesia, paracetamol and non-steroidal anti- inflammatory drugs. • In patients with large burns, continuous analgesia is required, beginning with infusions and continuing with oral tablets. • Powerful, short-acting analgesia should be administered before dressing changes.
  • 19. Investigations for major burns General • Full blood count, packed cell volume, urea and electrolyte concentration, clotting screen • Blood group, and save or crossmatch serum Electrical injuries • 12 lead electrocardiography • Cardiac enzymes (for high tension injuries) Inhalational injuries • Chest x ray • Arterial blood gas analysis Can be useful in any burn, as the base excess is predictive of the amount of fluid resuscitation required Helpful for determining success of fluid resuscitation and essential with inhalational injuries or exposure to carbon monoxide.
  • 20.
  • 21. Secondary Survey • This is a head to toe examination to look for any concomitant injuries. • History: This should aim at evaluating: • Time of burn • Possibility of being a medicolegal case. • AMPLE history Allergies Medications Past medical history Last meal Events and Environment of burn injury. B. Physical examination and evaluation of burn wound. • (i) Depth of burn I Degree burns: Minor epithelial damage, present as redness, clinically insignificant. II Degree burns : Partial thickness burns & scalds. These burns are painful III Degree burns: Full thickness burns, usually painless • (ii) Calculation of Surface area of burn. • Wallace's Rule of Nine is useful in adults. In children, Lund & Brewder's Chart can be used. • A rough guide is - surface area of palm is approximately equal to 1% of Total Body Surface Area (TBSA).
  • 22. I- Early Excision and wound debridement • Early excision and grafting of the burn, noted as crucial during post- burn days 2-12. • When burn patients undergo early excision and grafting, there is a decrease in the length of stay and faster healing time. • Goal is to safely excise and debride the largest surface areas first, such as the anterior or posterior trunk or large areas on the extremities. • For cosmetic areas and functional areas, excision should be performed at least within 7 to 14 days to improve outcomes. Burn Debridement, Grafting, and ReconstructionJordan A. Browning; Renford Cindass. Copyright © 2023, StatPearls Publishing LLC.
  • 23. • Surgical excision with the use of surgical knives such as the Weck/Goulian knife and the Blair knife has been the mainstay for surgical debridements. • When encountering a blister, it is best to un-roof it. If left intact, the blister becomes a potential source of infection, increases healing time, and negatively affects patient comfort and mobility. • Debridement techniques 1.Hydrosurgical debridement-Advantage Lowers operative cost 2. Autolytic/Enzymatic debridement- Disadvantage local redness raise cosmetic concerns, increase pain. 3. Mechanical debridement- Disadvantage causes significant pain 4. Sterile maggots- limits real world application. Burn Debridement, Grafting, and ReconstructionJordan A. Browning; Renford Cindass. Copyright © 2023, StatPearls Publishing LLC.
  • 24. Versajet™ hydrosurgery system Nexobrid ™ enzymatic debridement Pilling Weck Goulian Skin Graft Knife Goulian Skin graft knife Skin graft harvesting through the use of a Blair's knife
  • 25. II- Wound dressing • Aims 1.To protect damaged epithelium 2.Minimize bacterial and fungal contamination 3.Occlusive dressing prevents evaporation. 1st Degree burn- Expose the wound 2nd Degree (Superficial)- Vaseline/paraffin gauze - Collagen dressing (if not infected) 2nd Degree (Deep) - Collagen dressing (if not infected) - Hydrocolloid dressing Source: Sabiston Textbook of Surgery
  • 26. Special Agents;Antimicrobials • Available topical antibiotics can be divided into three classes: salves, soaks, and antimicrobial dressings. • Salves are generally applied directly to the wound with cotton dressings placed over them. • Soaks are solutions poured into cotton dressings on the wound, • Antimicrobial dressings contain active agents to inhibit microbial growth, generally some form of silver ion or other antibiotic. Source: Sabiston Textbook of Surgery
  • 28. Agent Advantages Disadvantages SSD (1%) Most commonly used,good against pseudomonas and gram negative bacteria 1.Frequent change of dressing. 2.Does not penetrate Eschar Silver nitrate Good action against pseudomonas, Little action against gram negative Mafenide acetate (5%) Penetrate Eschar 1.Painful application 2.Can induce Lactic Acidosis or metabolic acidosis Cerium nitrate Gram negative bacteria and fungi. Special Agents Source: Sabiston Textbook of Surgery
  • 29. • These CeO2 nanocoating's exhibit low toxicity, are easy to manufacture and have a high level of antimicrobial properties even at very low CeO2 concentrations. High-power ultrasonic treatment was used to coat the surface of cotton fabric with CeO2 nanoparticles. • Cerium Nitrate Treatment Provides Eschar Stabilization through Reduction in Bioburden, DAMPs, and Inflammatory Cytokines. https://pubmed.ncbi.nlm.nih.gov/31808807/
  • 30.
