role of vitamin d in the bone health

1. Bonoloact Probiotic

2. Probiotic IMS Markets
2019 2020 2021 2022
Row Labels Units Value Units Value Units Value Units Value
ANTIDIARR
MICRO-
ORGANISMS
1,097,123
39,496,428 1,244,176 44,790,336 1,444,631 52,006,716 1,434,769 65,685,887
BULK-FORMING
LAXATIVES 38,968
896,264 91 2,093
GYNAECOLOGIC
ANTISEPTICS
53,124 6,374,880 86,235 13,043,400 149,764 25,071,862

3. BULK-FORMING LAXATIVES
Colon Aid Capsule (Nerhadou)
Active ingredients Conc.
Citrus Pectin cellulose 10mg
Lactobacillus
Acidophilus
1mg
Wheat Grass 5mg
Goldenseal root 5mg
Gentian root 5mg
Black Walnut leaf 5mg
Orange peel 5mg
Psyllium husk 100mg
Bentonite 10mg
COLON AID NATURAL 30 TAB : 34.50 EGP

4. GYNAECOLOGIC ANTISEPTICS
Logus Gyn (Globe)
• A combination of Immuno Blend (ferments of Lactobacillus casei, Lb. acidophilus, Lb. plantarum,
Streptococcus thermophilus, Lactic Acid, Vitamin A & E.
• Recommended in case of bacterial vaginosis, mycotic vulvovaginitis
• Vaginal ovule
• 10 ovules 205L.E

5. 2019 2020 2021 2022
Row Labels Units Value Units Value Units Value Units Value
ORAL LIQUID ORDINARY
LACTEOL 961,748 34,622,928 1,020,511 36,738,396 1,098,869 39,559,284 1,012,516 46,712,265
ORAL SOLID ORDINARY
BIFOVAL 7,951 954,819
LACTEOL 135,375 4,873,500 223,665 8,051,940 345,762 12,447,432 398,400 16,109,165
ANTIDIARR MICRO-ORGANISMS

6. ANTIDIARR MICRO-ORGANISMS
Product Active ingredients Form & Price Company
LACTEOL LACTOBACILLUS ACIDOPHILUS
12 Capsule…60L.E
6 Sachet…84L.E
Rameda

7. Lacteol Rx Mat 2022
175,681 , 63%
38,337 , 14%
37,792 , 13%
14,211 , 5%
5,165 , 2%
3,972 , 1%
2,419 , 1% 1,707 , 1%
Mat 2022
PAED. IM G.P. GYN CARD. PULM ORTHO. ENDO/DIABET
2022 Total
Row Labels
LACTEOL 279,284
GASTRO & COLIT INFECT 231,932
UNS MT I/P DS CP PRG ETC 8,715
CONSTIPATION 6,200
ACUTE AMOEBIC DYSENTERY 5,561
OTH UNS IRRIT BOWEL SYND 4,733
NONINFECT NEONAT DIARR 4,521
LACTOSE INTOLERANCE UNSP 2,846
AMOEBIASIS UNSPECIFIED 2,748
GALACTORRHOEA 2,748
ALL/DIETET GASTROENT/COL 2,680

8. Bifoval Rx Mat 2022
2436, 100%
GYN
BIFOVAL
NOT STATED DIAG
DOC
2436

9. Another Probiotic products
Limitless Probiotic
2020 2021 2022 2023
Row Labels Units Value Units Value Units Value Units Value
ALL OTHER TONICS
ORAL SOLID ORDINARY
ASCORBIC ACID
LIMITLESS
BALANCE 2,882 374,660 411 53,435
MVIT + MIN PAEDIATRIC
ORAL SOLID ORDINARY
MULTIVITAMINS AND MINERALS
LIMITLESS KIDS 2,155 172,400 30,612 2,530,060 5,022 407,237 225,754 20,463,700

10. Product Form Price Company
LIMITLESS
BALANCE
Probiotic
30 dark chocolate 130L.E EVA
LIMITLESS Kids
probiotic
30 chocolate ball 130L.E EVA

