This curriculum vitae summarizes the qualifications and experience of Dr. Biplab Giri. He is currently an Assistant Professor of Physiology at West Bengal State University in India, with over 13 years of research experience and 8 years of teaching experience. He received his Ph.D. from the University of Calcutta and conducted postdoctoral research in cancer biology and stem cell biology in the United States, supported by NIH funding. His research interests include cancer biology, stem cell biology, regenerative medicine, and molecular pharmacology. He has published over a dozen research papers in international journals and contributes to scientific review boards.
The Effect of Green Tea Leaf Extract on Reproductive Function of Male Wistar ...ijtsrd
This study assessed the effects green leaf tea extract on male reproductive function of male albino wistar rats. Twenty rats weighing between 150 250g, grouped into 4 of 5 rats each, were used for the research that lasted for four weeks. Group I, the control group, received normal rat chow and water ad libitum. The three test groups II IV, received 2.5gm 100ml 0f water, 5gm 100ml of water, 7.5gm 100ml of water of green leaf tea extract given via oral administration with normal rat food and water for four weeks. Blood was collected via ocular puncture and serum was assayed for testosterone levels. Semen was also analyzed for sperm motility and sperm count. The testicular weight was recorded and net body weight gain was also recorded. The study showed significant decrease in net body weight gain and testicular weight. It has been shown that the reduction of body weight after application of green tea extract may be due to inhibition of catechol O methyl transferase transferase COMT enzyme by epigallocatechin gallate EGCG of the green tea. The study also showed significant decrease in sperm motility and sperm count. It also showed a significant decrease in testosterone levels. In conclusion, green leaf tea extract had a negative effect on male reproductive function and its use as a daily tea should be curtailed. Okonkwo, C. O. J | Maduka, S. O | Akude Harrison | Mmaju, C. I | Okwuonu, I. F1; Goji A. D "The Effect of Green Tea Leaf Extract on Reproductive Function of Male Wistar Rats" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd42471.pdf Paper URL: https://www.ijtsrd.commedicine/other/42471/the-effect-of-green-tea-leaf-extract-on-reproductive-function-of-male-wistar-rats/okonkwo-c-o-j
The Effect of Green Tea Leaf Extract on Reproductive Function of Male Wistar ...ijtsrd
This study assessed the effects green leaf tea extract on male reproductive function of male albino wistar rats. Twenty rats weighing between 150 250g, grouped into 4 of 5 rats each, were used for the research that lasted for four weeks. Group I, the control group, received normal rat chow and water ad libitum. The three test groups II IV, received 2.5gm 100ml 0f water, 5gm 100ml of water, 7.5gm 100ml of water of green leaf tea extract given via oral administration with normal rat food and water for four weeks. Blood was collected via ocular puncture and serum was assayed for testosterone levels. Semen was also analyzed for sperm motility and sperm count. The testicular weight was recorded and net body weight gain was also recorded. The study showed significant decrease in net body weight gain and testicular weight. It has been shown that the reduction of body weight after application of green tea extract may be due to inhibition of catechol O methyl transferase transferase COMT enzyme by epigallocatechin gallate EGCG of the green tea. The study also showed significant decrease in sperm motility and sperm count. It also showed a significant decrease in testosterone levels. In conclusion, green leaf tea extract had a negative effect on male reproductive function and its use as a daily tea should be curtailed. Okonkwo, C. O. J | Maduka, S. O | Akude Harrison | Mmaju, C. I | Okwuonu, I. F1; Goji A. D "The Effect of Green Tea Leaf Extract on Reproductive Function of Male Wistar Rats" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd42471.pdf Paper URL: https://www.ijtsrd.commedicine/other/42471/the-effect-of-green-tea-leaf-extract-on-reproductive-function-of-male-wistar-rats/okonkwo-c-o-j
Dr.Rahul Hajare is a post doctoral student of Renowned Scientist Respected Dr. R S. Paranjape Retired Director and Scientist ‘G’ National AIDS Research Institute India. He achieved his training at the National AIDS Research Institute, the reputed and primer HIV research institute in India. Dr. Hajare is board certified by Director-in-Charge, National AIDS Research Institute, the Secretory Board of Management KLE Society Belagavi, Registrar Vinayaka Mission’s Research Foundation, Aarti Drugs Limited and Shikshan Vikas Mandal. Dr Hajare won World Academic Championship-2017 in Pharmacy (Antiretroviral Therapy) and certified as Fellow, Directorate of Pharmacy, IASR (Lifetime Membership).
ABSTRACT- Valeriana jatamansii Linn (Valerianaceae) is a medicinal herb used in the traditional health care system of
Uttarakhand (India). The present study reports the anticonvulsant activities in the aqueous and ethanolic extracts of the
roots of Valeriana jatamansii on the rats, induced both chemically and electrically. The models chosen for the activity
were Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced convulsions in rats. The test dose studied were
400 and 600 mg/kg body weight orally of the extracts. Acute toxicity studies show that the extracts were non toxic up to
the recommended dose 2000mg/kg body weight orally as per OECD guideline no 423. In PTZ induced seizures, onset of
clonic convulsions were studied while in MES model, reduction in the mean duration of extensor phase was noted. Both
the extracts showed anticonvulsant activities against MES and PTZ animal models.
Key Words: Anticonvulsant activity, MES, PTZ, Herbal drug
Research by Mahendra Trivedi - Biofield Treatment: A Potential Strategy for M...Abby Keif
Research on Trivedi Effect - The objective of present research was to investigate the influence of biofield treatment on physical and thermal properties of indole. The study was performed in two groups (control and treated). The present study showed that biofield has substantially affected the physical and thermal nature of indole. Visit http://works.bepress.com/mahendra_trivedi/40/ for details.
Quantitative analysis of different soil microbial communities (Bacteria, Fungi, Actinomycetes) responsible for various biological processes and nutrient cycling (C, N and P) in terrestrial ecosystems.
Monitoring CH4, N2O and CO2 emission from rice and rice based cropping system and work out appropriate mitigation option.
Enumeration and isolation of GHG-mobilizing microbes (methanogens, methanotrophs, nitrifiers and denitrifiers).