  • 31. • Allografts- Skin allograft is obtained from a human donor (deceased or healthy) and used as a temporary cover for burn wounds. It can be classified into the following: 1. Viable: a. Fresh (freshly harvested from donor or refrigerated) b. Cryopreserved 2. Nonviable: a. Lyophilized (glycerol) b. Irradiated (gamma irradiation) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676815/ III- Synthetic and Biological Dressing
  • 32. • Full-thickness burn wounds should be excised and covered with split- thickness autograft. However, autograft has limitation of donor-site availability and morbidity. When autograft is not available, allograft can be used. Human Skin Allograft: Is it a Viable Option in Management of Burn Patients? Saurabh Gupta et al J Cutan Aesthet Surg. 2019 Apr-Jun; 12(2): 132–135. doi: 10.4103/JCAS.JCAS_83_18
  • 33. Porcine xenografts vs. (cryopreserved) allografts in the management of partial thickness burns: is there a clinical difference? • Both allografts and porcine xenograft seem to perform equally well clinically with regard to healing related outcomes • Clinical aspects being equal, other aspects such as price and availability should be used to decide which material to use for the management of partial thickness burns. By Michel H E Hermans Burns2014 May;40(3):408-15.doi: 10.1016/j.burns.2013.08.020. Epub 2013 Sep 6.
  • 34. Synthetic and Biological Dressing Acellular • Biobrane • Integra • Matriderm • ® Renoskin • Alloderm • Various forms of collagen (sheet/gel/flakes) Cellular allogeneic • Dermagraft • Apligraft (Graftskin) • Orcel • Hyalomatrix • TransCyte Cellular autologous • Cultured epidermal autograft (CEA) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676815/
  • 35. Smith & Nephew Biobrane 13 CM X 13 CM INTEGRA™ Bilayer Matrix Wound Dressing Acellular Synthetic Dressing Material
  • 36. Dermagraft®, a bioengineered human dermal equivalent Meat Band-Aids: Apligraf® Cellular Synthetic Dressing Material
  • 37. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676815/ Type Advantages Disadvantages Allograft 1.Presence of a basement membrane 2.More intact and natural extracellular matrix composition 3.Provides growth factors and cytokines (helps in wound bed preparation) 4.Excellent reepithelialisation rate 5. Relatively less expensive 1 Antigenicity (rejection) 2. Risk of infection 3. Availability of donor Synthetic skin substitutes 1.Controlled composition of scaffold 2.Growth factors and matrix components can be added as required 3.Reduces pain 4.Less frequent dressing change 1.Lack of basement membrane 2.High cost 3.Antigenicity (foreign body reaction) 4.Reepithelialization and engraftment rates are similar or less than allograft (inconclusive evidence)
  • 38. IV- Escharotomies • When there is deep partial-thickness or full-thickness burns encompass the circumference of an extremity, peripheral circulation to the limb can be compromised. • Development of generalized edema beneath a nonyielding eschar impedes venous outflow and eventually affects arterial inflow to the distal beds. • This is recognized by numbness and tingling in the limb and increased pain in the digits. • General rules- 1.Extend the wound beyond the deep burn. 2.Diathermy any significant bleeding vessels 3.Apply haemostatic dressing and elevate the limb postoperatively
  • 39. Bedside Escharotomies for Burns by Christine Yin et al Chapter First Online: 05 January 2019, Atlas of Critical Care Procedures pp 251–254.
