Autoimmune disease affects hundreds of millions of people worldwide, and its prevalence is increasing. There are 100+ known autoimmune disease types. Some of the more prevalent include type 1 diabetes, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and inflammatory bowel disease (IBD) For a patient with a history of chronic systemic inflammation and an antecedent, like an inflammatory diet or a psychological stressor could act as a trigger to precipitate autoimmune disease or disease flare-up.

1. The Link between Gut Health, Fasting, and
Autoimmune Diseases
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2. Prevalence and Types of Autoimmune Diseases
 Autoimmune disease affects hundreds of millions of people worldwide, and its
prevalence is increasing.
 There are 100+ known autoimmune disease types.
 Some of the more prevalent include type 1 diabetes, rheumatoid arthritis (RA),
systemic lupus erythematosus (SLE), and inflammatory bowel disease (IBD)
The Link between Gut Health, Fasting, and
Autoimmune Diseases
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3. Chronic Inflammation and Triggers
 For a patient with a history of chronic systemic inflammation
and an antecedent, like an inflammatory diet or a
psychological stressor could act as a trigger to precipitate
autoimmune disease or disease flare-up.
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4.  Genetic and environmental factors have long been understood to trigger
autoimmune disease.
 In 2000, a third element—intestinal permeability commonly known as leaky gut
which allows passage of antigens—macromolecules, toxins, food proteins, or
others—from the gut into the body: intestinal permeability was found, Zonulinis
the master regulator of intestinal permeability that opens the door to several
chronic inflammatory conditions.
 Zonulin is found in abundance in rheumatoid arthritis, systemic lupus
erythematosus, irritable bowel syndrome, and other autoimmune diseases
Using zonulin as a biomarker for leaky gut is linked to age-related inflammation
and frailty (decreased muscle strength).
 Pathogenic bacteria and gliadin are major triggers that cause the release of
zonulin. Lactobacillus rhamnosus GG inhibits gliadin from altering intestinal
permeability.
 This research contributes to a growing body of evidence showing the efficacy of
healthy bacteria in treating the chronic inflammation implicated in autoimmune
diseases.
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The Link between Intestinal Permeability and Autoimmune
Diseases

5.  Dysbiosis of gut microbiota has been closely linked to several
diseases, such as obesity, type 2 diabetes, hypertension, necrotizing
enterocolitis, and inflammatory bowel diseases.
 Healthy lifestyle factors, including a diversified diet, limited
consumption of processed and refined foods, and consumption of
adequate dietary fiber, may all promote a healthy microbiome.
 Foods and nutrients that potentially boost immune function also
tend to promote gut health.
 For example, consuming a diverse array of fruits and vegetables rich
in antioxidants, anti-inflammatory nutrients, and phytochemicals
may reduce oxidative stress, support the liver to promote efficient
biotransformation and detoxification, and boost overall immune
system function.
Gut Microbiome and Chronic
Diseases
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6.  Fasting is the fastest way to bring autoimmunity under control. After 72 hours of water-only fasting,
autophagy and apoptosis changed in a favorable direction.
 In addition, components of the innate immune system were boosted compared to baseline
measurements.
 Timed eating is another way to benefit the immune system. Timed eating is where you consume
three meals per day within an eight-hour time frame at 1 pm, 4 pm, and 8 pm.
 After 12 months of TRE, inflammatory markers (interleukin 6, interleukin 1-beta, and TNF-alpha)
were reduced, and both insulin sensitivity and lipid profiles were significantly improved compared
to controls.
 Intermittent fasting enhances beneficial gut bacteria and increases short-chain fatty acids that
promote healthy immune function. Please consult with your physician before engaging in any kind
of fasting routine as the extent of fasting and support during fasting should be personalized for
optimum outcome.
Strategies for Managing
Autoimmunity
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7. Thank You
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