Evaluation of the interactive effects of greenhouse gases (CO2, CH4 and N2O), temperature, hydrological and microbiological relations on soil carbon decomposition and nutrient release, and their impact on climate change.
Systemic health effects of areca nuts with particular emphasis on carcinogene...Innspub Net
Areca (betel) nut (Areca catechu) is regarded as one of the most addictive masticatory substances in the world, with approximately 600 million users globally. Extensively grown and found in India, China and Indonesia; areca nut is also native to many other countries of the South and Southeast Asia. Its usage and beneficial effects have been reviewed since centuries. The systemic effects associated with areca nut usage have been in the limelight for many years. This review provides a narrative insight to assess and collate published data that reports the harmful effects of areca nut. An electronic search amassed literature from the NCBI and Google Scholar databases with the help of keywords. Various studies on the correlation of areca nut and its effect on the oral health, metabolism and the incidence of cancer were selected. Its usage is reported to be associated with cancers of the oral cavity, esophagus, pharynx, liver and has been declared a human group 1 carcinogen by the International Agency for Research on Cancer (IARC). It is also associated with the incidence of cardiovascular disease and chronic kidney disease. Hence, there is a dire need to identify the role of areca nut as a causative agent of cancer and several other health disorders. Clinical evidence has indicated and proved that the use of areca nut causes several types of head and neck cancers, as to effects on intracellular levels of GSH, and on tumor suppressing gene P53 are quite evident clinical evidence has indicated and proved that the use of areca nut causes several types of head and neck cancers, as to effects on intracellular levels of GSH, and on tumor suppressing gene P53 are quite evident.
Background: The probable mechanism of an earlier reported capacity of palm oil extracts to confer protection
against high dose cadmium poisoning in rats was reported in this study. Similar experimental design earlier reported
by us was retained. Rats therefore were sacrificed at intervals of twelve; twenty four and forty eight hours post CdCl2
insult.
Results: Oxidative stress and antioxidant status (malondialdehyde, superoxide dismutase, catalase and glutathione)
were assessed in tissues (liver, kidney, heart, brain, muscle) and serum. Oxidative stress indicators showed a significantly
(p < 0.05) increased lipid peroxidation and alterations in antioxidant defence systems occasioned by drop in
catalase and superoxide dismutase enzymes (serum, liver, heart, brain and kidneys) of the rats. Also observed were
significant (p < 0.05) reduction in the non-enzymatic antioxidant reduced glutathione over time. Pre-administration of
rats with the crude palm oil and its extracts modulated cadmium mediated depletion of the antioxidant capacities of
rats acutely exposed to cadmium and rising lipid peroxidation profile.
Conclusions: Regulation of stress and antioxidant response was the underlying mechanism by which the extracts
conferred protection against high dose cadmium insult thus suggesting its potential as a viable therapeutic target
against its deleterious effects.
The use of medicinal plants in the treatment of harmful impacts of xenobiotics in animals is attracting an increasing attention in recent times. The aim of the current study is to assess the preventive potential of Costus afer aqueous leaves extract (CAAE) in treating metabolic aberrations imposed by crude oil contaminated diet in Wistar albino rats. Six groups of rats were treated as follows: A = Normal diet; B= Normal diet + 100 mg/kg body weight of CAAE; C =Normal diet + 200 mg/kg body weight of CAAE; D= Crude oil contaminated diet; E= crude oil contaminated diet + 100 mg/kg body weight of CAAE, F = crude oil contaminated diet + 200 mg/kg body weight of CAAE. After thirty days of exposure to the diet and administration of the corresponding plant extracts, the rats were sacrificed with chloroform and the required organs were excised. The hematological indices, as well as function indicators and levels of drug metabolizing enzymes in the liver and kidney, were investigated with standard protocols. The results indicated that the hematological parameters and kidney and liver function indices were altered in rats fed with crude oil contaminated diet. However, the values came close to those in control rats when Costus afer aqueous extracts were administered. Similarly, the activities of oxidase enzymes (aldehyde oxidase, monoamine oxidase, xanthine oxidase, and sulphite oxidase), following their inhibition by the ingestion of crude oil contaminated diet, equally restored close to control values upon treatment with Costus afer aqueous extract. This study, therefore, was able to establish an aqueous extract of Costus afer leave as an antidote for crude oil intoxication.
Dr.Rahul Hajare is a post doctoral student of Renowned Scientist Respected Dr. R S. Paranjape Retired Director and Scientist ‘G’ National AIDS Research Institute India. He achieved his training at the National AIDS Research Institute, the reputed and primer HIV research institute in India. Dr. Hajare is board certified by Director-in-Charge, National AIDS Research Institute, the Secretory Board of Management KLE Society Belagavi, Registrar Vinayaka Mission’s Research Foundation, Aarti Drugs Limited and Shikshan Vikas Mandal. Dr Hajare won World Academic Championship-2017 in Pharmacy (Antiretroviral Therapy) and certified as Fellow, Directorate of Pharmacy, IASR (Lifetime Membership).
ABSTRACT- Valeriana jatamansii Linn (Valerianaceae) is a medicinal herb used in the traditional health care system of
Uttarakhand (India). The present study reports the anticonvulsant activities in the aqueous and ethanolic extracts of the
roots of Valeriana jatamansii on the rats, induced both chemically and electrically. The models chosen for the activity
were Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced convulsions in rats. The test dose studied were
400 and 600 mg/kg body weight orally of the extracts. Acute toxicity studies show that the extracts were non toxic up to
the recommended dose 2000mg/kg body weight orally as per OECD guideline no 423. In PTZ induced seizures, onset of
clonic convulsions were studied while in MES model, reduction in the mean duration of extensor phase was noted. Both
the extracts showed anticonvulsant activities against MES and PTZ animal models.
Key Words: Anticonvulsant activity, MES, PTZ, Herbal drug
Research by Mahendra Trivedi - Biofield Treatment: A Potential Strategy for M...Abby Keif
Research on Trivedi Effect - The objective of present research was to investigate the influence of biofield treatment on physical and thermal properties of indole. The study was performed in two groups (control and treated). The present study showed that biofield has substantially affected the physical and thermal nature of indole. Visit http://works.bepress.com/mahendra_trivedi/40/ for details.