  • 40. V- Fasciotomies • Increase muscle compartment pressure after escharotomies may indicate fasciotomy.(tissue pressure >30 mmHg) • Fasciotomy or fasciectomy is a surgical procedure where the fascia is cut to relieve tension or pressure in order to treat the resulting loss of circulation to an area of tissue or muscle. Fasciotomy is a limb-saving procedure when used to treat acute compartment syndrome. Downloaded from https://academic.oup.com/jbcr/advance-article-abstract/doi/10.1093/jbcr/irz104/5518389 by guest on 13 September 2019
  • 41. VI- Skin Grafting • Langer’s Line-Skin tension line along longitudinal axis of elliptical wounds on skin of cadavers. • Relaxed skin tension lines (RSTL)-Parallel to wrinkles, perpendicular to underlying muscle. “Langer's lines have relevance to forensic science and the development of surgical techniques.”
  • 42. Skin graft STSG= Epidermis + Variable amount of dermis (Thiersch) Thin-0.15-0.3 mm Intermediate-0.3-0.45 mm Thick-0.45-0.6 mm FTSG= Epidermis + Entire dermis (Wolfe) • MC donor site- Anteromedial thigh, buttocks. • No need for suture • After Healing can be reused • MC donor site-Post auricular skin, supra/infraclavicular fossa and groin skin • Need for suture • After Healing cannot be reused • Primary Contracture Occurs at time of Harvest • Elastin mediated • Secondary Contracture Occurs at time of Healing • Myofibroblast mediated
  • 43. Humby’s Knife to raise STSG Advantages of Meshing of Skin graft 1.Increases Surface area by 1.5 times 2.Prevents Hematoma collection beneath the grafts
  • 44. Total full-thickness skin grafting for treating patients with extensive facial burn injury: A 10-year experience Author links open overlay panel Sergey B. Bogdanov et al, , Burns,Volume 47, Issue 6, September 2021, Pages 1389-1398
  • 46. Physiology of Graft Take • Graft take is the incorporation of the new graft into implanted site and can be divided into four main stages: • Haemostasis – Normal physiological response to prevent excessive bleeding following grafting. • Plasmatic imbibition – occurs around days 1-2, whereby initially fluid migrates into graft bed, becoming oedematous but remains avascular. • Inosculation – occurs around day 2-4, whereby a vascular network slowly begins to be established. • Neovascularisation – After 4 days , Angiogenesis established completely, Lymphatic channels established, Oedema resolves, Graft appears pink, Collagen links formed between graft and bed. • Cellular hyperplasia-After 1-2 weeks, Epidermis thickens 7-8 fold, Scaling and crusting returns to normal by 4 weeks. • Re-innervation – Begins 4-5 weeks after grafting completed by 12-24 months, pain returns first than light touch and temperature later.