11. Linex ( Sandoz )
150L.E.
2022 2023
Row Labels Units Value Units Value
ANTIDIARR MICRO-ORGANISMS
ORAL LIQUID ORDINARY
BIFIDOBACTERIUM BIFIDUS
LINEX Adult Sachets 115,297 11,529,682 171,432 22,286,160
LINEX Capsules
89,670 8,967,000 381,532 49,599,160
130 L.E

12. Direct Competitor
Biogaia Probiotic
Active
Ingredient
Concentration Price
Vitamin D3
400IU/5 Drops
5ml
300L.E
Lactobacillus
Reuteri
100*1000000/
5 Drops
BioGaia is a Swedish company (Mina Pharma)

13. What is the Difference Between Lactobacillus
Rhamnosus and Lactobacillus Reuteri?
• Lactobacillus rhamnosus
• is a bacterial species belonging to the genus Lactobacillus, which may sometimes be pathogenic in people
who have weakened immunity and infants,
• is mainly found in the intestine, oral cavity, and vagina of humans
• Lactobacillus reuteri
• is a bacterial species that belong to the genus Lactobacillus, which are generally non-pathogenic.
• is mainly found in the gastrointestinal tract, urinary tract, skin, and breast milk of humans.

14. bonolact Probiotic

15. Bonefit Probiotic
Bonefit Probiotic
Active Ingredient Concentration
Vitamin D 400IU/5 Drops
Lactobacillus
rhmonasus
> 1 Billion/5 Drops

16. Bone Fit Probiotic has synergistic formula
gastrointestinal
health
Improve
Immunity
Bone
Health
Infant colic.
Improves digestive health.
Pediatric diarrhea.
Immune enhancer.
Prophylaxis of Vitamin D deficiency
Immune enhancer.
VIT D3
Lactobacillus Rhmonasus

17. 75%
32%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Probiotec+ Vitamin D Control Group
%
of
infants
without
colic
Infants age 4-12 weeks
Bonefit Probiotic decreases cry and fuss time and provides a dietary
support in
exclusively breastfed infants with colic.(1)
Colic is estimated to affecting up to 40% of infants worldwide (2)

18. Indications
• Infants with Colic pain
• Cesarean-born neonates specially
• Infants suffer diarrhea specially with antibiotics
• Prophylaxes from vit D deficiency

19. Ref
1- Gerasimov S, Gantzel J, Role of Lactobacillus rhamnosus (FloraActive™) 19070-2 and Lactobacillus reuteri (FloraActive™) 12246 in Infant Colic: A
Randomized Dietary Study. Nutrients. 2018
2- Banks JB, Rouster AS, Chee J. Colic. [Updated 2022 Aug 1]. In: StatPearls
3- Li YT, Xu H, Ye JZ, Wu WR, Shi D, Fang DQ, Liu Y, Li LJ. Efficacy of Lactobacillus rhamnosus GG in treatment of acute pediatric diarrhea: A systematic review
with meta-analysis. World J Gastroenterol 2019; 25(33): 4999-5016
4- European Review for Medical and Pharmacological Sciences, effect of probiotics on the occurrence of nutrition absorption capacities in healthy children,
2019; 23: 8645-8657
5- K. Thandrayena, J. Pettiforb. The roles of vitamin D and dietary calcium in nutritional rickets. 2352-1872/ © 2018 Published by Elsevier Inc. This is an open access article
under the CC BY-NC-ND license
6- Aranow C. Vitamin D and the immune system. J Investig Med. 2011 Aug;59(6):881-6
7- Harsharnjit S Gill, Kay J Rutherfurd, effects of a newly characterized immunostimulatory strain Lactobacillus rhamnosus HN001 (DR20™) on leucocyte phagocytosis,Nutrition
Research,Volume 21, Issues 1–2,2001,Pages 183-189
8- S. Jadhav, C. Khanwelkar, A. Jadhav and et al. Vitamin D Supplementation in the Prevention of Recurrent Acute Respiratory Tract Infections in Children Aged <5 Years. J Med
Sci 2021;41(3):129-133.
Page 4