Quantitative analysis of different soil microbial communities (Bacteria, Fungi, Actinomycetes) responsible for various biological processes and nutrient cycling (C, N and P) in terrestrial ecosystems.
Monitoring CH4, N2O and CO2 emission from rice and rice based cropping system and work out appropriate mitigation option.
Enumeration and isolation of GHG-mobilizing microbes (methanogens, methanotrophs, nitrifiers and denitrifiers).
Evaluation of the interactive effects of greenhouse gases (CO2, CH4 and N2O), temperature, hydrological and microbiological relations on soil carbon decomposition and nutrient release, and their impact on climate change.
Systemic health effects of areca nuts with particular emphasis on carcinogene...Innspub Net
Areca (betel) nut (Areca catechu) is regarded as one of the most addictive masticatory substances in the world, with approximately 600 million users globally. Extensively grown and found in India, China and Indonesia; areca nut is also native to many other countries of the South and Southeast Asia. Its usage and beneficial effects have been reviewed since centuries. The systemic effects associated with areca nut usage have been in the limelight for many years. This review provides a narrative insight to assess and collate published data that reports the harmful effects of areca nut. An electronic search amassed literature from the NCBI and Google Scholar databases with the help of keywords. Various studies on the correlation of areca nut and its effect on the oral health, metabolism and the incidence of cancer were selected. Its usage is reported to be associated with cancers of the oral cavity, esophagus, pharynx, liver and has been declared a human group 1 carcinogen by the International Agency for Research on Cancer (IARC). It is also associated with the incidence of cardiovascular disease and chronic kidney disease. Hence, there is a dire need to identify the role of areca nut as a causative agent of cancer and several other health disorders. Clinical evidence has indicated and proved that the use of areca nut causes several types of head and neck cancers, as to effects on intracellular levels of GSH, and on tumor suppressing gene P53 are quite evident clinical evidence has indicated and proved that the use of areca nut causes several types of head and neck cancers, as to effects on intracellular levels of GSH, and on tumor suppressing gene P53 are quite evident.
Background: The probable mechanism of an earlier reported capacity of palm oil extracts to confer protection
against high dose cadmium poisoning in rats was reported in this study. Similar experimental design earlier reported
by us was retained. Rats therefore were sacrificed at intervals of twelve; twenty four and forty eight hours post CdCl2
insult.
Results: Oxidative stress and antioxidant status (malondialdehyde, superoxide dismutase, catalase and glutathione)
were assessed in tissues (liver, kidney, heart, brain, muscle) and serum. Oxidative stress indicators showed a significantly
(p < 0.05) increased lipid peroxidation and alterations in antioxidant defence systems occasioned by drop in
catalase and superoxide dismutase enzymes (serum, liver, heart, brain and kidneys) of the rats. Also observed were
significant (p < 0.05) reduction in the non-enzymatic antioxidant reduced glutathione over time. Pre-administration of
rats with the crude palm oil and its extracts modulated cadmium mediated depletion of the antioxidant capacities of
rats acutely exposed to cadmium and rising lipid peroxidation profile.
Conclusions: Regulation of stress and antioxidant response was the underlying mechanism by which the extracts
conferred protection against high dose cadmium insult thus suggesting its potential as a viable therapeutic target
against its deleterious effects.
The use of medicinal plants in the treatment of harmful impacts of xenobiotics in animals is attracting an increasing attention in recent times. The aim of the current study is to assess the preventive potential of Costus afer aqueous leaves extract (CAAE) in treating metabolic aberrations imposed by crude oil contaminated diet in Wistar albino rats. Six groups of rats were treated as follows: A = Normal diet; B= Normal diet + 100 mg/kg body weight of CAAE; C =Normal diet + 200 mg/kg body weight of CAAE; D= Crude oil contaminated diet; E= crude oil contaminated diet + 100 mg/kg body weight of CAAE, F = crude oil contaminated diet + 200 mg/kg body weight of CAAE. After thirty days of exposure to the diet and administration of the corresponding plant extracts, the rats were sacrificed with chloroform and the required organs were excised. The hematological indices, as well as function indicators and levels of drug metabolizing enzymes in the liver and kidney, were investigated with standard protocols. The results indicated that the hematological parameters and kidney and liver function indices were altered in rats fed with crude oil contaminated diet. However, the values came close to those in control rats when Costus afer aqueous extracts were administered. Similarly, the activities of oxidase enzymes (aldehyde oxidase, monoamine oxidase, xanthine oxidase, and sulphite oxidase), following their inhibition by the ingestion of crude oil contaminated diet, equally restored close to control values upon treatment with Costus afer aqueous extract. This study, therefore, was able to establish an aqueous extract of Costus afer leave as an antidote for crude oil intoxication.
'If you can't be kind, be scholarly': constructive peer reviewing (LILAC 2016)Emma Coonan
This workshop offers an introduction to the ‘what’ and ‘how’ of peer reviewing, suitable for both current and aspiring reviewers. It may also be useful for writers of academic articles. It explores what peer review is and how it serves scholarship; looks at an example of a peer review form; considers how to read an article critically and analytically; and suggests how to give constructive, courteous and workable feedback that will enhance the final article.
Microbiologist with proficient experience in teaching (2.5 yrs) as well as research (2.5 yrs) and eager to utilize best of my knowledge and experience as team-leader or member.
Polygonum Persicaria (Linn.) and its Active Principle have a hepatoprotective...AI Publications
The aim of this analysis was to see whether the aqueous extract of the roots of Polygonum persicaria (PP) and its active principle, Tannic Acid (TA), had a hepatoprotective and antioxidant effect in rats provided Carbon tetrachloride (1.5 ml/kg, i.p). Twenty albino wistar rats were divided into five groups: control, CCl4-induced hepatotoxicity, hepatotoxicity with Polygonum persicaria and Tannic acid, and a normal group given 100 mg/kg silymarin. After 14 days, the rats were sacrificed. Toxicity testing was carried out on 12 rats. They were randomly allocated to one of three groups: control, Polygonum persicaria 200 mg/kg (B.wt), and Tannic acid 200 mg/kg (B.wt). The amounts of liver homogenate enzymes (glutathione peroxidase, glutathione-S-transferase, glucose-6-phosphatase dehydrogenase, and glutathione reductase enzymes) were greatly restored by extracts of PP and TA at the tested concentrations, supporting the biochemical results. Tannic acid, in contrast to Polygonum persicaria, tends to have a greater liver defensive role toward carbon tetrachloride-induced hepatotoxicity, as well as antioxidant properties and mild anticancer activity against cell viability at higher concentrations. The histological alterations in the liver indicated the injury. Polygonum persicaria & its active principle Tannic acid has strong antioxidant properties as well as hepatoprotective effects against CCl4-induced hepatotoxicity, as demonstrated by these observations.
