The document discusses bone grafts, which are used to aid in healing and strengthening bones. There are several types of bone grafts, including autografts which use bone from the patient's own body, and allografts which use donated bone. Alternatives to bone grafts have also been developed, including substitutes made from ceramics, coral, or synthetic materials. The best type of bone graft depends on each patient's individual surgical situation and needs.
Bone graft materials | Bone grafting in Implantation | Periodontal surgeries ...Dr. Rajat Sachdeva
Bone grafting is a surgical procedure that replaces missing bone in order to repair bone fractures that are extremely complex, pose a significant health risk to the patient or fail to heal properly.
It is beneficial in fixing bone that are damaged from trauma.Its also useful for growing bone around an implanted device.
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The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
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Bone substitutes and void fillers in managing Cystic bone tumors and tumor li...BhaskarBorgohain4
In clinical settings there are several fairly common bone tumors or tumor like conditions that can causes a pathological bony cavity. These cavity can lead to pathological fracture. Giant cell tumors, simple bone cyst( SBC, UBC), fibrous dysplasia, giant cell tumors (GCT), aneurysm bone cysts( ABC) are well known entity. Autologous bone grafting , allograft or various bone substitutes are being increasingly used to fill up such voids or cavity after curettage to provide immediate cavity obliteration, provide mechanical support and promote long term healing the cavity.
Bone graft materials | Bone grafting in Implantation | Periodontal surgeries ...Dr. Rajat Sachdeva
Bone grafting is a surgical procedure that replaces missing bone in order to repair bone fractures that are extremely complex, pose a significant health risk to the patient or fail to heal properly.
It is beneficial in fixing bone that are damaged from trauma.Its also useful for growing bone around an implanted device.
Call us regarding Dental Treatment and Implants Placement:-
Dr. Rajat Sachdeva
+919818894041,01142464041
drrajatsachdeva@gmail.com
Follow us here:-
• Google+ link: https://goo.gl/vqAmvr
• Facebook link: https://goo.gl/tui98A
• Youtube link: https://goo.gl/mk7jfm
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• www.dentalclinicindelhi.com
• www.dentalimplantindia.co.in
• www.dentalcoursesdelhi.com
• www.facialaestheticsdelhi.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Bone substitutes and void fillers in managing Cystic bone tumors and tumor li...BhaskarBorgohain4
In clinical settings there are several fairly common bone tumors or tumor like conditions that can causes a pathological bony cavity. These cavity can lead to pathological fracture. Giant cell tumors, simple bone cyst( SBC, UBC), fibrous dysplasia, giant cell tumors (GCT), aneurysm bone cysts( ABC) are well known entity. Autologous bone grafting , allograft or various bone substitutes are being increasingly used to fill up such voids or cavity after curettage to provide immediate cavity obliteration, provide mechanical support and promote long term healing the cavity.
bone graft /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Bone Grafts /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
Bone replacement grafts are widely used to promote
bone formation and periodontal regeneration.
Xenografts are grafts shared between different species.
Currently, there are two available sources of xenografts
used as bone replacement grafts in periodontics: bovine
bone and natural coral.
An update on stem cell technologies, prp and orthobiologics. Nuffield Health, The Grosvenor Hospital Chester and Chester Knee Clinic GP Seminar, Ewloe, Wales, UK 6th May 2017
bone graft /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Bone Grafts /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
Bone replacement grafts are widely used to promote
bone formation and periodontal regeneration.
Xenografts are grafts shared between different species.
Currently, there are two available sources of xenografts
used as bone replacement grafts in periodontics: bovine
bone and natural coral.
An update on stem cell technologies, prp and orthobiologics. Nuffield Health, The Grosvenor Hospital Chester and Chester Knee Clinic GP Seminar, Ewloe, Wales, UK 6th May 2017
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Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Tissue reaction to dentofacial orthopedic appliances /certified fixed orthodo...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
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Spinal Fusion: For Athlete’s Better Spine HealthAnne_Stage
Although they are in better physical health than most people, athletes are prone to all kinds of health conditions, including degenerative disc disease (DDD), the breakdown of intervertebral discs. The most popular treatment for DDD is spinal fusion. The surgery corrects problems with two or more bones of the spine, fusing with the vertebrae to form a single bone.