  • 47. Causes of graft failure 1.Haematoma beneath the graft (MCC). 2.Infection 3.Movement or shearing force 4.Poor recipient bed
  • 48. VII- Skin Flaps • A skin flap is where tissue is transferred from a donor site to recipient site along with its corresponding blood supply. • Better cosmetic result and reduced chances of failure in comparison to skin graft. • One type is Random Flap-Randomly rotated and based on subdermal plexus • Limited – 3:1 (L:B) 3 1
  • 49. Z plasty V-Y plasty
  • 50. Nutrition in burn patient • Aggressive nutritional support to counterbalance the effect of Hypermetabolism and Protein catabolism following Burns • ENTERAL feeding is preferred over PARENTERAL feeding • NG tube if >15% BSA. • Basal energy expenditure in • Normal = 1 (20 Kcal/kg/day) • Mild/Moderate sepsis = 1.4 • Severe sepsis or shock = 1.8 • Severe burns – 2 (40 Kcal/kg/day). • Maximum nitrogen loss occurs between Day 5 – Day 10.Therefore 20% of all calories should come from protein. Davies formula- Children 3gm/kg+1 g x % TBSA Adults 1gm/kg+3g x %TBSA Source: Sabiston Textbook of Surgery
  • 51. • Burns patient is hypercatabolic – up to 150- 200% above baseline. • Burn patient caloric requirement 3000- 5000calories per day. • Butter milk diet 1cal/cc • 4 Eggs, 4 Bananas, 4tbs Sugar, 1 litre Curd and mixed with water to 1600cc. Predicting energy expenditures in burned patients,W W Turner Jr et al,PMID: 3965733,DOI: 10.1097/00005373-198501000-00002J Trauma,1985 Jan;25(1):11-6.doi: 10.1097/00005373-198501000-00002. Curreri formula: Age 16-59 years= (25)W + (40) TBSA Age >60 years=(20) W + (65) TBSA Sutherland formula: Children = 60 Kcal/kg + 35 Kcal x %TBSA Adults = 20 Kcal/kg + 70 Kcal x %TBSA
  • 52. Efficacy of CMC supplementary burns feed (SBF) in burns patients: A retrospective study Ashish Kumar Gupta et al Burns Open,Volume 4, Issue 1, January 2020, Pages 10-15
  • 53.
  • 54. Rehabilitation: An Important Step in Recovering From a Burn Injury • When a person experiences a serious burn, their life can be turned upside down. While initial treatment is focused on healing the burn itself, it's also important to begin the process of rehabilitation as soon as possible so the patient can regain a sense of normalcy.
  • 55. Rehabilitation • The rehabilitation phase is defined as beginning when the patient’s burn wounds are covered or healed and the patient is able to resume a level of self-care activity • Complications – Skin and joint contractures – Hypertrophic scarring • Both patient and family actively learn how to care for healing wounds • Role of exercise is emphasized • Constant encouragement and reassurance • Address spiritual and cultural needs • Maintain a high-calorie, high-protein diet • Occupational therapy – in order to meet the goals to develop, recover and improve skills needed for daily living and working.
  • 56. Zhou YQ, Zhou JY, Luo GX, Tan JL. Effects of early rehabilitation in improvement of paediatric burnt hands function. World J Clin Cases 2021; 9(32): 9741-9751 [PMID: 34877313 DOI: 10.12998/wjcc.v9.i32.9741] Scar massage by the rehabilitation therapist Active ROM exercise with grip Static orthoses used in an antideformity position Compression therapy with pressure garment
  • 57. Burn battle Survivor - Turia Pitt (36 yrs) • Pitt was competing in a 100 km ultramarathon through Western Australia's Kimberley region, when she was caught in a large bush fire. • Pitt sustained burns to 65 percent of her body. It was several hours before medical help arrived and she was air-lifted out. • As a result of her injuries in the fire, she was placed in a medically-induced coma for a month. • All the fingers of her right hand and two fingers on her left had to be amputated. • She endured six months in the hospital, underwent over 200 operations and spent two years in recovery. • During that time, she was required to wear a full-body compression suit and mask and only remove it for an hour daily. • The mask was needed to help smooth out the scars on her face and body. • She removed it for the first time on the 60 Minutes program revealing her face to the world on TV. French Polynesian born athlete, motivational speaker, author and mining engineer.

Editor's Notes

  1. Universal precautions include wearing gloves and protective eyewear during retrieval. Burning clothing should be extinguished and removed as soon as possible to prevent further injury. Any subsequent measures to cool the wound should be avoided to preclude hypothermia during resuscitation
  2. First, immediate life-threatening conditions are quickly identified and treated; in the secondary survey, a more thorough head-to-toe evaluation of the patient is undertaken.