To perform to my best ability in the field of pharmaceutical education and research in all personal and professional activities and get involved in the growth of the organization in a very responsible and honest way.
1. Curriculum Vitae
Dr. Biplab Giri, Ph.D.
Assistant Professor
Department of Physiology, West Bengal State University,
Barasat, Berunanpukuria, P.O. Malikapur, North 24 Parganas,
West Bengal, Kolkata- 700126; India
Email: bgiri.cu@gmail.com; bgiri.emscrl@gmail.com
Webpage: http://www.wbsubregistration.org/physiology.php
Brief Biography-
Biplab Giri is an Assistant Professor in the Department of Physiology, West Bengal
State University, India since 2009. He teaches Physiology, Pathophysiology,
Pharmacology and Stem Cell Biology at the Post Graduate Department in the
university. He is also the Co-ordinator of Health Care Centre, West Bengal State
University. Dr. Giri has substantial contribution to his field of expertise both as a
teacher as well as a researcher. He obtained his Masters in Physiology from the
University of Calcutta and was awarded D.N. Mallik award (Gold Medal) and
University Gold Medal for securing first rank with first class in Physiology. He received
his Ph.D. degree in the area of Cancer Biology from the University of Calcutta, India
and pursued post-doctoral research work in USA, sponsored by NIH/NHLBI, USA. He pursued his first
postdoctoral research on Cancer biology at Baylor College of Medicine, Houston, TX and University of Maryland,
Baltimore, MD and second postdoctoral work in Stem Cell Biology and Regenerative Medicine at University of
North Carolina, Chapel Hill, NC, USA. He received ‘SEBM Young Scientist Mentee award, USA’ in 2007, awarded
by the Society for Experimental Biology & Medicine, USA for his academic excellence and research credential.
The research team, he worked with at University of North Carolina, received first prize from the American Heart
Association for their research paper on “Wnt1 Mediated Dynamic Injury Response Activates the Epicardium and is
Critical for Cardiac Repair” in Louis N. and Arnold M. Katz Basic Science Research Prize session of AHA
Conference, USA (Circulation 2010;122:A541). His areas of research interest include Cancer Biology and Cancer
Stem Cell targeting, Stem cell Biology and Regenerative Medicine, Drug development against Cancer-Diabetes
condition and other metabolic disorders, Molecular Pharmacology & Melatonin research in health and diseases. He
has been handling a number of research projects and grants supported by Government of India. He has about 13
years of research and 8 years of teaching experiences. He has published a number of research papers in reputed
International Journals (e.g. Toxicon, Leukemia Research, Anticancer Research, Circulation, European Journal of
Pharmacology, RSC-Advances, APJTD, Pharmacological Reports etc.) and contributed an invited book chapter to
an edited volume published from Springer, Netherland. He is also a reviewer in Taylor & Francis, Springer,
iMedPub etc. Journals and Lead Guest Editor of ‘The Scientific World Journal’ 2015 (Hindawi). He has some
prestigious professional memberships in different National and International Scientific Societies.
2. Present Position
Assistant Professor, Department of Physiology, West Bengal State University (from 1st
April 2009- continuing).
Education
Post Doctoral Fellowship, sponsored by NIH/NHLBI, USA (from 2007 to 2009 – 2 years)
Doctorate (Ph.D.), June 2007 (submitted 13th
Dec. 2006), University of Calcutta, Kolkata, India
Master of Science in Physiology, 2002, University of Calcutta (First Class, ranked first).
Bachelor of Science in Physiology (Hons), 2000, University of Calcutta (First Class).
Higher Secondary from WBCHSE (First Division)
Madhyamik from WBBSE (First Division)
Achievements / Awards
Selected for the Scientist position in Chittaranjan National Cancer Research Institute, Kolkata,
Ministry of Health, Govt. of India (Appointment letter No. A-1.51(i)/05/Part-II/2280 dated 1st
July 2009).
American Heart Association awarded first prize for our research on “Wnt1 Mediated Dynamic Injury
Response Activates the Epicardium and is Critical for Cardiac Repair” in Louis N. and Arnold M. Katz
Basic Science Research Prize session of AHA Conference held on Nov14-16, 2010 in USA.
Post Doctoral Fellowship, sponsored by NIH/NHLBI, USA (from 2007 to 2009 – 2 years)
‘SEBM Young Scientist Mentee award 2007, USA’ - Awarded by the Society for Experimental Biology
& Medicine, USA (Ref.: Experimental Biology & Medicine, June 2007; 232)
Senior Research Fellow, Indian Council of Medical Research, Government of India (2006)
Research Fellow, University Grants Commission, Government of India, India (2003-2006)
Jawaharlal Nehru Memorial Award for the recognition of academic excellence for the year 2002
D.N. Mallik award (Gold Medal) for first class first in M.Sc. Physiology, 2002 (Awarded by The
Physiological Society of India).
First class first in Master of Science degree, 2002 (University of Calcutta); Gold Medal from the
University of Calcutta (Received on 22nd
Sept 2012).
