The drugs included in the presentation are Methotrexate, Cyclosporine, Azathioprine, Cyclophosphamide, Mycophenolate mofetil and Intravenous Immunoglobulin.
It is useful mainly for dermatologists.
This ppt discusses what factors to keep in mind while choosing an appropriate antimicrobial agent . It also discusses briefly when antimicrobial prophylaxis is justified as well as failure of antimicrobial therapy.
The drugs included in the presentation are Methotrexate, Cyclosporine, Azathioprine, Cyclophosphamide, Mycophenolate mofetil and Intravenous Immunoglobulin.
It is useful mainly for dermatologists.
This ppt discusses what factors to keep in mind while choosing an appropriate antimicrobial agent . It also discusses briefly when antimicrobial prophylaxis is justified as well as failure of antimicrobial therapy.
Pentoxifylline Associated with Other Antioxidants (Multimodal Therapy) on Pat...science journals
We carried out a controlled study on 240 patients diagnosed with Peyronie's Disease (PD). We have divided two treatment groups, which differ from each other only for the association with PTX-penile injection.
To Evaluate the Role of Inj. Ketamine (0.3mg/Kg) Intravenously, Before Skin I...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Comparitive Study of the Efficacy and Tolerance of Prokinetic Drugs - Metaclo...pharmaindexing
Comparitive Study of the Efficacy and Tolerance of Prokinetic Drugs - Metaclopramide and Cinetapride In the Treatment of Functional Dyspepsia - A Randomised Controlled Trial
Presentation on Sarcoidosis by S.K Jindal | Jindal Chest Clinic, ChandigarhJindal Chest Clinic
When the immune system overreacts, granulomas are formed, leading to a condition known as sarcoidosis. This disorder can cause mild to severe symptoms, or no symptoms at all. This Presentation describes sarcoidosis and gives an overview on Sarcoidosis including causes, symptoms, diagnosis, complications, supplements for sacrcoidosis, and treatment strategies. For more information, please contact us: 9779030507.
• Recognize that the majority of reported penicillin allergies are
not confirmed upon testing and expose patients to undue
harm
• Understand when diagnostic testing, including skin testing, is
indicated to confirm an antimicrobial allergy
• Employ strategies to determine if cephalosporins can be used
in patients with reported penicillin allergies.
Prof. mridul Panditrao explains his ideas about the anaphylactic reactions in the peri-operative( pre, intra and post) period, how to diagnose them, treat them and also to prevent them.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
NVBDCP.pptx Nation vector borne disease control program
Effectiveness of TNF-α blockers and IL-12/IL-23 blockers in the treatment of Psoriasis. Preliminary observations.
1. Effectiveness of TNF-α blockers and
IL-12/IL-23 blockers in the treatment of
Psoriasis.
Preliminary observations.
Wojciech Francuzik, Kinga Byczkowska
Student working group
at The Clinic of Skin Diseases and Medical Mycology,
Poznań University of Medical Sciences.
Supervisor: Professor Zygmunt Adamski MD PhD
2. Biological Agents
● Used in dermatology, rheumatology and
gastroenterology
● Block pathways of inflammtion
pharmatching.com
3. Interleukin IL-12 in the pathogenesis of
psoriasis
Dendritic Cells
Macrophages
Keratinocytes
Mast cells
Granulocytes
Th0
Th1
NK
Other
cytokines
IgG
IL-12
4. Interleukin IL-23 in the pathogenesis of
psoriasis
Langerhans C
Macrophages
Keratinocytes
Th17
Th17
activ
e
Induce
s
CD8+
cytotoxicit
y
IL-23
5. TNF-α in the pathogenesis of psoriasis
Langerhans C
Macrophages
Keratinocytes
Mast cells
● Elevated concentration in changed skin
● Induces migration of macrophages
● Stimulates LC maturation
● Stimulates proinflammatory cytokines production
● Induces proliferation of keratinocytes
6. Structure of cytokines important in the
pathogenesis of psoriasis
Nature Reviews Immunology
TNF-α
Acts trough:
TNF-RI
TNF-RII
Current Protocols.com
7. The agents used in the treatment of
psoriasis
Infliximab Etanercept Adalimumab Ustekinumab
Chimeric
antibody
Human
antibody
Human
fusion protein
Human
antibody
TNF-α blockers
IL-12, IL-23
Blocker
p40 subunit
i.v. 5mg/kg
0-2-4-8 w
Than every 8 w
s.c. 50 mg
Every week
i.m. 40 mg
Every 2 weeks
s.c. 45mg
0-4-12 w
Than every 12 w
8. Aim of this study:
To verify which biologic agent (infliximab,
adalimumab, etanercept, ustekinumab) used in
the treatment of psoriasis is the most effective
in reducing skin changes.