  3. Airway injury must be suspected with Facial burns, Singed nasal hairs, Carbonaceous sputum Tachypnoea
  4. Binds competitively to Hb with > 200× greater affinity than O2 to form carboxyhemoglobin Ž%O2 saturation of Hb.
  5. The contents of Ringer's lactate include sodium, chloride, potassium, calcium, and lactate in the form of sodium lactate, mixed into a solution with an osmolarity of 273 mOsm/L and pH of about 6.5. In comparison, normal saline (NS) has an osmolarity of about 286 mOsm/L. Hartmann’s-Compound Sodium Lactate (Hartmann's) contains sodium lactate (3.17g/L), sodium chloride (6.0g/L), potassium chloride (400 mg/L) and calcium chloride dihydrate (270mg/L) in water for injections. Hartmann’s solution contains lactate to generate alkalising HCO3– ions and thus, as an alkalising solution, it does not cause an acidosis. Normal saline is 0.9% saline. This means that there is 0.9 G of salt (NaCl) per 100 ml of solution, or 9 G per liter. This solution has 154 mEq of Na per liter. Rapid isotonic saline infusion predictably results in hyperchloraemic acidosis. The acidosis is due to a reduction in the strong anion gap by an excessive rise in plasma chloride as well as excessive renal bicarbonate elimination.
  6. 1.Plasma proteins are responsible for inward oncotic pressure that counteracts the outward capillary hydrostatic pressure. 2.The original Muir and Barclay formula utilised fresh-frozen plasma as the colloid of choice. Both albumin and fresh- frozen plasma are maintained in the blood bank and are more expensive; excessive use can cause additional pressure on the renal system. The key to monitoring of resuscitation is urine output. Urine output should be between 0.5 and 1.0 mL/kg body weight per hour. If the urine output drops and the patient is showing signs of hypoperfusion (tachy- cardia, cool peripheries and a high lactate/metabolic acidosis), then a bolus of 10 mL/kg body weight should be given. It is important that patients are not over-resuscitated; urine output in excess of 2 mL/kg body weight per hour should warrant a decrease in infusion. Article “Parkland or Brooke formulas. Both of these formulas include colloid supplementation after 24 h of resuscitation. Rescue albumin administration decreases the amount of fluid administered per %TBSA during resuscitation, and also increases end organ function as evidenced by increased urinary output. These effects occurred in patients who sustained larger burns and failed to respond to traditional crystalloid resuscitation.”
  7. Tramadol 100mg Ketamine 100mg Midazolam 10mg
  8. Aims 1.To protect damaged epithelium 2.Minimise bacterial and fungal contamination 3.Occlusive dressing- prevents evaporation
  9. Hydrosurgical debridement works by forcing a narrow stream of saline under high pressure out of a nozzle, using the Venturi effect, to remove the debrided tissue. It successfully clears bacteria from the wound bed, and this technique does not create bacterial seeding deeper into the wound bed. Autolytic Debridement with collagenase and papain/urea agents has shown success, but they are time and labor-intensive and not ideal in extensive TBSA burns.[8] Bromelain-based agents have some utility as they are highly specific for burn eschar.  Mechanical debridement can be utilized with frequent moist to dry dressing changes. This process involves placing a moist dressing over the affected area and then removing the dressing when it is dry
  10. NexoBrid, a concentrate of proteolytic enzymes enriched in bromelain, is an easy to use, topically-applied product that removes eschar in four hours
  11. Each of these classes of antimicrobials has advantages and disadvantages. Salves-Bacitracin,Neomycin,Bactroban(gram + painful),Polymyxin b(gram – painful),Nystatin(fungal) Salves may be applied daily but may lose their effectiveness between dressing changes. Solutions- Dakin’s Solution,(inhibit epitheliazation)Domboro’s solution(inhibits biofilm formation) Soaks remain effective because antibiotic solution can be added without removing the dressing; however, the underlying skin can become macerated.
  12. Salves-Bacitracin,Neomycin,Bactroban(gram + painful),Polymyxin b(gram – painful),Nystatin(fungal) Salves may be applied daily but may lose their effectiveness between dressing changes. Soaks- Dakin’s Solution,(inhibit epitheliazation) Dakin's solution is a dilute solution of sodium hypochlorite and other stabilizing ingredients, traditionally used as an antiseptic Domboro’s solution(inhibits biofilm formation) Domeboro are aluminum sulfate and calcium acetate. Soaks remain effective because antibiotic solution can be added without removing the dressing; however, the underlying skin can become macerated.