Reviewer, Drug Delivery (Impact Factor: 2.558), A ‘Taylor & Francis’ Journal published from UK and
USA [ISSN: 1071-7544 (Print), 1521-0464 (Online)]
Reviewer, Zoological Studies (Impact Factor: 0.78), A ‘Springer’ Journal published from Academia Sinica,
Taiwan [ISSN:1810-522X]
Reviewer, Journal of HIV for Clinical and Scientific Research, Peertechz, India
Reviewer, Health Science Journal (Impact Factor: 2.17), A ‘iMedPub’ Journal published from USA
[ISSN:1108-7366]
Lead Guest Editor, The Scientific World Journal 2015 (Hindawi) [ISSN: ISSN: 2356-6140 (Print),
1537-744X (Online)]; Special Issue on “Targeting Cancer Stem Cell and Role of Microenvironment in
Carcinogenesis” (http://www.hindawi.com/journals/tswj/si/105308/cfp/)
Professional Membership of the Scientific Society
Life Member, Physiological Society of India (since 2004)
Life Member, Indian Pharmacological Society (since 2005)
Life Member, Indian Science Congress Association (since 2005)
Member, Indian Association for Cancer Research (2004)
Member, International Society on Toxinology (UK), (2006-2009)
Life member, Toxinological Society of India, (since 2012)
3. List of Research Publications (with impact factors)
1. Labanyamoy Kole, Mrinmoy Sarkar, Anwesha Deb, Biplab Giri*. Pioglitazone, an anti-diabetic drug requires
sustained MAPK activation for its anti-tumor activity in breast cancer, independent of PPAR- pathway.
Pharmacological Reports 2016; 68: 144-154 (Elsevier, Poland; ISSN:1734-1140) - In Press IF: 2.206
2. Sujay Kumar Bhunia, Mrinmoy Sarkar, Asesh Banerjee, Biplab Giri*. An Update on Pathogenesis and
Management of Tuberculosis with Special Reference to Drug Resistance. Asian Pacific Journal of Tropical
Disease 2015; 9(5): 673-686 [Elsevier; ISSN: 2222-1808]
3. Suparna Saha, Priyabrata Sarkar, Mrinmoy Sarkar, Biplab Giri. Electroconductive smart polyacrylamide–
polypyrrole (PAC–PPY) hydrogel: a device for controlled release of risperidone. RSC- Advances 2015; 5:
27665-27673 [Royal Society of Chemistry, England] IF: 3.84
4. Soma Haldar, Sudeshna Bhattacharya, Biplab Giri, Shyamal Das Gupta, Niladri Shekhar Bhunia, Anindya
Sundar Bhunia, Sajal Ray, Mitali Ray, Rahul Bhattacharya, Pratiti Ghosh. Effect of Cold Stress on
Pyridostigmine Pretreated Rats Exposed to an Organophosphorous Compound. Journal of Life Sciences
Research 2014; 1(1): 10-15 [Asian Online Journal Publishing Group; ISSN: 2408-9184]
5. Sudeshna Bhattacharya, Soma Haldar, Sujata Roy, Biplab Giri, Shyamal Das Gupta, Rahul Bhattacharya,
Pratiti Ghosh. Pretreatment with Pyridostigmine Bromide Does not Induce Cellular Toxicity. Advances in Life
Sciences 2014; 4(5): 220-226 [USA; p-ISSN: 2163-1387; e-ISSN: 2163-1395]
6. Antony Gomes, Biplab Giri, Aftab Alam, Sanghamitra Mukherjee, Pushpak Bhattacharjee, Aparna Gomes.
Anticancer activity of a low immunogenic protein toxin (BMP1) from Indian toad (Bufo melanostictus,
Schneider) skin extract. Toxicon 2011; 58: 85-92 [Elsevier, UK; ISSN: 0041-0101]- IF: 2.766
7. Labanyamoy Kole*, Biplab Giri*, SK Manna, Biswajit Pal, Sajalendu Ghosh. Biochanin A, an isoflavon,
showed anti-proliferative and anti-inflammatory activities through the inhibition of iNOS expression, p38-
MAPK and ATF-2 phosphorylation and blocking NFB nuclear translocation. European Journal of
Pharmacology 2011;653(1-3) :8-15 [Elsevier; ISSN: 0014-2999] (*Joint first author)- IF: 2.754
8. Pushpak Bhattacharjee, Biplab Giri, Antony Gomes. Apoptogenic activity and toxicity studies of a
cytotoxic protein (BMP1) from the aqueous extract of the common Indian toad (Bufo melanostictus, Schneider)
skin. Toxicon 2011; 57: 225-236 [Elsevier, UK; ISSN: 0041-0101]- IF: 2.766
9. Anindita Debnath, Archita Saha, Antony Gomes, Sumit Biswas, Pinakpani Chakrabarti, Biplab Giri, Ajoy K
Biswas, Shubho Das Gupta, Aparna Gomes. A lethal cardiotoxic-cytotoxic protein from the Indian monocellate
cobra (Naja kaouthia) venom. Toxicon 2010; 56: 569-579 [Elsevier, UK; ISSN: 0041-0101]- IF: 2.766
10. Antony Gomes, Pushpak Bhattacharjee, Roshnara Mishra, Ajoy K Biswas, Subir C Dasgupta, Biplab Giri,
Anindita Debnath, Subho Dasgupta, Tanaya Das, Aparna Gomes. Anticancer potential of animal venoms and
toxins. Ind J Exp Biol 2010; 48: 93-103 [Review article]- IF: 0.753 (ISSN:0019-5189)
11. Subhash Haldar, Shubho Dasgupta, Aparna Gomes, Biplab Giri, Subir Chandra Das Gupta, Ajay K Biswas,
Roshnara Mishra, Antony Gomes. A high molecular weight protein HBF1 from the Indian black Scorpion
(Heterometrus bengalensis C.L.Koch) venom having anti osteoporosis activity in experimental animals.
