Parasitology - Brugia malayi

1. Brugia malayi

2. Brugia Malayi
 Common name: Malayan Filaria
 Geographic Distribution: Tropical; freshwater (but
limited in Asia)
 Habitat: lymphatics and Blood
 Periodicity: Nocturnal/Sub-periodic( present at all hours
but density increases during night or day)
 IH: Mansoniabonnae(freshwater swamps) and
Mansoniauniformis(rice fields); bite outdoors-night biters

3. Brugia Malayi
 Infective Stage: L3 Larva
 MOT: Bite from infected mosquito(anopheles, mansonia
Aedes)
 Diagnosis: Giemsa stained smear(collected at night)/
Knotts’s Technique
 Pathogenesis: Malayan filariasis

4. Morphology
 Microfilariae:
• Size: 177 to 230 um; smaller than W. bancrofti
• Shape/appearance: curved/kink/stiff
• Terminal nuclei: Two
• 2 columns of confluent nuclei(irregular/overlap)
• Sheathed
• Nocturnal periodicity
• Locomotion: S-shaped motion

5. Microfilariae

6. Morphology
 Adults
• Resemble those of W. bancrfofti but smaller
• Long and slender with a smooth cuticle
• Long cephalic space
• Ventrally curved tail
• Female worms are larger than males
 Disease:
• Elephantiasis(lower extremeties)
• Scrotal swelling(but rare)

7. Life cycle

8. Life cycle