  13. Eschar is composed of dead tissue and dried secretions from a skin wound following a burn or an infectious disease on the skin
  14. Types of Grafts- 1.Autograft- Same person 2.Isograft-Identical Twin 3.Allograft- Same species 4.Xenograft- Different species
  15. 1.Biologic grafts can be used on clean burn wounds. 2. They protect the wound from desiccation while promoting reepithelialisation. 3. The graft separates from the wound once it has reepithelialised Lyophilization or freeze drying is a process in which water is removed from a product after it is frozen and placed under a vacuum, allowing the ice to change directly from solid to vapor without passing through a liquid phase.
  16. Human skin allograft facilitates the excision of burn wounds during acute phase of burn injury in pediatric patients. Allograft avoids pain and risk of infection from frequent dressing changes. Availability of allograft and risk of infection are the two main constraints in its regular use
  17. How much does porcine xenograft cost? Cost. At the time of the study, the cost for the porcine xenograft was $0.26/cm2 compared with $0.15/cm2 for the biosynthetic cellulose.
  18. 1.Biobrane (Smith & Nephew UK Limited, London, UK) is an acellular biosynthetic temporary skin construct of a silicone film bonded to a porcine collagen cross-linked with trifilament nylon fabric. 2.INTEGRA™ Bilayer Matrix Wound Dressing is an advanced wound care device comprised of a porous matrix of cross-linked bovine tendon collagen and glycosaminoglycan and a semi-permeable polysiloxane (silicone layer). The semi-permeable silicone membrane controls water vapor loss, provides a flexible adherent covering for the wound surface and adds increased tear strength to the device. 3.Matriderm- MatriDerm® is a unique collagen-elastin-template, which serves as a dermal replacement scaffold and can be applied both in a One- and Multi-Step Procedure. Open porous matrix. No chemical cross-linking. Native collagen fibers. Contains elastin.
  19. DERMAGRAFT is manufactured from human fibroblast cells derived from newborn foreskin tissue. During the manufacturing process, the human fibroblasts are seeded onto a bioabsorbable polyglactin mesh scaffold. Apligraf is a full-thickness skin equivalent .It consists of bovine type I collagen matrix cultured with allogeneic male neonatal fibroblasts and keratinocytes, and the bilayered structure resembles normal human skin  After the advent of commercially available biological dressings (various skin substitutes), use of human skin allograft has decreased. Biological dressing materials also serve all the functions of allograft, but there are certain advantages of allograft. 
  20. Salves-Bacitracin,Neomycin,Bactroban(gram + painful),Polymyxin b(gram – painful),Nystatin(fungal) Solutions- Dakin’s Solution,(inhibit epitheliazation)Domboro’s solution(inhibits biofilm formation)
  21. Eschar is thickened tissue left after burns.Can cause compartment syndrome,Around chest wall-Hampers chest wall expansion.
  22. Upper limb- Mid axial,ant to elbow and medially to avoid ulnar nerve Hand- Midline in digits Lower limb- Mid axial,Post to ankle medially to avoid the saphenous vein Chest- Down the chest lateral to nipples, across the chest below the clavicle, and across the chest at the level of xiphisternum. (go down till deep fascia)
  23. Third-degree circular burn with open fasciotomy for absence of compartment. Third-degree thorax burn that we have opened an emergency fasciotomy to prevent asphyxia. In lower limbs – two incisions needed to release four compartments : Indications are >30 mmHg (or) Ischemia > 6 hours o Gradient < 35mm Hg (Gradient = Diastolic pressure – Compartment pressure) Lateral incision decompresses- Anterior and lateral compartments* Medial incision decompresses- Superficial and deep posterior compartments*
  24. FTSG-Cosmetically better, Resistant to trauma. STSG-Better take up/survival, Primary contracture is directly proportional to dermal component which is more in FTSG and secondary contracture is inversely porpotional to dermal component which is more in STSG
  25. Commonly used ratios include 3/8 to 1, 1 to 1, 2 to 1, 3 to 1, and even 6 to 1. The split-thickness skin graft gets placed into the mesher and hand-cranked through the machine. Meshing a skin graft allows the graft to stretch, increasing the area that can be covered by the skin graft.