Toxicon 2010; 55(2-3): 455-61 [Elsevier, UK; ISSN: 0041-0101]- IF: 2.766
12. Biplab Giri, Antony Gomes, Radha Sengupta, Sanjeev Banerjee, Jyoti Nautiyal , Fazlul H. Sarkar, Adhip P. N.
Majumdar. Curcumin Synergizes the Growth Inhibitory Properties of Indian Toad (Bufo melanostictus,
Schneider) Skin Derived Factor (BM-ANF1) in HCT-116 Colon Cancer Cells. Anticancer Research 2009;
29(1): 395-401 – IF: 1.872 [ISSN: 0250-7005]
4. 13. Antony Gomes, Subhash Haldar, Biplab Giri, Roshnara Mishra, Archita Saha, Shubho Das Gupta, Aparna
Gomes. Antiosteoporosis activity of the Indian black scorpion (Heterometrous bengalensis C.L.Koch) venom
on experimental osteoporosis female albino rats. Toxicon 2009; 53(1): 60-68 [Elsevier, UK; ISSN: 0041-0101]-
IF: 2.766
14. Antony Gomes, Biplab Giri, Labanyamoy Kole, Archita Saha, Anindita Debnath, Aparna Gomes. A crystalline
compound (BM-ANF1) from the Indian toad (Bufo melanostictus, Schneider) skin extract, induced
anti-proliferation & apoptosis in leukemic & hepatoma cell line involving cell cycle proteins. Toxicon 2007;
50(6): 835-849 [Elsevier, UK; ISSN: 0041-0101]- IF: 2.766
15. Antony Gomes, S Roy Choudhury, Archita Saha, R Mishra, Biplab Giri, AK Biswas, Anindita Debnath,
Aparna Gomes. A new protein toxin (drCT1) from Dabuia russellii venom having antiproliferative and
apoptogenic activity. Toxicon 2007; 49: 46-56 [Elsevier, UK; ISSN: 0041-0101]- IF: 2.766
16. Antony Gomes, Biplab Giri, Archita Saha, R Mishra, Subir C Dasgupta, A Debnath, Aparna Gomes. Bioactive
molecules from amphibian skin: Their biological activities with reference to therapeutic potentials for possible
drug development. Ind J Exp Biol 2007; 45(7): 579-593 [Review article]- IF: 0.753 (ISSN:0019-5189)
17. S Dasgupta, A Debnath, A Saha, B Giri, G Tripathi, A Gomes, JR Vedasiromoni, A Gomes. Indian black
scorpion (Heterometrus bengalensis, Koch) venom induced cytotoxic and apoptogenic activity against human
leukemic U937 and K562 cells. Leukemia Research 2007; 31: 817-825 [Elsevier, USA; ISSN: 0145-2126]-
IF: 2.692
18. B Giri, A Gomes, A Debnath, A Saha, A K Biswas, S C Dasgupta A Gomes. Antiproliferative, cytotoxic and
apoptogenic activity of Indian toad (Bufo melanostictus, Schneider) skin extract in U937 & K562 cells.
Toxicon 2006; 48(4): 388-400 [Elsevier, UK; ISSN: 0041-0101]- IF: 2.766
19. Archita Saha, Aparna Gomes, B Giri, A K Chakravarty, A K Biswas, S C Dasgupta and A. Gomes.
Occurrence of non-protein low molecular weight cardiotoxin in the Indian King cobra (Ophiophagus hannah)
venom. Ind J Exp Biol 2006; 44(4):279-285 - IF: 0.753 (ISSN:0019-5189)
20. A Saha, A Gomes, A K Chakravarty, A K Biswas, B Giri, S C Dasgupta and A Gomes. CNS and
anticonvulsant activity of a non-protein toxin (KC-MMTx) isolated from King cobra (Ophiophagus hannah)
venom. Toxicon 2006; 47(3):296-303 [Elsevier, UK; ISSN: 0041-0101]- IF: 2.766
21. JinZhu Duan, Costin Gherghe, Dianxin Liu, Eric Hamlett, Luxman Srikanth, Biplab Giri, Jenna Regan,
Laurel Rodgers, Jackie Kylander, Mauricio Rojas, Andrew Leask, Mark Majesky, Arjun Deb. Wnt1 Mediated
Dynamic Injury Response Activates the Epicardium and is Critical for Cardiac Repair. Circulation 2010;122:
A541- Impact Factor: 14.948 (Online ISSN:1942-3268) [full paper peer reviewed].
Book/Book Chapter:
22. Biplab Giri, Labanyamoy Kole. Combating the Perilous Consequence of Clostridial Gas Gangrene: An
Overview. Toxinology 2014; Vol. 36: pp 1-21 [Springer, Netherland; Online ISBN: 978-94-007-6645-7],
Toxinology: Biological Toxins and Bioterrorism- Invited book chapter [ISBN-10: 9400758685; ISBN-13: 978-
9400758681]
Research Paper Communicated
(Two papers communicated)
5. Google Scholar Citation Index:
Citation
indices
All
Since
2010
Citations 402 365
h-index 10 9
i10-index 10 9
-----------------------------------------------------------------------
Research news/views/translational citation:
1. Relocating fat to treat obesity, diabetes. Nature India. [doi:10.1038/nindia.2011.140 Published online
30 September 2011]
2. Drugs from poison. Nature India. (A citation and news from the actual publication: Giri et al., Anticancer
Research 2009;29(1): 395-401 [doi:10.1038/nindia.2010.175 Published online 14 December 2010]
3. Biochanin A (CAS 491-80-5). Santa Cruz Biotechnology, USA (http://www.scbt.com/datasheet-205603-
biochanin-a.html) [citation from the actual publication: Eur J Pharmacol 2011;653(1-3) :8-15]
4. Biochanin A (ab142834). abcam Biochemicals, USA (http://www.abcam.com/biochanin-a-ab142834.html)
[citation from the actual publication: Eur J Pharmacol 2011;653(1-3):8-15]
Papers presented in Conferences
International:
1. Biplab Giri*, Anindita Debnath, Pathikrit Bandyopadhyay, Antony Gomes. Antineoplastic activities of snake
venom cytotoxins- present status and future direction, presented in special lecture (oral) session in the 4th
Annual Conference of the Toxinological Society of India and International Colloquium on “Venom, Toxins and
Human Health- Revisiting the Translational Approach” held in Calcutta School of Tropical Medicine, Kolkata,
India on and from 20-22 November, 2014.
2. Mrinmoy Sarkar, Soma Halder, Antony Gomes, Biplab Giri*. A comparative analysis of anti-cancer effects of
pioglitazone and metformin in MCF7, K562 and HepG2 cells, presented in poster session in the 4th
Annual
Conference of the Toxinological Society of India and International Colloquium on “Venom, Toxins and Human
Health- Revisiting the Translational Approach” held in Calcutta School of Tropical Medicine, Kolkata, India on
and from 20-22 November, 2014.