Advancement in Scaffolds for Bone Tissue Engineering: A Reviewiosrjce
In last decade, Tissue Engineering has moved a way ahead and has proposed solutions by replacing
the permanently or severely damaged tissues of our body. The field has expanded to tissue regeneration of
cartilage, bone, blood vessels, skin, etc. The domain of tissue engineering is very wide and is the combination of
bioengineering, biology & biochemistry. This review is focus on recent research advancement in bone tissue
engineering. Bone grafting techniques are used to replace the severely damaged due to any accident, trauma or
any disease. These are either allograft, autologous or synthetic bone properties similar to bone. Bone Tissue
Engineering is part of a synthetic technique and overcome the limitations faced in other two mentioned
techniques. Bone Tissue engineering is rapidly developing field and has become important due to its remarkable
therapeutic properties. Mesenchymal stem cells are used as starting cells in tissue regeneration. These cells get
differentiated into bone cells and start multiplying to form bone. One inevitable requirement of these growing
human cells is a strong support which helps in the proper growth. This support is known as scaffold, in tissue
engineering. For proper regeneration of cells scaffold materials plays vital importance in the field of bone tissue engineering. This review attempts is illustrate the biology of natural bone, various desirable properties of scaffold, biomaterials used for fabrication of scaffold and various fabrication techniques with examples of bone regenerate.
The main concept of osseodensification technique is that the drill designing creates an environment which enhances the initial primary stability through densification of the osteotomy site walls by means of autografting of bone.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
3. WHAT ARE BONE GRAFTS?
Bone grafts are bone that is transplanted from
one area of the skeleton to another to aid in
healing, strengthening or improving function.
Bone or bone-like materials used in bone grafts
may come from you, from a donor or from a
man-made source. In many cases they are used
to fill in an empty space that may have been
created in or between the bones of the spine by
disease, injury, deformity or during a surgical
procedure such as spinal fusion.
Bone
graft fills
in space
between 2
vertebrae
after disc
has been
removed
4. WHAT TYPES OF BONE
GRAFTS ARE THERE?
Bone grafts that are transplanted directly from
one area of an individual’s skeleton into his
or her own spine are called autogenous bone
grafts, or bone autografts. In most cases,
these are the preferred bone grafts to use. The
graft bone is harvested, or taken, from the
bones of the hip, the ribs or the leg. Autograft
bone is one of the safest to use due to the low
risk of disease transmission. It also offers a
better chance of acceptance and effectiveness in
the transplant site, since it contains the greatest
amount of the patient’s own bone growing
cells and proteins. Autograft bone provides a
strong framework for the new bone to grow
into. The downsides of autograft bone are the
facts that it adds another surgical site to a spine
procedure (and therefore another location to
feel postoperative pain and discomfort) and it
can increase the cost of the spinal procedure.
Bone graft that comes from a donor is called
allograft bone. Allograft bone usually comes
from bone banks that harvest the bone from
cadavers. The types of allograft bone used
for spine surgery include fresh frozen and
lyophilized (freeze dried). The bone is cleaned
and disinfected to reduce the possibility of
disease transmission from donor to recipient.
Allograft, like autograft, provides a framework
for the new bone to grow on and into. Unlike
autograft bone, allograft bone does not always
have the same strength properties or the cells
and proteins that can influence the growth
5. of new bone. The advantages of allograft
bone are the elimination of the harvesting
surgical site, the related postoperative pain
and the added expense of a second operative
procedure. Disadvantages of allograft bone are
the slight chance of disease transmission and
a lessened effectiveness since the bone growth
cells and proteins are removed during the
cleansing and disinfecting process.
How safe is allograft bone?
As bone grafting using allograft bone has
become more widely used, the methods
of screening donors, bone preparation
and storage have been vastly improved in
regards to diminishing the chances of disease
transmission. Studies indicate that the risk of
contacting HIV infection through the use of
allograft bone is less than 1 per 1 million uses.
6. WHO NEEDS
BONE GRAFTING?