  26. The approach of facial burn treatment based on total full-thickness skin graft allows conditions for engraftment and adaptation of autograft, reduces the risk of scar developing and achieves maximum cosmetic results of treatment.
  27. Plasmatic imbitation-Ischaemic anaerobic phase,Nourishment by diffusion,grafting is going to appear edematous and white,fibrin attachment only. Inosculation-unidirectional angiogenesis at fibrin interface,microvascular growth of capillary sized vessels Neovascularization-
  28. Poor recipient bed- Excessive granulation, Lacks periosteum or perichondrium, Eschar present and infection
  29. However, flap failure remains a potential complication of the procedure. This can occur due to issues with either the arterial supply, presenting with signs of pallor and reduced perfusion, or venous supply, presenting with features of venous congestion. *Arterial issues need immediate return to theatre, whilst venous congestion often responds to conservative treatment. Random flap as it is randomy rotated blood supply is not that robust so therefore
  30. Z plasty -For every 15 angle increase we get 25% length gain V-Y plasty – For ectropion,cleft palate repairs Another expamples Rhomboid flap (Limberg flap)-Pilonidal sinus,BCC on forehead. Bilobed Flap – BCC over tip of nose. Bipedicle Flap - Eyelid reconstruction.
  31. Ileus in pt and can have vomiting that’s why tube feeding is recommended. Calorie : Nitrogen = 100 : 1 Protein requirement – Adult: 2g/ kg/ day,Child: 3g/ kg/ day Fat emulsion - 4g/ kg/ day max. Carbohydrate (glucose) -6.2mg/ kg/ min. max.
  32. 1mL of BMD provides 1 Calorie and 0.047gm protei
  33. Highlights •Early enteral feeds aid in reducing weight loss and overall morbidity and mortality. •Only four patients out of 40 (10%) had more than 10% weight loss. •Our Supplementary Burns Feed is relatively cheap, palatable & easily reproducible.
  34. 1.Most of the strains of organisms isolated were resistant to commonly used antibiotics in the hospital; Pseudomonas was found 100% resistant to a combination of ampicillin + sulbactum, ceftriaxone and was most often sensitive to imipenem, amikacin and vancomycin. Methicillin-resistant Staphylococcus aureus (MRSA) was also found resistant to commonly used antibiotics like ceftriaxone, ampicillin + sulbactum and ceftazidime + calvulanic acid. Linzolid and vancomycin were effective in 83% and 100% cases, respectively. 2.We believe better outcomes can be achieved in terms of reducing resistance development, which can be achieved through antibiotic and/or antiseptic stewardship. However, we are in favour of the use of topical antibiotic/antiseptic agents based on the previous culture and sensitivity pattern of the burn wards after taking the wound and blood specimen for culture and sensitivity. Once the microbiological agent sensitivity to the particular antibiotic/antiseptic agent has been confirmed, and that particular antimicrobial agent should be prescribed, which is the most scientific way to fight against the microbes and the development of resistance.
  35. These findings suggest that early rehabilitation might show better results in terms of ROM.
  36. She is an Ambassador for Interplast Australia & New Zealand (now called ReSurge International),[8] and has raised 1million dollar money for the organisation by leading trekking adventures. In that capacity, she walked the Great Wall of China in 2014, the Inca Trail in 2015, and the Kokoda Track in 2016. Turia Pitt is also a motivational speaker[11] and regularly appears at conferences and events. In 2022, Pitt appeared as a contestant on the sixth season of The Celebrity Apprentice Australia.[12] She also launched her podcast, "Hard Work".