3. Soma Halder, Mrinmoy Sarkar, Pathikrit Bandopadhyay, Sujay Bhunia, Biplab Giri*. Cytoprotective effect of
Red-Grape extract against acute heat stress induced testicular cytotoxicity, presented in poster session in the 4th
Annual Conference of the Toxinological Society of India and International Colloquium on “Venom, Toxins and
Human Health- Revisiting the Translational Approach” held in Calcutta School of Tropical Medicine, Kolkata,
India on and from 20-22 November, 2014.
4. Pathikrit Bandopadhyay, Biplab Giri*. In-Silico prediction of function of the protein Cardiotoxin-II isolated
from Taiwan cobra venom, presented in poster session in the 4th
Annual Conference of the Toxinological Society
of India and International Colloquium on “Venom, Toxins and Human Health- Revisiting the Translational
Approach” held in Calcutta School of Tropical Medicine, Kolkata, India on and from 20-22 November, 2014.
5. Sujay Kumar Bhunia, Sibnarayan Guria, Biplab Giri*. Mycobacterium tuberculosis – Study of
Epidemiological Correlates and Treatment Outcome of Tuberculosis in a Tuberculosis Unit of South 24 Parganas
District of West Bengal, presented in poster session in the 4th
Annual Conference of the Toxinological Society of
6. India and International Colloquium on “Venom, Toxins and Human Health- Revisiting the Translational
Approach” held in Calcutta School of Tropical Medicine, Kolkata, India on and from 20-22 November, 2014.
6. Biplab Giri*, Labanyamoy Kole, PPAR- independent anticancer activity of Pioglitazone in MCF-7 cell,
presented in oral session in the 3rd Annual Conference of the Toxinological Society of India and 1st International
Conference on “Biology of Natural Toxins” held in BITS Pilani K K Birla Goa Campus, Goa, India held on and
from 19-21 December, 2013.
7. Biplab Giri*, Targeting cancer stem cells for possible future cancer therapeutics, presented in Oral (invited)
lead lecture session in the International Conference on Molecules to Systems Physiology: 100 Years Journey
(ICMSP100), organized by Department of Physiology, University of Calcutta, held on Sept. 21-23, 2011.
8. Biplab Giri*, Labanyamoy Kole, Pioglitazone, an anti-diabetic drug requires sustained MAPK activation for its
anti-tumor activity in breast cancer, independent of PPAR pathway, presented (Poster) in the Indian
Association of Cancer Research 2011 Conference and International Symposium, organized by IICB, Jadavpur,
held on Feb. 6-9, 2011 at Kolkata.
9. Arjun Deb, Costin Gherghe, Dianxin Liu, Eric Hamlett, Luxman Srikanth, Biplab Giri, Jenna Regan, Laurel
Rodgers, Jackie Kylander, Mauricio Rojas, Andrew Leask, Mark Majesky, JinZhu Duan. Wnt1 Mediated
Dynamic Injury Response Activates the Epicardium and is Critical for Cardiac Repair. Circulation 2010;
122:A541 (an official Journal of American Heart Association) [this paper has been awarded the 1st
prize in Ya-
Louis N. and Arnold M. Katz Basic Science Research Prize for Young Investigator Finalists, American Heart
Association Conference, USA held on Nov 14th
-16th
2010]
10. Biplab Giri, Labanyamoy Kole, Biochanin A, an isoflavone showed anti-proliferative and anti-inflammatory
activities through the inhibition of iNOS expression, p38 phosphorylation and blocking NFB activation, in the
International Conference on Integrative Physiology: Modern Perspective & Platinum Jubilee Celebration of
Physiological Society of India, held on Nov 12-14, 2009 at the Science City Convention Centre, Kolkata, India.
11. Biplab Giri and Antony Gomes, Antineoplastic molecule from the Indian toad (Bufo melanostictus, Schneider)
skin extract, presented (oral) in International Conference on Frontier Research in Integrative Physiology
(ICFRIP), held on Kolkata on 8th
to 10th
January, 2007.
12. Biplab Giri, Subir Chandra Dasgupta and Antony Gomes, Antioxidant and antineoplastic activity of Indian
toad (Bufo melanostictus, Schneider) skin factor, presented (oral) in the Young Scientist competitive session in
the International conference on “Free Radicals and Antioxidants in Health, Disease and Radiation” held in
Kolkata on 16th
to 18th
January 2006.
13. B Giri, S C Dasgupta and A Gomes, Antineoplastic factor(s) from Indian common toad (Bufo melanostictus,
Schneider) Skin extract, in the International conference held on and from 25th
to 26th
February, 2005 at the
Indian Institute of Chemical Biology (CSIR), Kolkata in collaboration with Jadavpur University, Kolkata &
Drug Information Association (USA).
National:
14. Soma Halder, Mrinmoy Sarkar, Supriya Palit, Biplab Giri*, “Protective effects of red-grape-juice on
exogenously induced heat-stress model of male Wister rats” presented (poster) and won first prize in UGC
sponsored National Conference organized by Uluberia College, Howrah on 21-22 December 2013.
15. Biplab Giri, Subhash Haldar, Subho Dasgupta, Aparna Gomes, Antony Gomes, A multi action protein toxin
Bengalin from Indian black scorpion (Heterometrous bengalensis) venom having anti-osteoporosis and
anti-cancer activity, presented (oral) in the 1st
National Conference on Animal, Microbial, Plant Toxins &
Snakebite Management, jointly organized by Indian Institute of Chemical Biology, Kolkata and KPC Medical
College & Hospital, Kolkata, held on Dec.11-12, 2010.
7. 16. Subhash Haldar, Biplab Giri, Antony Gomes, Anticancer potentials of Indian toad (Bufo melanostictus)
skin derived non-protein and protein toxins on leukemic, hepatocarcinoma and colon cancer cells,
presented (poster) in the 1st
National Conference on Animal, Microbial, Plant Toxins & Snakebite Management,
jointly organized by Indian Institute of Chemical Biology, Kolkata and KPC Medical College & Hospital,
Kolkata, held on Dec.11-12, 2010.
17. Sailender S. Kanwar, Yingjie Yu, Bhaumik B. Patel, Jianhua Du, Jyoti Nautiyal, Biplab Giri, Antony Gomes,
Adhip P. N. Majumdar, Colon cancer stem cells: implications in carcinogenesis and development of
therapeutic strategies, presented in invited lecture session of 1st
National Conference on Animal, Microbial,
Plant Toxins & Snakebite Management, jointly organized by Indian Institute of Chemical Biology, Kolkata and
KPC Medical College & Hospital, Kolkata, held on Dec.11-12, 2010.