Your surgeon may want to use bone grafting
for a number of reasons. Possible reasons
include situations where healing may be
difficult due to the use of nicotine (which has
been shown in medical studies to limit healing
of the spine) or the presence of diseases such
as diabetes or autoimmune deficiencies. Other
possible reasons include a large amount of
bone or disc material that is removed during
surgery, or spinal procedures that span many
levels of vertebrae.
One of the most common uses of bone grafts
in spine surgery is during spinal fusion. The
use of autogenous bone grafts for spinal fusion
has been a standard in the spine community
for many years and is considered to be the
standard by which other bone grafts are
measured. Spinal fusions are performed to
relieve pain and provide stability to spines
in people who have experienced a vertebral
fracture or motion between the vertebrae
that causes pain, have a spinal deformity, or
who have some types of disc herniations. In
certain types of spinal fusion, bone grafts or
bone graft alternatives are used to replace the
cushioning disc material that lies between
the vertebrae. When the bone graft is placed
between the vertebrae it creates a framework
and support that eventually aids in joining the
two bones together. Once the bone “bridge”
between the vertebrae is in place, the spine
7. is stabilized and movement and pressure on
nerve roots is relieved, thus easing pain.
Bone grafts can also be used in surgical
procedures to stabilize the spine after a
fracture or to correct deformity.
8. WHAT ARE BONE GRAFT
SUBSTITUTES?
Since both allograft and autograft have
drawbacks, iscientists have long searched
for materials that could be used in place of
the transplanted bone. Although most of
the substitutes available possess some of
the positive properties of autograft, none
yet have all the benefits of one’s own bone.
Investigators hope one day to use these
substitutes to simultaneously be able to
stimulate bone healing and provide a strong and
biologically compatible framework for the new
bone to grow into.
Some of these bone graft alternatives include:
Demineralized Bone Matrix (DBM)—a
product of processed allograft bone. DMB
contains collagen, proteins and growth factors
that are extracted from the allograft bone. It
is available in the form of a powder, crushed
granules, putty, chips or as a gel that can be
injected through a syringe. DBM is extensively
processed and therefore has little risk for
disease transmission; however, because of the
form it takes it does not provide strength to the
surgical site.
Ceramics—Ceramics are also used as a
substitute for bone grafts. Ceramics offer no
possibility for disease transmission, although
they may be associated with inflammation in
some patients. They are available in many
forms such as porous and mesh. Although
ceramics may provide a framework for bone
growth, they contain none of the natural
proteins that influence bone growth.
9. Coral—Bone implants made from coral have
shown to be useful in the treatment of bone
defects due to trauma, tumors and cysts. It
is also used for spinal surgery as either a graft
additive, or extender, or as an implant to
provide a framework for bone to grow into.
The use of these substitutes, under certain
conditions, has had promising outcomes.
Graft Composites—A newer area of bone graft
substitutes, graft composites use combinations
of other bone grafting materials and/or bone
growth factors to gain the benefits of a variety
of substances. Among the combinations in use
are a collagen/ceramic composite, which closely
reproduces the composition of natural bone;
DBM combined with bone marrow cells, which
aid in the growth of new bone; and a collagen/
ceramic/autograft composite.
Bone Morphogenetic Proteins—Bone
morphogenetic proteins (BMPs) are produced
in our bodies and regulate bone formation
and healing. Scientists have discovered that
these proteins can speed up healing as well as
limit the negative reaction some people have
to donor bone and the nonbone substitutes.
Scientists have also discovered how to extract
these substances from human or cow bones
and even produce them in the laboratory.
Currently, the United States Food and Drug
Administration has not yet approved these
therapies; however, extensive research is being
undertaken in both humans and animals to
determine their safety and effectiveness.
10. WHICH TYPE OF BONE GRAFT
IS RIGHT FOR ME?
The determination if bone graft is to be used
and the type to be used is best made by your
surgeon. Different surgical situations may call
for different types of bone grafting and unique
bone graft materials. If your surgeon says that
he or she would like to use a bone graft on
your spine, you should discuss this decision
with him or her to determine which bone
graft material they feel is best suited for your
situation.
As with any medical procedure, you should
ask your surgeon about any questions or
concerns you may have and make sure all of
your questions are answered.