Brown rot, caused by the bacterium Ralstonia solanacearum, is one of the most destructive diseases of potato. It is the second most limiting factor to potato production in Nepal, causing losses between 10-70%. The disease spreads through infected seed tubers, soil, water, and farming tools. It favors warm, moist conditions and the presence of root-knot nematodes. Management strategies include planting certified disease-free seed, controlling weeds and nematodes, applying bleaching powder, practicing crop rotation, and destroying crop debris through burning.