[Nature India highlight ref.: doi:10.1038/nindia.2010.175; Published online 14 December 2010]
18. Giri B & Gomes A, Antineoplastic activity of Indian common toad (Bufo melanostictus, Schneider) skin
extract on EAC cell and human leukemic (HL60 & U937) cell line, in the 37th
annual conference of Indian
Pharmacology Society from 14th
to 16th
January 2005 held in Science City, Kolkata, India. (This Abstract
published in the supplementary of Indian Journal of Pharmacology, Vol 36, Dec 2004).
Research Project
1. “Experimental studies on the Interaction of Carbamate, Stress & Organophosphate”; DRDE, DRDO,
Govt. of India (2010-2012) [Co-PI]- completed [approx. grants- 9.5 Lac]
2. “Effects of Type-2 anti-diabetic drugs (Pioglitazone, Metformin and Sitagliptin) in Cancer: a
comparison at molecular level”; DST, Govt. of India (2012-2015) [PI]- running [grants- 23.8 Lac]
3. “Molecular response and role of heat shock proteins during heat stress induced deregulation of
testicular function”, UGC-RGNF (2013-2018)- running [approx. grants- 15 Lac]
4. “Molecular Analysis of Physiological alterations associated with Occupational Health Hazards and Risk
Factors during Heat Stress implicated with the circadian and ultradian system” (ICMR, Govt. of India;
Proposal ID: 2012-1927; Approved)- [PI]- 3 years project and not yet started. [approx. grants- 28 Lac]
5. Number of projects submitted for funding.
Research Experience (13 Years)
Postdoctoral research in the field of
April, 09-Till date Cancer Biology, Diabetes, EMT, Molecular Pharmacology &
Experimental Therapeutics. West Bengal State University, Kolkata.
2008-2009 “Biology of stem cells and mechanisms determining differentiation of adult
and embryonic stem cells with special emphasis on tissue regeneration” at
University of North Carolina, Chapel Hill, NC, USA.
2007-2008 “Radiation induced oxidative stress in NQO1 & NQO2 knockout mice with
special reference to leukemia & lymphoma” at Baylor College of Medicine,
Houston, TX /UMB, USA.
Feb, 07-March 07 SEBM, USA awarded research training (one month) at the Department of
Internal Medicine, Wayne State University, Detroit, Michigan, USA.
No. of M.S. students’ research project dissertation: 11 [9(Physiology students) and 2(Biochemistry students)
completed].
No. of Ph.D. students: 5 (4 Registered)
8. Predoctoral research in the field of
Jan, 2003 – Feb, 2007 (i) Cancer Biology (Molecular mechanism at the level of Cell Proliferation,
Apoptosis and Cell Signaling), Anticancer compound screening from Indian
toad (Bufo melanostictus) skin extract, snake venom, scorpion venom; its isolation
/ purification, characterization and mechanism of action.
Ph.D. Thesis entitled-“Studies on antineoplastic activities of the bioactive
molecule(s) from the skin of the Indian toad (Bufo melanostictus, Schneider)”
(ii) Osteoporosis & Osteoarthritis research in animal model; the isolation of
anti-osteoporosis factor(s) from scorpion venom.
(iii) Pharmacology –Toxicology & therapeutics of Venom & Toxins.
Department of Physiology, University of Calcutta, India
Teaching Experience (8 Years)
Post Graduate teaching in ‘Physiology’, Department of Physiology, West Bengal State University, Kolkata
(from 1st
April 2009 to till date).
Post Graduate teaching in ‘Stem cell Biology & Cloning’ to the Master Degree students of all Bioscience
Departments, West Bengal State University, Barasat, West Bengal (from 1st
April 2009 to 2012).
Post Graduate teaching in part of ‘Physiology & Nutrition’, Department of Food & Nutrition, West Bengal State
University, Kolkata (from 1st
April 2009 to 2012).
Post Graduate teaching in ‘Medical Biotechnology’ to the Master Degree students of the Department of
Biotechnology, Presidency College, Kolkata (from 2nd
Sept. 2010 to July 2011 as a Guest Professor).
Under Graduate Teaching in ‘Physiology’ to the B.Sc. Honors students of the Department of Physiology, Ananda
Mohan College, University of Calcutta, Kolkata (from 1st
Nov. 2002 to 31st
Dec. 2003 as part-time lecturer).
Training/Workshop/Orientation/Refresher/Methodology course:
1. UGC Orientation Course (28 Days), Organized by UGC Academic Staff College, University of Calcutta (2012).
2. UGC Refresher Course (22 Days), Organized by UGC Academic Staff College & Department of Zoology,
University of Calcutta (2013).
3. Microsoft Saksham IT Champion Training Course (one week), Organized by Department of Computer Science,
West Bengal State University (2015).
Administrative Experience:
1. Former Coordinator/Head, Department of Biochemistry, West Bengal State University (from 10.08.2012 to
31.11.2014).
2. Former Coordinator/Head, Department of Food & Nutrition, West Bengal State University (from Nov. 2012-
Sept. 2013).
3. Member, Post Graduate Board of Studies, Department of Physiology, West Bengal State University, India.
4. Former Member & Convener, UG Board of Studies in Physiology, West Bengal State University.
5. Former Convener, Post Graduate Board of Studies, Department of Biochemistry, West Bengal State University.
6. Former Convener, Post Graduate Board of Studies, Department of Food & Nutrition, West Bengal State
University.
7. Former Convener, UG Board of Studies in Food & Nutrition, West Bengal State University.
8. Former member, IQAC, West Bengal State University (from 07.02.2013 to till the starting of New IQAC on
Aug. 2014).
9. Coordinator/Head, Health Care Centre, West Bengal State University (2015-2017).
10. Member, BRS, Department of Physiology (from 2012 to 2014 & subsequently 2014 to 2018).
11. Member, PG Admission Committee, WBSU.
12. Member, University Pay Fixation Committee, WBSU.
13. Invitee Member, University 12b Committee, WBSU.