VM2M is a web-based application that combines virtual microscopy images and corresponding microarray data for cancer research, allowing researchers to search for tissue samples of interest and access both the whole slide images and microarray data for the same sample. The first version of VM2M was developed for a rhabdomyosarcoma study and currently contains 192 gene expression datasets linked to 146 tissue images. VIPER is an online pathology review system that provides pathologists from cancer groups with high-quality whole slide images, pathology reports, and review forms for pathology review of cases. The Biomedical Imaging Team develops digital pathology applications and provides services like pathology imaging, image analysis, and slide conferencing to customers.

1. VM2M
Biological Sciences: Cancer Microscopy & Microarray Database
Center for Childhood Cancer, Biopathology Center Imaging Core, The Research Institute at Nationwide Children’s Hospital &
Research Informatics Core, The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio
Virtual Microscopy to Microarray (VM2M) is a web-based application which combines vir-
tual microscopy images and corresponding microarray data for cancer research.
VM2M creates a web-based system where Virtual Microscopy data is made available along-
side microarray data for disease diagnosis and treatment allowing a researcher to search
for tissue samples of interest. The researcher can inspect the corresponding whole slide
image using a web based image viewer allowing the user to zoom and pan to the desired
parts of the image. The researcher will also have the ability to access the microarray data
that corresponds to the same tissue sample, along with results from an automated analysis
of the digital image. The first iteration of the VM2M application produced a flexible frame-
work that includes biology and molecular components for the COG IRSG (Rhabdomyosar-
coma) protocol. The VM2M application currently contains 192 cel files (expression data)
and 146 corresponding images.
VIPER
The VIPER (Virtual Imaging for Pathology, Education & Re-
search) is an online automated pathology review system that
provides expert pathologists from multiple cooperative cancer
groups with high quality whole-slide digital images, pathology
reports, and review forms necessary for pathology review.
Biomedical Imaging Team
The Biomedical Imaging Team is a multidisciplinary team consisting of healthcare and
informatics professionals working together to provide high quality digital images to
our customers.
Services provided include:
• Pathology Imaging • Image Analysis
• Automated Pathology Review Applications • Slide Conferencing
• Image Architecture Analysis & Development • Digitized Pathology Reports
• Online capture of pathology review data
http://imaging.nchresearch.org
Research Informatics Core
The Research Informatics Core is a multidisciplinary informatics application development
team dedicated to enhancing and expanding research through the scientific application of
information management and informatics innovation.
The Core is an award winning, service-oriented group which possesses the following capa-
bilities in these diverse areas:
• Custom computer application development • Database design and development
• Data and environment integration • Development of expert systems
• Development of data mining and reporting tools • Image analysis
• Systems Architecture • Informatics consulting
• Project management
http://informatics.nchresearch.org
Acknowledgements
• Children’s Oncology Group
• Gynecologic Oncology Group
• Ohio Supercomputer Center
• Aperio Technologies