This document discusses the rise of high performance computing and big data, and how they are transforming science, engineering, and business. It outlines how computational power is enabling new insights from massive data sets across many industries in just seconds rather than days. This requires infrastructure like Intel Xeon Phi coprocessors for parallel processing big data, solid state storage to efficiently capture and store large data volumes, and high speed 10 Gigabit Ethernet networks to rapidly import and share big data across multiple locations for processing.