9. Materials and methods:
51 psoriatic patients
Infliximab Etanercept Adalimumab Ustekinumab
15 12 11 13
PASI 0
(at day 0)
PASI 0
(at day 0)
PASI 0
(at day 0)
PASI 0
(at day 0)
After 4 weeks
of therapy
PASI 4 PASI 4 PASI 4 PASI 4
After 12 weeks
of therapy
PASI 12 PASI 12 PASI 12 PASI 12
10. ● Calculating a percentile PASI reduction after 4
weeks of therapy
● Calculating a percentile PASI reduction after 12
weeks of therapy
Materials and methods:
Pred4=
PASI 4
PASI 0
Pred12=
PASI 12
PASI 0
11. Results:
● There is a difference beetween means in the 4 agents
groups during fist 4 weeks of treatment
P=0.0196 (Kruskal-Wallis test)
I: infliximab, E: etanercept, A: adalimumab, U: ustekinumab
12. Results:
● There was a difference beeteween means of Pred4
between groups treated with etanercept and
adalimumab
P=0.0074 (Mann Whitney test)
Etanercept group mean = 51,42%
Adalimumab group mean = 72,00%
● There was a difference beeteween means of Pred4
between groups treated with etanercept and
infliximab P=0.0089 (Mann Whitney test)
Infliximab group mean = 73,07%
Etanercept group mean = 51,42%
13. Results:
● There was NO difference beeteween means of Pred4
inside each group considering common psoriasis and
psoriatic arthritis patients
● There was NO difference beeteween means of Pred4
inside each group considering patients with family
history of psoriasis and those without
● There was NO difference beeteween means of Pred12
between all groups
P=0.5238 (Kruskal-Wallis test)
14. Results:
● There was difference beeteween means of Pred4
between male and female patients in infliximab
group P=0,0077 (Mann Whitney test)
Im: infliximab in males, Ik: ifliximab in females
15. Results:
● There was difference beteween means of Pred4
between male patients in all groups.
● Significant difference was observed between
infliximab, etanercept and adalimumab groups.
I: infliximab, E: etanercept, A: adalimumab, U: ustekinumab, m for male patients
18. Conclusion
● The effectiveness of reducing PASI score was most
rapidly seen in infliximab group
● Etanercept group had longer response to therapy
time
● All agents were equally effective in reducing skin
changes during 12 weeks of treatment
● Male patients seamed to respond faster to Infliximab
than female patients.
● Male patients showed more varied response to
different agents than female patients
19. Thanks to:
● Professor Zygmunt Adamski MD PhD
● Staff of the Skin Disease Department of The
Regional Hospital in Poznań
Immunologia, Gołąb J, Jakóbisiak M, Lasek W (red.).
PWN Warszawa 2004
Tracey D, Klareskog L, Sasso EH et al. Tumor necrosis factor
antagonist mechanism of action: a comprehensive review.
Pharmacol Ther 2008; 117:224-79
Krueger JG. The immunologic basis for the treatment of psoriasis
with new biologic agents. J Am Acad Dermatol 2002; 25: 20-33
Liebwohl MG, Use of Etanercept in the dermatology setting.
Am J Acad Dermatol 2005; 6: 49-59